Wnt signalling in stem cells and cancer

Stem cells, cancer, and cancer stem cells

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Lessons from hereditary colorectal cancer

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Identification of c- <i>MYC</i> as a Target of the APC Pathway

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A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells1

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Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

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A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells

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β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

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Osteoblastic cells regulate the haematopoietic stem cell niche

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Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma

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Identification of the haematopoietic stem cell niche and control of the niche size

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Wnt proteins are lipid-modified and can act as stem cell growth factors

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A role for Wnt signalling in self-renewal of haematopoietic stem cells

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Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

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The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

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Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

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Cytological Demonstration of the Clonal Nature of Spleen Colonies Derived from Transplanted Mouse Marrow Cells

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Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

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Caught up in a Wnt storm: Wnt signaling in cancer

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Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors

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Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

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The Hedgehog and Wnt signalling pathways in cancer

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A Second Canon

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β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin

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β-Catenin and TCF Mediate Cell Positioning in the Intestinal Epithelium by Controlling the Expression of EphB/EphrinB

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De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin

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Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

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BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt–β-catenin signaling

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Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.Preprint

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Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

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Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation

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The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

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Translating Stem and Progenitor Cell Biology to the Clinic: Barriers and Opportunities

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Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migrationPreprint

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Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance

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Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation

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Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

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Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1

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Intestinal stem cells protect their genome by selective segregation of template DNA strands

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A common human skin tumour is caused by activating mutations in β-catenin

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An HMG-box-containing T-cell factor required for thymocyte differentiation

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Regulation of LEF-1/TCF transcription factors by Wnt and other signals.

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Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skinPreprint

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Stem cells in gastrointestinal epithelium: numbers, characteristics and death

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SIGNALING PATHWAYS IN INTESTINAL DEVELOPMENT AND CANCER

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Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells

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Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating β-catenin/TCF signalling

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β-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system

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Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate.Preprint

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Wnt Signaling Regulates B Lymphocyte Proliferation through a LEF-1 Dependent Mechanism

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Clonal analysis of mouse intestinal epithelial progenitors

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Manipulation of stem cell proliferation and lineage commitment:visualisation of label-retaining cells in wholemounts of mouse epidermis

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The multifaceted Paneth cell

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Instructive Role of Wnt/ß-Catenin in Sensory Fate Specification in Neural Crest Stem Cells

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β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis

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Sporadic medulloblastomas contain oncogenic beta-catenin mutations.

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Gut instincts: thoughts on intestinal epithelial stem cells

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Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signaling

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A Role for the Wnt Gene Family in Hematopoiesis: Expansion of Multilineage Progenitor Cells

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Transient activation of β-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours

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Role of Members of the Wnt Gene Family in Human Hematopoiesis

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Redundant Regulation of T Cell Differentiation and TCRα Gene Expression by the Transcription Factors LEF-1 and TCF-1

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Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue

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Illegitimate WNT signaling promotes proliferation of multiple myeloma cells

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Translocation Products in Acute Myeloid Leukemia Activate the Wnt Signaling Pathway in Hematopoietic Cells

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Expression of ΔNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours

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The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells

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Development of the pattern of cell renewal in the crypt-villus unit of chimaeric mouse small intestine

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β-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion

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Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas.

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Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo

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A molecular profile of a hematopoietic stem cell niche

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EPITHELIAL CELL MIGRATION IN THE INTESTINE

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Designer skin: lineage commitment in postnatal epidermis

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Mesenteric lymph nodes are critical for the induction of high-dose oral tolerance in the absence of Peyer's patches

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The complement of desmosomal plaque proteins in different cell types.

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LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesisPreprint

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Deletion of β-catenin impairs T cell development

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Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia

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AXIN1 mutations but not deletions in cerebellar medulloblastomas

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Wnt proteins promote neuronal differentiation in neural stem cell culture

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WNT Signaling and Lymphocyte Development

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Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice

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Wnt Regulation of Progenitor Maturation in the Cortex Depends on Shh or Fibroblast Growth Factor 2

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Frizzled 9 knock-out mice have abnormal B-cell development

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Wnt Activates the Tak1/Nemo-like Kinase Pathway

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Wnt signaling in the stem cell niche

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WNT signaling modulates the diversification of hematopoietic cells

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Wnt Signaling Regulates Hemopoiesis Through Stromal Cells

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-Catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells

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Revisiting the Bulge

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