Structure of the Protein Phosphatase 2A Holoenzyme

Xu, Yanhui, Xing, Yongna, Chen, Yu, Chao, Yang, Lin, Zheng, Fan, Eugene, Yu, Jong W., Strack, Stefan, Jeffrey, Philip D., Shi, Yigong·2006·Cell

DOI 10.1016/j.cell.2006.11.033

Cited by (450)

Items 301–400 of 450

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Tautomycetin Synthetic Analogues: Selective Inhibitors of Protein Phosphatase I
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The Activators of Type 2A Phosphatases (PP2A) Regulate Multiple Cellular Processes Via PP2A-Dependent and -Independent Mechanisms in Fusarium graminearum
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PP2Acα-B′/PR61 Holoenzyme of Toxoplasma gondii Is Required for the Amylopectin Metabolism and Proliferation of Tachyzoites
Mingxiu Zhao, Yi Yang, Yue Shi, Xueqiu Chen, Yimin Yang, Lingtao Pan, Zhendong Du, Hongchao Sun, Chaoqun Yao, Guangxu Ma et al. · 2023 · Microbiology Spectrum
PME-1 sensitizes glioblastoma cells to oxidative stress-induced cell death by attenuating PP2A-B55α-mediated inactivation of MAPKAPK2-RIPK1 signaling
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Qifa Liu, L Yi, Sara Sadiq-Ali, Sherry M. Koontz, Adam Wood, Nannan Zhu, S H Jackson · 2012 · Cell Death and Disease
Loss of PP2A and PTEN immunoexpression coexists with survivin overexpression in adenomyosis
Hui Zhang, Jing Liu, Xingbo Ζhao, Bo-ran Liang, Zeqing Wen, Mingjiang Li · 2014 · Reproductive Biology
Suppressor mutations identify amino acids in PAA-1/PR65 that facilitate regulatory RSA-1/B″ subunit targeting of PP2A to centrosomes in C. elegans
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Overexpression of Heat Shock Protein 70 Improves Cardiac Remodeling and Survival in Protein Phosphatase 2A-Expressing Transgenic Mice with Chronic Heart Failure
Somy Yoon, Ulrich Gergs, Julie R. McMullen, Gwang Hyeon Eom · 2021 · Cells
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A Protein Phosphatase 2A-Based Assay to Detect Okadaic Acids and Microcystins
Tsuyoshi Ikehara, Naomasa Oshiro · 2024 · Journal of Marine Science and Engineering
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Shouichi Ohno, Yoko Naito, S Mukai, Norikazu Yabuta, Hiroshi Nojima · 2015 · Oncogene
Identification and functional analyses of polymorphism haplotypes of protein phosphatase 2A-Aα gene promoter
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Xiaoxu Chen, Yang Tang, Meng Yao Wu, Yanni Zhang, Kai Chen, Zhaocai Zhou, Ge‐Min Fang · 2021 · Organic Letters
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Hu Fu, Haili Ma, ChunBing Zheng, Jia Lu, Xiang-Qian Yu, Chi Li, Yun-Lei Peng, Gao-Peng Liao, Wen-Bin Liu, Ya Xiao et al. · 2009 · Science in China Series C Life Sciences
Exosomal microRNA-20b-5p contributes to cytarabine resistance in acute myeloid leukemia via the microtubule-associated serine/threonine kinase-like–phosphatidylinositol 3-kinase–protein kinase B signaling axis
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Quantum-based modeling implies that bidentate Arg89-substrate binding enhances serine/threonine protein phosphatase-2A(PPP2R5D/PPP2R1A/PPP2CA)-mediated dephosphorylation
E. Alan Salter, Andrzej Wierzbicki, Richard E. Honkanen, Mark R. Swingle · 2023 · Frontiers in Cell and Developmental Biology
Structural characterization of methylation-independent PP2A assembly guides alphafold2Multimer prediction of family-wide PP2A complexes
Franziska Wachter, Radosław P. Nowak, Scott B. Ficarro, Jarrod A. Marto, Eric S. Fischer · 2024 · Journal of Biological Chemistry
Cytokinetic abscission in Toxoplasma gondii is governed by protein phosphatase 2A and the daughter cell scaffold complex
Jean‐Baptiste Marq, Margaux Gosetto, Aline Altenried, Oscar Vadas, Bohumil Maco, Nicolas Dos Santos Pacheco, Nicolò Tosetti, Dominique Soldati‐Favre, Gaëlle Lentini · 2024 · The EMBO Journal
Molecular cloning, expression and functional analysis of three subunits of protein phosphatase 2A (PP2A) from black tiger shrimps (Penaeus monodon)
Chao Zhao, Yan Wang, Mingjun Fu, Keng Yang, Lihua Qiu · 2016 · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology
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Anne‐Marie Labandera, R. Glen Uhrig, Keaton Colville, Greg B. G. Moorhead, Kenneth Kai-Sing Ng · 2018 · Science Signaling
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Xudong Ma, Yanfang Gu, Chanjuan Liang · 2022 · Environmental Science and Pollution Research
Identification of protein phosphatase interacting proteins from normal and UVA-irradiated HaCaT cell lysates by surface plasmon resonance based binding technique using biotin–microcystin-LR as phosphatase capturing molecule
Bálint Bécsi, Dóra Dedinszki, Gyöngyi Gyémánt, Csaba Máthé, Gábor Vasas, Beáta Lontay, Ferenc Erdődi · 2014 · Journal of Photochemistry and Photobiology B Biology
Inhibition of PP2A Activity Confers a TRAIL-Sensitive Phenotype during Malignant Transformation
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Satoko Komatsu‐Hirota, Keisuke Tabata, Yu‐shin Sou, Soichiro Kakuta, Jun-Ichi Sakamaki, Hikaru Tsuchiya, Jiachen Li, Hiroyuki Kumeta, Yuji Sakai, Yūko Fujioka et al. · 2026 · The EMBO Journal
Plant PP2A: A Versatile Enzyme with Key Physiological Functions
Juan I. Cortelezzi, Martina Zubillaga, Victoria R. Scardino, María Noelia Muñiz García, Daniela Andrea Capiati · 2025 · Kinases and Phosphatases
The PP2A phosphatase counteracts the function of the 9-1-1 axis in checkpoint activation
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Microcystins can be extracted from Microcystis aeruginosa using amino acid-derived biosurfactants
Tatiani B. Lima, Maria Estela Silva‐Stenico, Marli Fátima Fiore, Augusto Etchegaray · 2021 · Environmental Science and Pollution Research
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Dariia O. Samofalova, Pavel A. Karpov, A. Yu. Nuporko, Ya. B. Blume · 2011 · Cytology and Genetics
A PP2A active site mutant impedes growth and causes misregulation of native catalytic subunit expression
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A Nonsynonymous/Synonymous Substitution Analysis of the B56 Gene Family Aids in Understanding B56 Isoform Diversity
Osama Qureshi, Hyuk Cho, Madhusudan Choudhary, Joni M. Seeling · 2015 · PLoS ONE
Sodium butyrate ameliorates renal tubular lipid accumulation through a protein phosphatase 2A/transcription factor EB axis in diabetic nephropathy
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Protein phosphatase 2A B’α and B’β promote pollen wall construction partially through BRASSINAZOLE-RESISTANT 1-activated cysteine protease gene CEP1 in Arabidopsis
Yingjie Gao, Y. L. Zhang, Wenhui Wang, Ammara Latif, Yue-Tian Wang, Wenqiang Tang, Cui‐Xia Pu, Ying Sun · 2025 · Journal of Experimental Botany
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Molecular Cloning of the Genes Encoding the PR55/Bβ/δ Regulatory Subunits for PP-2A and Analysis of Their Functions in Regulating Development of Goldfish, Carassius auratus
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NEURONAL FUNCTIONS OF PROTEIN PHOSPHATASE 2A
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Down-regulation of miR-138-5p in PP2A KO mice promoted apoptosis of spermatocytes
Danni Wang, Xing Liu, Bingyan Chen, Yuwei Shang, Ting Wan, Shu Zhang, Huijun Liu, Yichao Shi, Xia Chen, Huiting Sun · 2024 · Molecular Biology Reports
The effect of deleting residue C269 in the β12–β13 loop of protein phosphatase 2A (PP2A)catalytic subunit on the interaction between PP2A and metal ions, especially Mn2+
Hui Li, Chao Liu, Hao Zhang, Qun Wei · 2011 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
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MdPP2AC interacting with MdCLC to mediate ALA-induced salt tolerance in apple
Kun Xiang, Jiayi Zhou, Jianting Zhang, Mohsin Iqbal, Liangju Wang · 2026 · Plant Physiology and Biochemistry
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John Jacob, Shahid Mehdi Nimjee, J. Bradley Elder, Arnab Chakravarti, Kamalakannan Palanichamy · 2026 · Cancer Letters
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Paul Borodin, Валентина Николаевна Карнаух · 2017 · Amur Medical Journal
The PP2A/4/6 subfamily of phosphoprotein phosphatases regulates DAF-16 and confers resistance to environmental stress in postreproductive adult C. elegans
Rebecca S. Rivard, Julia M. Morris, Matthew J. Youngman · 2020 · PLoS ONE
A recurrent variant in PPP2R5C identified in individuals with macrocephaly, intellectual disability, and seizures
Alison M. Muir, Adi Reich, Fanggeng Zou, Deanna Alexis Carere, Sue Moyer Harasink, Lily H. Tran, Bobbi McGivern · 2024 · Human Genetics and Genomics Advances
Cryo-EM structures reveal the PP2A–B55α and Eya3 interaction that can be disrupted by a peptide inhibitor
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Jae‐Hee Jeong, Yi-Seul Kim, Catleya Rojviriya, Hyung Jong Jin, Sung-Chul Ha, Yeon‐Gil Kim · 2013 · International Journal of Biological Macromolecules
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Phosphorylation dynamics in a flg22-induced, heterotrimeric G-protein dependent signaling network in Arabidopsis thaliana reveals a candidate PP2A phosphatase involved in AtRGS1 trafficking
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Jinlong Wang, Hui Li, Wei Dong Sun, Jiuyu Wang, Xiaodong Fang, Xiaoqi Yang, Chao Liu, Gang Sheng, Wenbo Ma, Yanli Wang · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
CqPP2A inhibits white spot syndrome virus infection by up-regulating antimicrobial substances expression in red claw crayfish Cherax quadricarinatus
Rui-lin Gao, Ling-ke Liu, Guo Li-mei, Kejian Wang, Haipeng Liu · 2020 · Developmental & Comparative Immunology
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Parveen Kumar, Subbareddy Maddika · 2017 · Journal of the Indian Institute of Science
Hyperglycemia reduces PP2A subunit B expression in a middle cerebral artery occlusion animal model
Dong-Ju Park, Phil‐Ok Koh · 2017 · Journal of Veterinary Medical Science
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Matthew Aaron Booker, Alison DeLong · 2017 · Plant Signaling & Behavior
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Tineke Lauwaet, Frances D. Gillin · 2011 · Springer eBooks
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Amit Saraf · 2008
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Dachen Wang · 2010 · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
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Laura Bel Borja, Flavie Soubigou, Samuel J.P. Taylor, Conchita Fraguas Bringas, Jacqueline Budrewicz, Pablo Lara-González, Christopher G. Sorensen Turpin, Joshua N. Bembenek, Dhanya K. Cheerambathur, Federico Pelisch · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
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Alyson K. Freeman · 2010 · Digital Commons - University of South Florida (University of South Florida)
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