The DOI matches its Crossref record; 53 of the 54 references it cites were found in a registry or an index.
Structure of Full-Length HIV-1 CA: A Model for the Mature Capsid Lattice
Open accessAbstract
The capsids of mature retroviruses perform the essential function of organizing the viral genome for efficient replication. These capsids are modeled as fullerene structures composed of closed hexameric arrays of the viral CA protein, but a high-resolution structure of the lattice has remained elusive. A three-dimensional map of two-dimensional crystals of the R18L mutant of HIV-1 CA was derived by electron cryocrystallography. The docking of high-resolution domain structures into the map yielded the first unambiguous model for full-length HIV-1 CA. Three important protein-protein assembly interfaces are required for capsid formation. Each CA hexamer is composed of an inner ring of six N-terminal domains and an outer ring of C-terminal domains that form dimeric linkers connecting neighboring hexamers. Interactions between the two domains of CA further stabilize the hexamer and provide a structural explanation for the mechanism of action of known HIV-1 assembly inhibitors.
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“In HIV six CA-NTDs form a hexameric ring with a central 18 helix bundle formed by helices 1, 2, and 3, providing the main intrahexamer stability”
From Retrovirus maturation-an extraordinary structural transformation (2016) · cites this paper as [52]
Citations
Cites
Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy
Henderson, R. A., Baldwin, J. M., Ceska, T. A., Zemlin, F., Beckmann, E., & Downing, K. H. (1990) · Journal of Molecular Biology · doi:10.1016/s0022-2836(05)80271-2 · Cited by 2,982
Automated molecular microscopy: The new Leginon system
Suloway, C. J. M., Pulokas, J., Fellmann, D., Cheng, A., Guerra, F., Quispe, J. D., Stagg, S. M., Potter, C. S., & Carragher, B. O. (2005) · Journal of Structural Biology · doi:10.1016/j.jsb.2005.03.010 · Cited by 1,695
Self-citationCrowther, R. A., Henderson, R. A., & Smith, J. M. (1996) · Journal of Structural Biology · doi:10.1006/jsbi.1996.0003 · Cited by 716
Crystal Structure of Human Cyclophilin A Bound to the Amino-Terminal Domain of HIV-1 Capsid
Gamble, T. R., Vajdos, F. F., Yoo, S., Worthylake, D. K., Houseweart, M., Sundquist, W. I., & Hill, C. P. (1996) · Cell · doi:10.1016/s0092-8674(00)81823-1 · Cited by 706 · cited 2×
“…the HIV-1 CA NTD is shaped as an arrowhead, with seven a helices (numbered 1–7) and an amino-terminal b-hairpin (Berthet-Colominas et al., 1999; Gamble et al., 1996; Gitti et al., 1996), while the CTD is more globular, with a single-turn 3 10 -helix and four short a helices (numbered 8–11)…”
Henderson, R. A., Baldwin, J. M., Downing, K. H., Lepault, J., & Zemlin, F. (1986) · Ultramicroscopy · doi:10.1016/0304-3991(86)90203-2 · Cited by 677
Assembly and Analysis of Conical Models for the HIV-1 Core
Ganser, B. K., Li, S., Klishko, V. Y., Finch, J. T., & Sundquist, W. I. (1999) · Science · doi:10.1126/science.283.5398.80 · Cited by 671
Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein
Gamble, T. R., Yoo, S., Vajdos, F. F., von Schwedler, U. K., Worthylake, D. K., Wang, H., McCutcheon, J. P., Sundquist, W. I., & Hill, C. P. (1997) · Science · doi:10.1126/science.278.5339.849 · Cited by 598 · cited 11×
“…CA proteins have revealed an atomic resolution model for the hexamer formed by the NTD of N-tropic murine leukemia virus (Mortuza et al., 2004) and several possible models for the CTD dimer (Gamble et al., 1997; Ivanov et al., 2007; Jin et al., 1999; Ternois et al., 2005; Worthylake et al., 1999).”
InfluentialThe stoichiometry of Gag protein in HIV-1
Briggs, J. A. G., Simon, M. N., Gross, I., Kräusslich, H.-G., Fuller, S. D., Vogt, V. M., & Johnson, M. C. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb785 · Cited by 539
Situs: A Package for Docking Crystal Structures into Low-Resolution Maps from Electron Microscopy
Wriggers, W. R., Milligan, R. A., & McCammon, J. A. (1999) · Journal of Structural Biology · doi:10.1006/jsbi.1998.4080 · Cited by 521
Three-dimensional structure determination by electron microscopy of two-dimensional crystals
Amos, L., Henderson, R. A., & Unwin, P. N. T. (1982) · Progress in Biophysics and Molecular Biology · doi:10.1016/0079-6107(83)90017-2 · Cited by 509
Cited by
Sorted by citations
HIV-1 assembly, budding, and maturation
Sundquist, W. I., & Krausslich, H.-G. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006924 · Cited by 814
Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics
Zhao, G., Perilla, J. R., Yufenyuy, E. L., Meng, X., Chen, B., Ning, J., Ahn, J., Gronenborn, A. M., Schulten, K., Aiken, C., et al. (2013) · Nature · doi:10.1038/nature12162 · Cited by 801
X-Ray Structures of the Hexameric Building Block of the HIV Capsid
Pornillos, O., Ganser-Pornillos, B. K., Kelly, B. N., Hua, Y., Whitby, F. G., Stout, C. D., Sundquist, W. I., Hill, C. P., & Yeager, M. (2009) · Cell · doi:10.1016/j.cell.2009.04.063 · Cited by 523
Self-citationThe structural biology of HIV assembly
Ganser‐Pornillos, B. K., Yeager, M. J., & Sundquist, W. I. (2008) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2008.02.001 · Cited by 500
Self-citationHIV-1 capsid: the multifaceted key player in HIV-1 infection
Campbell, E. M., & Hope, T. J. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3503 · Cited by 430
Metadata
- Authors
- Ganser-Pornillos, B. K., Cheng, A., & Yeager, M.
- Affiliations
- Scripps Research Institute (US)
- Corresponding author
- Yeager, Mark
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 131
- Issue
- 1
- Pages
- 70-79
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2034606779
- Cited by
- 321
- References
- 54
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 8 · 2023: 3 · 2022: 7 · 2021: 16 · 2020: 18 · 2019: 15 · 2018: 6 · 2017: 19 · 2016: 11 · 2015: 23 · 2014: 16 · 2013: 28 · 2012: 26
- FWCI
- 10.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2116 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (R01GM066087)
- National Institute of Allergy and Infectious Diseases (T32AI07244, T32AI007244)
- National Center for Research Resources (P41 RR17573, P41RR017573)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Advanced Electron Microscopy Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
- Keywords
- HIV-1 capsid protein, capsid lattice, hexamer assembly, protein-protein interaction, N-terminal domain, C-terminal domain, viral capsid structure
- MeSH terms
- Capsid, Humans, Models, Molecular, HIV-1, Crystallography, X-Ray, Cryoelectron Microscopy, Protein Structure, Quaternary, Capsid Proteins
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