HIV-1 capsid: the multifaceted key player in HIV-1 infection
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In a mature, infectious HIV-1 virion, the viral genome is housed within a conical capsid core made from the viral capsid (CA) protein. The CA protein and the structure into which it assembles facilitate virtually every step of infection through a series of interactions with multiple host cell factors. This Review describes our understanding of the interactions between the viral capsid core and several cellular factors that enable efficient HIV-1 genome replication, timely core disassembly, nuclear import and the integration of the viral genome into the genome of the target cell. We then discuss how elucidating these interactions can reveal new targets for therapeutic interactions against HIV-1.
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The reverse transcription complex is actively transported to the chromosomal DNA, where integration may occur.
“This RTC is actively transported to the chromosomal DNA, where integration may occur [6–9].”
From Clinical use of lentiviral vectors (2018) · cites this paper as [7]
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- Authors
- Campbell, E. M., & Hope, T. J.
- Affiliations
- Loyola University Chicago (US)
- Northwestern University (US)
- Corresponding author
- Hope, Thomas J.
- Venue
- Nature Reviews Microbiology
- Published
- 2015-07-16
- Volume
- 13
- Issue
- 8
- Pages
- 471-483
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- PMC
- PMC4876022
- OpenAlex
- W1572583106
- Cited by
- 430
- References
- 136
- Citations by year
- 2026: 23 · 2025: 19 · 2024: 33 · 2023: 27 · 2022: 43 · 2021: 58 · 2020: 52 · 2019: 50 · 2018: 51 · 2017: 35 · 2016: 35 · 2015: 3 · 2013: 1
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Microbiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (P50GM082545)
- National Institute of Allergy and Infectious Diseases (R01AI093258, R01AI120956)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Keywords
- HIV-1 capsid, capsid protein, viral genome replication, nuclear import, viral integration, host-virus interaction, antiviral drug targets, HIV-1 infection
- MeSH terms
- Humans, Virus Replication, HIV-1, HIV Infections, Gene Expression Regulation, Viral, Genome, Viral, Capsid Proteins
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