Cited by 430HIV Research and TreatmentHIV/AIDS drug development and treatmentVirus-based gene therapy research

HIV-1 capsid: the multifaceted key player in HIV-1 infection

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Campbell, Edward M., Hope, Thomas J.·2015·Nature Reviews Microbiology

Abstract

In a mature, infectious HIV-1 virion, the viral genome is housed within a conical capsid core made from the viral capsid (CA) protein. The CA protein and the structure into which it assembles facilitate virtually every step of infection through a series of interactions with multiple host cell factors. This Review describes our understanding of the interactions between the viral capsid core and several cellular factors that enable efficient HIV-1 genome replication, timely core disassembly, nuclear import and the integration of the viral genome into the genome of the target cell. We then discuss how elucidating these interactions can reveal new targets for therapeutic interactions against HIV-1.

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  • The reverse transcription complex is actively transported to the chromosomal DNA, where integration may occur.

    “This RTC is actively transported to the chromosomal DNA, where integration may occur [6–9].”

    From Clinical use of lentiviral vectors (2018) · cites this paper as [7]

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  1. [24]Hulme AE Kelley Z Foley D Hope TJ Complementary assays reveal a low level of CA associated with nuclear HIV-1 viral complexes J Virol 2015 PMC4442523 25741002

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Authors
Campbell, E. M., & Hope, T. J.
Affiliations
  • Loyola University Chicago (US)
  • Northwestern University (US)
Corresponding author
Hope, Thomas J.
Venue
Nature Reviews Microbiology
Published
2015-07-16
Volume
13
Issue
8
Pages
471-483
ISSN
  • 1740-1526 (ISSN-L)
  • 1740-1534
OpenAlex
W1572583106
Cited by
430
References
136
Citations by year
2026: 23 · 2025: 19 · 2024: 33 · 2023: 27 · 2022: 43 · 2021: 58 · 2020: 52 · 2019: 50 · 2018: 51 · 2017: 35 · 2016: 35 · 2015: 3 · 2013: 1
FWCI
5.55
Type
journal article
Language
en
Open access
Locations
  • Nature Reviews Microbiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of General Medical Sciences (P50GM082545)
  • National Institute of Allergy and Infectious Diseases (R01AI093258, R01AI120956)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Keywords
HIV-1 capsid, capsid protein, viral genome replication, nuclear import, viral integration, host-virus interaction, antiviral drug targets, HIV-1 infection
MeSH terms
Humans, Virus Replication, HIV-1, HIV Infections, Gene Expression Regulation, Viral, Genome, Viral, Capsid Proteins

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