The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Erythrocyte Glut1 Triggers Dehydroascorbic Acid Uptake in Mammals Unable to Synthesize Vitamin C
Open accessAbstract
Of all cells, human erythrocytes express the highest level of the Glut1 glucose transporter. However, the regulation and function of Glut1 during erythropoiesis are not known. Here, we report that glucose transport actually decreases during human erythropoiesis despite a >3-log increase in Glut1 transcripts. In contrast, Glut1-mediated transport of L-dehydroascorbic acid (DHA), an oxidized form of ascorbic acid (AA), is dramatically enhanced. We identified stomatin, an integral erythrocyte membrane protein, as regulating the switch from glucose to DHA transport. Notably though, we found that erythrocyte Glut1 and associated DHA uptake are unique traits of humans and the few other mammals that have lost the ability to synthesize AA from glucose. Accordingly, we show that mice, a species capable of synthesizing AA, express Glut4 but not Glut1 in mature erythrocytes. Thus, erythrocyte-specific coexpression of Glut1 with stomatin constitutes a compensatory mechanism in mammals that are unable to synthesize vitamin C.
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“The major transport mechanism of ascorbate into the RBC is attributed to glucose transporter 1 (116, 130).”
From Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia (2017) · cites this paper as [130]
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Cites
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Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid
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The Ubiquitous Glucose Transporter GLUT-1 Is a Receptor for HTLV
Manel, N., Kim, F. J., Kinet, S., Taylor, N. N., Sitbon, M., & Battini, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00881-x · Cited by 486
Self-citationGlucose Transporter Isoforms GLUT1 and GLUT3 Transport Dehydroascorbic Acid
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Research works printed but not linked: 1
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Vitamin C: The known and the unknown and Goldilocks
Padayatty, S., & Levine, M. (2016) · Oral Diseases · doi:10.1111/odi.12446 · Cited by 753
Vitamin C function in the brain: Vital role of the ascorbate transporter SVCT2
Harrison, F. E., & May, J. M. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.12.018 · Cited by 661
Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality
Chan, D. A., Sutphin, P. D., Nguyen, P., Turcotte, S., Lai, E. W., Banh, A., Reynolds, G. E., Chi, J., Wu, J. J., Solow-Cordero, D. E., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002394 · Cited by 563
Red Blood Cell Function and Dysfunction: Redox Regulation, Nitric Oxide Metabolism, Anemia
Kuhn, V., Diederich, L., Keller, T. C. S., Kramer, C. M., Lückstädt, W., Panknin, C., Suvorava, T., Isakson, B. E., Kelm, M., & Cortese-Krott, M. M. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6954 · Cited by 469
Vitamin C: Update on physiology and pharmacology
Mandl, J., Szarka, A., & Bánhegyi, G. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00282.x · Cited by 451
Metadata
- Authors
- Montel-Hagen, A., Kinet, S., Manel, N., Mongellaz, C., Prohaska, R., Battini, J.-L., Delaunay, J., Sitbon, M., & Taylor, N.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Max Perutz Labs (AT)
- Inserm (FR)
- Corresponding author
- Taylor, Naomi
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 132
- Issue
- 6
- Pages
- 1039-1048
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2040716137
- Cited by
- 243
- References
- 57
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 12 · 2023: 8 · 2022: 14 · 2021: 10 · 2020: 13 · 2019: 13 · 2018: 12 · 2017: 16 · 2016: 15 · 2015: 13 · 2014: 20 · 2013: 17 · 2012: 17
- FWCI
- 17.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI059349)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Physiology (medical) › Erythrocyte Function and Pathophysiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- GLUT1, stomatin, erythropoiesis, scurvy, vitamin C, GLUT4, glucose transporter regulation
- MeSH terms
- Animals, Ascorbic Acid, Biological Transport, Cell Line, Dehydroascorbic Acid, Erythrocytes, Erythropoiesis, Humans, Mammals, Membrane Proteins, Transfection, 5' Untranslated Regions, Glucose Transporter Type 1, Glucose Transporter Type 4
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