Cited by 243Vitamin C and Antioxidants ResearchErythrocyte Function and PathophysiologyMetabolism, Diabetes, and Cancer

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Erythrocyte Glut1 Triggers Dehydroascorbic Acid Uptake in Mammals Unable to Synthesize Vitamin C

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Montel-Hagen, Amélie, Kinet, Sandrina, Manel, Nicolas, Mongellaz, Cédric, Prohaska, Rainer, Battini, Jean-Luc, Delaunay, Jean, Sitbon, Marc, Taylor, Naomi·2008·Cell

DOI 10.1016/j.cell.2008.01.042

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Abstract

Of all cells, human erythrocytes express the highest level of the Glut1 glucose transporter. However, the regulation and function of Glut1 during erythropoiesis are not known. Here, we report that glucose transport actually decreases during human erythropoiesis despite a >3-log increase in Glut1 transcripts. In contrast, Glut1-mediated transport of L-dehydroascorbic acid (DHA), an oxidized form of ascorbic acid (AA), is dramatically enhanced. We identified stomatin, an integral erythrocyte membrane protein, as regulating the switch from glucose to DHA transport. Notably though, we found that erythrocyte Glut1 and associated DHA uptake are unique traits of humans and the few other mammals that have lost the ability to synthesize AA from glucose. Accordingly, we show that mice, a species capable of synthesizing AA, express Glut4 but not Glut1 in mature erythrocytes. Thus, erythrocyte-specific coexpression of Glut1 with stomatin constitutes a compensatory mechanism in mammals that are unable to synthesize vitamin C.

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Authors: Montel-Hagen, A., Kinet, S., Manel, N., Mongellaz, C., Prohaska, R., Battini, J.-L., Delaunay, J., Sitbon, M., & Taylor, N.
Affiliations: Centre National de la Recherche Scientifique (FR)
Max Perutz Labs (AT)
Inserm (FR)
Corresponding author: Taylor, Naomi
ORCID: Kinet, Sandrina
Manel, Nicolas
Mongellaz, Cédric
Prohaska, Rainer
Battini, Jean-Luc
Delaunay, Jean
Sitbon, Marc
Taylor, Naomi
Venue: Cell
Publisher: Elsevier BV
Published: 2008-03
Volume: 132
Issue: 6
Pages: 1039-1048
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2008.01.042
OpenAlex: W2040716137
Cited by: 243
References: 57
Citations by year: 2026: 5 · 2025: 4 · 2024: 12 · 2023: 8 · 2022: 14 · 2021: 10 · 2020: 13 · 2019: 13 · 2018: 12 · 2017: 16 · 2016: 15 · 2015: 13 · 2014: 20 · 2013: 17 · 2012: 17
FWCI: 17.17
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1964 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R01AI059349)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
Health Sciences › Medicine › Physiology (medical) › Erythrocyte Function and Pathophysiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: GLUT1, stomatin, erythropoiesis, scurvy, vitamin C, GLUT4, glucose transporter regulation
MeSH terms: Animals, Ascorbic Acid, Biological Transport, Cell Line, Dehydroascorbic Acid, Erythrocytes, Erythropoiesis, Humans, Mammals, Membrane Proteins, Transfection, 5' Untranslated Regions, Glucose Transporter Type 1, Glucose Transporter Type 4

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Erythrocyte Glut1 Triggers Dehydroascorbic Acid Uptake in Mammals Unable to Synthesize Vitamin C

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