The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Structural Basis for Cargo Regulation of COPII Coat Assembly
Open accessAbstract
SUMMARY Using cryo-electron microscopy, we have solved the structure of a novel icosidodecahedral COPII coat involved in cargo export from the endoplasmic reticulum (ER) co-assembled from purified cargo adaptor Sec23–24 and Sec13–31 lattice forming complexes. The coat structure shows a tetrameric assembly of the Sec23–24 adaptor layer that is positioned beneath the vertices and edges of the Sec13–31 lattice. Fitting the known crystal structures of the COPII proteins into the density map reveals a flexible hinge region stemming from interactions between WD40 β-propeller domains present in Sec13 and Sec31 at the vertices. The structure shows that the hinge region can direct geometric cage expansion to accommodate a wide range of bulky cargo including procollagen and chylomicrons that are sensitive to adaptor function in inherited disease. The COPII coat structure leads us to propose a new mechanism by which cargo drives cage assembly and membrane curvature for budding from the ER.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
EMAN: Semiautomated Software for High-Resolution Single-Particle Reconstructions
Ludtke, S. J., Baldwin, P. R., & Chiu, W. (1999) · Journal of Structural Biology · doi:10.1006/jsbi.1999.4174 · Cited by 2,391
SPIDER and WEB: Processing and Visualization of Images in 3D Electron Microscopy and Related Fields
Frank, J., Radermacher, M., Penczek, P., Zhu, J., Li, Y., Ladjadj, M., & Leith, A. (1996) · Journal of Structural Biology · doi:10.1006/jsbi.1996.0030 · Cited by 2,027
Automated molecular microscopy: The new Leginon system
Suloway, C., Pulokas, J., Fellmann, D., Cheng, A., Guerra, F., Quispe, J., Stagg, S., Potter, C. S., & Carragher, B. (2005) · Journal of Structural Biology · doi:10.1016/j.jsb.2005.03.010 · Cited by 1,764
Self-citationCoat Proteins and Vesicle Budding
Schekman, R., & Orci, L. (1996) · Science · doi:10.1126/science.271.5255.1526 · Cited by 944
BI-DIRECTIONAL PROTEIN TRANSPORT BETWEEN THE ER AND GOLGI
Lee, M. C. S., Miller, E. A., Goldberg, J., Orci, L., & Schekman, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.105307 · Cited by 813
Matsuoka, K., Orci, L., Amherdt, M., Bednarek, S. Y., Hamamoto, S., Schekman, R., & Yeung, T. (1998) · Cell · doi:10.1016/s0092-8674(00)81577-9 · Cited by 630
Sar1p N-Terminal Helix Initiates Membrane Curvature and Completes the Fission of a COPII Vesicle
Lee, M. C. S., Orci, L., Hamamoto, S., Futai, E., Ravazzola, M., & Schekman, R. (2005) · Cell · doi:10.1016/j.cell.2005.07.025 · Cited by 512
Structure of the Sec23/24–Sar1 pre-budding complex of the COPII vesicle coat
Bi, X., Corpina, R. A., & Goldberg, J. (2002) · Nature · doi:10.1038/nature01040 · Cited by 461
Requirement for a GTPase-Activating Protein in Vesicle Budding from the Endoplasmic Reticulum
Yoshihisa, T., Barlowe, C., & Schekman, R. (1993) · Science · doi:10.1126/science.8451644 · Cited by 384
Structure of the Sec13/31 COPII coat cage
Stagg, S. M., Gürkan, C., Fowler, D. M., LaPointe, P., Foss, T. R., Potter, C. S., Carragher, B., & Balch, W. E. (2006) · Nature · doi:10.1038/nature04339 · Cited by 334
Self-citation
Cited by
Organization of the ER–Golgi interface for membrane traffic control
Brandizzi, F., & Barlowe, C. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3588 · Cited by 522
Chakraborty, S., & Newkome, G. R. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00030a · Cited by 375
Golgi Bypass: Skirting Around the Heart of Classical Secretion
Grieve, A. G., & Rabouille, C. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005298 · Cited by 357
Ubiquitin-dependent regulation of COPII coat size and function
Jin, L., Pahuja, K. B., Wickliffe, K. E., Gorur, A., Baumgärtel, C., Schekman, R., & Rape, M. (2012) · Nature · doi:10.1038/nature10822 · Cited by 330
Tethering Factors as Organizers of Intracellular Vesicular Traffic
Yu, I.-M., & Hughson, F. M. (2010) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113327 · Cited by 323
Metadata
- Authors
- Stagg, S. M., LaPointe, P., Razvi, A., Gürkan, C., Potter, C. S., Carragher, B., & Balch, W. E.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 134
- Issue
- 3
- Pages
- 474-484
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2004247840
- Cited by
- 274
- References
- 37
- FWCI
- 9.99
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Structural Basis for Cargo Regulation of COPII Coat Assembly. https://app.cochat.ai/papers/10.1016/j.cell.2008.06.024
- The paper
- Stagg, S. M., LaPointe, P., Razvi, A., Gürkan, C., Potter, C. S., Carragher, B., & Balch, W. E. (2008). Structural Basis for Cargo Regulation of COPII Coat Assembly. Cell. https://doi.org/10.1016/j.cell.2008.06.024
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
