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Cited by 295

The DOI matches its Crossref record.

HIV Envelope-CXCR4 Signaling Activates Cofilin to Overcome Cortical Actin Restriction in Resting CD4 T Cells

Open access
Yoder, Alyson, Yu, Dongyang, Dong, Li, Iyer, Subashini R., Xu, Xuehua, Kelly, Jeremy, Liu, Juan, Wang, Weifeng, Vorster, Paul J., Agulto, Liane, Stephany, David A., Cooper, James N., Marsh, Jon W., Wu, Yuntao·2008·Cell
DOI 10.1016/j.cell.2008.06.036
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Abstract

SUMMARY Binding of the HIV envelope to the chemokine coreceptors triggers membrane fusion and signal transduction. The fusion process has been well characterized, yet the role of coreceptor signaling remains elusive. Here we describe a critical function of the chemokine coreceptor signaling in facilitating HIV infection of resting CD4 T cells. We find that static cortical actin in resting T cells represents a restriction, and HIV utilizes the Gαi-dependent signaling from the chemokine coreceptor CXCR4 to activate a cellular actin depolymerizing factor, cofilin, to overcome this restriction. HIV envelope-mediated cofilin activation and actin dynamics are important for a post entry process that leads to viral nuclear localization. Inhibition of HIV-mediated actin rearrangement markedly diminishes viral latent infection of resting T cells. Conversely, induction of active cofilin greatly facilitates it. These findings shed new light on viral exploitation of cellular machinery in resting T cells, where chemokine receptor signaling becomes obligatory.

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Authors
Yoder, A., Yu, D., Dong, L., Iyer, S. R., Xu, X., Kelly, J., Liu, J., Wang, W., Vorster, P. J., Agulto, L., Stephany, D. A., Cooper, J. N., Marsh, J. W., & Wu, Y.
Venue
Cell
Publisher
Elsevier BV
Published
2008-09
Volume
134
Issue
5
Pages
782-792
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2008.06.036
OpenAlex
W2041982728
Cited by
295
References
0
FWCI
8.60
Type
journal article
Language
en
Open access
bronze

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