HIV: Cell Binding and Entry

Wilen, C. B.; Tilton, J. C.; Doms, R. W.

doi:10.1101/cshperspect.a006866

Cited by 658HIV Research and TreatmentHIV/AIDS drug development and treatmentT-cell and Retrovirus Studies

HIV: Cell Binding and Entry

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Wilen, C. B., Tilton, J. C., Doms, R. W.·2012·Cold Spring Harbor Perspectives in Medicine

DOI 10.1101/cshperspect.a006866PMC PMC3405824

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Abstract

The first step of the human immunodeficiency virus (HIV) replication cycle-binding and entry into the host cell-plays a major role in determining viral tropism and the ability of HIV to degrade the human immune system. HIV uses a complex series of steps to deliver its genome into the host cell cytoplasm while simultaneously evading the host immune response. To infect cells, the HIV protein envelope (Env) binds to the primary cellular receptor CD4 and then to a cellular coreceptor. This sequential binding triggers fusion of the viral and host cell membranes, initiating infection. Revealing the mechanism of HIV entry has profound implications for viral tropism, transmission, pathogenesis, and therapeutic intervention. Here, we provide an overview into the mechanism of HIV entry, provide historical context to key discoveries, discuss recent advances, and speculate on future directions in the field.

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HIV is only capable of infecting CD4+ T cells.
“As HIV is only capable of infecting CD4+ T cells (Wilen et al, 2012), it is possible that the virus directly induces VIS in these cells.”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Wilen et al, 2012

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HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor
Feng, Y. Y., Broder, C. C., Kennedy, P. E., & Berger, E. A. (1996) · Science · doi:10.1126/science.272.5263.872 · Cited by 4,169 · see citing works
Identification of a major co-receptor for primary isolates of HIV-1
Deng, H., Liu, R., Ellmeier, W., Choe, S. S., Unutmaz, D., Burkhart, M. D., Marzio, P. D., Marmon, S., Sutton, R. E., Hill, C. M., et al. (1996) · Nature · doi:10.1038/381661a0 · Cited by 3,640 · see citing works
HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
Dragic, T., Litwin, V., Allaway, G. P., Martin, S. R., Huang, Y., Nagashima, K. A., Cayanan, C. S., Maddon, P. J., Koup, R. A., Moore, J. P., et al. (1996) · Nature · doi:10.1038/381667a0 · Cited by 3,173 · see citing works
Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection
Liu, R., Paxton, W. A., Choe, S., Ceradini, D., Martin, S. R., Horuk, R., MacDonald, M. E., Stuhlmann, H., Koup, R. A., & Landau, N. R. (1996) · Cell · doi:10.1016/s0092-8674(00)80110-5 · Cited by 3,074 · see citing works
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
Kwong, P. D., Wyatt, R. T., Robinson, J. E., Sweet, R. W., Sodroski, J., & Hendrickson, W. A. (1998) · Nature · doi:10.1038/31405 · Cited by 2,963 · see citing works
Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
Samson, M., Libert, F., Doranz, B. J., Rucker, J. B., Liesnard, C., Farber, C., Saragosti, S., Lapouméroulie, C., Cognaux, J., Forceille, C., et al. (1996) · Nature · doi:10.1038/382722a0 · Cited by 2,885 · see citing works
Self-citation
Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8 + T Cells
Cocchi, F., DeVico, A. L., Demo, A. G., Arya, S. K., Gallo, R. C., & Lusso, P. (1995) · Science · doi:10.1126/science.270.5243.1811 · Cited by 2,867 · see citing works
Pneumocystis cariniiPneumonia and Mucosal Candidiasis in Previously Healthy Homosexual Men
Gottlieb, M. S., Schroff, R. W., Schanker, H. M., Weisman, J. D., Fan, P. T., Wolf, R. A., & Saxon, A. (1981) · New England Journal of Medicine · doi:10.1056/nejm198112103052401 · Cited by 2,723 · see citing works
CC CKR5: A RANTES, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1
Alkhatib, G., Combadière, C., Broder, C. C., Feng, Y., Kennedy, P. E., Murphy, P. M., & Berger, E. A. (1996) · Science · doi:10.1126/science.272.5270.1955 · Cited by 2,703 · see citing works
Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene
Dean, M. C., Carrington, M. N., Winkler, C. A., Huttley, G. A., Smith, M. W., Allikmets, R. L., Goedert, J. J., Buchbinder, S., Vittinghoff, E., Gomperts, E. D., et al. (1996) · Science · doi:10.1126/science.273.5283.1856 · Cited by 2,499 · see citing works
DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells
Geijtenbeek, T. B. H., Kwon, D. S., Torensma, R., van Vliet, S. J., van Duijnhoven, G. C. F., Middel, J., Cornelissen, I. L. M. H. A., Nottet, H. S. L. M., KewalRamani, V. N., Littman, D. R., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)80694-7 · Cited by 2,447 · see citing works
The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates
Choe, H., Farzan, M., Sun, Y., Sullivan, N. J., Rollins, B. J., Ponath, P. D., Wu, L., Mackay, C. R., LaRosa, G. J., Newman, W., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81313-6 · Cited by 2,286 · see citing works
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
Maddon, P. J., Dalgleish, A. G., McDougal, J. S., Clapham, P. R., Weiss, R. A., & Axel, R. (1986) · Cell · doi:10.1016/0092-8674(86)90590-8 · Cited by 2,003 · see citing works
Core Structure of gp41 from the HIV Envelope Glycoprotein
Chan, D. C., Fass, D., Berger, J. M., & Kim, P. S. (1997) · Cell · doi:10.1016/s0092-8674(00)80205-6 · Cited by 1,961 · see citing works
Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
Keele, B. F., Giorgi, E. E., Salazar-Gonzalez, J. F., Decker, J. M., Pham, K. T., Salazar, M. G., Sun, C., Grayson, T. B., Wang, S., Li, H., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802203105 · Cited by 1,913 · see citing works
A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the β-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion Cofactors
Doranz, B. J., Rucker, J. B., Yi, Y., Smyth, R. J., Samson, M., Peiper, S. C., Parmentier, M., Collman, R. G., & Doms, R. W. (1996) · Cell · doi:10.1016/s0092-8674(00)81314-8 · Cited by 1,833 · see citing works
Self-citation
Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists
Wu, B., Chien, E. Y. T., Mol, C. D., Fenalti, G., Liu, W., Katritch, V., Abagyan, R. A., Brooun, A., Wells, P. G., Bi, F. C., et al. (2010) · Science · doi:10.1126/science.1194396 · Cited by 1,785 · see citing works
Atomic structure of the ectodomain from HIV-1 gp41
Weissenhorn, W., Dessen, A., Harrison, S. C., Skehel, J. J., & Wiley, D. C. (1997) · Nature · doi:10.1038/387426a0 · Cited by 1,625 · see citing works
The role of a mutant CCR5 allele in HIV–1 transmission and disease progression
Huang, Y., Paxton, W. A., Wolinsky, S. M., Neumann, A. U., Zhang, L., Tian, H., Kang, S., Ceradini, D. J., Jin, Z., Yazdanbakhsh, K., et al. (1996) · Nature Medicine · doi:10.1038/nm1196-1240 · Cited by 1,359 · see citing works
Change in Coreceptor Use Correlates with Disease Progression in HIV-1–Infected Individuals
Connor, R. I., Sheridan, K. E., Ceradini, D. J., Choe, S. S., & Landau, N. R. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.4.621 · Cited by 1,356 · see citing works
Virus Entry: Open Sesame
Marsh, M., & Helenius, A. (2006) · Cell · doi:10.1016/j.cell.2006.02.007 · Cited by 1,186 · see citing works
Maraviroc (UK-427,857), a Potent, Orally Bioavailable, and Selective Small-Molecule Inhibitor of Chemokine Receptor CCR5 with Broad-Spectrum Anti-Human Immunodeficiency Virus Type 1 Activity
Dorr, P. K., Westby, M., Dobbs, S., Griffin, P., Irvine, B., Macartney, M. J., Mori, J., Rickett, G., Smith‐Burchnell, C., Napier, C. M., et al. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.11.4721-4732.2005 · Cited by 1,154 · see citing works
Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population
Schuitemaker, H., KOOT, M., Kootstra, N. A., Dercksen, M. W., de Goede, R. E. Y., van Steenwijk, R. P., Lange, J. M. A., Schattenkerk, J. K. M. E., Miedema, F. F., & Tersmette, M. (1992) · Journal of Virology · doi:10.1128/jvi.66.3.1354-1360.1992 · Cited by 1,031 · see citing works
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases
Perez, E. E., Wang, J., Miller, J. C., Jouvenot, Y., Kim, K. A., Liu, O., Wang, N., Lee, G., Bartsevich, V. V., Lee, Y.-L., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1410 · Cited by 999 · see citing works
Binding of HTLV-III/LAV to T4 + T Cells by a Complex of the 110K Viral Protein and the T4 Molecule
McDougal, J. S., Kennedy, M. S., Sligh, J. M., Cort, S. P., Mawle, A. C., & Nicholson, J. K. A. (1986) · Science · doi:10.1126/science.3001934 · Cited by 989 · see citing works
The Immunological Synapse
Bromley, S. K., Burack, R., Johnson, K. G., Somersalo, K., Sims, T. N., Sumen, C., Davis, M. M., Shaw, A. S., Allen, P. M., & Dustin, M. L. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.375 · Cited by 979 · see citing works
Selective Tropism of Lymphadenopathy Associated Virus (LAV) for Helper-Inducer T Lymphocytes
Klatzmann, D., Barré‐Sinoussi, F., Nugeyre, M.-T., Danguet, C., VILMER, E., Griscelli, C., Brun‐Vézinet, F., Rouzioux, C., Gluckman, J. C., Chermann, J., et al. (1984) · Science · doi:10.1126/science.6328660 · Cited by 969 · see citing works
Enfuvirtide, an HIV-1 Fusion Inhibitor, for Drug-Resistant HIV Infection in North and South America
Lalezari, J. P., Henry, K., O’Hearn, M., Montaner, J. S. G., Piliero, P. J., Trottier, B., Walmsley, S. L., Cohen, C. J., Kuritzkes, D. R., Eron, J. J., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035026 · Cited by 915 · see citing works
A new classification for HIV-1
Berger, E. A., Doms, R. W., Fenyö, E. M., Korber, B., Littman, D. R., Moore, J. P., Sattentau, Q. J., Schuitemaker, H., Sodroski, J., & Weiss, R. A. (1998) · Nature · doi:10.1038/34571 · Cited by 825 · see citing works
Self-citation
Spread of HTLV-I Between Lymphocytes by Virus-Induced Polarization of the Cytoskeleton
Igakura, T., Stinchcombe, J. C., Goon, P. K. C., Taylor, G. P., Weber, J. N., Griffiths, G. M., Tanaka, Y., Osame, M., & Bangham, C. R. M. (2003) · Science · doi:10.1126/science.1080115 · Cited by 755 · see citing works
Structure of a V3-Containing HIV-1 gp120 Core
Huang, C.-C., Tang, M., Zhang, M.-Y., Majeed, S., Montabana, E. A., Stanfield, R. L., Dimitrov, D. S., Korber, B., Sodroski, J., Wilson, I. A., et al. (2005) · Science · doi:10.1126/science.1118398 · Cited by 731 · see citing works
Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease
Hernandez, P. A., Gorlin, R. J., Lukens, J. N., Taniuchi, S., Bohinjec, J., Francois, F., Klotman, M. E., & Diaz, G. A. (2003) · Nature Genetics · doi:10.1038/ng1149 · Cited by 722 · cited 2× · see citing works
“Although the implications of CXCR4 dimerization remain unclear for HIV infection, it may explain the dominant phenotype of a carboxyterminal CXCR4 human mutation that results in WHIM syndrome, which is characterized by warts, hypogammaglobulinemia, infections, and myelokathexis (retention of neutrophils in the bone ma…”
Background
Recruitment of HIV and Its Receptors to Dendritic Cell-T Cell Junctions
McDonald, D., Wu, L., Bohks, S. M., KewalRamani, V. N., Unutmaz, D., & Hope, T. J. (2003) · Science · doi:10.1126/science.1084238 · Cited by 707 · see citing works
HIV Enters Cells via Endocytosis and Dynamin-Dependent Fusion with Endosomes
Miyauchi, K., Kim, Y., Latinovic, O., Va, M., & Melikyan, G. B. (2009) · Cell · doi:10.1016/j.cell.2009.02.046 · Cited by 682 · see citing works
Efficacy of Enfuvirtide in Patients Infected with Drug-Resistant HIV-1 in Europe and Australia
Lazzarin, A., Clotet, B., Cooper, D. A., Reynes, J., Arastéh, K., Nelson, M. R., Katlama, C., Stellbrink, H.-J., Delfraissy, J., Lange, J. M. A., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035211 · Cited by 654 · see citing works
Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates
Tersmette, M., Gruters, R. A., de Wolf, F., de Goede, R. E. Y., Lange, J. M. A., Schellekens, P. T. A., Goudsmit, J., Huisman, H. G., & Miedema, F. F. (1989) · Journal of Virology · doi:10.1128/jvi.63.5.2118-2125.1989 · Cited by 636 · see citing works
pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane
Stein, B. S., Gowda, S. D., Lifson, J. D., Penhallow, R. C., Bensch, K. G., & Engleman, E. G. (1987) · Cell · doi:10.1016/0092-8674(87)90542-3 · Cited by 627 · see citing works
Dendritic Cells Exposed to Human Immunodeficiency Virus Type-1 Transmit a Vigorous Cytopathic Infection to CD4 + T Cells
Cameron, P. U., Freudenthal, P. S., Barker, J., Gezelter, S., Inaba, K., & Steinman, R. M. (1992) · Science · doi:10.1126/science.1352913 · Cited by 621 · see citing works
HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells
Arthos, J. A., Cicala, C., Martinelli, E., Macleod, K., Ryk, D. V., Wei, D., Xiao, Z., Veenstra, T. D., Conrad, T., Lempicki, R. A., et al. (2008) · Nature Immunology · doi:10.1038/ni1566 · Cited by 580 · see citing works
Virus-Induced Abl and Fyn Kinase Signals Permit Coxsackievirus Entry through Epithelial Tight Junctions
Coyne, C. B., & Bergelson, J. M. (2006) · Cell · doi:10.1016/j.cell.2005.10.035 · Cited by 547 · see citing works
Structure of an unliganded simian immunodeficiency virus gp120 core
Chen, B., Vogan, E. M., Gong, H., Skehel, J. J., Wiley, D. C., & Harrison, S. C. (2005) · Nature · doi:10.1038/nature03327 · Cited by 520 · see citing works
Diversity of receptors binding HIV on dendritic cell subsets
Turville, S. G., Cameron, P. U., Handley, A. J., Lin, G. G.-H., Pöhlmann, S., Doms, R. W., & Cunningham, A. L. (2002) · Nature Immunology · doi:10.1038/ni841 · Cited by 515 · see citing works
Self-citation
The V3 domain of the HIV–1 gp120 envelope glycoprotein is critical for chemokine–mediated blockade of infection
Cocchi, F., DeVico, A. L., Demo, A. G., Cara, A., Gallo, R. C., & Lusso, P. (1996) · Nature Medicine · doi:10.1038/nm1196-1244 · Cited by 494 · see citing works
pH-Dependent Entry of Severe Acute Respiratory Syndrome Coronavirus Is Mediated by the Spike Glycoprotein and Enhanced by Dendritic Cell Transfer through DC-SIGN
Yang, Z., Huang, Y. M., Lakshmanan, G., Leung, K., Kong, W., Schwartz, O., Subbarao, K., & Nabel, G. J. (2004) · Journal of Virology · doi:10.1128/jvi.78.11.5642-5650.2004 · Cited by 488 · see citing works
Quantitative 3D Video Microscopy of HIV Transfer Across T Cell Virological Synapses
Hübner, W., McNerney, G. P., Chen, P., Dale, B. M., Gordon, R. E., Chuang, F. Y. S., Li, X.-D., Asmuth, D. M., Huser, T., & Chen, B. K. (2009) · Science · doi:10.1126/science.1167525 · Cited by 486 · see citing works
A synthetic peptide inhibitor of human immunodeficiency virus replication: correlation between solution structure and viral inhibition.
Wild, C. T., Oas, T. G., McDanal, C. B., Bolognesi, D. P., & Matthews, T. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10537 · Cited by 485 · see citing works
Inhibiting HIV-1 Entry
Eckert, D. M., Malashkevich, V. N., Hong, L. H., Carr, P. A., & Kim, P. S. (1999) · Cell · doi:10.1016/s0092-8674(00)80066-5 · Cited by 442 · see citing works
The CD4 antigen: Physiological ligand and HIV receptor
Sattentau, Q. J., & Weiss, R. A. (1988) · Cell · doi:10.1016/0092-8674(88)90397-2 · Cited by 416 · see citing works
A Synthetic Peptide from HIV-1 gp41 Is a Potent Inhibitor of Virus-Mediated Cell—Cell Fusion
Wild, C. T., Greenwell, T., & Matthews, T. J. (1993) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1993.9.1051 · Cited by 405 · see citing works
Actin- and myosin-driven movement of viruses along filopodia precedes their entry into cells
Lehmann, M. J., Sherer, N. M., Marks, C. B., Pypaert, M., & Mothes, W. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200503059 · Cited by 403 · see citing works
Structure-activity relationships of chemokines
Clark‐Lewis, I., Kim, K., Rajarathnam, K., Gong, J.-H., Dewald, B., Moser, B., Baggiolini, M., & Sykes, B. D. (1995) · Journal of Leukocyte Biology · doi:10.1002/jlb.57.5.703 · Cited by 361 · see citing works
Translational Suppression by Trinucleotide Repeat Expansion at <i>FMR1</i>
Feng, Y., Zhang, F., Lokey, L. K., Chastain, J. L., Lakkis, L., Eberhart, D., & Warren, S. T. (1995) · Science · doi:10.1126/science.7732383 · Cited by 358 · see citing works
HIV Envelope-CXCR4 Signaling Activates Cofilin to Overcome Cortical Actin Restriction in Resting CD4 T Cells
Yoder, A., Yu, D., Dong, L., Iyer, S. R., Xu, X., Kelly, J., Liu, J., Wang, W., Vorster, P. J., Agulto, L., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.036 · Cited by 297 · see citing works
Human immunodeficiency virus infection of CD4-bearing cells occurs by a pH-independent mechanism
McClure, M. O., Marsh, M., & Weiss, R. A. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02839.x · Cited by 295 · see citing works
V3: HIV's Switch-Hitter
Hartley, O., Klasse, P. J., Sattentau, Q. J., & Moore, J. P. (2005) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2005.21.171 · Cited by 290 · see citing works
The integrin α 4 β 7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1
Cicala, C., Martinelli, E., McNally, J. P., Goode, D. J., Gopaul, R., Hiatt, J. B., Jelicic, K., Kottilil, S., Macleod, K., O'Shea, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911796106 · Cited by 285 · see citing works
HIV-1 infection in a man homozygous for CCR5▵32
OʼBrien, T. R., Winkler, C. A., Dean, M. C., Nelson, J. A. E., Carrington, M. N., Michael, N. L., & White, G. (1997) · The Lancet · doi:10.1016/s0140-6736(97)24017-1 · Cited by 262 · see citing works
Syndecans Serve as Attachment Receptors for Human Immunodeficiency Virus Type 1 on Macrophages
Saphire, A. C. S., Bobardt, M. D., Zhang, Z., David, G., & Gallay, P. A. (2001) · Journal of Virology · doi:10.1128/jvi.75.19.9187-9200.2001 · Cited by 258 · see citing works
Potent D-peptide inhibitors of HIV-1 entry
Welch, B. D., VanDemark, A. P., Heroux, A., Hill, C. P., & Kay, M. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708109104 · Cited by 250 · see citing works
HIV-1 infection in an individual homozygous for CCR5▵32
Theodorou, L., Meyer, L., Magierowska, M., Katlama, C., & Rouzioux, C. (1997) · The Lancet · doi:10.1016/s0140-6736(05)62411-7 · Cited by 240 · see citing works
Selective transmission of CCR5-utilizing HIV-1: the 'gatekeeper' problem resolved?
Margolis, L. B., & Shattock, R. J. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1387 · Cited by 234 · see citing works
HIV infection does not require endocytosis of its receptor, CD4
Maddon, P. J., McDougal, J. S., Clapham, P. R., Dalgleish, A. G., Jamal, S., Weiss, R. A., & Axel, R. (1988) · Cell · doi:10.1016/s0092-8674(88)91241-x · Cited by 232 · see citing works
HIV-1 attachment: another look
Ugolini, S., Mondor, I., & Sattentau, Q. J. (1999) · Trends in Microbiology · doi:10.1016/s0966-842x(99)01474-2 · Cited by 229 · see citing works
Ligand-independent Dimerization of CXCR4, a Principal HIV-1 Coreceptor
Babcock, G. J., Farzan, M., & Sodroski, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210140200 · Cited by 221 · see citing works
T Cell Activation Antigen, CD26, as a Cofactor for Entry of HIV in CD4 + Cells
Callebaut, C., Krust, B., Jacotot, E. D., & Hovanessian, A. G. (1993) · Science · doi:10.1126/science.7903479 · Cited by 219 · see citing works
The interaction of HIV with dendritic cells: outcomes and pathways
Piguet, V., & Steinman, R. M. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.07.010 · Cited by 217 · see citing works
HIV-1 Coreceptor Activity of CCR5 and Its Inhibition by Chemokines: Independence from G Protein Signaling and Importance of Coreceptor Downmodulation
Alkhatib, G., Locati, M., Kennedy, P. E., Murphy, P. M., & Berger, E. A. (1997) · Virology · doi:10.1006/viro.1997.8673 · Cited by 210 · see citing works
Entry inhibitors in the treatment of HIV-1 infection
Tilton, J. C., & Doms, R. W. (2009) · Antiviral Research · doi:10.1016/j.antiviral.2009.07.022 · Cited by 208 · see citing works
Self-citation
ITAM-mediated Signaling by the T-Cell Antigen ReceptorPreprint
Love, P. E., & Hayes, S. M. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002485 · Cited by 197 · see citing works
Characterization of V3 Sequence Heterogeneity in Subtype C Human Immunodeficiency Virus Type 1 Isolates from Malawi: Underrepresentation of X4 Variants
Ping, L., Nelson, J. A. E., Hoffman, I., Schock, J., Lamers, S. L., Goodman, M., Vernazza, P., Kazembe, P. N., Maida, M., Zimba, D., et al. (1999) · Journal of Virology · doi:10.1128/jvi.73.8.6271-6281.1999 · Cited by 196 · see citing works
Common principles and intermediates of viral protein-mediated fusion: the HIV-1 paradigm
Melikyan, G. B. (2008) · Retrovirology · doi:10.1186/1742-4690-5-111 · Cited by 186 · see citing works
3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells
Felts, R. L., Narayan, K., Estes, J. D., Shi, D., Trubey, C. M., Fu, J., Hartnell, L. M., Ruthel, G. T., Schneider, D. K., Nagashima, K., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003040107 · Cited by 184 · see citing works
HIV-1 Entry and Macrophage Inflammatory Protein-1β-mediated Signaling Are Independent Functions of the Chemokine Receptor CCR5
Farzan, M., Choe, H., Martin, K. A., Sun, Y., Sidelko, M., Mackay, C. R., Gerard, N. P., Sodroski, J., & Gerard, C. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.11.6854 · Cited by 181 · see citing works
Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activity
Gosling, J., Monteclaro, F. S., Atchison, R. E., Arai, H., Tsou, C.-L., Goldsmith, M. A., & Charo, I. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5061 · Cited by 174 · see citing works
Coreceptor Tropism in Human Immunodeficiency Virus Type 1 Subtype D: High Prevalence of CXCR4 Tropism and Heterogeneous Composition of Viral Populations
Huang, W., Eshleman, S. H., Toma, J., Fransen, S., Stawiski, E. W., Paxinos, E. E., Whitcomb, J. M., Young, A., Donnell, D. J., Mmiro, F. A., et al. (2007) · Journal of Virology · doi:10.1128/jvi.00218-07 · Cited by 172 · see citing works
Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the Protean Effects of “Selective” Antagonists
Sohy, D., Yano, H., de Nadaı̈, P., Urizar, E., Guillabert, A., Javitch, J. A., Parmentier, M., & Springael, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.054809 · Cited by 163 · see citing works
Design of a Potent d -Peptide HIV-1 Entry Inhibitor with a Strong Barrier to Resistance
Welch, B. D., Francis, J. N., Redman, J. S., Paul, S., Weinstock, M. T., Reeves, J. D., Lie, Y., Whitby, F. G., Eckert, D. M., Hill, C. P., et al. (2010) · Journal of Virology · doi:10.1128/jvi.01339-10 · Cited by 159 · see citing works
Allosteric Transinhibition by Specific Antagonists in CCR2/CXCR4 Heterodimers
Sohy, D., Parmentier, M., & Springael, J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705302200 · Cited by 150 · see citing works
Chemokine Coreceptor Signaling in HIV-1 Infection and Pathogenesis
Wu, Y., & Yoder, A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000520 · Cited by 145 · see citing works
Pneumocystis Carinii Pneumonia and Mucosal Candidiasis in Previously Healthy Homosexual Men. Evidence of a New Acquired Cellular Immunodeficiency
Gottlieb, M. S., Schroff, R. W., Schanker, H. M., Weisman, J. D., Fan, P. T., Wolf, R., & Saxon, A. (1982) · The Journal of Urology · doi:10.1016/s0022-5347(17)52990-0 · Cited by 144 · see citing works
Absence of Coreceptor Switch with Disease Progression in Human Immunodeficiency Virus Infections in India
Cecilia, D., Kulkarni, S., Tripathy, S. P., Gangakhedkar, R., Paranjape, R., & Gadkari, D. A. (2000) · Virology · doi:10.1006/viro.2000.0297 · Cited by 143 · see citing works
Homozygous Δ32 deletion of the CCR-5 chemokine receptor gene in an HIV-1-infected patient
Balotta, C., Bagnarelli, P., Violin, M., Ridolfo, A. L., Zhou, D., Berlusconi, A., Corvasce, S., Corbellino, M., Clementi, M., Clerici, M., et al. (1997) · AIDS · doi:10.1097/00002030-199710000-00001 · Cited by 123 · see citing works
Role of Abl Kinase and the Wave2 Signaling Complex in HIV-1 Entry at a Post-Hemifusion Step
Harmon, B., Campbell, N., & Ratner, L. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000956 · Cited by 112 · see citing works
The Maturation of Dendritic Cells Results in Postintegration Inhibition of HIV-1 Replication
Bakri, Y., Schiffer, C., Zennou, V., Charneau, P., Kahn, E., Benjouad, A., Gluckman, J. C., & Canque, B. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.6.3780 · Cited by 101 · see citing works
Human immunodeficiency virus gp120 and derived peptides activate protein tyrosine kinase p56Ick in human CD4 T lymphocytes
Hivroz, C., Mazerolles, F., Soula-Rothhut, M., Fagard, R., Graton, S., Meloche, S., Sékaly, R., & Fischer, A. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230303 · Cited by 99 · see citing works
Effect of human immunodeficiency virus gp120 glycoprotein on the association of the protein tyrosine kinase p56lck with CD4 in human T lymphocytes
Juszczak, R. J., Turchin, H. A., Truneh, A., Culp, J. S., & Kassis, S. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99145-3 · Cited by 85 · see citing works
Human Immunodeficiency Virus Type 1 Envelope gp120-Induced Partial T-Cell Receptor Signaling Creates an F-Actin-Depleted Zone in the Virological Synapse
Vasiliver-Shamis, G., Cho, M. W., Hioe, C. E., & Dustin, M. L. (2009) · Journal of Virology · doi:10.1128/jvi.01440-09 · Cited by 84 · see citing works
Primary SIVsm Isolates Use the CCR5 Coreceptor from Sooty Mangabeys Naturally Infected in West Africa: A Comparison of Coreceptor Usage of Primary SIVsm, HIV-2, and SIVmac
Chen, Z., Gettie, A., Ho, D. D., & Marx, P. A. (1998) · Virology · doi:10.1006/viro.1998.9174 · Cited by 81 · see citing works
The cytoplasmic domain of CD4 plays a critical role during the early stages of HIV infection in T‐cells.
Benkirane, M., Jeang, K.-T., & Devaux, C. A. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06893.x · Cited by 72 · see citing works
Association of p56lck with the cytoplasmic domain of CD4 modulates HIV‐1 expression.
Tremblay, M. J., Meloche, S., Gratton, S., Wainberg, M. A., & Sékaly, R. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06320.x · Cited by 65 · see citing works
Human Immunodeficiency Virus Type 1 Envelope gp120 Induces a Stop Signal and Virological Synapse Formation in Noninfected CD4+T Cells
Vasiliver-Shamis, G., Tuen, M., Wu, T. W., Starr, T., Cameron, T. O., Thomson, R. P., Kaur, G., Liu, J., Visciano, M. L., Li, H., et al. (2008) · Journal of Virology · doi:10.1128/jvi.00835-08 · Cited by 62 · see citing works
Penetration of CD4 T cells by HIV-1. The CD4 receptor does not internalize with HIV, and CD4-related signal transduction events are not required for entry
ORLOFF, G. M., Orloff, S. L., Kennedy, M. S., Maddon, P. J., & McDougal, J. S. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.8.2578 · Cited by 54 · see citing works
HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse
Vasiliver-Shamis, G., Dustin, M. L., & Hioe, C. E. (2010) · Viruses · doi:10.3390/v2051239 · Cited by 54 · see citing works
Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
Haynes, B. F., Saag, M. S., Sun, C., Busch, M. P., Pham, K. T., Ping, L.-H., Salazar-Gonzalez, J. F., Goepfert, P. A., Wei, X., Wang, S., et al. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/nta4-xh14 · Cited by 51 · see citing works
Directional Spread of Surface-Associated Retroviruses Regulated by Differential Virus-Cell Interactions
Sherer, N. M., Jin, J., & Mothes, W. (2010) · Journal of Virology · doi:10.1128/jvi.02155-09 · Cited by 47 · see citing works
The Protein Tyrosine Kinase p56lckIs Required for Triggering NF-κB Activation upon Interaction of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein gp120 with Cell Surface CD4
Briant, L., Robert-Hebmann, V., Acquaviva, C., Pelchen–Matthews, A., Marsh, M., & Devaux, C. A. (1998) · Journal of Virology · doi:10.1128/jvi.72.7.6207-6214.1998 · Cited by 47 · see citing works
Immunological synapse: a multi‐protein signalling cellular apparatus for controlling gene expression
Padhan, K., & Varma, R. (2010) · Immunology · doi:10.1111/j.1365-2567.2009.03241.x · Cited by 37 · see citing works
Factors involved in entry of the human immunodeficiency virus type 1 into permissive cells: lack of evidence of a role for CD26
Lazaro, I., Naniche, D., Signoret, N. Y. M., Bernard, A., Marguet, D., Klatzmann, D., Dragic, T., Alizon, M., & Sattentau, Q. J. (1994) · Journal of Virology · doi:10.1128/jvi.68.10.6535-6546.1994 · Cited by 29 · see citing works
HIV Entry Revisited
Uchil, P. D., & Mothes, W. (2009) · Cell · doi:10.1016/j.cell.2009.04.033 · Cited by 25 · see citing works
Enfuvirtide, an HIV-1 Fusion Inhibitor, for Drug-Resistant HIV Infection in North and South America
(2003) · New England Journal of Medicine · doi:10.1056/nejm200309113491126 · Cited by 25 · see citing works
Design of a Potent D-Peptide HIV-1 Entry Inhibitor with a Strong Barrier to Resistance
Welch, B. D., Francis, J. N., Redman, J. S., Paul, S., Weinstock, M. T., Reeves, J. D., Lie, Y., Whitby, F. G., Eckert, D. M., Hill, C. P., et al. (2013) · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) · Cited by 24 · see citing works
Structure-activity relationships of chemokines
Clark‐Lewis, I., Anderson, J., Owen, P., Vo, L., & Gong, J.-H. (1998) · doi:10.1093/oso/9780199636471.003.0005 · Cited by 9 · see citing works
CD26 is not involved in infection of peripheral blood mononuclear cells by HIV-1
Stamatatos, L., & Levy, J. A. (1994) · AIDS · doi:10.1097/00002030-199412000-00014 · Cited by 7 · see citing works
Characterization of V3 Sequence Heterogeneity in Subtype C Human Immunodeficiency Virus Type 1 Isolates from Malawi: Underrepresentation of X4 Variants
The University of North Carolina at Chapel Hill University Libraries (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/kwqf-0266 · Cited by 6 · see citing works

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Arts, E. J., & Hazuda, D. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007161 · Cited by 856 · see citing works
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Hu, W.-S., & Hughes, S. H. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006882 · Cited by 515 · see citing works
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Maginnis, M. S. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.06.024 · Cited by 415 · see citing works
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White, J. M., & Whittaker, G. R. (2016) · Traffic · doi:10.1111/tra.12389 · Cited by 400 · see citing works
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Shaw, G. M., & Hunter, E. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006965 · Cited by 328 · see citing works
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Ghassemi, S., Durgin, J. S., Nuñez-Cruz, S., Patel, J., Leferovich, J. M., Pinzone, M. R., Shen, F., Cummins, K. D., Plesa, G., Cantu, V. A., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00842-6 · Cited by 311 · see citing works
Human Coronavirus NL63 Utilizes Heparan Sulfate Proteoglycans for Attachment to Target Cells
Milewska, A., Zarębski, M., Nowak, P., Stożek, K., Potempa, J., & Pyrć, K. (2014) · Journal of Virology · doi:10.1128/jvi.02078-14 · Cited by 289 · see citing works
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Rakowska, P. D., Tiddia, M., Faruqui, N., Bankier, C., Pei, Y., Pollard, A. J., Zhang, J., & Gilmore, I. S. (2021) · Communications Materials · doi:10.1038/s43246-021-00153-y · Cited by 271 · see citing works
Wuhan to World: The COVID-19 Pandemic
Kumar, A., Singh, R. G., Kaur, J., Pandey, S., Sharma, V., Thakur, L., Sati, S., Mani, S., Asthana, S., Sharma, T. K., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.596201 · Cited by 241 · see citing works
Maraviroc: a review of its use in HIV infection and beyond
Kanmogne, G. D., & Woollard, S. M. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s90580 · Cited by 213 · see citing works
Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives
Xiao, S., Tian, Z., Wang, Y., Si, L., Zhang, L., & Zhou, D. (2018) · Medicinal Research Reviews · doi:10.1002/med.21484 · Cited by 212 · see citing works
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Pawig, L., Klasen, C., Weber, C., Bernhagen, J., & Noels, H. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00429 · Cited by 207 · see citing works
Molecular basis of human immunodeficiency virus type 1 drug resistance: Overview and recent developments
Menéndez‐Arias, L. (2013) · Antiviral Research · doi:10.1016/j.antiviral.2013.01.007 · Cited by 208 · see citing works
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Ma, Y., Frutos-Beltrán, E., Kang, D., Pannecouque, C. C., Clercq, E. D., Menéndez‐Arias, L., Liu, X., & Zhan, P. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01084g · Cited by 208 · see citing works
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Yan, H., Peng, X., He, W., Zhong, G., Qi, Y., Ren, B., Gao, Z., Jing, Z., Song, M. L., Xu, G., et al. (2013) · Journal of Virology · doi:10.1128/jvi.03540-12 · Cited by 202 · see citing works
HIV-1 target cells in the CNS
Joseph, S., Arrildt, K. T., Sturdevant, C. B., & Swanstrom, R. I. (2014) · Journal of NeuroVirology · doi:10.1007/s13365-014-0287-x · Cited by 186 · see citing works
Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction
Foster, T. L., Wilson, H., Iyer, S. S., Coss, K. P., Doores, K. J., Smith, S. E., Kellam, P., Finzi, A., Borrow, P., Hahn, B. H., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.08.006 · Cited by 172 · see citing works
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Roychoudhury, S., Das, A., Sengupta, P., Dutta, S., Roychoudhury, S., Roychoudhury, S., Ahmed, A. B. F., Bhattacharjee, S., & Sláma, P. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17249411 · Cited by 160 · see citing works
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Yang, S., Kiessling, V., & Tamm, L. K. (2016) · Nature Communications · doi:10.1038/ncomms11401 · Cited by 159 · see citing works
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Groß, A., Hashimoto, C., Sticht, H., & Eichler, J. (2016) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2015.00211 · Cited by 154 · see citing works
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Swanstrom, R., & Coffin, J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007443 · Cited by 134 · see citing works
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Zaitseva, E., Zaitsev, E. N., Melikov, K., Arakelyan, A., Marin, M., Villasmil, R., Margolis, L. B., Melikyan, G. B., & Chernomordik, L. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.06.012 · Cited by 132 · see citing works
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Ji, X., & Li, Z. (2020) · Medicinal Research Reviews · doi:10.1002/med.21664 · Cited by 125 · see citing works
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Kerry, R. G., Malik, S., Redda, Y. T., Sahoo, S., Patra, J. K., & Majhi, S. (2019) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2019.03.004 · Cited by 124 · see citing works
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Swaminathan, G., Navas, S., & Martín‐García, J. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.12.017 · Cited by 115 · see citing works
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Crenshaw, B. J., Gu, L., Sims, B., & Matthews, Q. L. (2018) · The Open Virology Journal · doi:10.2174/1874357901812010134 · Cited by 113 · see citing works
HIV virions sense plasma membrane heterogeneity for cell entry
Yang, S., Kreutzberger, A. J. B., Kiessling, V., Ganser‐Pornillos, B. K., White, J. M., & Tamm, L. K. (2017) · Science Advances · doi:10.1126/sciadv.1700338 · Cited by 106 · see citing works
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Masenga, S. K., Mweene, B. C., Luwaya, E. L., Muchaili, L., Chona, M., & Kirabo, A. (2023) · Cells · doi:10.3390/cells12101351 · Cited by 106 · see citing works
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Quantitative Phosphoproteomics Reveals Extensive Cellular Reprogramming During HIV-1 Entry
Wojcechowskyj, J. A., Didigu, C. A., Lee, J. Y., Parrish, N., Sinha, R., Hahn, B., Bushman, F., Jensen, S. T., Seeholzer, S., & Doms, R. (2013) · Cell Host and Microbe · doi:10.1016/j.chom.2013.04.011 · Cited by 109 · see citing works
Self-citation
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Courter, J. R., Madani, N., Sodroski, J., Schön, A., Freire, E., Kwong, P. D., Hendrickson, W. A., CHAIKEN, I. M., LaLonde, J. M., & Smith, A. B. (2014) · Accounts of Chemical Research · doi:10.1021/ar4002735 · Cited by 93 · see citing works
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HIV-associated cellular senescence: A contributor to accelerated aging
Cohen, J., & Torres, C. A. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.12.004 · Cited by 87 · see citing works
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Chen, H., Fang, Z., Chen, Y., Chen, Y., Yao, B., Cheng, J.-Y., Chien, C.-Y., Chang, Y., & Hu, C. J. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b09931 · Cited by 79 · see citing works
Mechanisms of Virologic Control and Clinical Characteristics of HIV+ Elite/Viremic Controllers.
Gonzalo-Gil, E., Ikediobi, U., & Sutton, R. E. (2017) · Europe PMC (PubMed Central) · Cited by 79 · see citing works
The role of miR‐146a in viral infection
Nahand, J. S., Karimzadeh, M. R., Nezamnia, M., Fatemipour, M., Khatami, A., Jamshidi, S., Moghoofei, M., Taghizadieh, M., Hajighadimi, S., Shafiee, A., et al. (2019) · IUBMB Life · doi:10.1002/iub.2222 · Cited by 81 · see citing works
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Graziano, V. R., Wei, J., & Wilen, C. B. (2019) · Viruses · doi:10.3390/v11060495 · Cited by 78 · see citing works
Self-citation
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Balasubramaniam, M., Pandhare, J., & Dash, C. (2018) · Viruses · doi:10.3390/v10030110 · Cited by 77 · see citing works
Novel activities of safe-in-human broad-spectrum antiviral agents
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Reynolds, D., Huesemann, M. H., Edmundson, S. J., Sims, A. M., Hurst, B. L., Cady, S. L., Beirne, N., Freeman, J., Berger, A., & Gao, S. (2021) · Algal Research · doi:10.1016/j.algal.2021.102331 · Cited by 76 · see citing works
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A Versatile Tool for Live-Cell Imaging and Super-Resolution Nanoscopy Studies of HIV-1 Env Distribution and Mobility.
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Hantak, M. P., Einstein, J., Kearns, R. B., & Shepherd, J. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2020.12.003 · Cited by 49 · see citing works
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Voshavar, C. (2019) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026619666190619115243 · Cited by 70 · see citing works
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Structure of the Ebola virus envelope protein MPER/TM domain and its interaction with the fusion loop explains their fusion activity
Lee, J., Nyenhuis, D. A., Nelson, E. A., Cafiso, D. S., White, J. M., & Tamm, L. K. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1708052114 · Cited by 69 · see citing works
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Petrina, M., Martin, J., & Basta, S. (2021) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2021.01.001 · Cited by 67 · see citing works
Role of autophagy in HIV infection and pathogenesis
Nardacci, R., Ciccosanti, F., Marsella, C., Ippolito, G., Piacentini, M., & Fimia, G. M. (2017) · Journal of Internal Medicine · doi:10.1111/joim.12596 · Cited by 66 · see citing works
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HIV infection of non-classical cells in the brain
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Figueroa, S. M., Fleischmann, D., & Göpferich, A. M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.045 · Cited by 60 · see citing works
Insights into HIV-1 Reverse Transcriptase (RT) Inhibition and Drug Resistance from Thirty Years of Structural Studies
Singh, A. K., & Das, K. (2022) · Viruses · doi:10.3390/v14051027 · Cited by 58 · see citing works
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Fülöp, T., Witkowski, J. M., Larbi, A., Khalil, A., Herbein, G., & Frost, E. H. (2019) · Journal of NeuroVirology · doi:10.1007/s13365-019-00732-3 · Cited by 58 · see citing works
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Buren, T. W. V., Floryan, D., & Smits, A. J. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139058995.006 · Cited by 57 · see citing works
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Song, J., Gao, P., Kong, C., Zhou, L., Ge, X., Guo, X., Han, J., & Yang, H. (2019) · Journal of Virology · doi:10.1128/jvi.01436-19 · Cited by 57 · see citing works
The lipid membrane of HIV-1 stabilizes the viral envelope glycoproteins and modulates their sensitivity to antibody neutralization
Salimi, H., Johnson, J., Flores, M. G., Zhang, M. S., O’Malley, Y., Houtman, J. C. D., Schlievert, P. M., & Haim, H. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009481 · Cited by 57 · see citing works
Maternal natural killer cells at the intersection between reproduction and mucosal immunity
Shmeleva, E. V., & Colucci, F. (2021) · Mucosal Immunology · doi:10.1038/s41385-020-00374-3 · Cited by 56 · see citing works
HIV-Infected Dendritic Cells Present Endogenous MHC Class II–Restricted Antigens to HIV-Specific CD4+ T Cells
Coulon, P.-G. A., Richetta, C., Rouers, A., Blanchet, F. P., Urrutia, A., Guerbois, M., Piguet, V., Theodorou, I. D., Bet, A., Schwartz, O., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600286 · Cited by 56 · see citing works
Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4
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Balasubramaniam, M., Pandhare, J., & Dash, C. (2019) · JoLS Journal of Life Sciences · doi:10.36069/jols/20190603 · Cited by 53 · see citing works
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Gale, P. (2020) · Microbial Risk Analysis · doi:10.1016/j.mran.2020.100104 · Cited by 53 · see citing works
Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120
Yolitz, J., Schwing, C., Chang, J., Ryk, D. V., Nawaz, F., Wei, D., Cicala, C., Arthos, J. A., & Fauci, A. S. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1722627115 · Cited by 53 · see citing works
The struggle of a good friend getting old: cellular senescence in viral responses and therapy
Kohli, J., Veenstra, I., & Demaria, M. (2021) · The EMBO Reports · doi:10.15252/embr.202052243 · Cited by 52 · see citing works
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Štukovnik, Z., & Bren, U. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415922 · Cited by 53 · see citing works
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Glatzová, D., & Cebecauer, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00618 · Cited by 52 · see citing works
Inhibition of HIV Entry by Targeting the Envelope Transmembrane Subunit gp41
Yi, H. A., Fochtman, B. C., Rizzo, R. C., & Jacobs, A. (2016) · Current HIV Research · doi:10.2174/1570162x14999160224103908 · Cited by 51 · see citing works
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Welch, J. L., Xiang, J., Okeoma, C. M., Schlievert, P. M., & Stapleton, J. T. (2020) · mBio · doi:10.1128/mbio.00686-20 · Cited by 51 · see citing works
Tea catechin as antiviral agent via apoptosis agonist and triple inhibitor mechanism against HIV-1 infection: A bioinformatics approach
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Optimal management of cervical cancer in HIV ‐positive patients: a systematic review
Ntekim, A., Campbell, O. B., & Rothenbacher, D. (2015) · Cancer Medicine · doi:10.1002/cam4.485 · Cited by 50 · see citing works
HIV, Combination Antiretroviral Therapy, and Vascular Diseases in Men and Women
Kovács, L., Kress, T. C., & de Chantemèle, E. J. B. (2022) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2021.10.017 · Cited by 49 · see citing works
HIV-1 gp120 as a therapeutic target: navigating a moving labyrinth
Acharya, P., Lusvarghi, S., Bewley, C. A., & Kwong, P. D. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1010513 · Cited by 48 · see citing works
HIV-1 envelope proteins up-regulate N6-methyladenosine levels of cellular RNA independently of viral replication
Tirumuru, N., & Wu, L. J. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005608 · Cited by 48 · see citing works
Vehicles of intercellular communication: exosomes and HIV-1
Welch, J. L., Stapleton, J. T., & Okeoma, C. M. (2019) · Journal of General Virology · doi:10.1099/jgv.0.001193 · Cited by 48 · see citing works
Functional organization of the HIV lipid envelope
Huarte, N., Carravilla, P., Cruz, A., Lorizate, M., Nieto‐Garai, J. A., Kräusslich, H., Pérez‐Gil, J., Requejo‐Isidro, J., & Nieva, J. L. (2016) · Scientific Reports · doi:10.1038/srep34190 · Cited by 47 · see citing works
Biomimetic Nanomaterial Strategies for Virus Targeting: Antiviral Therapies and Vaccines
Jackman, J. A., Yoon, B. K., Ouyang, L., Wang, N., Ferhan, A. R., Kim, J., Majima, T., & Cho, N. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202008352 · Cited by 46 · see citing works
Chemokine Oligomerization in Cell Signaling and Migration
Wang, X., Sharp, J. S., Handel, T. M., & Prestegard, J. H. (2013) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-386931-9.00020-9 · Cited by 45 · see citing works
HIV internalization into oral and genital epithelial cells by endocytosis and macropinocytosis leads to viral sequestration in the vesicles
Yasen, A., Herrera, R., Rosbe, K. W., Lien, K., & Tugizov, S. M. (2017) · Virology · doi:10.1016/j.virol.2017.12.012 · Cited by 45 · see citing works
PF74 Inhibits HIV-1 Integration by Altering the Composition of the Preintegration Complex
Balasubramaniam, M., Zhou, J., Addai, A. B., Martinez, P., Pandhare, J., Aiken, C., & Dash, C. (2018) · Journal of Virology · doi:10.1128/jvi.01741-18 · Cited by 45 · see citing works
Comparative mapping of host–pathogen protein–protein interactions
Shah, P. S., Wojcechowskyj, J. A., Eckhardt, M., & Krogan, N. J. (2015) · Current Opinion in Microbiology · doi:10.1016/j.mib.2015.07.008 · Cited by 42 · see citing works
Sialic acid-binding Ig-like lectin-7 interacts with HIV-1 gp120 and facilitates infection of CD4posT cells and macrophages
Varchetta, S., Lusso, P., Hudspeth, K. L., Mikulak, J., Mele, D., Paolucci, S., Cimbro, R., Malnati, M., Riva, A., Maserati, R., et al. (2013) · Retrovirology · doi:10.1186/1742-4690-10-154 · Cited by 44 · see citing works
Co-receptor signaling in the pathogenesis of neuroHIV
Nickoloff-Bybel, E. A., Festa, L. K., Meucci, O., & Gaskill, P. J. (2021) · Retrovirology · doi:10.1186/s12977-021-00569-x · Cited by 43 · see citing works
Vesicular Trafficking to the Immune Synapse: How to Assemble Receptor-Tailored Pathways from a Basic Building Set
Onnis, A., Finetti, F., & Baldari, C. T. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00050 · Cited by 43 · see citing works
Altered Immune Cytokine Expression Associated with KoRV B Infection and Season in Captive Koalas
Maher, I. E., & Higgins, D. P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163780 · Cited by 43 · see citing works
Unprecedented Role of Hybrid N- Glycans as Ligands for HIV-1 Broadly Neutralizing Antibodies
Shivatare, V. S., Shivatare, S. S., Lee, C.-C. D., Liang, C. J., Liao, K., Cheng, Y., Saidachary, G., Wu, C., Lin, N., Kwong, P. D., et al. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b00896 · Cited by 43 · see citing works
Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120
Curreli, F., Belov, D. S., Kwon, Y. D., Ramesh, R. R., Furimsky, A. M., O’Loughlin, K. G., Byrge, P. C., Iyer, L., Mirsalis, J. C., Kurkin, A. V., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.04.062 · Cited by 43 · see citing works
Design, synthesis and biological evaluation of novel 5-((substituted quinolin-3-yl/1-naphthyl) methylene)-3-substituted imidazolidin-2,4-dione as HIV-1 fusion inhibitors
Ibrahim, T. S., Bokhtia, R. M., Al‐Mahmoudy, A. M. M., Taher, E. S., AlAwadh, M. A., Elagawany, M., Abdel‐Aal, E. H., Panda, S. S., Gouda, A. M., Asfour, H. Z., et al. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.103782 · Cited by 43 · see citing works
Host Defence RNases as Antiviral Agents against Enveloped Single Stranded RNA Viruses
Li, J. R., & Boix, E. (2021) · Virulence · doi:10.1080/21505594.2021.1871823 · Cited by 42 · see citing works
An Overview of Human Immunodeficiency Virus-1 Antiretroviral Drugs: General Principles and Current Status
Shin, Y. H., Park, C. M., & Yoon, C. (2021) · Infection and Chemotherapy · doi:10.3947/ic.2020.0100 · Cited by 43 · see citing works

Authors: Wilen, C. B., Tilton, J. C., & Doms, R. W.
Affiliations: University of Pennsylvania (US)
Case Western Reserve University (US)
ORCID: Wilen, C. B.
Tilton, J. C.
Venue: Cold Spring Harbor Perspectives in Medicine
Publisher: Cold Spring Harbor Laboratory
Published: 2012-04-10
Volume: 2
Issue: 8
Pages: a006866-a006866
ISSN: 2157-1422 (ISSN-L)
DOI: 10.1101/cshperspect.a006866
PMC: PMC3405824
OpenAlex: W2118545611
Cited by: 654
References: 106
Citations by year: 2026: 19 · 2025: 33 · 2024: 49 · 2023: 49 · 2022: 58 · 2021: 73 · 2020: 66 · 2019: 61 · 2018: 68 · 2017: 47 · 2016: 43 · 2015: 33 · 2014: 21 · 2013: 25 · 2012: 8
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Cold Spring Harbor Perspectives in Medicine (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (T32 AI000632, R01AI040880, F32AI077370, F32 1F32AI077370)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
Keywords: HIV entry, CD4 receptor, co-receptors, viral envelope glycoprotein, membrane fusion, viral tropism, HIV pathogenesis, HIV transmission, host immune evasion, HIV replication cycle
MeSH terms: Cell Transformation, Viral, HIV, Humans, Protein Binding, Virion, Signal Transduction, CD4-Positive T-Lymphocytes, HIV Infections, HIV Envelope Protein gp120, CD4 Antigens, Integrins, Receptors, CCR5, env Gene Products, Human Immunodeficiency Virus, Receptors, CCR4

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