The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Cancer Cell Metabolism: Warburg and Beyond
Open accessAbstract
Described decades ago, the Warburg effect of aerobic glycolysis is a key metabolic hallmark of cancer, yet its significance remains unclear. In this Essay, we re-examine the Warburg effect and establish a framework for understanding its contribution to the altered metabolism of cancer cells.
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“These findings provide evidence for the Warburg hypothesis, that cancer cells shift toward glycolytic metabolic pathways (28, 29).”
From Comparative proteomic phenotyping of cell lines and primary cells to assess preservation of cell type-specific functions (2009) · cites this paper as [29]
Citations
Cites
AKT/PKB signaling: navigating downstream
Manning, B. D., & Cantley, L. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.009 · Cited by 6,115 · cited 1×
“…well-characterized downstream effector of insulin signaling, reprises its role in glucose uptake and utilization in the cancer setting (reviewed in Manning and Cantley, 2007), whereas the Myc transcription factor upregulates the expression of various metabolic genes (reviewed in Gordan et al.,…”
BackgroundWhy Do Cancers Have High Aerobic Glycolysis?
Gatenby, R. A., & Gillies, R. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1478 · Cited by 4,784 · cited 2×
“Blood vessels recruited to the tumor microenvironment, however, are disorganized, may not deliver blood effectively, and therefore do not completely alleviate hypoxia (reviewed in Gatenby and Gillies, 2004).”
BackgroundOn Respiratory Impairment in Cancer Cells
Warburg, O. H. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,472
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.
Kaelin, W. G., & Ratcliffe, P. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.009 · Cited by 3,251 · cited 2×
“HIF initiates a transcriptional program that provides multiple solutions to hypoxic stress (reviewed in Kaelin and Ratcliffe, 2008).”
BackgroundFatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Menendez, J. A., & Lupu, R. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2222 · Cited by 2,941 · cited 1×
“Fatty acid synthase, expressed at low levels in normal tissues, is upregulated in cancer and may also be required for tumorigenesis (reviewed in Menendez and Lupu, 2007).”
BackgroundThe M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Christofk, H. R., Vander Heiden, M. G., Harris, M. H., Ramanathan, A., Gerszten, R. E., Wei, R., Fleming, M. D., Schreiber, S. L., & Cantley, L. C. (2008) · Nature · doi:10.1038/nature06734 · Cited by 2,820 · cited 1×
“Recent work has found that the cancer-specific M2-PK causes an increase in the incorporation of glucose carbons into lipids and, expanding the connection between growth factor sig- naling and cancer metabolism, may be regulated by phosphotyrosine binding (Christofk et al., 2008a, 2008b).”
BackgroundThe Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., & Sabatini, D. M. (2008) · Science · doi:10.1126/science.1157535 · Cited by 2,773 · cited 1×
“It is well established that AMP-kinase senses the AMP/ATP ratio (reviewed in Hardie, 2007), whereas mTOR (the mammalian target of rapamycin) senses cellular amino acid concentrations (Kim et al., 2008; Sancak et al., 2008).”
BackgroundSelf-citationDeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622 · cited 1×
“Recently, it has been demonstrated that glutamine may be metabolized by the citric acid cycle in cancer cells and converted into lactate, producing NADPH for lipid biosynthesis and oxaloacetate for replenishment of Krebs cycle intermediates (DeBerardinis et al., 2007).”
BackgroundAMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
Hardie, D. G. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2249 · Cited by 2,261 · cited 1×
“It is well established that AMP-kinase senses the AMP/ATP ratio (reviewed in Hardie, 2007), whereas mTOR (the mammalian target of rapamycin) senses cellular amino acid concentrations (Kim et al., 2008; Sancak et al., 2008).”
Background(1999) · PubMed · Cited by 2,204
Flagged first, then by citations
Research works printed but not linked: 3
- Fukumura, 2001, Cancer Res., 61, 6020
- Wiesener, 2001, Cancer Res., 61, 5215
- Zhong, 1999, Cancer Res., 59, 5830
Cited by
Sorted by citations
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
“They do so in part by upregulating glucose transporters, notably GLUT1, which substantially increases glucose import into the cytoplasm (Jones and Thompson, 2009; DeBerardinis et al., 2008; Hsu and Sabatini, 2008).”
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
mTOR: from growth signal integration to cancer, diabetes and ageing
Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941
“Akt promotes proliferation, survival and nutrient uptake in cancer cells (reviewed in Ref”
BackgroundSelf-citationOtto Warburg's contributions to current concepts of cancer metabolism
Koppenol, W. H., Bounds, P. L., & Dang, C. V. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3038 · Cited by 3,427
Reactive oxygen species in cancer
Liou, G., & Störz, P. (2010) · Free Radical Research · doi:10.3109/10715761003667554 · Cited by 3,528
Metadata
- Authors
- Hsu, P. P., & Sabatini, D. M.
- Affiliations
- Broad Institute (US)
- Corresponding author
- Sabatini, David M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 134
- Issue
- 5
- Pages
- 703-707
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2022101765
- Semantic Scholar
- eb48a9ee1047d39abd15070d0ffa0430d74d5d8a
- Cited by
- 2,452
- References
- 41
- Citations by year
- 2026: 62 · 2025: 113 · 2024: 162 · 2023: 153 · 2022: 191 · 2021: 160 · 2020: 232 · 2019: 160 · 2018: 147 · 2017: 166 · 2016: 151 · 2015: 141 · 2014: 148 · 2013: 121 · 2012: 119
- FWCI
- 25.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R01CA129105)
- National Institute of General Medical Sciences (T32GM007753)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- cancer metabolism, Warburg effect, aerobic glycolysis, metabolic reprogramming
- MeSH terms
- Animals, Energy Metabolism, Glycolysis, Humans, Neoplasms, Cell Respiration, Biosynthetic Pathways
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