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Cancer Cell Metabolism: Warburg and Beyond
Open accessAbstract
Described decades ago, the Warburg effect of aerobic glycolysis is a key metabolic hallmark of cancer, yet its significance remains unclear. In this Essay, we re-examine the Warburg effect and establish a framework for understanding its contribution to the altered metabolism of cancer cells.
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“These findings provide evidence for the Warburg hypothesis, that cancer cells shift toward glycolytic metabolic pathways (28, 29).”
From Comparative proteomic phenotyping of cell lines and primary cells to assess preservation of cell type-specific functions (2009) · cites this paper as [29]
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“…switch from respiration to the glycolytic pathway (the Warburg effect) and promoting tumor cell survival under hypoxic conditions (Papandreou et al., 2006; Hsu and Sabatini, 2008), our study indicates that miR-210 has an important role in cancer cells’ adaptation to hypoxic microenvironment.”
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“Emerging evidence indicates that impaired cellular metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin (Hsu and Sabatini, 2008).”
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“role in regulating cell cycle, proliferation, and apoptosis (7).”
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“Since then this phenotype has been observed in a number of highly proliferative cell types (Hsu and Sabatini, 2008; Vander Heiden et al., 2009).”
BackgroundCancer‐generated lactic acid: a regulatory, immunosuppressive metabolite?
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“Aerobic glycolysis and increased glutaminolysis are collectively regarded as ‘reprogrammed energy metabolism’, a phenomenon now generally accepted as a key metabolic hallmark of cancer [3,8,9].”
BackgroundInfluentialEnhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock
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“One example of issues arising from our findings is that metabolic profiling for development of ‘‘personal’’ therapeutic strategies to target cancer stem cells (Hsu and Sabatini, 2008; Kamleh et al., 2011; Wood et al., 2014) may not accurately represent the metabolism of these cells as they exist in their native hypoxi…”
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“An emerging hallmark of cancer is reprogramming of cellular metabolism (Hanahan and Weinberg, 2000, 2011; Hsu and Sabatini, 2008; Pavlova and Thompson, 2016).”
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“Cancer cells aremetabolically altered to be addicted to glycolysis and produce lactate rigorously from pyruvate (Hsu and Sabatini, 2008).”
BackgroundBiomolecular Condensates and Cancer
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“The metabolic phenotype exhibited by tumor cells—known as the Warburg effect—is characterized by high rates of aerobic glycolysis and has been a topic of special interest in cancer research (Hsu and Sabatini, 2008; Liberti and Locasale, 2016; Warburg, 1956).”
Background
Metadata
- Authors
- Hsu, P. P., & Sabatini, D. M.
- Affiliations
- Broad Institute (US)
- Corresponding author
- Sabatini, David M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 134
- Issue
- 5
- Pages
- 703-707
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2022101765
- Semantic Scholar
- eb48a9ee1047d39abd15070d0ffa0430d74d5d8a
- Cited by
- 2,452
- References
- 41
- Citations by year
- 2026: 62 · 2025: 113 · 2024: 162 · 2023: 153 · 2022: 191 · 2021: 160 · 2020: 232 · 2019: 160 · 2018: 147 · 2017: 166 · 2016: 151 · 2015: 141 · 2014: 148 · 2013: 121 · 2012: 119
- FWCI
- 25.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R01CA129105)
- National Institute of General Medical Sciences (T32GM007753)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Keywords
- cancer metabolism, Warburg effect, aerobic glycolysis, metabolic reprogramming
- MeSH terms
- Animals, Energy Metabolism, Glycolysis, Humans, Neoplasms, Cell Respiration, Biosynthetic Pathways
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