The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Anatomical Profiling of G Protein-Coupled Receptor Expression
Open accessAbstract
Summary G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane signaling molecules and regulate a host of physiological and disease processes. To better understand the functions of GPCRs in vivo, we quantified transcript levels of 353 non-odorant GPCRs in 41 adult mouse tissues. Cluster analysis placed many GPCRs into anticipated anatomical and functional groups and predicted novel roles for less studied receptors. From one such prediction, we showed that the Gpr91 ligand succinate can regulate lipolysis in white adipose tissue suggesting that signaling by this citric acid cycle intermediate may regulate energy homeostasis. We also showed that pairwise analysis of GPCR expression across tissues may help predict drug side effects. This resource will aid studies to understand GPCR function in vivo and may assist in the identification of therapeutic targets.
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Cites
Cluster analysis and display of genome-wide expression patterns
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“The concentration of succinate in plasma has been reported at 5–125 mM, a range that surrounds the EC50 for Gpr91 activation (He et al., 2004) and the IC50 for inhibition of lipolysis in WAT (Figure 4).”
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Cited by
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International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors
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The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases
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Short chain fatty acids and their receptors: new metabolic targets
Layden, B. T., Angueira, A. R., Brodsky, M., Durai, V., & Lowe, W. L. (2013) · Translational Research · doi:10.1016/j.trsl.2012.10.007 · Cited by 357
Metadata
- Authors
- Regard, J. B., Sato, I. T., & Coughlin, S. R.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 135
- Issue
- 3
- Pages
- 561-571
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2086687315
- Cited by
- 693
- References
- 14
- FWCI
- 6.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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