Endothelin

Davenport, Anthony P.; Hyndman, Kelly A.; Dhaun, Neeraj; Southan, Christopher; Kohan, Donald E.; Pollock, Jennifer S.; Pollock, David M.; Webb, David J.; Maguire, Janet J.

doi:10.1124/pr.115.011833

Cited by 772Nitric Oxide and Endothelin EffectsRenin-Angiotensin System StudiesCardiovascular, Neuropeptides, and Oxidative Stress Research

Endothelin

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Davenport, Anthony P., Hyndman, Kelly A., Dhaun, Neeraj, Southan, Christopher, Kohan, Donald E., Pollock, Jennifer S., Pollock, David M., Webb, David J. +1 more·2016·Pharmacological Reviews

DOI 10.1124/pr.115.011833PMC PMC4815360

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Abstract

injury; AMP, cyclic adenosine monophosphate; ANGII, angiotensin II; ANP, atrial natriuretic peptide; AQP2, Aquaporin 2; AVP, arginine vasopressin; Big ET-1, big endothelin-1; Big ET-2, ; big endothelin-2, ; Big ET-3, big endothelin-3; BP, blood pressure; BQ123, cyclo-[D-Asp-L-Pro-D-Val-L-Leu-D-Trp-]; BQ3020, [Ala11,15]Ac-ET-1(6-21); BQ3020 ([Ala 11,15 ]Ac-ET-1 (6-21) ); BQ788 (D-Norleucine, N-(((2R,6S)-2,6-dimethyl-1-piperidinyl)carbonyl)-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-); CD, collecting duct; CHF, chronic heart failure; CKD, chronic kidney disease; CNS, central nervous system; CPP, cell penetrating peptide; C terminus, carboxy terminus; darusentan, LU135252, (2S)-2-[(4,6-Dimethoxy-2-pyrimidinyl)oxy]-3-methoxy-3,3-diphenylpropanoic acid; ddAVP, desmopressin; DOCA, deoxycorticosterone acetate; DbH, dopamine-b-hydroxylase; E, embryonic day; EC, endothelial cell; ECE-1, converting enzyme-1; ECE-2, converting enzyme-2; EDNRB, ET B gene; ENaC, epithelial sodium channel; ESRD, end stage renal disease; ET-1, endothelin-1; ET-2, endothelin-2; ET-3, endothelin-3; ET A , endothelin A receptor; ET B , endothelin B receptor; FR139317, N-[(hexahydro-1-azepinyl)carbonyl]L-Leu(1-Me)D-Trp-3(2-pyridyl)-D-Ala; GFR, glomerular filtration rate; GPCR, G-protein coupled receptor; H, high expressing; IRL1620, Suc-(Glu9, Ala11,15)-ET-1(8-21); IRL-2500, (2S)-2-({(2R)-3-(4-Biphenylyl)-2-[(3,5-dimethylbenzoyl)(methyl)amino]propanoyl}amino)-3-(1H-indol-3-yl)propanoic acid; K D , equilibrium dissociation constant; K i , inhibition constant; KO, knockout; L, low expressing; L-NAME, LU420627, (S)-3-[2-(3,4-dimethoxyphenyl)ethoxy]-2-(4,6-dimethylpyrimidin-2yloxy)-3,3-diphenylpropionic acid; N v -nitro-L-arginine methyl ester; NEP, neutral endopeptidase or neprilysin; NOS, nitric oxide synthase; NOx, nitrite and nitrate; N terminus, amino terminus or NH 2 terminus; PAH, pulmonary arterial hypertension; PD156707 (Sodium, (2Z)-2-(1,3benzodioxol-5-yl)-4-(4-methoxyphenyl)-4-oxo-3-(3,4,5-trimethoxybenzyl)-2-butenoate); PET, positron emission tomography; PGE 2 , prostaglandin E2; preproET, pre-proendothelin; RO 46-2005 (4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)pyrimidin-4-yl]benzenesulfonamide); RO468443, N-{6-[(2R)-2,3-Dihydroxypropoxy]-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)-4-pyrimidinyl}-4-(2-methyl-2-propanyl)benzenesulfonamide; ROS, reactive oxygen species; RVSP, right ventricular systolic pressure; SAH, subarachnoid hemorrhage; SB209670, (1S,2R,3S)-1-(1,3-Benzodioxol-5-yl)-3-[2-(carboxymethoxy)-4-methoxyphenyl]-5-propoxy-2-indanecarboxylic acid; SM, smooth muscle; TGF, tissue growth factor; VEETKO, vascular endothelial cell ET-1 knockout mouse; VIC, vasoactive intestinal contractor.358

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ET-1 causes vasoconstriction mainly via ET-A, which represents the principle subtype in the vascular medial layer of large arteries.
“ET-1 causes vasoconstriction mainly via ET-A, which represents the principle subtype in the vascular medial layer of large arteries [36].”
From Transcriptome analysis of skin fibroblasts with dominant negative COL3A1 mutations provides molecular insights into the etiopathology of vascular Ehlers-Danlos syndrome (2018) · cites this paper as [36]

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Authors: Davenport, A. P., Hyndman, K. A., Dhaun, N., Southan, C., Kohan, D. E., Pollock, J. S., Pollock, D. M., Webb, D. J., & Maguire, J. J.
Affiliations: University of Utah (US)
Corresponding author: Davenport, Anthony P.
ORCID: Davenport, Anthony P.
Hyndman, Kelly A.
Dhaun, Neeraj
Southan, Christopher
Kohan, Donald E.
Pollock, Jennifer S.
Pollock, David M.
Webb, David J.
Maguire, Janet J.
Venue: Pharmacological Reviews
Publisher: Elsevier BV
Published: 2016-04
Volume: 68
Issue: 2
Pages: 357-418
ISSN: 0031-6997 (ISSN-L)
DOI: 10.1124/pr.115.011833
PMC: PMC4815360
OpenAlex: W4210343616
Cited by: 772
References: 650
Citations by year: 2026: 49 · 2025: 81 · 2024: 68 · 2023: 85 · 2022: 91 · 2021: 96 · 2020: 82 · 2019: 83 · 2018: 58 · 2017: 61 · 2016: 17 · 2015: 1
FWCI: 8.64
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: public-domain
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 3197 d)
Locations: Pharmacological Reviews (publishedVersion, public-domain)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
Funders: Pulmonary Hypertension Association
Wellcome Trust (WT107715/Z/15/Z, 096822/Z/11/Z, 099156/Z/12/Z)
National Institute for Health and Care Research
British Heart Foundation (FS/13/30/29994, PS/02/001, PG/05/127/19872, FS/12/64/13000, FS/12/64/130001)
NIHR Cambridge Biomedical Research Centre
National Heart, Lung, and Blood Institute (U01HL117684, P01 HL 69999, P01HL095499, P01HL069999, P01 HL95499, HL95499, HL 69999)
National Institute of Diabetes and Digestive and Kidney Diseases (K01DK105038)
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
Keywords: endothelin, endothelin receptors, endothelin-1, endothelin-2, endothelin-3, big endothelin, endothelin receptor antagonists, BQ-123, BQ-788, FR139317, darusentan, chronic kidney disease, chronic heart failure, endothelial dysfunction
MeSH terms: Animals, Humans, Endothelins, Receptors, Endothelin, Endothelin Receptor Antagonists

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