Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
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- Cycloheximide resistant ribosomes reveal adaptive translation dynamics in C. elegansQiuxia Zhao, B. Bolton, Reed Rothe, Reiko Tachibana, Can Cenik, Elif Sarinay Cenik · 2025 · Genetics
- TOB Proteins Repress Translation via the CCR4–NOT Deadenylase Complex Independent of DeadenylationKanae Miyazaki, T. Tomohiro, Yoshinori Funakami, Akira Fukao, Toru Suzuki, Tadashi Yamamoto, Toshinobu Fujiwara · 2025 · Genes to Cells
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- BLF1 Affects ATP Hydrolysis Catalyzed by Native and Mutated eIF4A1 and eIF4A2 ProteinsMin-Gyu An, Xin Cheng, Yu Zhang, Jiang Gu, Xu-Hu Mao · 2025 · Toxins
- Régénération axonale : une question de traductionJulia Schaeffer, Stéphane Belin · 2025 · Comptes Rendus Biologies
- Trypanosoma brucei L19 is essential for ribosomal functionJuan Manuel Zárate, Leandro Simonetti, María Jimena Manzur, Juan Arturo Gómez Barroso, Alejandra C. Schoijet, G. Alonso, Maximiliano Juri Ayub · 2025 · Biochemical and Biophysical Research Communications
- Evaluating the Impact of Variants on Translation Initiation Sites for Accurate Identification of Functional Open Reading Frames (ORFs)Thanos Lakes, V. Efstathiou, Nikos Perdikopanis · 2024 · IEEE International Conference on Bioinformatics and Biomedicine
- Scalable Synthesis of an Acid Stable Analogue of Hippuristanol.Ellen MacDonald, Peter Blencowe, Jennifer Baker, Charlotte Bennett, S. Boyd, K. Fowler, Laurent Rigoreau, Emma Stanway, Morag Watson, Hai-Bin Mao et al. · 2024 · Organic Letters
- Investigation of COVID-19 virus mutagenicity and the effect of the NSP13, NSP14, and NSP16 on the -1 ribosomal frameshiftingAli Khanifar, Azin Najafi, Jaber Hemmati, Fatemeh Nouri, Seyed Ali Hosseini, Mohammad Taheri · 2024 · Frontiers in Virology
- Ribosome decision graphs for the representation of eukaryotic RNA translation complexityJack A. S. Tierney, Michał I. Świrski, Håkon Tjeldnes, Jonathan M. Mudge, Joanna Kufel, Nicola Whiffin, Eivind Valen, Pavel V. Baranov · 2024 · Genome Research
- RNA Activators of Stress Kinase PKR within Human Genes That Control Splicing or Translation Create Novel Targets for Hereditary DiseasesRaymond Kaempfer · 2024 · International Journal of Molecular Sciences
- Intermolecular base‐pairing interactions, a unique topology and exoribonuclease‐resistant noncoding RNAs drive formation of viral chimeric RNAs in plantsKatalin Nemes, Jose Fernando Gil, Sebastian Liebe, Mansi Mansi, Efstratia Poimenopoulou, Britt‐Louise Lennefors, Mark Varrelmann, Eugene I. Savenkov · 2023 · New Phytologist
- Editorial: RNA machinesNikolay E. Shirokikh, Kirk B. Jensen, Nehal Thakor · 2023 · Frontiers in Genetics
- Prefrontal cortex proteomic alteration after social instability stress in adolescents ratsEvelyn C. S. Santos, Ana Filipa Terceiro, Rui Miguel Pinheiro Vitorino, Igor Moreira Lopes, Renata L. Alves, João Bettencourt Relvas, Teresa Summavielle, Ana Magalhães · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Mathematical modelling of non-feedback and feedback modes within eIF2 machinery: Limited data aided with well-studied in-vivo system of yeastM. F. Khan, Mohammad Mursaleen · 2023 · 2023 International Conference on Computational Intelligence and Sustainable Engineering Solutions (CISES)
- Positive Regulation of Splicing of Cellular and Viral mRNA by Intragenic RNA Elements That Activate the Stress Kinase PKR, an Antiviral MechanismRaymond O.R. Kaempfer · 2023 · Genes
- Coronavirus endoribonuclease nsp15 induces host cellular protein synthesis shutoffXiao-Qian Gong, Shan Feng, Bo Gao, Shou-Guo Fang, Wen-Lian Weng, Wen-Xiang Xue, Hong-Yan Chu, Yan-Mei Yuan, Yu-Qiang Cheng, Ying-Jie Sun et al. · 2023 · bioRxiv
- The nutrient-sensing GCN2 signaling pathway is essential for circadian clock function by regulating histone acetylation under amino acid starvationXiao-Lan Liu, Yu-Lin Yang, Yue Hu, Jingjing Wu, Chu-Qiao Han, Xihui Gan, Qiaojia Lu, Shaohua Qi, Jin-Hu Guo, Qun He et al. · 2022 · bioRxiv
- A retrograde GCN2/eIF2α, but ATF4 independent, mechanism maintains synaptic strength under acute amino acid scarcity at the NMJGrant Kauwe, Megumi Mori, Edward H. Liao, G. Scott, A. Haghighi · 2022 · bioRxiv
- Protein expression and purification protein expression and purification, molecular interaction, and X-ray crystallographic analysis of baculovirus protein PK2.D. Takeshita · 2022 · Protein Expression and Purification
- Genome-wide regulatory effects of STRs stabilized by elevated expression of antioxidant genes in C. elegansGaotian Zhang, Erik C. Andersen · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Head and Neck Cancer-derived small extracellular vesicles sensitize TRPV1+ neurons to mediate cancer painKufreobong E. Inyang, Christine M. Evans, Matthew Heussner, M. Petroff, M. Reimers, P. Vermeer, Nathan Tykocki, J. Folger, G. Laumet · 2022 · bioRxiv
- Initiator tRNA lacking 1-methyladenosine is unexpectedly targeted by the rapid tRNA decay pathway in evolutionarily distant yeast speciesMonika Tasak, E. Phizicky · 2022 · bioRxiv
- ZNF598 responds to mitochondrial stress to abort stalled translation on mitochondrial outer membrane and maintain tissue homeostasisJinzhu Geng, Yu Li, Zhi-Hao Wu, Rani Ohja, Shuangxi Li, Bing-Wei Lu · 2022 · bioRxiv
- Transcriptome Analysis of the Nematode Caenorhabditis elegans and Litoditis marina in a Chemically Defined Food EnvironmentPeiqi Sun, Xuwen Cao, Liusuo Zhang · 2022 · bioRxiv
- Ribosome changes elicit non-canonical translation for chemosurvival in G0 leukemic cellsC. Datta, S. Truesdell, S. Bukhari, H. Ngue, B. Buchanan, Ke Wu, O. Le Tonqueze, S. Lee, M. Granovetter, M. Boukhali et al. · 2021 · bioRxiv
- Target of Rapamycin drives unequal responses to essential amino acid depletion in egg layingA. N. Alves, C. Sgrò, Matthew W. D. Piper, C. Mirth · 2021
- Functional Characterization of 5’ UTR Cis-Acting Sequence Elements That Modulate Translational Efficiency in P. Falciparum and HumansValentina E. Garcia, Rebekah L. Dial, J. Derisi · 2021
- A specific eIF4A paralog facilitates LARP1-mediated translation repression during mTORC1 inhibitionYuichi Shichino, Mari Mito, Kazuhiro Kashiwagi, Mari Takahashi, Takuhiro Ito, Nicholas T. Ingolia, Shintaro Iwasaki · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Functional characterization of 5’ UTR cis-acting sequence elements that modulate translational efficiency in P. falciparum and humansValentina E. Garcia, Rebekah L. Dial, J. Derisi · 2021 · bioRxiv
- Tandem repeats ubiquitously flank and select translation initiation sites.Ali M. A. Maddi, Kaveh Kavousi, Masoud Arabfard, Hamid Ohadi, Mina Ohadi · 2021 · Research Square
- Inhibition of Mul1-mediated ubiquitination promotes mitochondria-associated translationYuan Gao, M. Cardamone, Julian Kwan, Joseph Orofino, R. Hekman, Shawn M. Lyons, A. Emili, Valentina Perissi · 2021 · bioRxiv
- Дофаминовый нейротрофический фактор мозга (CDNF): структура, функции и терапевтический потенциалД. В. Ерёмин, Т. В. Ильчибаева, А. С. Цыбко · 2021 · Биохимия
- A protein-trap allele reveals roles for Drosophila ATF4 in photoreceptor degeneration, oocyte maturation and wing developmentDeepika Vasudevan, Hidetaka Katow, Grace Tang, H. Ryoo · 2021 · bioRxiv
- Decreased HECTD1 mRNA expression is associated with poor prognosis and enhanced mitochondrial cellular respiratory function in breast cancerYasuaki Uemoto, E. Katsuta, Naoto Kondo, Y. Wanifuchi-Endo, T. Fujita, Tomoko Asano, T. Hisada, M. Terada, Akiko Kato, K. Okuda et al. · 2021
- The CTEXT complex in Saccharomyces cerevisiae plays a crucial role in degrading distinct sets of aberrant mRNAs by the nuclear exosomeUpasana Saha, Rajlaxmi Gaine, Sunirmal Paira, Satarupa Das, Biswadip Das · 2021 · bioRxiv
- A novel type of IRES having variable numbers of eIF4E-binding site and synergistic effect in RNA2 of WYMV isolatesGuo-Wei Geng, Cheng-Ming Yu, Xiang-Dong Li, Ke-Rong Shi, Xue-Feng Yuan · 2021 · bioRxiv
- Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1, a novel oncogene in AMLL. Nicosia, F. Boffo, E. Ceccacci, I. Pallavicini, Fabio Bedin, Enrico Massignani, R. Ravasio, S. Minucci, T. Bonaldi · 2021 · bioRxiv
- Paip2 associates with PABPC1 on mRNA, and may facilitate PABPC1 dissociation from mRNA upon deadenylationJing-Wei Xie, Xiaoyu Wei, G. Kozlov, Y. Chen, Marie Ménade · 2021 · bioRxiv
- Upregulation of eIF4E, but not other translation initiation factors, in dendritic spines during memory consolidationS. Gindina, Benjamin Botsford, K. Cowansage, Joseph E LeDoux, E. Klann, Charles A. Hoeffer, Linnaea E. Ostroff · 2021 · bioRxiv
- Roles Of HIF and 2-Oxoglutarate Dependent Enzymes in Controlling Gene Expression In HypoxiaJulianty Frost, M. Frost, Michael Batie, Hao Jiang, S. Rocha · 2020
- Lifespan Regulation by Insulin Signaling Through Phosphorylation of Proteins Beyond FOXOWen-Jun Li, Li Tao, Chen-Wei Wang, Yong-Hong Yan, Mei-Jun Zhang, Ze-Xian Liu, Yu-Xin Li, Hanqing Zhao, Xue-Mei Li, Xian-Dong He et al. · 2020
- Obestatin signaling controls Schwann cells and axonal transport to counteract neuromuscular synaptic loss in skeletal muscleJ. Camiña, A. Sánchez-Temprano, S. Leal-Lopez, Jessica González-Sánchez, C. S. Mosteiro, R. Gallego, J. Relova, Y. Pazos · 2020
- Multivalent interactions between eIF4G1, Pub1 and Pab1 drive the formation of protein condensatesB. Chaves-Arquero, S. Martínez-Lumbreras, N. Sibille, S. Camero, P. Bernadó, M. Jiménez, S. Zorrilla, J. Pérez-Cañadillas · 2020
- A prion accelerates proliferation at the expense of lifespanDavid M. Garcia, E. Campbell, Christopher M. Jakobson, Mitsuhiro Tsuchiya, Acadia L. DiNardo, M. Kaeberlein, Dan Jarosz · 2020 · bioRxiv
- Mitochondria Controlled mTORC1 Activation Compartmentalizes Translation Initiation Factor eIF4E to Augment Intracellular Trafficking and Extracellular Export of miRNA in Mammalian CellsSusanta Chatterjee, Yogaditya Chakrabarty, Saikat Banerjee, Souvik Ghosh, S. Bhattacharyya · 2020 · bioRxiv
- Investigation of mTOR-independent regulation of macroautophagyRichard I. Odle · 2020
- Role of CDK1 in Translational Regulation in the M-PhaseJ. Kalous, Denisa Jansová, A. Šušor · 2020
- Defining the molecular determinants required for RNA binding functions of the Bicaudal‐C (Bicc1) translational repressor proteinSonam Dolma, Tomasso Tonelli, Megan E. Dowdle, M. Sheets · 2020 · The FASEB Journal