The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
HIV Enters Cells via Endocytosis and Dynamin-Dependent Fusion with Endosomes
Open accessAbstract
Summary Enveloped viruses that rely on a low pH-dependent step for entry initiate infection by fusing with acidic endosomes, whereas the entry sites for pH-independent viruses, such as HIV-1, have not been defined. These viruses have long been assumed to fuse directly with the plasma membrane. Here we used population-based measurements of the viral content delivery into the cytosol and time-resolved imaging of single viruses to demonstrate that complete HIV-1 fusion occurred in endosomes. In contrast, viral fusion with the plasma membrane did not progress beyond the lipid mixing step. HIV-1 underwent receptor-mediated internalization long before endosomal fusion, thus minimizing the surface exposure of conserved viral epitopes during fusion and reducing the efficacy of inhibitors targeting these epitopes. We also show that, strikingly, endosomal fusion is sensitive to a dynamin inhibitor. These findings imply that HIV-1 infects cells via envelope glycoprotein- and dynamin-dependent fusion with intracellular compartments.
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Wei, X., Decker, J. M., Liu, H., Zhang, Z., Arani, R. B., Kilby, J. M., Saag, M. S., Wu, X., Shaw, G. M., & Kappes, J. C. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.6.1896-1905.2002 · Cited by 1,569
pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane
Stein, B. S., Gowda, S. D., Lifson, J. D., Penhallow, R. C., Bensch, K. G., & Engleman, E. G. (1987) · Cell · doi:10.1016/0092-8674(87)90542-3 · Cited by 627
A sensitive and specific enzyme-based assay detecting HIV-1 virion fusion in primary T lymphocytes
Cavrois, M., de Noronha, C., & Greene, W. C. (2002) · Nature Biotechnology · doi:10.1038/nbt745 · Cited by 475
Human immunodeficiency virus infection of CD4-bearing cells occurs by a pH-independent mechanism
McClure, M. O., Marsh, M., & Weiss, R. A. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02839.x · Cited by 295
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Mercer, J., Schelhaas, M., & Helenius, A. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060208-104626 · Cited by 1,057
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Metadata
- Authors
- Miyauchi, K., Kim, Y., Latinovic, O., Morozov, V., & Melikyan, G. B.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 137
- Issue
- 3
- Pages
- 433-444
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2016967864
- Cited by
- 681
- References
- 4
- FWCI
- 28.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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