The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Ars2 Regulates Both miRNA- and siRNA- Dependent Silencing and Suppresses RNA Virus Infection in Drosophila
Open accessAbstract
Summary Intrinsic immune responses autonomously inhibit viral replication and spread. One pathway that restricts viral infection in plants and insects is RNA interference (RNAi), which targets and degrades viral RNA to limit infection. To identify additional genes involved in intrinsic antiviral immunity, we screened Drosophila cells for modulators of viral infection using an RNAi library. We identified Ars2 (CG7843) as a key component of Drosophila antiviral immunity. Loss of Ars2 in cells, or in flies, increases susceptibility to RNA viruses. Consistent with its antiviral properties, we found that Ars2 physically interacts with Dcr-2, modulates its activity in vitro and is required for siRNA-mediated silencing. Furthermore, we show that Ars2 plays an essential role in miRNA-mediated silencing, interacting with the Microprocessor and stabilizing pri-miRNAs. The identification of Ars2 as a player in these small RNA pathways provides new insight into the biogenesis of small RNAs that may be extended to other systems.
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Cites
Processing of primary microRNAs by the Microprocessor complex
Denli, A. M., Tops, B. B. J., Plasterk, R. H. A., Ketting, R. F., & Hannon, G. J. (2004) · Nature · doi:10.1038/nature03049 · Cited by 2,784
Endogenous siRNAs Derived from Transposons and mRNAs in Drosophila Somatic Cells
Ghildiyal, M., Seitz, H., Horwich, M. D., Li, C., Du, T., Lee, S., Xu, J., Kittler, E. L. W., Zapp, M. L., Weng, Z., et al. (2008) · Science · doi:10.1126/science.1157396 · Cited by 645
Cited by
The widespread regulation of microRNA biogenesis, function and decay
Krol, J., Loedige, I., & Filipowicz, W. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2843 · Cited by 4,672
Immunity in Drosophila melanogaster — from microbial recognition to whole-organism physiology
Buchon, N., Silverman, N., & Cherry, S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3763 · Cited by 866
Self-citationSmall RNA sorting: matchmaking for Argonautes
Czech, B., & Hannon, G. J. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2916 · Cited by 605
Posttranscriptional Regulation of MicroRNA Biogenesis in Animals
Siomi, H., & Siomi, M. C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.013 · Cited by 578
Félix, M.-A., Ashe, A., Piffaretti, J., Wu, G., Nuez, I., Bélicard, T., Jiang, Y., Zhao, G., Franz, C. J., Goldstein, L. D., et al. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000586 · Cited by 416
Metadata
- Authors
- Sabin, L. R., Zhou, R., Gruber, J. J., Lukinova, N., Bambina, S., Berman, A., Lau, C.-K., Thompson, C. B., & Cherry, S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 138
- Issue
- 2
- Pages
- 340-351
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2064539804
- Cited by
- 215
- References
- 2
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Sabin, L. R., Zhou, R., Gruber, J. J., Lukinova, N., Bambina, S., Berman, A., Lau, C.-K., Thompson, C. B., & Cherry, S. (2009). Ars2 Regulates Both miRNA- and siRNA- Dependent Silencing and Suppresses RNA Virus Infection in Drosophila. Cell. https://doi.org/10.1016/j.cell.2009.04.045
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