The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells
Open accessAbstract
We have previously reported that the loss of Arx and/or Pax4 gene activity leads to a shift in the fate of the different endocrine cell subtypes in the mouse pancreas, without affecting the total endocrine cell numbers. Here, we conditionally and ectopically express Pax4 using different cell-specific promoters and demonstrate that Pax4 forces endocrine precursor cells, as well as mature alpha cells, to adopt a beta cell destiny. This results in a glucagon deficiency that provokes a compensatory and continuous glucagon+ cell neogenesis requiring the re-expression of the proendocrine gene Ngn3. However, the newly formed alpha cells fail to correct the hypoglucagonemia since they subsequently acquire a beta cell phenotype upon Pax4 ectopic expression. Notably, this cycle of neogenesis and redifferentiation caused by ectopic expression of Pax4 in alpha cells is capable of restoring a functional beta cell mass and curing diabetes in animals that have been chemically depleted of beta cells.
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Cites
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
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In vivo reprogramming of adult pancreatic exocrine cells to β-cells
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PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
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neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
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β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas
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Self-citationAhlgren, U., Jonsson, J., Jonsson, L., Simu, K., & Edlund, H. (1998) · Genes & Development · doi:10.1101/gad.12.12.1763 · Cited by 918
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Self-citationAdult insulin- and glucagon-producing cells differentiate from two independent cell lineages
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Cited by
Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss
Thorel, F., Népote, V., Avril, I., Kohno, K., Desgraz, R., Chera, S., & Herrera, P. L. (2010) · Nature · doi:10.1038/nature08894 · Cited by 1,136
Single-Cell Transcriptomics of the Human Endocrine Pancreas
Wang, Y. J., Schug, J., Won, K.-J., Liu, C., Naji, A., Avrahami, D., Golson, M. L., & Kaestner, K. H. (2016) · Diabetes · doi:10.2337/db16-0405 · Cited by 432
Kelly, O. G., Chan, M. Y., Martinson, L. A., Kadoya, K., Ostertag, T. M., Ross, K. G., Richardson, M., Carpenter, M. K., D'Amour, K. A., Kroon, E., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1931 · Cited by 348
Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis
Ben-Othman, N., Vieira, A., Courtney, M., Record, F., Gjernes, E., Avolio, F., Hadzic, B., Druelle, N., Napolitano, T., Navarro-Sanz, S., et al. (2017) · Cell · doi:10.1016/j.cell.2016.11.002 · Cited by 322
Self-citationIslet α cells and glucagon--critical regulators of energy homeostasis
Campbell, J. E., & Drucker, D. J. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.51 · Cited by 266
Metadata
- Authors
- Collombat, P., Xu, X., Ravassard, P., Sosa-Pineda, B., Dussaud, S., Billestrup, N., Madsen, O. D., Serup, P., Heimberg, H., & Mansouri, A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 138
- Issue
- 3
- Pages
- 449-462
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2057361172
- Cited by
- 549
- References
- 30
- FWCI
- 35.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Collombat, P., Xu, X., Ravassard, P., Sosa-Pineda, B., Dussaud, S., Billestrup, N., Madsen, O. D., Serup, P., Heimberg, H., & Mansouri, A. (2009). The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells. Cell. https://doi.org/10.1016/j.cell.2009.05.035
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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