The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication
Open accessAbstract
Telomeres protect chromosome ends through the interaction of telomeric repeats with shelterin, a protein complex that represses DNA damage signaling and DNA repair reactions. The telomeric repeats are maintained by telomerase, which solves the end replication problem. We report that the TTAGGG repeat arrays of mammalian telomeres pose a challenge to the DNA replication machinery, giving rise to replication-dependent defects that resemble those of aphidicolin-induced common fragile sites. Gene deletion experiments showed that efficient duplication of telomeres requires the shelterin component TRF1. Without TRF1, telomeres activate the ATR kinase in S phase and show a fragile-site phenotype in metaphase. Single-molecule analysis of replicating telomeres showed that TRF1 promotes efficient replication of TTAGGG repeats and prevents fork stalling. Two helicases implicated in the removal of G4 DNA structures, BLM and RTEL1, were required to repress the fragile-telomere phenotype. These results identify a second telomere replication problem that is solved by the shelterin component TRF1.
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“TRF1 can serve to modulate telomere length, but it also serves to facilitate DNA replication through the telomere repeats, which acts as fragile DNA sites (5)(6)(7).”
From Telomeres and telomerase in cancer (2010) · cites this paper as [7]
In the citing paper
“The shelterin protein complex protects telomeres, facilitates replication and controls access of telomerase.”
From Telomeres and telomerase in cancer (2010) · cites this paper as Sfeir,A. et al. (2009)
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Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
Identification of a specific telomere terminal transferase activity in tetrahymena extracts
Greider, C. W., & Blackburn, E. H. (1985) · Cell · doi:10.1016/0092-8674(85)90170-9 · Cited by 3,400
Shelterin: the protein complex that shapes and safeguards human telomeres
de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056
How Shelterin Protects Mammalian Telomeres
Palm, W., & de Lange, T. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130350 · Cited by 1,802
Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia
Barlow, C., Hirotsune, S., Paylor, R. E., Liyanage, M., Eckhaus, M., Collins, F. S., Shiloh, Y., Crawley, J. N., Ried, T., Tagle, D. A., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80086-0 · Cited by 1,465
DNA Damage Foci at Dysfunctional Telomeres
Takai, H., Smogorzewska, A., & de Lange, T. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00542-6 · Cited by 1,409
Telomeric Repeat–Containing RNA and RNA Surveillance Factors at Mammalian Chromosome Ends
Azzalin, C. M., Reichenbach, P., Khoriauli, L., Giulotto, E., & Lingner, J. (2007) · Science · doi:10.1126/science.1147182 · Cited by 1,379
Control of telomere length by the human telomeric protein TRF1
van Steensel, B., & de Lange, T. (1997) · Nature · doi:10.1038/385740a0 · Cited by 1,219
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
Denchi, E. L., & de Lange, T. (2007) · Nature · doi:10.1038/nature06065 · Cited by 880
Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II
Schoeftner, S., & Blasco, M. A. (2007) · Nature Cell Biology · doi:10.1038/ncb1685 · Cited by 828
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Self-citationCopy number variation and selection during reprogramming to pluripotency
Hussein, S. M. I., Batada, N. N., Vuoristo, S., Ching, R. W., Autio, R., Närvä, E., Ng, S. H. S., Sourour, M., Hämäläinen, R. H., Olsson, C., et al. (2011) · Nature · doi:10.1038/nature09871 · Cited by 980
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Metadata
- Authors
- Sfeir, A., Kosiyatrakul, S. T., Hockemeyer, D., MacRae, S. L., Karlseder, J., Schildkraut, C. L., & de Lange, T.
- Affiliations
- Rockefeller University (US)
- Albert Einstein College of Medicine (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 138
- Issue
- 1
- Pages
- 90-103
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2723738
- OpenAlex
- W2161232591
- Cited by
- 990
- References
- 73
- Citations by year
- 2026: 28 · 2025: 50 · 2024: 44 · 2023: 60 · 2022: 42 · 2021: 60 · 2020: 83 · 2019: 59 · 2018: 57 · 2017: 54 · 2016: 61 · 2015: 66 · 2014: 73 · 2013: 67 · 2012: 67
- FWCI
- 41.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1477 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Susan G. Komen
- National Institutes of Health
- U.S. Bureau of Land Management
- National Institute on Aging (R01AG016642)
- National Cancer Institute (R01CA076027)
- National Institute of General Medical Sciences (R37GM049046)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- telomeres, TRF1, shelterin, fragile sites, DNA replication, TTAGGG repeats, ATR kinase, BLM helicase, RTEL1, telomere maintenance, mammalian cells
- MeSH terms
- Animals, DNA Replication, Humans, Metaphase, Aphidicolin, Telomere, Chromosomes, Mammalian, Telomeric Repeat Binding Protein 1, Chromosome Fragile Sites, Mice
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