The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening
Open accessAbstract
Summary Screens for agents that specifically kill epithelial cancer stem cells (CSCs) have not been possible due to the rarity of these cells within tumor cell populations and their relative instability in culture. We describe here a novel approach to screening for agents with epithelial CSC-specific toxicity. We have implemented this method in the context of a chemical screen and have discovered compounds showing selective toxicity for breast CSCs. In functional assays, one compound (salinomycin) reduced the proportion of CSCs by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug. Treatment of mice with salinomycin inhibits mammary tumor growth in vivo and induces increased epithelial differentiation of tumor cells. In addition, global gene expression analyses show that salinomycin but not paclitaxel treatment results in the loss of expression of breast CSC genes previously identified by analyses of breast tissues isolated directly from patients. This study demonstrates that it is possible to identify agents with specific toxicity for epithelial CSCs as well as providing a practical approach for doing so.
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Self-citationProspective identification of tumorigenic breast cancer cells
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Self-citationThe Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
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Self-citationGlioma stem cells promote radioresistance by preferential activation of the DNA damage response
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A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
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Identification and expansion of human colon-cancer-initiating cells
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Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
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Self-citationTumour stem cells and drug resistance
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Identification of Pancreatic Cancer Stem Cells
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Cited by
Epithelial-Mesenchymal Transitions in Development and Disease
Thiery, J. P., Acloque, H., Huang, R. Y. J., & Nieto, M. A. (2009) · Cell · doi:10.1016/j.cell.2009.11.007 · Cited by 9,931
Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492
Greaves, M., & Maley, C. C. (2012) · Nature · doi:10.1038/nature10762 · Cited by 3,162
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
Singh, A., & Settleman, J. (2010) · Oncogene · doi:10.1038/onc.2010.215 · Cited by 2,545
EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
Shibue, T., & Weinberg, R. A. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.44 · Cited by 2,539
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Metadata
- Authors
- Gupta, P. B., Onder, T. T., Jiang, G., Tao, K., Kuperwasser, C., Weinberg, R. A., & Lander, E. S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 138
- Issue
- 4
- Pages
- 645-659
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2120656656
- Cited by
- 2,389
- References
- 34
- FWCI
- 78.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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