The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells
Open accessAbstract
Summary Human breast tumors contain a breast cancer stem cell (BCSC) population with properties reminiscent of normal stem cells. We found 37 microRNAs that were differentially expressed between human BCSCs and non-tumorigenic cancer cells. Three clusters, miR-200c-141, miR-200b-200a-429 and miR-183-96-182 were down-regulated in human BCSCs, normal human and murine mammary stem/progenitor cells and embryonal carcinoma cells. Expression of BMI1, a known regulator of stem cell self-renewal, was modulated by miR-200c. MiR-200c inhibited the clonogenicity of breast cancer cells and suppressed the growth of embryonal carcinoma cells in vitro. Most importantly, miR-200c strongly suppressed the ability of normal mammary stem cells to form mammary ducts and tumor formation driven by human BCSCs in vivo. The coordinated down-regulation of three microRNA clusters and the similar functional regulation of clonogenicity by miR-200c provide a molecular link that connects breast cancer stem cells with normal stem cells.
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Metadata
- Authors
- Shimono, Y., Zabala, M., Cho, R. W., Lobo, N., Dalerba, P., Qian, D., Diehn, M., Liu, H., Panula, S. P., Chiao, E., Dirbas, F. M., Somlo, G., Pera, R. A. R., Lao, K., & Clarke, M. F.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 138
- Issue
- 3
- Pages
- 592-603
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2129355962
- Cited by
- 1,213
- References
- 6
- FWCI
- 32.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Shimono, Y., Zabala, M., Cho, R. W., Lobo, N., Dalerba, P., Qian, D., Diehn, M., Liu, H., Panula, S. P., Chiao, E., Dirbas, F. M., Somlo, G., Pera, R. A. R., Lao, K., & Clarke, M. F. (2009). Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells. Cell. https://doi.org/10.1016/j.cell.2009.07.011
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