The DOI matches its Crossref record.
Cytoskeletal Forces Span the Nuclear Envelope to Coordinate Meiotic Chromosome Pairing and Synapsis
Open accessAbstract
Summary Sexual reproduction requires the unique cell division called meiosis, in which a diploid cell undergoes a reductional division to generate haploid gametes. A hallmark of meiotic prophase is the formation of pairwise linkages between homologous chromosomes, which later enable them to segregate from each other. In most organisms the pairing of homologous chromosomes is reinforced by synapsis, the polymerization of the synaptonemal complex (SC) between paired chromosome axes. The primary questions addressed here are: 1) how pairing is accomplished and 2) how synapsis is regulated so that it occurs selectively between homologs. We provide evidence that a connection between the chromosomes and the microtubule cytoskeleton via a bridge across the nuclear envelope is critical for both of these mechanisms. Our results indicate the existence of a mechanism that uses dynein to assess homology before licensing SC polymerization. The molecular components of this mechanism are conserved from fungi to mammals.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Zhang, L., Ward, J. D., Cheng, Z., & Dernburg, A. F. (2015) · Development · doi:10.1242/dev.129635 · Cited by 599
Self-citationFunctions and mechanics of dynein motor proteins
Roberts, A. J., Kon, T., Knight, P. J., Sutoh, K., & Burgess, S. A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3667 · Cited by 537
Chiolo, I., Minoda, A., Colmenares, S. U., Polyzos, A., Costes, S. V., & Karpen, G. H. (2011) · Cell · doi:10.1016/j.cell.2011.02.012 · Cited by 527
Broad chromosomal domains of histone modification patterns in C. elegans
Liu, T., Rechtsteiner, A., Egelhofer, T. A., Vielle, A., Latorre, I., Cheung, M.-S., Ercan, S., Ikegami, K., Jensen, M., Kolasinska-Zwierz, P., et al. (2011) · Genome Research · doi:10.1101/gr.115519.110 · Cited by 298
Self-citationChain reaction: LINC complexes and nuclear positioning
Burke, B. (2019) · F1000Research · doi:10.12688/f1000research.16877.1 · Cited by 35
Metadata
- Authors
- Sato, A., Isaac, B., Phillips, C. M., Rillo, R., Carlton, P. M., Wynne, D. J., Kasad, R. A., & Dernburg, A. F.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 139
- Issue
- 5
- Pages
- 907-919
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1992267971
- Cited by
- 285
- References
- 0
- FWCI
- 7.27
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cytoskeletal Forces Span the Nuclear Envelope to Coordinate Meiotic Chromosome Pairing and Synapsis. https://app.cochat.ai/papers/10.1016/j.cell.2009.10.039
- The paper
- Sato, A., Isaac, B., Phillips, C. M., Rillo, R., Carlton, P. M., Wynne, D. J., Kasad, R. A., & Dernburg, A. F. (2009). Cytoskeletal Forces Span the Nuclear Envelope to Coordinate Meiotic Chromosome Pairing and Synapsis. Cell. https://doi.org/10.1016/j.cell.2009.10.039
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
