The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.
Functions and mechanics of dynein motor proteins
Open accessAbstract
Fuelled by ATP hydrolysis, dyneins generate force and movement on microtubules in a wealth of biological processes, including ciliary beating, cell division and intracellular transport. The large mass and complexity of dynein motors have made elucidating their mechanisms a sizable task. Yet, through a combination of approaches, including X-ray crystallography, cryo-electron microscopy, single-molecule assays and biochemical experiments, important progress has been made towards understanding how these giant motor proteins work. From these studies, a model for the mechanochemical cycle of dynein is emerging, in which nucleotide-driven flexing motions within the AAA+ ring of dynein alter the affinity of its microtubule-binding stalk and reshape its mechanical element to generate movement.
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Cites
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Cited by
Axonal transport: cargo-specific mechanisms of motility and regulation
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Cryo-EM shows how dynactin recruits two dyneins for faster movement
Urnavicius, L., Lau, C. K., Elshenawy, M. M., Morales-Rios, E., Motz, C., Yildiz, A., & Carter, A. P. (2018) · Nature · doi:10.1038/nature25462 · Cited by 283
Tyrosination of α‐tubulin controls the initiation of processive dynein–dynactin motility
McKenney, R. J., Huynh, W., Vale, R. D., & Sirajuddin, M. (2016) · The EMBO Journal · doi:10.15252/embj.201593071 · Cited by 232
Advances in the Genetics of Primary Ciliary Dyskinesia
Horani, A., & Ferkol, T. W. (2018) · Chest · doi:10.1016/j.chest.2018.05.007 · Cited by 147
Propulsive nanomachines: the convergent evolution of archaella, flagella and cilia
Beeby, M., Ferreira, J. L., Tripp, P., Albers, S.-V., & Mitchell, D. R. (2020) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaa006 · Cited by 110
Metadata
- Authors
- Roberts, A. J., Kon, T., Knight, P. J., Sutoh, K., & Burgess, S. A.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2013-09-25
- Volume
- 14
- Issue
- 11
- Pages
- 713-726
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2010366657
- Cited by
- 537
- References
- 147
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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