The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus
Open accessAbstract
Summary Influenza viruses exploit host cell machinery to replicate, resulting in epidemics of respiratory illness. In turn, the host expresses anti-viral restriction factors to defend against infection. To find host-cell modifiers of influenza A H1N1 viral infection, we used a functional genomic screen and identified over 120 influenza A virus-dependency factors with roles in endosomal acidification, vesicular trafficking, mitochondrial metabolism and RNA splicing. We discovered that the interferon-inducible trans-membrane proteins, IFITM1, 2 and 3, restrict an early step in influenza A viral replication. The IFITM proteins confer basal resistance to influenza A virus, but are also inducible by interferons type I and II, and are critical for interferon's virustatic actions. Further characterization revealed that the IFITM proteins inhibit the early replication of flaviviruses, including dengue virus and West Nile virus. Collectively this work identifies a new family of anti-viral restriction factors that mediate cellular resistance to at least three major human pathogens.
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“…S2), including a summary comparison of enriched GO categories for three whole-genome screens for host-factor modifiers of viral infection (HIV, [Brass et al., 2008], influenza A virus [this study], and WNV [Krishnan et al., 2008]), wherein each screen’s respective candidate gene list was…”
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Self-citationSARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies
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Metadata
- Authors
- Brass, A. L., Huang, I.-C., Benita, Y., John, S. P., Krishnan, M. N., Feeley, E. M., Ryan, B. J., Weyer, J. L., van der Weyden, L., Fikrig, E., Adams, D. J., Xavier, R. J., Farzan, M., & Elledge, S. J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 139
- Issue
- 7
- Pages
- 1243-1254
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2003988251
- Cited by
- 1,269
- References
- 3
- FWCI
- 23.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Brass, A. L., Huang, I.-C., Benita, Y., John, S. P., Krishnan, M. N., Feeley, E. M., Ryan, B. J., Weyer, J. L., van der Weyden, L., Fikrig, E., Adams, D. J., Xavier, R. J., Farzan, M., & Elledge, S. J. (2009). The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus. Cell. https://doi.org/10.1016/j.cell.2009.12.017
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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