The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
A Physical and Regulatory Map of Host-Influenza Interactions Reveals Pathways in H1N1 Infection
Open accessAbstract
Summary During the course of a viral infection, viral proteins interact with an array of host proteins and pathways. Here we present a systematic strategy to elucidate the dynamic interactions between H1N1 influenza and its human host. A combination of yeast two hybrid analysis and genome-wide expression profiling implicated hundreds of human factors in mediating viral-host interactions. These factors were then examined functionally through depletion analyses in primary lung cells. The resulting data point to potential roles for some unanticipated host and viral proteins in viral infection and the host response, including a network of RNA binding proteins, components of WNT signaling and viral polymerase subunits. This multilayered approach provides a comprehensive and unbiased physical and regulatory model of influenza-host interactions, and demonstrates a general strategy for uncovering complex host-pathogen relationships.
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Gene Ontology: tool for the unification of biology
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Self-citationCluster analysis and display of genome-wide expression patterns
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“Previous studies on viral and host factors have focused on specific interactions but have not produced global models of the viral-host relationship, with few exceptions (Brass et al., 2008; Bushman et al., 2009; König et al., 2008; Krishnan et al., 2008; Li et al., 2009).”
BackgroundEpstein–Barr virus and virus human protein interaction maps
Calderwood, M. A., Venkatesan, K., Xing, L., Chase, M. R., Vazquez, A., Holthaus, A. M., Ewence, A. E., Li, N., Hirozane-Kishikawa, T., Hill, D. E., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702332104 · Cited by 388
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A promoter-level mammalian expression atlas
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Interactome Networks and Human Disease
Vidal, M., Cusick, M. E., & Barabási, A.-L. (2011) · Cell · doi:10.1016/j.cell.2011.02.016 · Cited by 1,771
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Jäger, S., Cimermancic, P., Gulbahce, N., Johnson, J. R., McGovern, K. E., Clarke, S. C., Shales, M., Mercenne, G., Pache, L., Li, K., et al. (2012) · Nature · doi:10.1038/nature10719 · Cited by 731
Jensen, S., & Thomsen, A. R. (2012) · Journal of Virology · doi:10.1128/jvi.05738-11 · Cited by 604
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Metadata
- Authors
- Shapira, S. D., Gat-Viks, I., Shum, B. O. V., Dricot, A., de Grace, M. M., Wu, L., Gupta, P. B., Hao, T., Silver, S. J., Root, D. E., Hill, D. E., Regev, A., & Hacohen, N.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 139
- Issue
- 7
- Pages
- 1255-1267
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1551693619
- Cited by
- 635
- References
- 6
- FWCI
- 34.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Shapira, S. D., Gat-Viks, I., Shum, B. O. V., Dricot, A., de Grace, M. M., Wu, L., Gupta, P. B., Hao, T., Silver, S. J., Root, D. E., Hill, D. E., Regev, A., & Hacohen, N. (2009). A Physical and Regulatory Map of Host-Influenza Interactions Reveals Pathways in H1N1 Infection. Cell. https://doi.org/10.1016/j.cell.2009.12.018
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
