The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Q System: A Repressible Binary System for Transgene Expression, Lineage Tracing, and Mosaic Analysis
Open accessAbstract
Summary We describe a new repressible binary expression system based on the regulatory genes from the Neurospora qa gene cluster. This ‘Q system’ offers attractive features for transgene expression in Drosophila and mammalian cells: low basal expression in the absence of the transcriptional activator QF, high QF-induced expression, and QF repression by its repressor QS. Additionally, feeding flies quinic acid can relieve QS repression. The Q system offers many applications including: 1) intersectional ‘logic gates’ with the GAL4 system for manipulating transgene expression patterns, 2) GAL4-independent MARCM analysis, 3) coupled MARCM analysis to independently visualize and genetically manipulate siblings from any cell division. We demonstrate the utility of the Q system in determining cell division patterns of a neuronal lineage and gene function in cell growth and proliferation, and in dissecting neurons responsible for olfactory attraction. The Q system can be expanded to other uses in Drosophila, and to any organism conducive to transgenesis.
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Cites
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.
Gossen, M., & Bujard, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5547 · Cited by 4,943 · cited 2×
“A number of binary expression systems have been established in genetic model organisms, including tetracycline-regulable tTA/TRE in mice (Gossen and Bujard, 1992) and GAL4/UAS in flies (Fischer et al.”
Developmentally programmed remodeling of the Drosophila olfactory circuit
Marin, E. C., Watts, R. J., Tanaka, N. K., Ito, K., & Luo, L. (2005) · Development · doi:10.1242/dev.01614 · Cited by 177
Self-citation
Cited by
Refinement of Tools for Targeted Gene Expression in Drosophila
Pfeiffer, B. D., Ngo, T.-T. B., Hibbard, K. L., Murphy, C., Jenett, A., Truman, J. W., & Rubin, G. M. (2010) · Genetics · doi:10.1534/genetics.110.119917 · Cited by 1,153
The neuronal architecture of the mushroom body provides a logic for associative learning
Aso, Y., Hattori, D., Yu, Y., Johnston, R. M., Iyer, N. A., Ngo, T.-T., Dionne, H., Abbott, L., Axel, R., Tanimoto, H., et al. (2014) · eLife · doi:10.7554/elife.04577 · Cited by 1,051
Daigle, T. L., Madisen, L., Hage, T. A., Valley, M. T., Knoblich, U., Larsen, R. S., Takeno, M. M., Huang, L., Gu, H., Larsen, R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.06.035 · Cited by 817
Self-citationVenken, K. J. T., Schulze, K. L., Haelterman, N. A., Pan, H., He, Y., Evans-Holm, M., Carlson, J. W., Levis, R. W., Spradling, A. C., Hoskins, R. A., et al. (2011) · Nature Methods · doi:10.1038/nmeth.1662 · Cited by 675
Genetic Manipulation of Genes and Cells in the Nervous System of the Fruit Fly
Venken, K. J. T., Simpson, J. H., & Bellen, H. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.021 · Cited by 450
Metadata
- Authors
- Potter, C. J., Tasic, B., Russler, E. V., Liang, L., & Luo, L.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 141
- Issue
- 3
- Pages
- 536-548
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2157071511
- Cited by
- 604
- References
- 2
- FWCI
- 13.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Potter, C. J., Tasic, B., Russler, E. V., Liang, L., & Luo, L. (2010). The Q System: A Repressible Binary System for Transgene Expression, Lineage Tracing, and Mosaic Analysis. Cell. https://doi.org/10.1016/j.cell.2010.02.025
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