The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.
Origin of Chromosomal Translocations in Lymphoid Cancer
Open accessAbstract
Summary Aberrant fusions between heterologous chromosomes are among the most prevalent cytogenetic abnormalities found in cancer cells. Oncogenic chromosomal translocations provide cells with a proliferative or survival advantage. They may either initiate transformation or be acquired secondarily as a result of genomic instability. Here we highlight recent advances toward understanding the origin of chromosomal translocations in incipient lymphoid cancers and how tumor-suppressive pathways normally limit the frequency of these aberrant recombination events. Deciphering the mechanisms that mediate chromosomal fusions will open new avenues for developing therapeutic strategies aimed at eliminating lesions that lead to the initiation, maintenance, and progression of cancer.
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Metadata
- Authors
- Nussenzweig, A., & Nussenzweig, M. C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 141
- Issue
- 1
- Pages
- 27-38
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2117973542
- Cited by
- 317
- References
- 123
- FWCI
- 18.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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