The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Basal Dynamics of p53 Reveal Transcriptionally Attenuated Pulses in Cycling Cells
Open accessAbstract
Summary The tumor suppressor p53 is activated by stress and leads to cellular outcomes such as apoptosis and cell cycle arrest. Its activation must be highly sensitive to ensure that cells react appropriately to damage. However, proliferating cells often encounter transient damage during normal growth, where cell cycle arrest or apoptosis may be unfavorable. How does the p53 pathway achieve the right balance between high sensitivity and tolerance to intrinsic damage? Using quantitative time-lapse microscopy of individual human cells we found that proliferating cells show spontaneous pulses of p53, which are triggered by an excitable mechanism during cell cycle phases associated with intrinsic DNA damage. However, in the absence of sustained damage, post-translational modifications keep p53 inactive, preventing it from inducing p21 expression and cell cycle arrest. Our approach of quantifying basal dynamics in individual cells can now be used to study how other pathways in human cells achieve sensitivity in noisy environments.
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Cites
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“in Cycling Cells”
BackgroundDNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
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Network motifs: theory and experimental approaches
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Blinded by the Light: The Growing Complexity of p53
Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163
The p53 pathway: positive and negative feedback loops
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Transcriptional control of human p53-regulated genes
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“in Cycling Cells”
BackgroundRegulating the p53 pathway: in vitro hypotheses, in vivo veritas
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Post-translational modification of p53 in tumorigenesis
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Cited by
Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence
Li, T., Kon, N., Jiang, L., Tan, M., Ludwig, T., Zhao, Y., Baer, R., & Gu, W. (2012) · Cell · doi:10.1016/j.cell.2012.04.026 · Cited by 912
p53 Dynamics Control Cell Fate
Purvis, J. E., Karhohs, K. W., Mock, C., Batchelor, E., Loewer, A., & Lahav, G. (2012) · Science · doi:10.1126/science.1218351 · Cited by 770
Self-citationBarr, A. R., Cooper, S., Heldt, F. S., Butera, F., Stoy, H., Mansfeld, J., Novák, B., & Bakal, C. (2017) · Nature Communications · doi:10.1038/ncomms14728 · Cited by 403
Cell-to-cell variation in p53 dynamics leads to fractional killing.
Paek, A. L., Liu, J. C., Loewer, A., Forrester, W. C., & Lahav, G. (2016) · Cell · doi:10.1016/j.cell.2016.03.025 · Cited by 292
Self-citationImpulse Control: Temporal Dynamics in Gene Transcription
Yosef, N., & Regev, A. (2011) · Cell · doi:10.1016/j.cell.2011.02.015 · Cited by 258
Metadata
- Authors
- Loewer, A., Batchelor, E., Gaglia, G., & Lahav, G.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 142
- Issue
- 1
- Pages
- 89-100
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1977497204
- Cited by
- 234
- References
- 14
- FWCI
- 8.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Loewer, A., Batchelor, E., Gaglia, G., & Lahav, G. (2010). Basal Dynamics of p53 Reveal Transcriptionally Attenuated Pulses in Cycling Cells. Cell. https://doi.org/10.1016/j.cell.2010.05.031
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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