The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5
Open accessAbstract
Summary Activation induced cytidine deaminase (AID) initiates antibody gene diversification by creating U:G mismatches. However, AID is not specific for antibody genes. Off-target lesions can activate oncogenes or cause chromosome translocations. Despite its importance in these transactions little is known about how AID finds its targets. To address this, we performed an shRNA screen. We found that Spt5, a factor associated with stalled RNA polymerase II (Pol II) and single stranded DNA (ssDNA), is required for class switch recombination (CSR). Spt5 interacts with AID, it is required for the association of AID and Pol II, and for AID recruitment to Ig switch regions and non-Ig targets. ChIP-seq experiments reveal that Spt5 co-localizes with AID and stalled Pol II. Further, Spt5 accumulation at sites of Pol II stalling is predictive of AID-induced mutation. We propose that AID is targeted to sites of Pol II stalling in part via its association with Spt5.
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Control of RNA Polymerase II Elongation Potential by a Novel Carboxyl-terminal Domain Kinase
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Nechaev, S., Fargo, D. C., dos Santos, G., Liu, L., Gao, Y., & Adelman, K. (2010) · Science · doi:10.1126/science.1181421 · Cited by 424
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Victora, G. D., & Nussenzweig, M. C. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075032 · Cited by 1,878
Self-citationNoncoding RNA transcription targets AID to divergently transcribed loci in B cells
Pefanis, E., Wang, J., Rothschild, G., Lim, J., Chao, J., Rabadan, R., Economides, A. N., & Basu, U. (2014) · Nature · doi:10.1038/nature13580 · Cited by 201
Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination
Hwang*, J. K., Alt*, F. W., & Yeap, L.-S. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.mdna3-0037-2014 · Cited by 126
Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells
Compagno, M., Wang, Q., Pighi, C., Cheong, T.-C., Meng, F.-L., Poggio, T., Yeap, L.-S., Karaca, E., Blasco, R. B., Langellotto, F., et al. (2017) · Nature · doi:10.1038/nature21406 · Cited by 126
Stanlie, A., Yousif, A. S., Akiyama, H., Honjo, T., & Begum, N. A. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.018 · Cited by 101
Metadata
- Authors
- Pavri, R., Gazumyan, A., Jankovic, M., Di Virgilio, M., Klein, I., Ansarah-Sobrinho, C., Resch, W., Yamane, A., San-Martin, B. R., Barreto, V., Nieland, T. J., Root, D. E., Casellas, R., & Nussenzweig, M. C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 143
- Issue
- 1
- Pages
- 122-133
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2017629702
- Cited by
- 378
- References
- 3
- FWCI
- 15.24
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Pavri, R., Gazumyan, A., Jankovic, M., Di Virgilio, M., Klein, I., Ansarah-Sobrinho, C., Resch, W., Yamane, A., San-Martin, B. R., Barreto, V., Nieland, T. J., Root, D. E., Casellas, R., & Nussenzweig, M. C. (2010). Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5. Cell. https://doi.org/10.1016/j.cell.2010.09.017
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