The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
The Long Noncoding RNA, Jpx, Is a Molecular Switch for X Chromosome Inactivation
Open accessAbstract
SUMMARY Once protein-coding, the X-inactivation center (Xic) is now dominated by large noncoding RNAs (ncRNA). X-chromosome inactivation (XCI) equalizes gene expression between mammalian males and females by inactivating one X in female cells. XCI requires Xist, a ncRNA that coats the X and recruits Polycomb proteins. How Xist is controlled remains unclear but likely involves negative and positive regulators. For the active X, the antisense Tsix RNA is an established Xist repressor. For the inactive X, here we identify Xic-encoded Jpx as an Xist activator. Jpx is developmentally regulated and accumulates during XCI. Deleting Jpx blocks XCI and is female-lethal. Posttranscriptional Jpx knockdown recapitulates the knockout, while supplying Jpx in trans rescues lethality. Thus, Jpx is trans-acting and functions as ncRNA. Furthermore, ΔJpx is rescued by truncating Tsix, indicating an antagonistic relationship between the ncRNAs. We conclude that Xist is controlled by two RNA-based switches – Tsix for Xa, and Jpx for Xi.
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Fatica, A., & Bozzoni, I. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3606 · Cited by 2,980
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Batista, P. J., & Chang, H. Y. (2013) · Cell · doi:10.1016/j.cell.2013.02.012 · Cited by 2,531
Long noncoding RNAs: past, present, and future
Kung, J. T. Y., Colognori, D., & Lee, J. T. (2013) · Genetics · doi:10.1534/genetics.112.146704 · Cited by 1,874
Self-citationThe functional role of long non-coding RNA in human carcinomas
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Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis
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Metadata
- Authors
- Tian, D., Sun, S., & Lee, J. T.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 143
- Issue
- 3
- Pages
- 390-403
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2135302954
- Cited by
- 522
- References
- 59
- FWCI
- 22.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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