The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates
Open accessAbstract
SUMMARY Activation Induced cytidine Deaminase (AID) initiates Immunoglobulin (Ig) heavy chain (IgH) class switch recombination (CSR) and Ig variable region somatic hypermutation (SHM) in B lymphocytes by deaminating cytidines on template and non-template strands of transcribed DNA substrates. However, the mechanism of AID access to the template DNA strand, particularly when hybridized to a nascent RNA transcript, has been an enigma. We now implicate the RNA exosome, a cellular RNA processing/degradation complex, in targeting AID to both DNA strands. In B-lineage cells activated for CSR, the RNA exosome associates with AID, accumulates on IgH switch regions in an AID-dependent fashion, and is required for optimal CSR. Moreover, both the cellular RNA exosome complex and a recombinant RNA exosome core complex impart robust AID- and transcription-dependent DNA deamination of both strands of transcribed SHM substrates in vitro. Our findings reveal a role for non-coding RNA surveillance machinery in generating antibody diversity.
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Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y., & Honjo, T. (2000) · Cell · doi:10.1016/s0092-8674(00)00078-7 · Cited by 3,474
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
Lieber, M. R. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.093131 · Cited by 2,882
Revy, P., Muto, T., Levy, Y., Geissmann, F., Plebani, A., Sanal, O., Catalan, N., Forveille, M., Dufourcq-Lagelouse, R., Gennery, A., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00079-9 · Cited by 1,647
Molecular Mechanisms of Antibody Somatic Hypermutation
Di Noia, J. M., & Neuberger, M. S. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.061705.090740 · Cited by 1,106
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification
Petersen-Mahrt, S. K., Harris, R. S., & Neuberger, M. S. (2002) · Nature · doi:10.1038/nature00862 · Cited by 897
RNA Degradation by the Exosome Is Promoted by a Nuclear Polyadenylation Complex
LaCava, J., Houseley, J., Saveanu, C., Petfalski, E., Thompson, E., Jacquier, A., & Tollervey, D. (2005) · Cell · doi:10.1016/j.cell.2005.04.029 · Cited by 879
RNA Exosome Depletion Reveals Transcription Upstream of Active Human Promoters
Preker, P., Nielsen, J., Kammler, S., Lykke-Andersen, S., Christensen, M. S., Mapendano, C. K., Schierup, M. H., & Jensen, T. H. (2008) · Science · doi:10.1126/science.1164096 · Cited by 791
Inactivation of the SR Protein Splicing Factor ASF/SF2 Results in Genomic Instability
Li, X., & Manley, J. L. (2005) · Cell · doi:10.1016/j.cell.2005.06.008 · Cited by 769
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
Yu, K., Chedin, F., Hsieh, C.-L., Wilson, T. E., & Lieber, M. R. (2003) · Nature Immunology · doi:10.1038/ni919 · Cited by 746
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
Chaudhuri, J., Tian, M., Khuong, C., Chua, K., Pinaud, E., & Alt, F. W. (2003) · Nature · doi:10.1038/nature01574 · Cited by 746
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Victora, G. D., & Nussenzweig, M. C. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075032 · Cited by 1,878
Skourti-Stathaki, K., & Proudfoot, N. J. (2014) · Genes & Development · doi:10.1101/gad.242990.114 · Cited by 532
Mechanisms of Programmed DNA Lesions and Genomic Instability in the Immune System
Alt, F. W., Zhang, Y., Meng, F.-L., Guo, C., & Schwer, B. (2013) · Cell · doi:10.1016/j.cell.2013.01.007 · Cited by 484
Self-citationAguilera, A., & García-Muse, T. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-111212-133232 · Cited by 476
RNA Exosome-Regulated Long Non-Coding RNA Transcription Controls Super-Enhancer Activity
Pefanis, E., Wang, J., Rothschild, G., Lim, J., Kazadi, D., Sun, J., Federation, A., Chao, J., Elliott, O., Liu, Z.-P., et al. (2015) · Cell · doi:10.1016/j.cell.2015.04.034 · Cited by 464
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Metadata
- Authors
- Basu, U., Meng, F.-L., Keim, C., Grinstein, V., Pefanis, E., Eccleston, J., Zhang, T., Myers, D., Wasserman, C. R., Wesemann, D. R., Januszyk, K., Gregory, R. I., Deng, H., Lima, C. D., & Alt, F. W.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 144
- Issue
- 3
- Pages
- 353-363
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2121647638
- Cited by
- 313
- References
- 77
- FWCI
- 13.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Basu, U., Meng, F.-L., Keim, C., Grinstein, V., Pefanis, E., Eccleston, J., Zhang, T., Myers, D., Wasserman, C. R., Wesemann, D. R., Januszyk, K., Gregory, R. I., Deng, H., Lima, C. D., & Alt, F. W. (2011). The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates. Cell. https://doi.org/10.1016/j.cell.2011.01.001
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