The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
Open accessAbstract
Double-strand DNA breaks are common events in eukaryotic cells, and there are two major pathways for repairing them: homologous recombination (HR) and nonhomologous DNA end joining (NHEJ). The various causes of double-strand breaks (DSBs) result in a diverse chemistry of DNA ends that must be repaired. Across NHEJ evolution, the enzymes of the NHEJ pathway exhibit a remarkable degree of structural tolerance in the range of DNA end substrate configurations upon which they can act. In vertebrate cells, the nuclease, DNA polymerases, and ligase of NHEJ are the most mechanistically flexible and multifunctional enzymes in each of their classes. Unlike repair pathways for more defined lesions, NHEJ repair enzymes act iteratively, act in any order, and can function independently of one another at each of the two DNA ends being joined. NHEJ is critical not only for the repair of pathologic DSBs as in chromosomal translocations, but also for the repair of physiologic DSBs created during variable (diversity) joining [V(D)J] recombination and class switch recombination (CSR). Therefore, patients lacking normal NHEJ are not only sensitive to ionizing radiation (IR), but also severely immunodeficient.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some non-recurrent deletion CNVs have 2-20 bp of microhomology at their breakpoints and are predicted to arise through MMEJ.
“Breakpoints of some non-recurrent deletion CNVs have sequences with very short (2–20 basepairs) stretches of nucleotide identity. These are predicted to be formed by an alternative microhomology mediated end joining (MMEJ) mechanism (Lieber, 2010).”
From CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics (2012) · cites this paper as Lieber, 2010
NHEJ repairs breaks induced by ionizing radiation, oxidative free radicals, misappropriate enzymatic action at sensitive sites, inhibition of topoisomerases, and other mechanical stresses.
“DNA double-strand break repair or non-homologous end joining (NHEJ) repairs breaks induced by ionizing radiation (IR), oxidative free radicals, misappropriate enzymatic action at sensitive sites, inhibition of topoisomerases, and other mechanical stresses [54].”
From Integration of DNA damage and repair with murine double-minute 2 (Mdm2) in tumorigenesis (2012) · cites this paper as [54]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hydroperoxide metabolism in mammalian organs.
Chance, B., Sies, H., & Boveris, A. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.3.527 · Cited by 5,827 · see citing works
Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683 · see citing works
Mechanism of Eukaryotic Homologous Recombination
Filippo, J. S., Sung, P., & Klein, H. L. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061306.125255 · Cited by 1,686 · see citing works
Meiotic Chromosomes: Integrating Structure and Function
Zickler, D., & Kleckner, N. E. (1999) · Annual Review of Genetics · doi:10.1146/annurev.genet.33.1.603 · Cited by 1,256 · see citing works
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
Falck, J., Coates, J., & Jackson, S. P. (2005) · Nature · doi:10.1038/nature03442 · Cited by 1,248 · see citing works
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
Walker, J. R., Corpina, R. A., & Goldberg, J. D. (2001) · Nature · doi:10.1038/35088000 · Cited by 1,216 · see citing works
Walker, E. H., Pacold, M. E., Perišić, O., Stephens, L., Hawkins, P. T., Wymann, M. P., & Williams, R. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00089-4 · Cited by 1,211 · see citing works
Ma, Y., Pannicke, U., Schwarz, K., & Lieber, M. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00671-2 · Cited by 1,166 · see citing works
Self-citationATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation
Stiff, T., O’Driscoll, M., Rief, N., Iwabuchi, K., Löbrich, M., & Jeggo, P. A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3207 · Cited by 1,010 · see citing works
Mechanism and regulation of human non-homologous DNA end-joining
Lieber, M. R., Ma, Y., Pannicke, U., & Schwarz, K. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1202 · Cited by 973 · see citing works
Self-citationThe Mechanism and Regulation of Chromosomal V(D)J Recombination
Bassing, C. H., Swat, W., & Alt, F. W. (2002) · Cell · doi:10.1016/s0092-8674(02)00675-x · Cited by 968 · see citing works
Lee, J. A., Carvalho, C. M. B., & Lupski, J. R. (2007) · Cell · doi:10.1016/j.cell.2007.11.037 · Cited by 914 · see citing works
Blunt, T., Finnie, N., Taccioli, G. E., Smith, G. C. M., Demengeot, J., Gottlieb, T. M., Mizuta, R., Varghese, A. J., Alt, F. W., Jeggo, P. A., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90360-7 · Cited by 865 · see citing works
Riballo, E., Kühne, M., Rief, N., Doherty, A., Smith, G. C. M., Recio, M.-J., Reis, C., Dahm, K., Fricke, A., Krempler, A., et al. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.10.029 · Cited by 837 · see citing works
Hastings, P. J., Ira, G., & Lupski, J. R. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000327 · Cited by 818 · see citing works
XLF Interacts with the XRCC4-DNA Ligase IV Complex to Promote DNA Nonhomologous End-Joining
Ahnesorg, P., Smith, P., & Jackson, S. P. (2006) · Cell · doi:10.1016/j.cell.2005.12.031 · Cited by 794 · see citing works
R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells
Yu, K.-F., Chédin, F., Hsieh, C.-L., Wilson, T. E., & Lieber, M. (2003) · Nature Immunology · doi:10.1038/ni919 · Cited by 767 · see citing works
Self-citationThe SCID Mouse Mutant: Definition, Characterization, and Potential Uses
Bosma, M. J., & Carroll, A. M. (1991) · Annual Review of Immunology · doi:10.1146/annurev.iy.09.040191.001543 · Cited by 757 · see citing works
V(D)J Recombination: RAG Proteins, Repair Factors, and Regulation
Gellert, M. F. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.090501.150203 · Cited by 752 · see citing works
Hartley, K. O., Gell, D. A., Smith, G. C. M., Zhang, H., Divecha, N., Connelly, M. A., Admon, A., Lees‐Miller, S. P., Anderson, C. W., & Jackson, S. P. (1995) · Cell · doi:10.1016/0092-8674(95)90482-4 · Cited by 745 · see citing works
Moore, J. K., & Haber, J. E. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2164 · Cited by 728 · see citing works
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
Mahaney, B. L., Meek, K., & Lees‐Miller, S. P. (2009) · Biochemical Journal · doi:10.1042/bj20080413 · Cited by 722 · see citing works
Buck, D., Malivert, L., de Chasseval, R., Barraud, A., Fondanèche, M.-C., Sanal, O., Plebani, A., Stéphan, J.-L., Hufnagel, M., le Deist, F., et al. (2006) · Cell · doi:10.1016/j.cell.2005.12.030 · Cited by 722 · see citing works
The mechanism of human nonhomologous DNA end joining
Lieber, M. R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r700039200 · Cited by 720 · see citing works
Self-citationMechanism of homologous recombination: mediators and helicases take on regulatory functions
Sung, P., & Klein, H. L. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2008 · Cited by 697 · see citing works
Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells
Grawunder, U., Wilm, M. S., Wu, X., Kulesza, P., Wilson, T. E., Mann, M., & Lieber, M. R. (1997) · Nature · doi:10.1038/41358 · Cited by 694 · see citing works
Self-citationIgH class switching and translocations use a robust non-classical end-joining pathway
Yan, C. T., Boboilă, C., Souza, E. K., Franco, S., Hickernell, T. R., Murphy, M., Gumaste, S., Geyer, M. B., Zarrin, A. A., Manis, J. P., et al. (2007) · Nature · doi:10.1038/nature06020 · Cited by 598 · see citing works
MECHANISM AND CONTROL OF V(D)J RECOMBINATION AT THE IMMUNOGLOBULIN HEAVY CHAIN LOCUS
Jung, D., Giallourakis, C. C., Mostoslavsky, R., & Alt, F. W. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115830 · Cited by 578 · see citing works
Sonoda, E., Hochegger, H., Saberi, A., Taniguchi, Y., & Takeda, S. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.05.022 · Cited by 527 · see citing works
Mechanism of interaction between Ku protein and DNA.
Mimori, T., & Hardin, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67534-9 · Cited by 504 · see citing works
SAP – a putative DNA-binding motif involved in chromosomal organization
Aravind, L., & Koonin, E. V. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01537-6 · Cited by 502 · see citing works
Roth, D. B., & Wilson, J. H. (1986) · Molecular and Cellular Biology · doi:10.1128/mcb.6.12.4295 · Cited by 461 · see citing works
A Targeted DNA-PKcs-Null Mutation Reveals DNA-PK-Independent Functions for KU in V(D)J Recombination
Gao, Y., Chaudhuri, J., Zhu, C., Davidson, L., Weaver, D. T., & Alt, F. W. (1998) · Immunity · doi:10.1016/s1074-7613(00)80619-6 · Cited by 432 · see citing works
Nonhomologous End Joining in Yeast
Daley, J. M., Palmbos, P. L., Wu, D. L., & Wilson, T. E. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.073003.113340 · Cited by 408 · see citing works
Ku Recruits the XRCC4-Ligase IV Complex to DNA Ends
McElhinny, S. A. N., McCarville, J., Snowden, C. M., & Ramsden, D. A. (2020) · PubMed Central · doi:10.17615/5hds-gb46 · Cited by 402 · see citing works
A means to a DNA end: the many roles of Ku
Downs, J. A., & Jackson, S. P. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1367 · Cited by 393 · see citing works
The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates
Ahel, I., Rass, U., El‐Khamisy, S. F., Katyal, S., Clements, P. M., McKinnon, P. J., Caldecott, K. W., & West, S. C. (2006) · Nature · doi:10.1038/nature05164 · Cited by 383 · see citing works
Schlissel, M. S., Constantinescu, A., Morrow, T., McDonald and Company Baxter, & Peng, A. (1993) · Genes & Development · doi:10.1101/gad.7.12b.2520 · Cited by 376 · see citing works
A Biochemically Defined System for Mammalian Nonhomologous DNA End Joining
Ma, Y., Lu, H., Tippin, B. L., Goodman, M. F., Shimazaki, N., Koiwai, O., Hsieh, C., Schwarz, K., & Lieber, M. R. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.11.017 · Cited by 357 · see citing works
Self-citationIdentification of a DNA Nonhomologous End-Joining Complex in Bacteria
Weller, G. R., Kysela, B. P., Roy, R., Tonkin, L. M., Scanlan, E., Della, M., Devine, S. K., Day, J. P., Wilkinson, A., di Fagagna, F. D., et al. (2002) · Science · doi:10.1126/science.1074584 · Cited by 343 · see citing works
DNA‐PK autophosphorylation facilitates Artemis endonuclease activity
Goodarzi, A. A., Yu, Y., Riballo, E., Douglas, P., Walker, S. A., Ye, R., Härer, C. J., Marchetti, C., MORRICE, N. A., Jeggo, P. A., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601255 · Cited by 342 · see citing works
DNA double strand break repair and chromosomal translocation: Lessons from animal models
Ferguson, D. O., & Alt, F. W. (2001) · Oncogene · doi:10.1038/sj.onc.1204767 · Cited by 333 · see citing works
Blier, P. R., Griffith, A. J., Craft, J. E., & Hardin, J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53216-6 · Cited by 327 · see citing works
McElhinny, S. A. N., Havener, J. M., García–Díaz, M., Juárez, R., Bębenek, K., Kee, B. L., Blanco, L., Kunkel, T. A., & Ramsden, D. A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.06.012 · Cited by 327 · see citing works
Yaneva, M., Kowalewski, T., & Lieber, M. R. (1997) · The EMBO Journal · doi:10.1093/emboj/16.16.5098 · Cited by 324 · see citing works
Self-citationBinding of double-strand breaks in DNA by human Rad52 protein
Dyck, E. V., Stasiak, A. Z., Stasiak, A., & West, S. C. (1999) · Nature · doi:10.1038/19560 · Cited by 316 · see citing works
Dudley, D. D., Chaudhuri, J., Bassing, C. H., & Alt, F. W. (2005) · Advances in immunology · doi:10.1016/s0065-2776(04)86002-4 · Cited by 315 · see citing works
Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family
Callebaut, I. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf470 · Cited by 311 · see citing works
Bacterial DNA repair by non-homologous end joining
Shuman, S., & Glickman, M. S. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1768 · Cited by 301 · see citing works
DNA Ligases: Structure, Reaction Mechanism, and Function
Tomkinson, A. E., Vijayakumar, S., Pascal, J. M., & Ellenberger, T. (2006) · Chemical Reviews · doi:10.1021/cr040498d · Cited by 297 · see citing works
Aravind, L., & Koonin, E. V. (2001) · Genome Research · doi:10.1101/gr.181001 · Cited by 291 · see citing works
van der Burg, M., IJspeert, H., Verkaik, N. S., Turul, T., Wiegant, W. W., Morotomi‐Yano, K., Mari, P., Tezcan, İ., Chen, D. J., Zdzienicka, M. Z., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci37141 · Cited by 288 · see citing works
Leaky Scid Phenotype Associated with Defective V(D)J Coding End Processing in Artemis-Deficient Mice
Rooney, S., Sekiguchi, J., Zhu, C., Cheng, H.-L., Manis, J. P., Whitlow, S. R., DeVido, J., Foy, D., Chaudhuri, J., Lombard, D. B., et al. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00755-4 · Cited by 278 · see citing works
Parp‐1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells
Hochegger, H., Dejsuphong, D., Fukushima, T., Morrison, C. G., Sonoda, E., Schreiber, V., Zhao, G., Saberi, A., Masutani, M., Adachi, N., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601015 · Cited by 276 · see citing works
de Vries, E., van Driel, W., Bergsma, W. G., Arnberg, A. C., & van der Vliet, P. C. (1989) · Journal of Molecular Biology · doi:10.1016/0022-2836(89)90088-0 · Cited by 276 · see citing works
Meek, K., Dang, V. D., & Lees‐Miller, S. P. (2008) · Advances in immunology · doi:10.1016/s0065-2776(08)00602-0 · Cited by 271 · see citing works
Spagnolo, L., Rivera-Calzada, Á., Pearl, L. H., & Llorca, Ó. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.04.013 · Cited by 270 · see citing works
DNA polymerase mu (Pol μ), homologous to TdT, could act as a DNA mutator in eukaryotic cells
Domı́nguez, O., Ruiz, J. F., de Lera, T. L., García–Díaz, M., González, M. A., Kirchhoff, T., Martínez‐A, C., Bernad, A., & Blanco, L. (2000) · The EMBO Journal · doi:10.1093/emboj/19.7.1731 · Cited by 268 · see citing works
Heo, K., Kim, H., Choi, S. H., Choi, J., Kim, K., Gu, J., Lieber, M. R., Yang, A. S., & An, W. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.02.029 · Cited by 263 · see citing works
Self-citationCrystal structure of an Xrcc4-DNA ligase IV complex.
Sibanda, B. L., Critchlow, S. E., Begun, J., Pei, X. Y., Jackson, S. P., Blundell, T. L., & Pellegrini, L. (2001) · Nature Structural Biology · doi:10.1038/nsb725 · Cited by 256 · see citing works
Falzon, M., Fewell, J. W., & Kuff, E. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82233-5 · Cited by 245 · see citing works
Telomeres, chromosome instability and cancer
Bailey, S. M. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl303 · Cited by 242 · see citing works
DNA-dependent protein kinase: DNA binding and activation in the absence of Ku
Hammarsten, O., & Chu, G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.525 · Cited by 238 · see citing works
Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV
Koch, C. A., Agyei, R., Galicia, S., Metalnikov, P. S., O’Donnell, E., Starostine, A., Weinfeld, M., & Durocher, D. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600375 · Cited by 237 · see citing works
Interactions of the DNA Ligase IV-XRCC4 Complex with DNA Ends and the DNA-dependent Protein Kinase
Chen, L., Trujillo, K. M., Sung, P., & Tomkinson, A. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000491200 · Cited by 237 · see citing works
Tsai, A. G., Lu, H., Raghavan, S. C., Müschen, M., Hsieh, C., & Lieber, M. R. (2008) · Cell · doi:10.1016/j.cell.2008.10.035 · Cited by 237 · see citing works
Self-citationWerner Syndrome Protein Is Regulated and Phosphorylated by DNA-dependent Protein Kinase
Yannone, S. M., Roy, S., Chan, D. W., Murphy, M. B., Huang, S., Campisi, J., & Chen, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101913200 · Cited by 221 · see citing works
The influence of transcriptional orientation on endogenous switch region function
Shinkura, R., Tian, M., Smith, M., Chua, K. F., Fujiwara, Y., & Alt, F. W. (2003) · Nature Immunology · doi:10.1038/ni918 · Cited by 215 · see citing works
The Molecular Architecture of the Mammalian DNA Repair Enzyme, Polynucleotide Kinase
Bernstein, N. K., Williams, R. S., Rakovszky, M. L., Cui, D., Green, R., Karimi‐Busheri, F., Mani, R. S., Galicia, S., Koch, C. A., Cass, C. E., et al. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.02.012 · Cited by 212 · see citing works
Lee, J. W., Blanco, L., Zhou, T., García–Díaz, M., Bębenek, K., Kunkel, T. A., Wang, Z., & Povirk, L. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307913200 · Cited by 212 · see citing works
Efficient Processing of DNA Ends during Yeast Nonhomologous End Joining
Wilson, T. E., & Lieber, M. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.23599 · Cited by 211 · see citing works
Self-citationDefective DNA Repair and Increased Genomic Instability in Artemis-deficient Murine Cells
Rooney, S., Alt, F. W., Lombard, D. B., Whitlow, S. R., Eckersdorff, M., Fleming, J., Fugmann, S. D., Ferguson, D. O., Schatz, D. G., & Sekiguchi, J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021891 · Cited by 206 · see citing works
Stahl, F. W. (1987) · Scientific American · doi:10.1038/scientificamerican0287-90 · Cited by 199 · see citing works
The XRCC4 Gene Product Is a Target for and Interacts with the DNA-dependent Protein Kinase
Leber, R., Wise, T. W., Mizuta, R., & Meek, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.3.1794 · Cited by 195 · see citing works
Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends
Tsai, C. J., Kim, S. A., & Chu, G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702620104 · Cited by 194 · see citing works
The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps
Ma, Y., Schwarz, K., & Lieber, M. R. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.04.013 · Cited by 191 · see citing works
Self-citationCrystal structure of the Xrcc4 DNA repair protein and implications for end joining
Junop, M. S., Modesti, M., Guarné, A., Ghirlando, R., Gellert, M., & Yang, W. (2000) · The EMBO Journal · doi:10.1093/emboj/19.22.5962 · Cited by 191 · see citing works
Lymphocyte-Specific Compensation for XLF/Cernunnos End-Joining Functions in V(D)J Recombination
Li, G., Alt, F. W., Cheng, H.-L., Brush, J. W., Goff, P. H., Murphy, M., Franco, S., Zhang, Y., & Zha, S. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.07.017 · Cited by 191 · see citing works
Bertocci, B., Smet, A. D., Weill, J., & Reynaud, C. (2006) · Immunity · doi:10.1016/j.immuni.2006.04.013 · Cited by 186 · see citing works
The X family portrait: Structural insights into biological functions of X family polymerases
Moon, A. F., García–Díaz, M., Batra, V. K., Beard, W. A., Bębenek, K., Kunkel, T. A., Wilson, S. H., & Pedersen, L. C. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.05.009 · Cited by 185 · see citing works
Jackson, S. P. (1997) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(97)00006-x · Cited by 181 · see citing works
XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps
Gu, J., Lu, H., Tippin, B. L., Shimazaki, N., Goodman, M. F., & Lieber, M. R. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601559 · Cited by 180 · see citing works
Self-citationThe Yeast Chromatin Remodeler RSC Complex Facilitates End Joining Repair of DNA Double-Strand Breaks
Shim, E. Y., Ma, N. J.-L., Oum, J., Yanez, Y., & Lee, S. E. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.10.3934-3944.2005 · Cited by 178 · see citing works
Polymerase Mu Is a DNA-Directed DNA/RNA Polymerase
McElhinny, S. A. N., & Ramsden, D. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.7.2309-2315.2003 · Cited by 175 · see citing works
Telomeres and chromosome instability
Murnane, J. P. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.05.030 · Cited by 174 · see citing works
Productive and Nonproductive Complexes of Ku and DNA-Dependent Protein Kinase at DNA Termini
West, R. B., Yaneva, M., & Lieber, M. R. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.10.5908 · Cited by 170 · see citing works
Self-citationFormation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70
Weinstock, D. M., Brunet, E., & Jasin, M. (2007) · Nature Cell Biology · doi:10.1038/ncb1624 · Cited by 167 · see citing works
Cathepsin L activity controls adipogenesis and glucose tolerance
Yang, M., Zhang, Y., Pan, J., Sun, J., Liu, J., Libby, P., Sukhova, G. K., Doria, A., Katunuma, N., Peroni, O. D., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1623 · Cited by 167 · see citing works
Lymphoid V(D)J recombination: nucleotide insertion at signal joints as well as coding joints.
Lieber, M. R., Hesse, J. E., Mizuuchi, K., & Gellert, M. F. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.22.8588 · Cited by 167 · see citing works
Self-citationMechanistic Constraints on Diversity in Human V(D)J Recombination
Gauss, G. H., & Lieber, M. R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.1.258 · Cited by 165 · see citing works
Self-citationNonhomologous End-Joining in Bacteria: A Microbial Perspective
Pitcher, R. S., Brissett, N. C., & Doherty, A. J. (2007) · Annual Review of Microbiology · doi:10.1146/annurev.micro.61.080706.093354 · Cited by 163 · see citing works
Jäger, U., Böcskör, S., Le, T., Mitterbauer, G., Bolz, I., Chott, A., Kneba, M., Mannhalter, C., & Nadel, B. (2000) · Blood · doi:10.1182/blood.v95.11.3520 · Cited by 161 · see citing works
Characterization of broken DNA molecules associated with V(D)J recombination.
Roth, D. B., Zhu, C., & Gellert, M. F. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.22.10788 · Cited by 161 · see citing works
Iles, N., Rulten, S. L., El‐Khamisy, S. F., & Caldecott, K. W. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02269-06 · Cited by 159 · see citing works
Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination
Soulas-Sprauel, P., Guyader, G. L., Rivera-Muñoz, P., Abramowski, V., Olivier, C., Goujet‐Zalc, C., Charneau, P., & de Villartay, J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070255 · Cited by 156 · see citing works
Kanno, S., Kuzuoka, H., Sasao, S., Hong, Z., Lan, L., Nakajima, S., & Yasui, A. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601663 · Cited by 153 · see citing works
Crystal Structure of Human XLF: A Twist in Nonhomologous DNA End-Joining
Andres, S. N., Modesti, M., Tsai, C. J., Chu, G., & Junop, M. S. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.10.024 · Cited by 148 · see citing works
Hypersensitivity of Nonhomologous DNA End-joining Mutants to VP-16 and ICRF-193
Adachi, N., Suzuki, H., Iiizumi, S., & Koyama, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306500200 · Cited by 148 · see citing works
Identification of bacterial homologues of the Ku DNA repair proteins
Doherty, A. J., Jackson, S. P., & Weller, G. R. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02589-3 · Cited by 147 · see citing works
The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis
Ma, Y., Pannicke, U., Lu, H., Niewolik, D., Schwarz, K., & Lieber, M. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507113200 · Cited by 144 · see citing works
Self-citationFeeney, A. J. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.1.222 · Cited by 142 · see citing works
Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK
Costantini, S., Woodbine, L. J., Andreoli, L., Jeggo, P. A., & Vindigni, A. (2007) · DNA repair · doi:10.1016/j.dnarep.2006.12.007 · Cited by 141 · see citing works
Zhang, Y., Hefferin, M. L., Chen, L., Shim, E. Y., Tseng, H.-M., Kwon, Y., Sung, P., Lee, S. E., & Tomkinson, A. E. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1261 · Cited by 140 · see citing works
Gu, J., Lu, H., Tsai, A. G., Schwarz, K., & Lieber, M. R. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm579 · Cited by 136 · see citing works
Self-citationBiochemical mechanisms of chromosomal translocations resulting from DNA double-strand breaks
Povirk, L. F. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.05.016 · Cited by 131 · see citing works
Shimazaki, N., Tsai, A. G., & Lieber, M. (2009) · Molecules and Cells · doi:10.1016/j.molcel.2009.05.011 · Cited by 130 · see citing works
Self-citationCallebaut, I., Malivert, L., Fischer, A., Mornon, J.-P., Revy, P., & de Villartay, J.-P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c500473200 · Cited by 130 · see citing works
Roth, D. B., Chang, X. B., & Wilson, J. H. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.7.3049 · Cited by 129 · see citing works
Structure of DNA‐dependent protein kinase: implications for its regulation by DNA
Leuther, K. K., Hammarsten, O., Kornberg, R. D., & Chu, G. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1114 · Cited by 127 · see citing works
Functional and biochemical dissection of the structure-specific nuclease ARTEMIS
Pannicke, U., Ma, Y., Hopfner, K., Niewolik, D., Lieber, M. R., & Schwarz, K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600206 · Cited by 127 · see citing works
Self-citationAgeing, repetitive genomes and DNA damage
Lieber, M. R., & Karanjawala, Z. E. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1281 · Cited by 126 · see citing works
Self-citationThe pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA endsPreprint
Aniukwu, J., Glickman, M. S., & Shuman, S. (2008) · Genes & Development · doi:10.1101/gad.1631908 · Cited by 125 · see citing works
Coding end sequence can markedly affect the initiation of V(D)J recombination.Preprint
Gerstein, R. M., & Lieber, M. R. (1993) · Genes & Development · doi:10.1101/gad.7.7b.1459 · Cited by 122 · see citing works
Self-citationThe bounty of RAGs: recombination signal complexes and reaction outcomes
Swanson, P. C. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00159.x · Cited by 119 · see citing works
Han, L., & Yu, K. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081623 · Cited by 119 · see citing works
Defining interactions between DNA-PK and ligase IV/XRCC4
Hsu, H.-L., Yannone, S. M., & Chen, D. J. (2002) · DNA repair · doi:10.1016/s1568-7864(01)00018-0 · Cited by 117 · see citing works
DNA Joint Dependence of Pol X Family Polymerase Action in Nonhomologous End Joining
Daley, J. M., Laan, R. L. V., Suresh, A., & Wilson, T. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505277200 · Cited by 117 · see citing works
Li, Y., Chirgadze, D. Y., Bolaños-García, V. M., Sibanda, B. L., Davies, O. R., Ahnesorg, P., Jackson, S. P., & Blundell, T. L. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601942 · Cited by 116 · see citing works
Nucleases of the Metallo-β-lactamase Family and Their Role in DNA and RNA Metabolism
Domiński, Z. (2007) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230701279118 · Cited by 115 · see citing works
Rejoining of DNA Double-Strand Breaks as a Function of Overhang Length
Daley, J. M., & Wilson, T. E. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.3.896-906.2005 · Cited by 112 · see citing works
The DNA-Activated Protein Kinase — DNA-PK
Anderson, C. W., & Carter, T. H. (1996) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-50140-1_7 · Cited by 111 · see citing works
Tseng, H.-M., & Tomkinson, A. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206861200 · Cited by 111 · see citing works
Activation of DNA-dependent Protein Kinase by Single-stranded DNA Ends
Hammarsten, O., DeFazio, L. G., & Chu, G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.3.1541 · Cited by 109 · see citing works
Processing of 3′-Phosphoglycolate-terminated DNA Double Strand Breaks by Artemis Nuclease
Povirk, L. F., Zhou, T., Zhou, R., Cowan, M. J., & Yannone, S. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607745200 · Cited by 106 · see citing works
The Frameshift Infidelity of Human DNA Polymerase λ
Bebenek, K., Garcia-Diaz, M., Blanco, L., & Kunkel, T. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305705200 · Cited by 104 · see citing works
Welzel, N., Le, T., Marculescu, R., Mitterbauer, G., Chott, A., Pott, C., Kneba, M., Du, M., Kušec, R., Drach, J. W., et al. (2001) · PubMed · Cited by 103 · see citing works
Macrae, C. J., McCulloch, R. D., Ylanko, J., Durocher, D., & Koch, C. A. (2008) · DNA repair · doi:10.1016/j.dnarep.2007.10.008 · Cited by 102 · see citing works
Palindrome-mediated chromosomal translocations in humans.
Kurahashi, H., Inagaki, H., Ohye, T., Kogo, H., Kato, T., & Emanuel, B. (2006) · DNA Repair · doi:10.1016/j.dnarep.2006.05.035 · Cited by 100 · see citing works
Structural insight into the substrate specificity of DNA Polymerase μ
Moon, A. F., García–Díaz, M., Bębenek, K., Davis, B. J., Zhong, X., Ramsden, D. A., Kunkel, T. A., & Pedersen, L. C. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1180 · Cited by 99 · see citing works
Jin, S., Kharbanda, S. M., Mayer, B. J., Kufe, D. W., & Weaver, D. T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.24763 · Cited by 97 · see citing works
Nucleic acid structures and enzymes in the immunoglobulin class switch recombination mechanism
Yu, K., & Lieber, M. R. (2003) · DNA repair · doi:10.1016/j.dnarep.2003.08.010 · Cited by 96 · see citing works
Self-citationPhotocross-linking of an Oriented DNA Repair Complex
Yoo, S., Kimzey, A. L., & Dynan, W. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.20034 · Cited by 91 · see citing works
Extent to which homology can constrain coding exon junctional diversity in V(D)J recombination
Gerstein, R. M., & Lieber, M. R. (1993) · Nature · doi:10.1038/363625a0 · Cited by 90 · see citing works
Self-citationNHEJ protects mycobacteria in stationary phase against the harmful effects of desiccation
Pitcher, R. S., Green, A., Brzostek, A. M., Korycka‐Machała, M., Dziadek, J., & Doherty, A. J. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.02.009 · Cited by 88 · see citing works
Ramadan, K., Shevelev, I. V., Maga, G., & Hübscher, U. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.03.056 · Cited by 83 · see citing works
Structure of Nonhairpin Coding-End DNA Breaks in Cells Undergoing V(D)J Recombination
Schlissel, M. S. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.4.2029 · Cited by 83 · see citing works
Phosphorylation and Regulation of DNA Ligase IV Stability by DNA-dependent Protein Kinase
Wang, Y., Nnakwe, C. C., Lane, W. S., Modesti, M., & Frank, K. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401217200 · Cited by 80 · see citing works
Ramadan, K., Maga, G., Shevelev, I. V., Villani, G., Blanco, L., & Hübscher, U. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00265-1 · Cited by 78 · see citing works
Williams, D., Lee, K. J., Shi, J. R., Chen, D. J., & Stewart, P. L. (2008) · Structure · doi:10.1016/j.str.2007.12.014 · Cited by 77 · see citing works
Wang, J. H., Alt, F. W., Gostissa, M., Datta, A., Murphy, M., Alimzhanov, M. B., Coakley, K. M., Rajewsky, K., Manis, J. P., & Yan, C. T. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20082271 · Cited by 77 · see citing works
Modesti, M., Junop, M. S., Ghirlando, R., van de Rakt, M. W. M. M., Gellert, M. F., Yang, W., & Kanaar, R. (2003) · Journal of Molecular Biology · doi:10.1016/j.jmb.2003.09.031 · Cited by 77 · see citing works
Martin, G. M., Smith, A. C., Ketterer, D. J., Ogburn, C. E., & Distèche, C. M. (1985) · PubMed · Cited by 76 · see citing works
Molecular Biology of Terminal Transferas
Chang, L. M. S., Bollum, F. J., & Gallo, R. C. (1986) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238609113608 · Cited by 76 · see citing works
Deshpande, R. A., & Wilson, T. E. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.04.014 · Cited by 75 · see citing works
The Gam protein of bacteriophage Mu is an orthologue of eukaryotic Ku
di Fagagna, F. D., Weller, G. R., Doherty, A. J., & Jackson, S. P. (2003) · EMBO Reports · doi:10.1038/sj.embor.embor709 · Cited by 75 · see citing works
Juárez, R., Ruiz, J. F., McElhinny, S. A. N., Ramsden, D. A., & Blanco, L. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl457 · Cited by 72 · see citing works
Yannone, S. M., Khan, I. S., Zhou, R., Zhou, T., Valerie, K. C., & Povirk, L. F. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn205 · Cited by 70 · see citing works
Biochemical Properties of Saccharomyces cerevisiae DNA Polymerase IV
Bębenek, K., García–Díaz, M., Patishall, S. R., & Kunkel, T. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501981200 · Cited by 64 · see citing works
Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein
Ли, Б. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf488 · Cited by 64 · see citing works
Williamson, E. A., Rasila, K. K., Corwin, L. K., Wray, J. W., Beck, B. D., Severns, V., Mobarak, C. D., Lee, S., Nickoloff, J. A., & Hromas, R. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn560 · Cited by 62 · see citing works
Davis, B. J., Havener, J. M., & Ramsden, D. A. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn164 · Cited by 62 · see citing works
To Slip or Skip, Visualizing Frameshift Mutation Dynamics for Error-prone DNA Polymerases
Tippin, B. L., Kobayashi, S., Bertram, J. G., & Goodman, M. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408600200 · Cited by 61 · see citing works
Hamer, G., Roepers‐Gajadien, H. L., van Duyn-Goedhart, A., Gademan, I. S., Kal, H. B., van Buul, P. P. W., Ashley, T., & de Rooij, D. G. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.102.008920 · Cited by 59 · see citing works
Hromas, R., Wray, J. W., Lee, S., Martinez, L., Farrington, J., Corwin, L. K., Ramsey, H. E., Nickoloff, J. A., & Williamson, E. A. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.08.002 · Cited by 53 · see citing works
Loading of the Nonhomologous End Joining Factor, Ku, on Protein-occluded DNA Ends
Roberts, S. A., & Ramsden, D. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611125200 · Cited by 50 · see citing works
Gu, J., & Lieber, M. R. (2008) · Genes & Development · doi:10.1101/gad.1646608 · Cited by 45 · see citing works
Self-citationA Biochemically Defined System for Coding Joint Formation in V(D)J Recombination
Lu, H., Shimazaki, N., Raval, P., Gu, J., Watanabe, G., Schwarz, K., Swanson, P. C., & Lieber, M. R. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.029 · Cited by 45 · see citing works
Self-citationConformational Variants of Duplex DNA Correlated with Cytosine-rich Chromosomal Fragile Sites
Tsai, A. G., Engelhart, A. E., Hatmal, M. M., Houston, S. I., Hud, N. V., Haworth, I. S., & Lieber, M. R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806866200 · Cited by 44 · see citing works
Self-citationLi, L., SALIDO, E. C., Zhou, Y., Bhattacharyya, S., Yannone, S. M., Dunn, E., Meneses, J. J., Feeney, A. J., & Cowan, M. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2420 · Cited by 41 · see citing works
Molecular Mechanism of DNA Deadenylation by the Neurological Disease Protein Aprataxin
Rass, U., Ahel, I., & West, S. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807124200 · Cited by 39 · see citing works
Jovanović, M. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj504 · Cited by 39 · see citing works
Bernstein, N. K., Karimi‐Busheri, F., Rasouli‐Nia, A., Mani, R. S., Dianov, G. L., Glover, J. N. M., & Weinfeld, M. (2008) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152008784220311 · Cited by 37 · see citing works
Structural basis for phosphorylation-dependent signaling in the DNA-damage response
Williams, R. S., Bernstein, N. K., Lee, M. S., Rakovszky, M. L., Cui, D., Green, R., Weinfeld, M., & Glover, J. N. M. (2005) · Biochemistry and Cell Biology · doi:10.1139/o05-153 · Cited by 35 · see citing works
V(D)J recombination coding junction formation without DNA homology: processing of coding termini.
Boubnov, N. V., Wills, Z. P., & Weaver, D. T. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.11.6957 · Cited by 35 · see citing works
Collateral Damage from Antigen Receptor Gene Diversification
Mahowald, G. K., Baron, J. M., & Sleckman, B. P. (2008) · Cell · doi:10.1016/j.cell.2008.11.024 · Cited by 28 · see citing works
Xiao, Z., Dunn, E., Singh, K., Khan, I. S., Yannone, S. M., & Cowan, M. J. (2009) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2008.10.026 · Cited by 18 · see citing works
Ku Recruits the XRCC4-Ligase IV Complex to DNA Ends
McElhinny, S. A. N., Snowden, C. M., McCarville, J., & Ramsden, D. A. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.9.2996-3003.2000 · Cited by 9 · see citing works
Wilson, T. E. (2008) · Wiley Encyclopedia of Chemical Biology · doi:10.1002/9780470048672.wecb396 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [25]Wilson TE Nonhomologous recombination. Encyclopedia of Chemical Biology 2008 Wiley
Cited by
Sorted by citations
Genome editing with engineered zinc finger nucleases
Urnov, F. D., Rebar, E. J., Holmes, M. C., Zhang, H. S., & Gregory, P. D. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2842 · Cited by 2,285 · see citing works
Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
Anzalone, A. V., Koblan, L. W., & Liu, D. R. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0561-9 · Cited by 2,237 · see citing works
CRISPR–Cas9 Structures and Mechanisms
Jiang, F., & Doudna, J. A. (2017) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-062215-010822 · Cited by 2,029 · see citing works
Non-homologous DNA end joining and alternative pathways to double-strand break repair
Chang, H. H. Y., Pannunzio, N. R., Adachi, N., & Lieber, M. R. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.48 · Cited by 1,757 · see citing works
Self-citationPlaying the End Game: DNA Double-Strand Break Repair Pathway Choice
Chapman, J. R., Taylor, M. R. G., & Boulton, S. J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.029 · Cited by 1,622 · see citing works
Targeting the DNA Damage Response in Cancer
O’Connor, M. J. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.10.040 · Cited by 1,551 · see citing works
Double-Strand Break End Resection and Repair Pathway Choice
Symington, L. S., & Gautier, J. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132435 · Cited by 1,481 · see citing works
Chu, V. T., Weber, T., Wefers, B., Wurst, W., Sander, S., Rajewsky, K., & Kühn, R. (2015) · Nature Biotechnology · doi:10.1038/nbt.3198 · Cited by 1,210 · see citing works
CRISPR/Cas9 in Genome Editing and Beyond
Wang, H., Russa, M. F. L., & Qi, L. S. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014607 · Cited by 1,165 · see citing works
In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration
Suzuki, K., Tsunekawa, Y., Hernandez-Benitez, R., Wu, J., Zhu, J., Kim, E. J., Hatanaka, F., Yamamoto, M., Araoka, T., Li, Z., et al. (2016) · Nature · doi:10.1038/nature20565 · Cited by 1,150 · see citing works
Double-strand break repair: 53BP1 comes into focus
Panier, S., & Boulton, S. J. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3719 · Cited by 1,090 · see citing works
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
Polo, S. E., & Jackson, S. P. (2011) · Genes & Development · doi:10.1101/gad.2021311 · Cited by 1,092 · see citing works
Gantz, V. M., Jasinskiene, N., Tatarenkova, O., Fazekas, A., Macias, V. M., Bier, E., & James, A. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521077112 · Cited by 943 · see citing works
HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B
Nassal, M. (2015) · Gut · doi:10.1136/gutjnl-2015-309809 · Cited by 906 · see citing works
CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics
Malhotra, D., & Sebat, J. (2012) · Cell · doi:10.1016/j.cell.2012.02.039 · Cited by 854 · see citing works
Biological Consequences of Radiation-induced DNA Damage: Relevance to Radiotherapy
Lomax, M. E., Folkes, L. K., & O'Neill, P. (2013) · Clinical Oncology · doi:10.1016/j.clon.2013.06.007 · Cited by 738 · see citing works
The control of DNA repair by the cell cycle
Hustedt, N., & Durocher, D. (2017) · Nature Cell Biology · doi:10.1038/ncb3452 · Cited by 738 · see citing works
The MRE11 complex: starting from the ends
Stracker, T. H., & Petrini, J. H. J. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3047 · Cited by 734 · see citing works
DNA repair mechanisms in dividing and non-dividing cells
Iyama, T., & Wilson, D. M. (2013) · DNA Repair · doi:10.1016/j.dnarep.2013.04.015 · Cited by 697 · see citing works
Prime editing for precise and highly versatile genome manipulation
Chen, P. J., & Liu, D. R. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00541-1 · Cited by 621 · see citing works
Fanconi anaemia and the repair of Watson and Crick DNA crosslinks
Kottemann, M. C., & Smogorzewska, A. (2013) · Nature · doi:10.1038/nature11863 · Cited by 608 · see citing works
Chapman, J. R., Barral, P., Vannier, J., Borel, V., Steger, M., Tomás‐Loba, A., Sartori, A. A., Adams, I. R., Batista, F. D., & Boulton, S. J. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.002 · Cited by 624 · see citing works
A Role for Small RNAs in DNA Double-Strand Break Repair
Wei, W., Ba, Z., Gao, M., Wu, Y., Ma, Y., Amiard, S., White, C. I., Danielsen, J. M. R., Yang, Y., & Qi, Y. (2012) · Cell · doi:10.1016/j.cell.2012.03.002 · Cited by 575 · see citing works
Therapeutic in vivo delivery of gene editing agents
Raguram, A., Banskota, S., & Liu, D. R. (2022) · Cell · doi:10.1016/j.cell.2022.03.045 · Cited by 532 · see citing works
Truong, L. N., Li, Y., Shi, L. Z., Hwang, P. Y.-H., He, J. N., Wang, H., Razavian, N. B., Berns, M. W., & Wu, X. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213431110 · Cited by 513 · see citing works
Hooked! Modeling human disease in zebrafish
Santoriello, C., & Zon, L. I. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60434 · Cited by 511 · see citing works
The multifaceted functions of sirtuins in cancer
Chalkiadaki, A., & Guarente, L. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3985 · Cited by 501 · see citing works
Mechanisms and Consequences of Double‐Strand DNA Break Formation in Chromatin
Cannan, W. J., & Pederson, D. S. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25048 · Cited by 499 · see citing works
“There are several excellent, recent reviews of DSB repair for readers looking for more detailed expositions (e.g., San Filippo et al., 2008; Lieber, 2010; Polo and Jackson, 2011; Asaithamby and Chen, 2011; Thompson, 2012; Mehta and Haber, 2014).”
BackgroundThe diverse roles and clinical relevance of PARPs in DNA damage repair: Current state of the art
Vos, M. D., Schreiber, V., & Dantzer, F. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.03.018 · Cited by 491 · see citing works
Super-Resolution Fluorescence Imaging of Telomeres Reveals TRF2-Dependent T-loop Formation
Doksani, Y., Wu, J. Y., de Lange, T., & Zhuang, X. (2013) · Cell · doi:10.1016/j.cell.2013.09.048 · Cited by 493 · see citing works
Nonhomologous DNA end-joining for repair of DNA double-strand breaks
Pannunzio, N. R., Watanabe, G., & Lieber, M. R. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.tm117.000374 · Cited by 492 · see citing works
Self-citationMechanisms of Programmed DNA Lesions and Genomic Instability in the Immune System
Alt, F. W., Zhang, Y., Meng, F., Guo, C., & Schwer, B. (2013) · Cell · doi:10.1016/j.cell.2013.01.007 · Cited by 477 · see citing works
Functional horizontal gene transfer from bacteria to eukaryotes
Husník, F., & McCutcheon, J. P. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.137 · Cited by 475 · see citing works
Factors determining DNA double‐strand break repair pathway choice in G2 phase
Shibata, A., Conrad, S., Birraux, J., Geuting, V., Barton, O., Ismail, A., Kakarougkas, A., Meek, K., Taucher-Scholz, G., Löbrich, M., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.27 · Cited by 481 · see citing works
Chiarle, R., Zhang, Y., Frock, R. L., Lewis, S. M., Molinié, B., Ho, Y.-J., Myers, D. R., Choi, V. W., Compagno, M., Malkin, D. J., et al. (2011) · Cell · doi:10.1016/j.cell.2011.07.049 · Cited by 475 · see citing works
Regulation of Single-Strand Annealing and its Role in Genome Maintenance
Bhargava, R., Onyango, D. O., & Stark, J. M. (2016) · Trends in Genetics · doi:10.1016/j.tig.2016.06.007 · Cited by 475 · see citing works
Pfister, S. X., Ahrabi, S., Zalmas, L., Sarkar, S., Aymard, F., Bachrati, C. Z., Helleday, T., Legube, G., Thangue, N. B. L., Porter, A. C. G., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.05.026 · Cited by 465 · see citing works
ATM Mutations in Cancer: Therapeutic Implications
Choi, M. P., Kipps, T. J., & Kurzrock, R. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0945 · Cited by 456 · see citing works
CHK2 kinase in the DNA damage response and beyond
Zannini, L., Delia, D., & Buscemi, G. (2014) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mju045 · Cited by 455 · see citing works
Modernizing the Nonhomologous End-Joining Repertoire: Alternative and Classical NHEJ Share the Stage
Deriano, L., & Roth, D. B. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-110711-155540 · Cited by 448 · see citing works
DNA repair pathways and cisplatin resistance: an intimate relationship
Rocha, C. R. R., Silva, M. M., Quinet, A., Cabral-Neto, J. B., & Menck, C. F. M. (2018) · Clinics · doi:10.6061/clinics/2018/e478s · Cited by 450 · see citing works
E3 ubiquitin ligases: styles, structures and functions
Yang, Q., Zhao, J., Chen, D., & Wang, Y. (2021) · Molecular Biomedicine · doi:10.1186/s43556-021-00043-2 · Cited by 435 · see citing works
CRISPR/Cas9-induced knockout and knock-in mutations in Chlamydomonas reinhardtii
Shin, S.-E., Lim, J., Koh, H. G., Kim, E. K., Kang, N. K., Jeon, S., Kwon, S., Shin, W.-S., Lee, B., Hwangbo, K., et al. (2016) · Scientific Reports · doi:10.1038/srep27810 · Cited by 421 · see citing works
Maier, P., Hartmann, L., Wenz, F. K., & Herskind, C. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17010102 · Cited by 417 · see citing works
Silva, G., Poirot, L., Galetto, R., Smith, J. N. P., Montoya, G., Duchateau, P. N., & Pâques, F. (2011) · Current Gene Therapy · doi:10.2174/156652311794520111 · Cited by 413 · see citing works
Xu, Y., & Li, Z. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.08.031 · Cited by 424 · see citing works
Moyal, L., Lerenthal, Y., Gana‐Weisz, M., Mass, G., So, S., Wang, S., Eppink, B., Chung, Y. M., Shalev, G., Shema, E., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.02.015 · Cited by 402 · see citing works
The molecular basis and disease relevance of non-homologous DNA end joining
Zhao, B., Rothenberg, E., Ramsden, D. A., & Lieber, M. R. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00297-8 · Cited by 389 · see citing works
Self-citationThe role of DNA damage and repair in aging through the prism of Koch-like criteria
Moskalev, A. A., Shaposhnikov, M. V., Plyusnina, E. N., Zhavoronkov, A., Budovsky, A., Yanai, H., & Fraifeld, V. E. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.02.001 · Cited by 387 · see citing works
The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer
Alves-Fernandes, D. K., & Jasiulionis, M. G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133153 · Cited by 385 · see citing works
The origins of vertebrate adaptive immunity
Litman, G. W., Rast, J. P., & Fugmann, S. D. (2010) · Nature reviews. Immunology · doi:10.1038/nri2807 · Cited by 383 · see citing works
Mladenov, E., & Iliakis, G. E. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.02.005 · Cited by 381 · see citing works
DNA Damage/Repair Management in Cancers
Alhmoud, J. F., Woolley, J. F., Moustafa, A. A., & Malki, M. I. (2020) · Cancers · doi:10.3390/cancers12041050 · Cited by 378 · see citing works
Srivastava, M., Nambiar, M., Sharma, S., Karki, S. S., Goldsmith, G., Hegde, M. B., Kumar, S., Pandey, M., Singh, R. K., Ray, P., et al. (2012) · Cell · doi:10.1016/j.cell.2012.11.054 · Cited by 374 · see citing works
A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult
Goodwin, J. F., Schiewer, M. J., Dean, J. L., Schrecengost, R. S., de Leeuw, R., Han, S., Ma, T., Den, R. B., Dicker, A. P., Feng, F. Y.-C., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0108 · Cited by 362 · see citing works
Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers
Schwertman, P., Bekker‐Jensen, S., & Mailand, N. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.58 · Cited by 354 · see citing works
Gunn, A., & Stark, J. M. (2012) · Methods in molecular biology · doi:10.1007/978-1-61779-998-3_27 · Cited by 363 · see citing works
End-joining, translocations and cancer
Bunting, S. F., & Nussenzweig, A. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3537 · Cited by 359 · see citing works
Thompson, L. H. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.06.002 · Cited by 357 · see citing works
Poly (ADP-Ribose) Polymerase Inhibitors: Recent Advances and Future Development
Scott, C. L., Swisher, E. M., & Kaufmann, S. H. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.58.8848 · Cited by 356 · see citing works
Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining
Ghezraoui, H., Piganeau, M., Renouf, B., Renaud, J.-B., Sallmyr, A., Ruis, B., Oh, S., Tomkinson, A. E., Hendrickson, E. A., Giovannangeli, C., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.002 · Cited by 351 · see citing works
“NALM6 junctions without insertions showed longer microhomology than is typical of wild-type cells, raising the possibility that some of the junctions that did not engage TdT did not join by c-NHEJ; alternatively, TdT may have created microhomology in some of these junctions (Lieber, 2010).”
BackgroundDNA double-strand break repair pathway choice and cancer
Aparicio, T., Baer, R., & Gautier, J. (2014) · DNA Repair · doi:10.1016/j.dnarep.2014.03.014 · Cited by 347 · see citing works
He, X., Tan, C., Wang, F., Wang, Y., Zhou, R., Cui, D., You, W., Zhao, H., Ren, J., & Feng, B. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw064 · Cited by 338 · see citing works
Fok, J. H. L., Ramos‐Montoya, A., Vázquez–Chantada, M., Wijnhoven, P. W. G., Follia, V., James, N. H., Farrington, P. M., Karmokar, A., Willis, S. E., Cairns, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12836-9 · Cited by 337 · see citing works
Zhang, C., Chen, L., Peng, D., Jiang, A., He, Y., Zeng, Y., Xie, C., Zhou, H., Luo, X., Liu, H., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.06.017 · Cited by 333 · see citing works
Zhang, Y., He, Q., Hu, Z., Feng, Y., Fan, L., Tang, Z., Yuan, J., Shan, W., Li, C., Hu, Z., et al. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3211 · Cited by 332 · see citing works
Simsek, D., Brunet, E., Wong, S., Katyal, S., Gao, Y., McKinnon, P. J., Lou, J. F., Zhang, L., Li, J., Rebar, E. J., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002080 · Cited by 327 · see citing works
DNA-PK: A dynamic enzyme in a versatile DSB repair pathway
Davis, A. J., Chen, B. P. C., & Chen, D. J. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.02.020 · Cited by 320 · see citing works
Chromothripsis as a mechanism driving complex de novo structural rearrangements in the germline†
Kloosterman, W. P., Guryev, V., van Roosmalen, M. J., Duran, K. J., de Bruijn, E., Bakker, S. C. M., Letteboer, T. G. W., van Nesselrooij, B. P. M., Hochstenbach, R., Poot, M., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr073 · Cited by 320 · see citing works
Basu, U., Meng, F., Keim, C., Grinstein, V., Pefanis, E., Eccleston, J., Zhang, T., Myers, D. R., Wasserman, C. R., Wesemann, D. R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.01.001 · Cited by 315 · see citing works
DNA damage and repair in plants – from models to crops
Manova, V. I., & Gruszka, D. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2015.00885 · Cited by 313 · see citing works
Holland, A. J., & Cleveland, D. W. (2012) · Nature Medicine · doi:10.1038/nm.2988 · Cited by 304 · see citing works
Pathway choice in DNA double strand break repair: observations of a balancing act
Brandsma, I., & van Gent, D. C. (2012) · Genome Integrity · doi:10.1186/2041-9414-3-9 · Cited by 304 · see citing works
Mitra, J., Guerrero, E. N., Hegde, P. M., Liachko, N. F., Wang, H., Vasquez, V., Gao, J., Pandey, A., Taylor, J. P., Kraemer, B. C., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1818415116 · Cited by 305 · see citing works
Efficient targeted mutagenesis of rice and tobacco genomes using Cpf1 from Francisella novicida
Endo, A., Mikami, M., Kaya, H., & Toki, S. (2016) · Scientific Reports · doi:10.1038/srep38169 · Cited by 297 · see citing works
Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN
Arnoult, N., Correia, A., Ma, J., Merlo, A., Garcia-Gomez, S., Maric, M., Tognetti, M., Benner, C. W., Boulton, S. J., Saghatelian, A., et al. (2017) · Nature · doi:10.1038/nature24023 · Cited by 299 · see citing works
Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all
Oei, A. L., Vriend, L. E. M., Crezee, J., Franken, N. A. P., & Krawczyk, P. M. (2015) · Radiation Oncology · doi:10.1186/s13014-015-0462-0 · Cited by 296 · see citing works
Functions of PARylation in DNA Damage Repair Pathways
Wei, H., & Yu, X. (2016) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2016.05.001 · Cited by 296 · see citing works
IgH Chain Class Switch Recombination: Mechanism and Regulation
Stavnezer, J., & Schrader, C. E. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401849 · Cited by 295 · see citing works
Mladenov, E., Magin, S., Soni, A., & Iliakis, G. E. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00113 · Cited by 292 · see citing works
Schipler, A., & Iliakis, G. E. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt556 · Cited by 290 · see citing works
Statistical inference of the generation probability of T-cell receptors from sequence repertoires
Murugan, A., Mora, T., Walczak, A. M., & Callan, C. G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212755109 · Cited by 292 · see citing works
Jette, N., & Lees‐Miller, S. P. (2014) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2014.12.003 · Cited by 285 · see citing works
Focus on histone variant H2AX: To be or not to be
Yuan, J., Adamski, R., & Chen, J. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.05.021 · Cited by 280 · see citing works
DNA DSB repair pathway choice: an orchestrated handover mechanism
Kakarougkas, A., & Jeggo, P. A. (2013) · British Journal of Radiology · doi:10.1259/bjr.20130685 · Cited by 279 · see citing works
CRISPR Crops: Plant Genome Editing Toward Disease Resistance
Langner, T., Kamoun, S., & Belhaj, K. (2018) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-080417-050158 · Cited by 290 · see citing works
TALEN and CRISPR/Cas Genome Editing Systems: Tools of Discovery
Nemudryi, A. A., Valetdinova, K. R., Medvedev, S. P., & Zakian, S. M. (2014) · Acta Naturae · doi:10.32607/20758251-2014-6-3-19-40 · Cited by 284 · see citing works
Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells
Wei, P.-C., Chang, A. N., Kao, J., Du, Z., Meyers, R. M., Alt, F. W., & Schwer, B. (2016) · Cell · doi:10.1016/j.cell.2015.12.039 · Cited by 280 · see citing works
Cancer-specific defects in DNA repair pathways as targets for personalized therapeutic approaches
Dietlein, F., Thelen, L., & Reinhardt, H. C. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.06.003 · Cited by 280 · see citing works
Kinetics and Fidelity of the Repair of Cas9-Induced Double-Strand DNA Breaks
Brinkman, E. K., Chen, T., de Haas, M., Holland, H. A., Akhtar, W., & van Steensel, B. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.04.016 · Cited by 274 · see citing works
Luijsterburg, M. S., de Krijger, I., Wiegant, W. W., Shah, R. G., Smeenk, G., de Groot, A. J. L., Pines, A., Vertegaal, A. C. O., Jacobs, J. J. L., Shah, G. M., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.01.019 · Cited by 277 · see citing works
Britton, S., Coates, J., & Jackson, S. P. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201303073 · Cited by 272 · see citing works
Boboilă, C., Alt, F. W., & Schwer, B. (2012) · Advances in immunology · doi:10.1016/b978-0-12-394300-2.00001-6 · Cited by 273 · see citing works
BRCA Genes: The Role in Genome Stability, Cancer Stemness and Therapy Resistance
Gorodetska, I., Kozeretska, I. A., & Dubrovska, A. (2019) · Journal of Cancer · doi:10.7150/jca.30410 · Cited by 279 · see citing works
A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair
Stingele, J., Schwarz, M. S., Bloemeke, N., Wolf, P., & Jentsch, S. (2014) · Cell · doi:10.1016/j.cell.2014.04.053 · Cited by 261 · see citing works
SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint
Carvalho, S., Vítor, A. C., Sridhara, S. R. C., Martins, F. B., Raposo, A. C., Desterro, J. M. P., Ferreira, J. A., & de Almeida, S. F. (2014) · eLife · doi:10.7554/elife.02482 · Cited by 266 · see citing works
CRISPR technologies for genome, epigenome and transcriptome editing
Villiger, L., Joung, J., Koblan, L. W., Weissman, J. S., Abudayyeh, O. O., & Gootenberg, J. S. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00697-6 · Cited by 264 · see citing works
Wang, H., Shi, L. Z., Wong, C. C. L., Han, X., Hwang, P. Y.-H., Truong, L. N., Zhu, Q., Shao, Z., Chen, D. J., Berns, M. W., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003277 · Cited by 254 · see citing works
Beyond DNA Repair: DNA-PK Function in Cancer
Goodwin, J. F., & Knudsen, K. E. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0358 · Cited by 258 · see citing works
Human Structural Variation: Mechanisms of Chromosome Rearrangements
Weckselblatt, B., & Rudd, M. K. (2015) · Trends in Genetics · doi:10.1016/j.tig.2015.05.010 · Cited by 254 · see citing works
- Authors
- Lieber, M. R.
- Affiliations
- University of Southern California (US)
- Corresponding author
- Lieber, Michael R.
- ORCID
- Lieber, Michael R.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2010-06-07
- Volume
- 79
- Issue
- 1
- Pages
- 181-211
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- PMC
- PMC3079308
- OpenAlex
- W2164995160
- Cited by
- 2,882
- References
- 168
- Citations by year
- 2026: 103 · 2025: 144 · 2024: 176 · 2023: 148 · 2022: 199 · 2021: 238 · 2020: 209 · 2019: 187 · 2018: 201 · 2017: 215 · 2016: 212 · 2015: 183 · 2014: 199 · 2013: 168 · 2012: 148
- FWCI
- 13.03
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Annual Review of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA100504)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Keywords
- DNA double-strand break repair, non-homologous end joining, homologous recombination, DNA ligase IV, DNA polymerase IV, chromosomal translocation, V(D)J recombination, class switch recombination, immunodeficiency, radiosensitivity
- MeSH terms
- Animals, Deoxyribonucleases, DNA-Directed DNA Polymerase, DNA Repair, Humans, DNA Ligases, DNA Breaks, Double-Stranded
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review