The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Ribosome-Mediated Specificity in Hox mRNA Translation and Vertebrate Tissue Patterning
Open accessAbstract
Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather than regulatory capacity in mRNA translation. Here we identify mutations of the Ribosomal Protein L38 (Rpl38) gene in mice exhibiting surprising tissue specific patterning defects, including pronounced homeotic transformations of the axial skeleton. In Rpl38 mutant embryos, global protein synthesis is unchanged however the translation of a select subset of Homeobox mRNAs is perturbed. Our data reveal that RPL38 facilitates 80S complex formation on these mRNAs as a regulatory component of the ribosome to confer transcript-specific translational control. We further show that Rpl38 expression is markedly enriched in regions of the embryo where loss-of-function phenotypes occur. Unexpectedly, a ribosomal protein (RP) expression screen reveals dynamic regulation of individual RPs within the vertebrate embryo. Collectively, these findings suggest that RP activity may be highly regulated to impart a new layer of specificity in the control of gene expression and mammalian development.
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Cluster analysis and display of genome-wide expression patterns
Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 16,184
Histones: annotating chromatin
Campos, E. I., & Reinberg, D. (2009) · Annual Review of Genetics · doi:10.1146/annurev.genet.032608.103928 · Cited by 852
The power of the 3′ UTR: translational control and development.
Kuersten, S., & Goodwin, E. B. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1125 · Cited by 530
Chapter 9 Hox Genes and Vertebrate Axial Pattern
Wellik, D. M. (2009) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(09)88009-5 · Cited by 203 · cited 1×
“Targeted loss and gain of function analysis in the mouse have clearly demonstrated that Hox genes are the key regulators of morphology along the axial skeleton (2009; Deschamps and van Nes, 2005; Wellik, 2009).”
Cited by
Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them
Leppek, K., Das, R., & Barna, M. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.103 · Cited by 949
Self-citationThe Central Dogma Decentralized: New Perspectives on RNA Function and Local Translation in Neurons
Holt, C. E., & Schuman, E. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.036 · Cited by 525
The discovery of ribosome heterogeneity and its implications for gene regulation and organismal life
Genuth, N. R., & Barna, M. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.07.018 · Cited by 511
Self-citationOne core, two shells: bacterial and eukaryotic ribosomes
Melnikov, S., Ben-Shem, A., Garreau de Loubresse, N., Jenner, L., Yusupova, G., & Yusupov, M. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2313 · Cited by 477
Hox Genes: Choreographers in Neural Development, Architects of Circuit Organization
Philippidou, P., & Dasen, J. S. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.020 · Cited by 423
Metadata
- Authors
- Kondrashov, N., Pusic, A., Stumpf, C. R., Shimizu, K., Hsieh, A. C., Xue, S., Ishijima, J., Shiroishi, T., & Barna, M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 145
- Issue
- 3
- Pages
- 383-397
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2171323620
- Cited by
- 586
- References
- 4
- FWCI
- 15.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kondrashov, N., Pusic, A., Stumpf, C. R., Shimizu, K., Hsieh, A. C., Xue, S., Ishijima, J., Shiroishi, T., & Barna, M. (2011). Ribosome-Mediated Specificity in Hox mRNA Translation and Vertebrate Tissue Patterning. Cell. https://doi.org/10.1016/j.cell.2011.03.028
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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