The power of the 3′ UTR: translational control and development.

Kuersten, Scott; Goodwin, Elizabeth B.

doi:10.1038/nrg1125

Cited by 530RNA Research and SplicingRNA and protein synthesis mechanismsDevelopmental Biology and Gene Regulation

The power of the 3′ UTR: translational control and development.

Kuersten, Scott, Goodwin, Elizabeth B.·2003·Nature Reviews Genetics

DOI 10.1038/nrg1125

Open this paper in CoChat — free account

Abstract

Many crucial decisions, such as the location and timing of cell division, cell-fate determination, and embryonic axes establishment, are made in the early embryo, a time in development when there is often little or no transcription. For this reason, the control of variation in gene expression in the early embryo often relies on post-transcriptional control of maternal genes. Although the early embryo is rife with translational control, controlling mRNA activity is also important in other developmental processes, such as stem-cell proliferation, sex determination, neurogenesis and erythropoiesis.

Integrity signals

Registry

Crossref · 10.1038/nrg1125

Cites

123 of 123 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

3′ untranslated regions often contain several regulatory elements that govern the spatial and temporal expression of an mRNA.
“3′ untranslated regions (3′ UTRs) often contain several regulatory elements that govern the spatial and temporal expression of an mRNA. [55]”
From The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task (2009) · cites this paper as [55]

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948 · see citing works
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
Reinhart, B. J., Slack, F. J., Basson, M., Pasquinelli, A. E., Bettinger, J. C., Rougvie, A. E., Horvitz, H. R., & Ruvkun, G. (2000) · Nature · doi:10.1038/35002607 · Cited by 4,989 · see citing works
An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans
Lau, N. C., Lim, L. P., Weinstein, E. G., & Bartel, D. P. (2001) · Science · doi:10.1126/science.1065062 · Cited by 2,713 · see citing works
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
Pasquinelli, A. E., Reinhart, B. J., Slack, F. J., Martindale, M. Q., Kuroda, M. I., Maller, B., Hayward, D. C., Ball, E. E., Degnan, B. M., Müller, P., et al. (2000) · Nature · doi:10.1038/35040556 · Cited by 2,568 · see citing works
An Extensive Class of Small RNAs in Caenorhabditis elegans
Lee, R. C., & Ambros, V. (2001) · Science · doi:10.1126/science.1065329 · Cited by 2,358 · see citing works
MicroRNAs in plantsPreprint
Reinhart, B. J., Weinstein, E. G., Jones-Rhoades, M. W., Bartel, B., & Bartel, D. P. (2002) · Genes & Development · doi:10.1101/gad.1004402 · Cited by 2,001 · see citing works
bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila
Brennecke, J., Hipfner, D. R., Stark, A., Russell, R. B., & Cohen, S. M. (2003) · Cell · doi:10.1016/s0092-8674(03)00231-9 · Cited by 1,721 · see citing works
Translational control of gene expression
Sonenberg, N., Hershey, J. W. B., & Mathews, M. B. (2000) · Cold Spring Harbor Laboratory eBooks · Cited by 1,379 · see citing works
Translational control of gene expression
Hannig, E. M. (2001) · BioEssays · doi:10.1002/bies.1108 · Cited by 1,194 · see citing works
The lin-4 Regulatory RNA Controls Developmental Timing in Caenorhabditis elegans by Blocking LIN-14 Protein Synthesis after the Initiation of Translation
Olsen, P. H., & Ambros, V. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9523 · Cited by 969 · see citing works
oskar organizes the germ plasm and directs localization of the posterior determinant nanos
Ephrussi, A., Dickinson, L. K., & Lehmann, R. (1991) · Cell · doi:10.1016/0092-8674(91)90137-n · Cited by 803 · see citing works
Synapse-specific, long-term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storage.
Martin, K. C., Casadio, A., Zhu, H.-X., Yaping, E., Rose, J. C., Chen, M. C., Bailey, C. H., & Kandel, E. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80484-5 · Cited by 752 · see citing works
The lin-41 RBCC Gene Acts in the C. elegans Heterochronic Pathway between the let-7 Regulatory RNA and the LIN-29 Transcription Factor
Slack, F. J., Basson, M., Liu, Z., Ambros, V., Horvitz, H. R., & Ruvkun, G. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80245-2 · Cited by 751 · see citing works
How introns influence and enhance eukaryotic gene expression
Hir, H. L., Nott, A., & Moore, M. J. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00052-5 · Cited by 734 · see citing works
A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary
Lin, H., & Spradling, A. C. (1997) · Development · doi:10.1242/dev.124.12.2463 · Cited by 714 · see citing works
New microRNAs from mouse and human
LAGOS-QUINTANA, M., RAUHUT, R., MEYER, J., BORKHARDT, A., & TUSCHL, T. (2003) · RNA · doi:10.1261/rna.2146903 · Cited by 714 · see citing works
Translational control by CPEB: a means to the end
Méndez, R., & Richter, J. D. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35080081 · Cited by 609 · see citing works
Evidence for a Pioneer Round of mRNA Translation
Ishigaki, Y., Li, X., Serin, G., & Maquat, L. E. (2001) · Cell · doi:10.1016/s0092-8674(01)00475-5 · Cited by 583 · see citing works
A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line
Zhang, B., Gallegos, M. E., Puoti, A., Durkin, E., Fields, S., Kimble, J. E., & Wickens, M. (1997) · Nature · doi:10.1038/37297 · Cited by 510 · see citing works
mRNA Silencing in Erythroid Differentiation: hnRNP K and hnRNP E1 Regulate 15-Lipoxygenase Translation from the 3′ End
Ostareck, D. H., Ostareck‐Lederer, A., Wilm, M. S., Thiele, B. J., Mann, M., & Hentze, M. W. (1997) · Cell · doi:10.1016/s0092-8674(00)80241-x · Cited by 503 · see citing works
CONTROL OF TRANSLATION INITIATION IN ANIMALS
Gray, N. K., & Wickens, M. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.399 · Cited by 500 · see citing works
Nanos and Pumilio have critical roles in the development and function of Drosophila germline stem cells
Forbes, A. J., & Lehmann, R. (1998) · Development · doi:10.1242/dev.125.4.679 · Cited by 486 · see citing works
Translational regulation of oskar mRNA by Bruno, an ovarian RNA-binding protein, is essential
Kim‐Ha, J., Kerr, K., & Macdonald, P. M. (1995) · Cell · doi:10.1016/0092-8674(95)90393-3 · Cited by 466 · see citing works
A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans
Crittenden, S. L., Bernstein, D. S., Bachorik, J. L., Thompson, B. E., Gallegos, M. E., Petcherski, A. G., Moulder, G. L., Barstead, R. J., Wickens, M., & Kimble, J. E. (2002) · Nature · doi:10.1038/nature754 · Cited by 421 · see citing works
A quantitative analysis of intron effects on mammalian gene expression
Nott, A., MEISLIN, S. H., & Moore, M. J. (2003) · RNA · doi:10.1261/rna.5250403 · Cited by 417 · see citing works
Binding of pumilio to maternal hunchback mRNA is required for posterior patterning in drosophila embryos
Murata, Y., & Wharton, R. P. (1995) · Cell · doi:10.1016/0092-8674(95)90353-4 · Cited by 414 · see citing works
Localization of nanos RNA controls embryonic polarity
Gavis, E. R., & Lehmann, R. (1992) · Cell · doi:10.1016/0092-8674(92)90358-j · Cited by 391 · see citing works
RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos
Wharton, R. P., & Struhl, G. (1991) · Cell · doi:10.1016/0092-8674(91)90368-9 · Cited by 386 · see citing works
Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae
Kennedy, B. K., Gotta, M., Sinclair, D. A., Mills, K., McNabb, D. S., Murthy, M., Pak, S. M., Laroche, T., Gasser, S. M., & Guarente, L. (1997) · Cell · doi:10.1016/s0092-8674(00)80219-6 · Cited by 375 · see citing works
Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA
Méndez, R., Hake, L. E., Andrésson, Þ., Littlepage, L. E., RUDERMAN, J. V., & Richter, J. D. (2000) · Nature · doi:10.1038/35005126 · Cited by 369 · see citing works
gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegans.
Francis, R., Barton, M. K., Kimble, J. E., & Schedl, T. (1995) · Genetics · doi:10.1093/genetics/139.2.579 · Cited by 355 · see citing works
The Caenorhabditis elegans hunchback-like Gene lin-57/hbl-1 Controls Developmental Time and Is Regulated by MicroRNAs
Abrahante, J. E., Daul, A. L., Li, M., Volk, M. L., Tennessen, J. M., Miller, E. A., & Rougvie, A. E. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00127-8 · Cited by 354 · see citing works
The C. elegans hunchback Homolog, hbl-1, Controls Temporal Patterning and Is a Probable MicroRNA Target
Lin, S.-Y., Johnson, S., Abraham, M. C., Vella, M. C., Pasquinelli, A. E., Gamberi, C., Gottlieb, E., & Slack, F. J. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00124-2 · Cited by 351 · see citing works
aubergineencodes aDrosophilapolar granule component required for pole cell formation and related to eIF2C
Harris, A. N., & Macdonald, P. M. (2001) · Development · doi:10.1242/dev.128.14.2823 · Cited by 329 · see citing works
Drosophila Brain Tumor is a translational repressor
Sonoda, J., & Wharton, R. P. (2001) · Genes & Development · doi:10.1101/gad.870801 · Cited by 329 · see citing works
Translational Regulation and RNA Localization in Drosophila Oocytes and Embryos
Johnstone, O., & Lasko, P. F. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.090756 · Cited by 322 · see citing works
Recruitment of Nanos to hunchback mRNA by PumilioPreprint
Sonoda, J., & Wharton, R. P. (1999) · Genes & Development · doi:10.1101/gad.13.20.2704 · Cited by 321 · see citing works
Gene regulation by Y-box proteins: coupling control of transcription and translation
Matsumoto, K., & Wolffe, A. P. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01300-2 · Cited by 306 · see citing works
Cellular interactions in early C. elegans embryos
Priess, J. R., & Thomson, J. N. (1987) · Cell · doi:10.1016/0092-8674(87)90427-2 · Cited by 304 · see citing works
STAR, a gene family involved in signal transduction and activation of RNA
Vernet, C., & Artzt, K. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(97)01269-9 · Cited by 301 · see citing works
MEX-3 Is a KH Domain Protein That Regulates Blastomere Identity in Early C. elegans Embryos
Draper, B. W., Mello, C. C., Bowerman, B. A., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81339-2 · Cited by 294 · see citing works
THE LIN-12/Notch SIGNALING PATHWAY AND ITS REGULATION
Kimble, J. E., & Simpson, P. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.333 · Cited by 293 · see citing works
A regulatory cytoplasmic poly(A) polymerase in Caenorhabditis elegans
Wang, L., Eckmann, C. R., Kadyk, L. C., Wickens, M., & Kimble, J. E. (2002) · Nature · doi:10.1038/nature01039 · Cited by 289 · see citing works
Lipoxygenase mRNA silencing in erythroid differentiation: The 3'UTR regulatory complex controls 60S ribosomal subunit joining.
Ostareck, D., Ostareck-Lederer, A., Shatsky, I., & Hentze, M. (2001) · Cell · doi:10.1016/s0092-8674(01)00212-4 · Cited by 280 · see citing works
The Role of the Cap Structure in RNA Processing and Nuclear Export
LEWIS, J. D., & Izaurflde, E. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00461.x · Cited by 269 · see citing works
NANOS-3 and FBF proteins physically interact to control the sperm–oocyte switch in Caenorhabditis elegans
Kraemer, B., Crittenden, S. L., Gallegos, M. E., Moulder, G. L., Barstead, R. J., Kimble, J. E., & Wickens, M. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80449-7 · Cited by 265 · see citing works
Sex lethal controls dosage compensation in Drosophila by a non-splicing mechanism
Kelley, R. L., Wang, J., Bell, L. R., & Kuroda, M. I. (1997) · Nature · doi:10.1038/387195a0 · Cited by 260 · see citing works
Translation of 15‐lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3′ untranslated region.
Ostareck‐Lederer, A., Ostareck, D. H., Standart, N., & Thiele, B. J. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06402.x · Cited by 257 · see citing works
MEX-5 and MEX-6 Function to Establish Soma/Germline Asymmetry in Early C. elegans Embryos
Schubert, C., Lin, R., de Vries, C. J., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80246-4 · Cited by 252 · see citing works
Phosphorylation of CPEB by Eg2 Mediates the Recruitment of CPSF into an Active Cytoplasmic Polyadenylation Complex
Méndez, R., Murthy, K. G. K., Ryan, K., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00121-0 · Cited by 249 · see citing works
Distinct roles of two conserved Staufen domains in oskar mRNA localization and translation
Micklem, D., Adams, J., Grünert, S., et al. (2000) · The EMBO Journal · doi:10.1093/emboj/19.6.1366 · Cited by 244 · see citing works
Smaug, a Novel RNA-Binding Protein that Operates a Translational Switch in Drosophila
Dahanukar, A. A., Walker, J. A., & Wharton, R. P. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80368-8 · Cited by 243 · see citing works
pos-1 encodes a cytoplasmic zinc-finger protein essential for germline specification in C. elegans
Tabara, H., Hill, R. J., Mello, C. C., et al. (1999) · Development · doi:10.1242/dev.126.1.1 · Cited by 242 · see citing works
Translational control of oskar generates Short OSK, the isoform that induces pole plasm assembly
Markussen, F.-H., Michon, A., Breitwieser, W., & Ephrussi, A. (1995) · Development · doi:10.1242/dev.121.11.3723 · Cited by 240 · see citing works
The STAR protein, GLD‐1, is a translational regulator of sexual identity in Caenorhabditis elegans
Jan, E., Motzny, C. K., Graves, L. E., & Goodwin, E. B. (1999) · The EMBO Journal · doi:10.1093/emboj/18.1.258 · Cited by 239 · see citing works
Self-citation
smaug protein represses translation of unlocalized nanos mRNA in the Drosophila embryo.Preprint
Smibert, C. A., Wilson, J. E., Kerr, K., et al. (1996) · Genes & Development · doi:10.1101/gad.10.20.2600 · Cited by 237 · see citing works
Translational control of maternal glp-1 mRNA establishes an asymmetry in the C. elegans embryo
Evans, T. C., Crittenden, S. L., Kodoyianni, V., & Kimble, J. E. (1994) · Cell · doi:10.1016/0092-8674(94)90311-5 · Cited by 237 · see citing works
The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo
Mello, C., Draper, B. W., & Prless, J. R. (1994) · Cell · doi:10.1016/0092-8674(94)90238-0 · Cited by 235 · see citing works
Genetic regulation of entry into meiosis in Caenorhabditis elegans
Kadyk, L. C., & Kimble, J. E. (1998) · Development · doi:10.1242/dev.125.10.1803 · Cited by 235 · see citing works
Germ Cell Differentiation and Synaptonemal Complex Formation Are Disrupted in CPEB Knockout Mice
Tay, J., & Richter, J. D. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00025-9 · Cited by 231 · see citing works
Spatial and Temporal Controls Target pal-1 Blastomere-Specification Activity to a Single Blastomere Lineage in C. elegans Embryos
Hunter, C. P., & Kenyon, C. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81340-9 · Cited by 224 · see citing works
c-Src-Mediated Phosphorylation of hnRNP K Drives Translational Activation of Specifically Silenced mRNAs
Ostareck‐Lederer, A., Ostareck, D. H., Cans, C., Neubauer, G., Bomsztyk, K., Superti‐Furga, G., & Hentze, M. W. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.13.4535-4543.2002 · Cited by 222 · see citing works
Dissolution of the maskin–eIF4E complex by cytoplasmic polyadenylation and poly(A)‐binding protein controls cyclin B1 mRNA translation and oocyte maturation
Cao, Q., & Richter, J. D. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf353 · Cited by 219 · see citing works
Localization of oskar RNA regulates oskar translation and requires Oskar protein
Rongo, C., Gavis, E. R., & Lehmann, R. (1995) · Development · doi:10.1242/dev.121.9.2737 · Cited by 213 · see citing works
The Regulation of the Drosophila Gene Reveals a Function for in Translational Control
Bashaw, G. J., & Baker, B. S. (1997) · Cell · doi:10.1016/s0092-8674(00)80262-7 · Cited by 212 · see citing works
Translational repressorbruno plays multiple roles in development and is widely conservedPreprint
Webster, P. J., Liang, L., Berg, C. A., Lasko, P. F., & Macdonald, P. M. (1997) · Genes & Development · doi:10.1101/gad.11.19.2510 · Cited by 211 · see citing works
Nuclear history of a pre‐mRNA determines the translational activity of cytoplasmic mRNA
Matsumoto, K., Wassarman, K. M., & Wolffe, A. P. (1998) · The EMBO Journal · doi:10.1093/emboj/17.7.2107 · Cited by 208 · see citing works
Overexpression of oskar directs ectopic activation of nanos and presumptive pole cell formation in Drosophila embryos
Smith, J. L., Wilson, J. E. B., & Macdonald, P. M. (1992) · Cell · doi:10.1016/0092-8674(92)90318-7 · Cited by 200 · see citing works
Analysis of the multiple roles of gld-1 in germline development: interactions with the sex determination cascade and the glp-1 signaling pathway.
Francis, R., Maine, E. M., & Schedl, T. (1995) · Genetics · doi:10.1093/genetics/139.2.607 · Cited by 187 · see citing works
Translational regulation of tra-2 by its 3′ untranslated region controls sexual identity in C. elegans
Goodwin, E. B., Okkema, P. G., Evans, T. C., & Kimble, J. E. (1993) · Cell · doi:10.1016/0092-8674(93)80074-o · Cited by 184 · see citing works
Self-citation
RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-EPreprint
Kennerdell, J. R., Yamaguchi, S., & Carthew, R. W. (2002) · Genes & Development · doi:10.1101/gad.990802 · Cited by 184 · see citing works
Role for mRNA localization in translational activation but not spatial restriction of nanos RNA
Bergsten, S. E., & Gavis, E. R. (1999) · Development · doi:10.1242/dev.126.4.659 · Cited by 180 · see citing works
aubergine enhances oskar translation in the Drosophila ovary
Wilson, J. E. B., Connell, J. E., & Macdonald, P. M. (1996) · Development · doi:10.1242/dev.122.5.1631 · Cited by 167 · see citing works
Identification of in vivo mRNA targets of GLD-1, a maxi-KH motif containing protein required for C. elegans germ cell developmentPreprint
Lee, M. H., & Schedl, T. (2001) · Genes & Development · doi:10.1101/gad.915901 · Cited by 164 · see citing works
FOG-2, a novel F-box containing protein, associates with the GLD-1 RNA binding protein and directs male sex determination in the C. elegans hermaphrodite germline
Clifford, R., Lee, M., Nayak, S., Ohmachi, M., Giorgini, F., & Schedl, T. (2000) · Development · doi:10.1242/dev.127.24.5265 · Cited by 164 · see citing works
Analysis of the stimulatory effect of splicing on mRNA production and utilization in mammalian cells
Lu, S., & Cullen, B. R. (2003) · RNA · doi:10.1261/rna.5260303 · Cited by 163 · see citing works
A double-stranded RNA binding protein required for activation of repressed messages in mammalian germ cells
Zhong, J. W., Peters, A. H. F. M., Lee, K., et al. (1999) · Nature Genetics · doi:10.1038/9684 · Cited by 162 · see citing works
Binding of a phosphoprotein to the 3' untranslated region of the mouse protamine 2 mRNA temporally represses its translation.
Kwon, Y. K., & Hecht, N. B. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6547 · Cited by 157 · see citing works
The Drosophila CPEB Homolog, Orb, Is Required for Oskar Protein Expression in Oocytes
Chang, J. S., Tan, L., & Schedl, P. D. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9444 · Cited by 154 · see citing works
Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells
Jaruzelska, J., Kotecki, M., Kusz-Zamelczyk, K., et al. (2003) · Development Genes and Evolution · doi:10.1007/s00427-003-0303-2 · Cited by 153 · see citing works
Smaug, a novel and conserved protein, contributes to repression of nanos mRNA translation in vitro
Smibert, C. A., Lie, Y. S., Shillinglaw, W., et al. (1999) · RNA · doi:10.1017/s1355838299991392 · Cited by 152 · see citing works
GLD-3, a Bicaudal-C Homolog that Inhibits FBF to Control Germline Sex Determination in C. elegans
Eckmann, C. R., Kraemer, B. C., Wickens, M., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00322-2 · Cited by 147 · see citing works
Cytoplasmic protein binding to highly conserved sequences in the 3' untranslated region of mouse protamine 2 mRNA, a translationally regulated transcript of male germ cells.
Kwon, Y. K., & Hecht, N. B. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3584 · Cited by 142 · see citing works
Localization-dependent translation requires a functional interaction between the 5′ and 3′ ends ofoskar mRNAPreprint
Gunkel, N., Yano, T., Markussen, F.-H., et al. (1998) · Genes & Development · doi:10.1101/gad.12.11.1652 · Cited by 142 · see citing works
Sex-lethal, the master sex-determining gene in Drosophila, is not sex-specifically regulated in Musca domestica
Meise, M., Hilfiker‐Kleiner, D., Dübendorfer, A., et al. (1998) · Development · doi:10.1242/dev.125.8.1487 · Cited by 136 · see citing works
Translational control of dosage compensation in Drosophila by Sex‐lethal: cooperative silencing via the 5′ and 3′ UTRs of msl‐2 mRNA is independent of the poly(A) tail
Gebauer, F., Corona, D. F. V., Preiß, T., Becker, P. B., & Hentze, M. W. (1999) · The EMBO Journal · doi:10.1093/emboj/18.21.6146 · Cited by 134 · see citing works
Control of developmental timing in animals
Rougvie, A. E. (2001) · Nature Reviews Genetics · doi:10.1038/35088566 · Cited by 127 · see citing works
Anterior-Posterior Polarity in C. elegans and Drosophila --PARallels and Differences
Pellettieri, J., & Seydoux, G. (2002) · Science · doi:10.1126/science.1072162 · Cited by 124 · see citing works
Orb and a long poly(A) tail are required for efficientoskartranslation at the posterior pole of theDrosophilaoocyte
Castagnetti, S., & Ephrussi, A. (2003) · Development · doi:10.1242/dev.00309 · Cited by 119 · see citing works
6 Regulation of Ribosomal Recruitment in EukaryotesPreprint
Raught, B., Gingras, A., & Sonenberg, N. (2000) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969618.39.245 · Cited by 117 · see citing works
Translational control of maternal glp-1 mRNA by POS-1 and its interacting protein SPN-4 in Caenorhabditis elegans
Ogura, K., Kishimoto, N., Mitani, S., Gengyo‐Ando, K., & Kohara, Y. (2003) · Development · doi:10.1242/dev.00469 · Cited by 109 · see citing works
Translational repression of aC. elegansNotch mRNA by the STAR/KH domain protein GLD-1
Marin, V. A., & Evans, T. C. (2003) · Development · doi:10.1242/dev.00486 · Cited by 107 · see citing works
Starvation promotes Dictyostelium development by relieving PufA inhibition of PKA translation through the YakA kinase pathway
Souza, G. M., da Silva, A. M., & Kuspa, A. (1999) · Development · doi:10.1242/dev.126.14.3263 · Cited by 106 · see citing works
3 Maternal Control of Pattern Formation in Early Caenorhabditis elegans Embryos
Bowerman, B. A. (1998) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)60453-6 · Cited by 105 · see citing works
Synthesis of the posterior determinant Nanos is spatially restricted by a novel cotranslational regulatory mechanism
Clark, I. E., Wyckoff, D., & Gavis, E. R. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00754-5 · Cited by 103 · see citing works
A TB-RBP and Ter ATPase Complex Accompanies Specific mRNAs from Nuclei through the Nuclear Pores and into Intercellular Bridges in Mouse Male Germ Cells
Morales, C. R., Lefrançois, S., Chennathukuzhi, V. M., et al. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0679 · Cited by 99 · see citing works
The Yeast Nuclear Cap Binding Complex Can Interact with Translation Factor eIF4G and Mediate Translation Initiation
Fortes, P., Inada, T., Preiß, T., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00003-1 · Cited by 99 · see citing works
The Drosophila splicing regulator sex-lethal directly inhibits translation of male-specific-lethal 2 mRNA.
Gebauer, F., Merendino, L., Hentze, M. W., & Valcárcel, J. (1998) · Europe PMC (PubMed Central) · Cited by 92 · see citing works
The RNA-binding protein, TB-RBP, is the mouse homologue of translin, a recombination protein associated with chromosomal translocations
Wu, X., Gu, W., Meng, X., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.11.5640 · Cited by 88 · see citing works
MicroRNAs: deviants no longer
Pasquinelli, A. E. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(01)02624-5 · Cited by 87 · see citing works
MSY2 and MSY4 Bind a Conserved Sequence in the 3′ Untranslated Region of Protamine 1 mRNA In Vitro and In Vivo
Giorgini, F., Davies, H. G., & Braun, R. E. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.20.7010-7019.2001 · Cited by 83 · see citing works
A Sequence-Specific RNA Binding Complex Expressed in Murine Germ Cells Contains MSY2 and MSY4
Davies, H. G., Giorgini, F., Fajardo, M. A., et al. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9658 · Cited by 81 · see citing works
Translational repression by MSY4 inhibits spermatid differentiation in mice
Giorgini, F., Davies, H. G., & Braun, R. E. (2002) · Development · doi:10.1242/dev.129.15.3669 · Cited by 81 · see citing works
An anterior function for theDrosophilaposterior determinant Pumilio
Gamberi, C., Peterson, D. S., He, L., & Gottlieb, E. (2002) · Development · doi:10.1242/dev.129.11.2699 · Cited by 81 · see citing works
Temporal control of protein synthesis during spermatogenesis
Braun, R. E. (2000) · International Journal of Andrology · doi:10.1046/j.1365-2605.2000.00027.x · Cited by 79 · see citing works
Turning Clustering Loops: Sex Determination in Caenorhabditis elegans
Goodwin, E. B., & Ellis, R. E. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00675-9 · Cited by 76 · see citing works
Self-citation
Testis-Brain RNA-Binding Protein, a Testicular Translational Regulatory RNA-Binding Protein, is Present in the Brain and Binds to the 3′ Untranslated Regions of Transported Brain mRNAs1
Han, J., Gu, W., & Hecht, N. B. (1995) · Biology of Reproduction · doi:10.1095/biolreprod53.3.707 · Cited by 76 · see citing works
Deviants — or emissaries
Wickens, M., & Takayama, K. M. (1994) · Nature · doi:10.1038/367017a0 · Cited by 71 · see citing works
Translational regulation of oskar mRNA occurs independent of the cap and poly(A) tail in Drosophila ovarian extracts
Lie, Y. S., & Macdonald, P. M. (1999) · Development · doi:10.1242/dev.126.22.4989 · Cited by 66 · see citing works
Selective silencing of cell communication influences anteroposterior pattern formation in C. elegans
Waring, D. A., & Kenyon, C. J. (1990) · Cell · doi:10.1016/0092-8674(90)90722-q · Cited by 63 · see citing works
MEX-3 interacting proteins link cell polarity to asymmetric gene expression inCaenorhabditis elegans
Huang, N. N., Mootz, D. E., Walhout, A. J. M., et al. (2002) · Development · doi:10.1242/dev.129.3.747 · Cited by 63 · see citing works
Conservation of the C.elegans tra‐2 3′UTR translational control
Jan, E., Yoon, J. W., Walterhouse, D., et al. (1997) · The EMBO Journal · doi:10.1093/emboj/16.20.6301 · Cited by 60 · see citing works
Somatodendritic Localization of Translin, a Component of the Translin/Trax RNA Binding Complex
Finkenstadt, P. M., Kang, W., Jeon, M.-H., Taira, E., Tang, W., & Baraban, J. M. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751754.x · Cited by 60 · see citing works
Apontic binds the translational repressor Bruno and is implicated in regulation of oskar mRNA translation
Lie, Y. S., & Macdonald, P. M. (1999) · Development · doi:10.1242/dev.126.6.1129 · Cited by 59 · see citing works
The Caenorhabditis elegans heterochronic gene lin-29 coordinates the vulval–uterine–epidermal connections
Newman, A. P., Inoue, T., Wang, M., & Sternberg, P. W. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00827-7 · Cited by 57 · see citing works
The maternal genespn-4encodes a predicted RRM protein required for mitotic spindle orientation and cell fate patterning in earlyC. elegansembryos
Gomes, J., Encalada, S. E., Swan, K. A., Shelton, C. A., Carter, J. C., & Bowerman, B. A. (2001) · Development · doi:10.1242/dev.128.21.4301 · Cited by 54 · see citing works
Conservation of glp-1 Regulation and Function in Nematodes
Rudel, D., & Kimble, J. E. (2001) · Genetics · doi:10.1093/genetics/157.2.639 · Cited by 53 · see citing works
The Dendritic Translocation of Translin Protein in the Form of BC1 RNA Protein Particles in Developing Rat Hippocampal Neurons in Primary Culture
Kobayashi, S., Takashima, A., & Anzai, K. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9704 · Cited by 50 · see citing works
Caenorhabditis elegans MES-3 Is a Target of GLD-1 and Functions Epigenetically in Germline Development
Xu, L., Paulsen, J. E., Yoo, Y., Goodwin, E. B., & Strome, S. (2001) · Genetics · doi:10.1093/genetics/159.3.1007 · Cited by 49 · see citing works
Self-citation
A genetic pathway for regulation of tra-2 translation
Goodwin, E. B., Hofstra, K., Hurney, C. A., et al. (1997) · Development · doi:10.1242/dev.124.3.749 · Cited by 48 · see citing works
Self-citation
Efficient translation and phosphorylation of Oskar require Oskar protein and the RNA helicase Vasa.
Markussen, F.-H., Breitwieser, W., & Ephrussi, A. (1997) · PubMed · Cited by 33 · see citing works
MicroRNAs: Something New Under the Sun
Moss, E. G., & Poethig, R. S. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01206-x · Cited by 29 · see citing works
Translational repressors in Drosophila
Dean, K. A., Aggarwal, A. K., & Wharton, R. P. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02792-0 · Cited by 22 · see citing works

Flagged first, then by citations

Sorted by citations

Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals
Xie, X., Lu, J., Kulbokas, E. J., Golub, T. R., Mootha, V., Lindblad-Toh, K., Lander, E. S., & Kellis, M. (2005) · Nature · doi:10.1038/nature03441 · Cited by 1,872 · see citing works
The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task
Israel, S., Lerer, E., Shalev, I., Uzefovsky, F., Riebold, M., Laiba, E., Bachner-Melman, R., Maril, A., Bornstein, G., Knafo, A., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005535 · Cited by 278 · see citing works
Vasa genes: Emerging roles in the germ line and in multipotent cells
Gustafson, E. A., & Wessel, G. M. (2010) · BioEssays · doi:10.1002/bies.201000001 · Cited by 173 · see citing works
Cellular oxygen sensing, signalling and how to survive translational arrest in hypoxia
Fähling, M. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2008.01894.x · Cited by 57 · see citing works
Improved translation efficiency of injected mRNA during early embryonic development
Fink, M., Flekna, G., Ludwig, A., Heimbucher, T., & Czerny, T. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20995 · Cited by 40 · see citing works

Translational regulation and deregulation in erythropoiesis
Vatikioti, A., Karkoulia, E., Ioannou, M., & Strouboulis, J. (2019) · Experimental Hematology · doi:10.1016/j.exphem.2019.05.004 · Cited by 23 · see citing works
Regulation and dysregulation of 3′UTR-mediated translational control
Jia, J., Yao, P., Arif, A., & Fox, P. L. (2013) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.12.004 · Cited by 92 · see citing works
The 5′-Untranslated Region of GLUT1 Glucose Transporter mRNA Causes Differential Regulation of the Translational Rate in Plant and Animal Systems
Boado, R. J., & Pardridge, W. M. (1997) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s0305-0491(97)00170-3 · Cited by 9 · see citing works
3′ UTR-isoform choice has limited influence on the stability and translational efficiency of most mRNAs in mouse fibroblastsPreprint
Spies, N., Burge, C. B., & Bartel, D. P. (2013) · Genome Research · doi:10.1101/gr.156919.113 · Cited by 209 · see citing works
Mechanism of translational regulation by miR-2 from sites in the 5' untranslated region or the open reading frame.
Moretti, F., Thermann, R., & Hentze, M. (2010) · RNA: A publication of the RNA Society · doi:10.1261/rna.2384610 · Cited by 183 · see citing works

Authors: Kuersten, S., & Goodwin, E. B.
Affiliations: University of Wisconsin–Madison (US)
ORCID: Kuersten, Scott
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2003-08
Volume: 4
Issue: 8
Pages: 626-637
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg1125
OpenAlex: W2018548355
Cited by: 530
References: 123
Citations by year: 2026: 6 · 2025: 11 · 2024: 9 · 2023: 13 · 2022: 10 · 2021: 13 · 2020: 12 · 2019: 19 · 2018: 20 · 2017: 17 · 2016: 21 · 2015: 16 · 2014: 22 · 2013: 31 · 2012: 34
FWCI: 3.34
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: 3' untranslated region, translational regulation, post-transcriptional regulation, maternal gene expression, early embryo, embryonic development, cell fate determination, cell division timing, stem cell proliferation, sex determination, neurogenesis, erythropoiesis
MeSH terms: Animals, Cell Division, Cell Nucleus, Drosophila, Female, Meiosis, Mitosis, Models, Biological, Mothers, RNA, RNA, Messenger, Protein Biosynthesis, Caenorhabditis elegans, Gene Expression Regulation, Developmental, Cell Lineage, Sex Determination Processes, 3' Untranslated Regions, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The power of the 3′ UTR: translational control and development.

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks