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Cited by 1,001Olfactory and Sensory Function StudiesIon Channels and ReceptorsBiochemical Analysis and Sensing Techniques

A novel family of genes encoding putative pheromone receptors in mammals

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Dulac, Catherine, Axel, Richard·1995·Cell
DOI 10.1016/0092-8674(95)90161-2
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Abstract

In mammals, olfactory sensory perception is mediated by two anatomically and functionally distinct sensory organs: the main olfactory epithelium (MOE) and the vomeronasal organ (VNO). Pheromones activate the VNO and elicit a characteristic array of innate reproductive and social behaviors, along with dramatic neuroendocrine responses. Differential screening of cDNA libraries constructed from single sensory neurons from the rat VNO has led to the isolation of a family of about 30 putative receptor genes. Sequence analysis indicates that these genes comprise a novel family of seven transmembrane domain proteins unrelated to the receptors expressed in the MOE. Moreover, the expression of each member of the gene family is restricted to a small subpopulation of VNO neurons. These genes are likely to encode mammalian pheromone receptors.

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  • Mammalian species with functional VNOs express two families of genes (V1R and V2R) that appear to code for 'seven transmembrane domain' membrane proteins thought to be the chemoreceptor molecules themselves.

    “Recent evidence (Dulac and Axel, 1995;Herrada and Dulac, 1997;Matsunami and Buck, 1997;Ryba and Tirrindelli, 1997) suggests that mammalian species with functional VNOs express two families of genes (V1R and V2R) that appear to code for 'seven transmembrane domain' membrane proteins thought to be the chemoreceptor molecules themselves.”

    From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Dulac and Axel, 1995

  • Genes similar to the vomeronasal receptor genes are also present in the human genome; those found in initial searches are clearly pseudogenes.

    “Genes similar to the vomeronasal receptor genes are also present in the human genome.Those found in initial searches through the genome are clearly pseudogenes (Dulac and Axel, 1995;Herrada and Dulac, 1997), i.e. they have defects in their sequence that would prevent transcription and translation of the expected transmembrane protein.”

    From Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases (2001) · cites this paper as Dulac and Axel, 1995

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Authors
Dulac, C., & Axel, R.
Affiliations
  • Columbia University (US)
  • Howard Hughes Medical Institute (US)
ORCID
Venue
Cell
Publisher
Elsevier BV
Published
1995-10
Volume
83
Issue
2
Pages
195-206
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/0092-8674(95)90161-2
OpenAlex
W2020791858
Cited by
1,001
References
62
Citations by year
2026: 7 · 2025: 16 · 2024: 27 · 2023: 20 · 2022: 18 · 2021: 25 · 2020: 19 · 2019: 31 · 2018: 19 · 2017: 17 · 2016: 30 · 2015: 24 · 2014: 33 · 2013: 30 · 2012: 31
FWCI
19.89
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Institutes of Health (5p01ns029832-10)
  • National Institute of Neurological Disorders and Stroke (NS 29832-04)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords
pheromone receptors, vomeronasal organ, vomeronasal sensory neurons, seven-transmembrane proteins, olfactory sensory neurons, gene family, cDNA cloning, rats, social behavior, reproductive behavior, neuroendocrine response
MeSH terms
Amino Acid Sequence, Animals, Base Sequence, Multigene Family, Membrane Proteins, Molecular Sequence Data, Nasal Septum, Nose, Pheromones, Smell, Blotting, Southern, Gene Library, Sequence Homology, Amino Acid, In Situ Hybridization, Sequence Analysis, DNA, Olfactory Receptor Neurons, DNA, Complementary, Rats

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