The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The Eph-Receptor A7 Is a Soluble Tumor Suppressor for Follicular Lymphoma
Open accessAbstract
Insights into cancer genetics can lead to therapeutic opportunities. By cross-referencing chromosomal changes with an unbiased genetic screen we identify the ephrin receptor A7 (EPHA7) as a tumor suppressor in follicular lymphoma (FL). EPHA7 is a target of 6q deletions and inactivated in 72 % of FLs. Knockdown of EPHA7 drives lymphoma development in a murine FL model. In analogy to its physiological function in brain development, a soluble splice variant of EPHA7 (EPHA7TR) interferes with another Eph-receptor and blocks oncogenic signals in lymphoma cells. Consistent with this drug-like activity, administration of the purified EPHA7TR protein produces anti-tumor effects against xenografted human lymphomas. Further, by fusing EPHA7TR to the anti-CD20 antibody (rituximab) we can directly target this tumor suppressor to lymphomas in vivo. Our study attests to the power of combining descriptive tumor genomics with functional screens and reveals EPHA7TR as tumor suppressor with immediate therapeutic potential.
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Somatic mutations affect key pathways in lung adenocarcinoma
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Restoration of p53 function leads to tumour regression in vivo
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IRF4 addiction in multiple myeloma
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Cited by
Eph Receptor Signaling and Ephrins
Lisabeth, E. M., Falivelli, G., & Pasquale, E. B. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009159 · Cited by 425
Green, M. R., Kihira, S., Liu, C. L., Nair, R. V., Salari, R., Gentles, A. J., Irish, J., Stehr, H., Vicente-Dueñas, C., Romero-Camarero, I., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501199112 · Cited by 355
Pathogenesis of follicular lymphoma
Kridel, R., Sehn, L. H., & Gascoyne, R. D. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63186 · Cited by 310
A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway
Mohseni, M., Sun, J., Lau, A., Curtis, S., Goldsmith, J., Fox, V. L., Wei, C., Frazier, M., Samson, O., Wong, K.-K., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2884 · Cited by 294
Eph Receptors and Ephrins: Therapeutic Opportunities
Barquilla, A., & Pasquale, E. B. (2015) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140226 · Cited by 294
Metadata
- Authors
- Oricchio, E., Nanjangud, G., Wolfe, A. L., Schatz, J. H., Mavrakis, K. J., Jiang, M., Liu, X., Bruno, J., Heguy, A., Olshen, A. B., Socci, N. D., Teruya-Feldstein, J., Weis-Garcia, F., Tam, W., Shaknovich, R., Melnick, A., Himanen, J. P., Chaganti, R. S. K., & Wendel, H.-G.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 147
- Issue
- 3
- Pages
- 554-564
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2114625470
- Cited by
- 172
- References
- 5
- FWCI
- 10.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Oricchio, E., Nanjangud, G., Wolfe, A. L., Schatz, J. H., Mavrakis, K. J., Jiang, M., Liu, X., Bruno, J., Heguy, A., Olshen, A. B., Socci, N. D., Teruya-Feldstein, J., Weis-Garcia, F., Tam, W., Shaknovich, R., Melnick, A., Himanen, J. P., Chaganti, R. S. K., & Wendel, H.-G. (2011). The Eph-Receptor A7 Is a Soluble Tumor Suppressor for Follicular Lymphoma. Cell. https://doi.org/10.1016/j.cell.2011.09.035
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
