The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation
Open accessAbstract
Significance: Follicular lymphoma (FL) is a disease characterized by multiple relapses that are linked by a common progenitor bearing only a subset of the mutations found within the tumor that presents clinically. Inability to cure this disease may therefore be linked to the failure of current therapies to clear these early tumor-propagating clones. Here we further define the genetic hallmarks of this disease and model the steps in evolution through phylogenetic analysis of serial tumor biopsies. This identified CREBBP mutations as early events in genome evolution that are enriched within tumor cell progenitors and provided evidence that these mutations act by allowing immune evasion. This highlights CREBBP mutations as an attractive therapeutic target in FL and provides insight into their pathogenic mechanism.
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Metadata
- Authors
- Green, M. R., Kihira, S., Liu, C. L., Nair, R. V., Salari, R., Gentles, A. J., Irish, J., Stehr, H., Vicente-Dueñas, C., Romero-Camarero, I., Sanchez-Garcia, I., Plevritis, S. K., Arber, D. A., Batzoglou, S., Levy, R., & Alizadeh, A. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-02-23
- Volume
- 112
- Issue
- 10
- Pages
- E1116-25
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2148687964
- Cited by
- 355
- References
- 53
- FWCI
- 26.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- Funders
- Leukemia and Lymphoma Society (3407-13)
- HHS | National Institutes of Health (S10 RR02933801, R01 CA151748)
- Lymphoma Research Foundation (245480)
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- Green, M. R., Kihira, S., Liu, C. L., Nair, R. V., Salari, R., Gentles, A. J., Irish, J., Stehr, H., Vicente-Dueñas, C., Romero-Camarero, I., Sanchez-Garcia, I., Plevritis, S. K., Arber, D. A., Batzoglou, S., Levy, R., & Alizadeh, A. A. (2015). Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1501199112
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