Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

Ying, Haoqiang, Kimmelman, Alec C., Lyssiotis, Costas A., Hua, Sujun, Chu, Gerald C., Fletcher-Sananikone, Eliot, Locasale, Jason W., Son, Jaekyoung +23 more·2012·Cell

DOI 10.1016/j.cell.2012.01.058

Cited by (1,006)

Items 601–700 of 1,006

Type I conventional dendritic cells facilitate immunotherapy in pancreatic cancer
Krishnan K. Mahadevan, Allison M. Dyevoich, Yang Chen, Bingrui Li, Hikaru Sugimoto, Amari M. Sockwell, Kathleen M. McAndrews, Lakshmi Kavitha Sthanam, Huamin Wang, Shabnam Shalapour et al. · 2024 · Science
The tumour microenvironment in pancreatic cancer — new clinical challenges, but more opportunities
Heng‐Chung Kung, Kevin Zheng, Jacquelyn W. Zimmerman, Lei Zheng · 2025 · Nature Reviews Clinical Oncology
HuR is a post-transcriptional regulator of core metabolic enzymes in pancreatic cancer
Richard Andrew Burkhart, Danielle M. Pineda, Saswati N. Chand, Carmella Romeo, Eric R. Londin, Edward D. Karoly, Joseph A. Cozzitorto, Isidore Rigoutsos, Charles J. Yeo, Jonathan Robert Brody et al. · 2013 · RNA Biology
Autophagy and cell reprogramming
Shuo Wang, Pengyan Xia, Markus Rehm, Zusen Fan · 2015 · Cellular and Molecular Life Sciences
PET/MRI in pancreatic and periampullary cancer: correlating diffusion-weighted imaging, MR spectroscopy and glucose metabolic activity with clinical stage and prognosis
Bang‐Bin Chen, Yu‐Wen Tien, Ming‐Chu Chang, Mei‐Fang Cheng, Yu‐Ting Chang, Chih‐Horng Wu, Xin-Jia Chen, Ting‐Chun Kuo, Shih‐Hung Yang, I‐Lun Shih et al. · 2016 · European Journal of Nuclear Medicine and Molecular Imaging
Reg proteins promote acinar-to-ductal metaplasia and act as novel diagnostic and prognostic markers in pancreatic ductal adenocarcinoma
Qing Li, Hao Wang, George Zogopoulos, Qin Shao, Kun Dong, Fudong Lv, Karam Nwilati, Xianyong Sean Gui, Adeline Cuggia, Jun‐Li Liu et al. · 2016 · Oncotarget
Mitochondrial mutations and metabolic adaptation in pancreatic cancer
Australian Pancreatic Cancer Genome Initiative, Rae‐Anne Hardie, Ellen van Dam, Mark J. Cowley, Ting-Li Han, Seher Balaban, Marina Pajic, Mark Pinese, Mary Iconomou, Robert F. Shearer et al. · 2017 · Cancer & Metabolism
KRAS Mutation Status Is Associated with Enhanced Dependency on Folate Metabolism Pathways in Non–Small Cell Lung Cancer Cells
Moran, Diarmuid M., Trusk, Patricia B., Pry, Karen, Paz, Keren, Sidransky, David, Bacus, Sarah S. · 2014 · Molecular Cancer Therapeutics
The roles of intratumour heterogeneity in the biology and treatment of pancreatic ductal adenocarcinoma
Theodore Evan, Victoria M.-Y. Wang, Axel Behrens · 2022 · Oncogene
Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming
Raquel Buj, Chi‐Wei Chen, Erika S. Dahl, Kelly E. Leon, Rostislav Kuskovsky, Natella Maglakelidze, Maithili Navaratnarajah, Gao Zhang, Mary T. Doan, Helen Jiang et al. · 2019 · Cell Reports
Neoplasms of the Exocrine Pancreas
Robert A. Wolff, Christopher H. Crane, Donghui Li, Douglas B. Evans, Anirban Maitra, Susan Tsai · 2017 · Wiley eBooks
Concurrent Inhibition of IGF1R and ERK Increases Pancreatic Cancer Sensitivity to Autophagy Inhibitors
Clint A. Stalnecker, Kajal R. Grover, A. Cole Edwards, Michael F. Coleman, Runying Yang, Jonathan M. DeLiberty, Björn Papke, Craig M. Goodwin, Mariaelena Pierobon, Emanuel F. Petricoin et al. · 2021 · Cancer Research
Interplays of glucose metabolism and KRAS mutation in pancreatic ductal adenocarcinoma
Yu-Huei Liu, Chun‐Mei Hu, Yuan-Sheng Hsu, Wen‐Hwa Lee · 2022 · Cell Death and Disease
Fructose consumption and cancer
Ava M. Port, Megan R. Ruth, Nawfal W. Istfan · 2012 · Current Opinion in Endocrinology Diabetes and Obesity
Histone deacetylase inhibitor-induced cancer stem cells exhibit high pentose phosphate pathway metabolism
Bisrat Godefay Debeb, Lara Lacerda, Richard A. Larson, Adam R. Wolfe, Savitri Krishnamurthy, James M. Reuben, Naoto Tada Ueno, Michael Z. Gilcrease, Wendy A. Woodward · 2016 · Oncotarget
Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1
Hirotada Tajiri, Takehito Uruno, Takahiro Shirai, Daisuke Takaya, Shigeki Matsunaga, Daiki Setoyama, Mayuki Watanabe, Mutsuko Kukimoto‐Niino, Kounosuke Oisaki, Miho Ushijima et al. · 2017 · Cell Reports
A combinatorial strategy using YAP and pan-RAF inhibitors for treating KRAS-mutant pancreatic cancer
Xiao Zhao, Xiuchao Wang, Lijun Fang, Chungen Lan, Xiaowei Zheng, Yongwei Wang, Yinlong Zhang, Xuexiang Han, Shaoli Liu, Keman Cheng et al. · 2017 · Cancer Letters
Metabolic interactions in cancer: cellular metabolism at the interface between the microenvironment, the cancer cell phenotype and the epigenetic landscape
Gianmarco Rinaldi, Matteo Rossi, Sarah‐Maria Fendt · 2017 · WIREs Systems Biology and Medicine
Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous
Wei‐Jen Chung, Anneleen Daemen, Jason H. Cheng, Jason E. Long, Jonathan E. Cooper, Bu-Er Wang, Christopher Tran, Mallika Singh, Florian Gnad, Zora D. Modrusan et al. · 2017 · Proceedings of the National Academy of Sciences
Inhibition of Glucose-6-Phosphate Dehydrogenase Reverses Cisplatin Resistance in Lung Cancer Cells via the Redox System
Weipeng Hong, Peiheng Cai, Chuncao Xu, Di Cao, Wei‐Bang Yu, Zhongxiang Zhao, Min Huang, Jing Jin · 2018 · Frontiers in Pharmacology
Autophagy and cancer cell metabolism
Cara M. Anderson, Kay F. Macleod · 2019 · International review of cytology
Engineered exosomes with KrasG12D specific siRNA in pancreatic cancer: a phase I study with immunological correlates
Kalluri, Valerie S., Smaglo, Brandon G., Mahadevan, Krishnan K., Kirtley, Michelle L., McAndrews, Kathleen M., Mendt, Mayela, Yang, Sujuan, Maldonado, Ana S., Sugimoto, Hikaru, Salvatierra, Maria E. et al. · 2025 · Nature Communications
PRKAR2B‐HIF‐1α loop promotes aerobic glycolysis and tumour growth in prostate cancer
Lei Xia, Jian Sun, Shaowei Xie, Chenfei Chi, Yinjie Zhu, Jiahua Pan, Baijun Dong, Yong Huang, Weiliang Xia, Jianjun Sha et al. · 2020 · Cell Proliferation
Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1
Pei-Yun Tsai, Min-Sik Lee, Unmesh Jadhav, Insia Naqvi, Shariq Madha, Ashley Adler, Meeta Mistry, Sergey Naumenko, Caroline A. Lewis, Daniel S. Hitchcock et al. · 2021 · Proceedings of the National Academy of Sciences
KRAS mutation increases histone H3 lysine 9 lactylation (H3K9la) to promote colorectal cancer progression by facilitating cholesterol transporter GRAMD1A expression
Chi Zhang, Runfeng Yu, Senmao Li, Ming Yuan, Tuo Hu, Jiaqi Liu, Haoxian Ke, Shubiao Ye, Jihye Yun, Junfeng Huang et al. · 2025 · Cell Death and Differentiation
Modeling Targeted Inhibition of MEK and PI3 Kinase in Human Pancreatic Cancer
Melissa R. Junttila, Vidusha Devasthali, Jason H. Cheng, Joseph Castillo, Ciara Metcalfe, Anne C. Clermont, Douglas Den Otter, Emily Chan, Hani Bou-Reslan, Tim C. Cao et al. · 2014 · Molecular Cancer Therapeutics
A KRAS wild type mutational status confers a survival advantage in pancreatic ductal adenocarcinoma
Annika Lisbeth Windon, Arturo Loaiza‐Bonilla, Christopher Edward Jensen, Michael P. Randall, Jennifer J. D. Morrissette, Stuti G. Shroff · 2018 · Journal of Gastrointestinal Oncology
An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma
Chenlei Wen, Ke Huang, Lu-Lu Jiang, Xiongxiong Lu, Yuting Dai, Min-Min Shi, Xiao-Mei Tang, Qingbing Wang, Xiaodan Zhang, Peng‐Hui Wang et al. · 2019 · Proceedings of the National Academy of Sciences
Vitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxylic acid (TCA) cycle in hypoxic KRAS mutant colon cancer
Aiora Cenigaonandia‐Campillo, Roberto Serna‐Blasco, Laura Gómez-Ocabo, Sonia Solanes Casado, Natalia Baños‐Herraiz, Laura del Puerto‐Nevado, J. A. Cañas, María Jesús Fernández‐Aceñero, Jesús García‐Foncillas, Óscar Aguilera · 2021 · Theranostics
Role of the tumor microenvironment in cancer hallmarks and targeted therapy (Review)
Naser, Rayan, Fakhoury, Isabelle, El‑Fouani, Adam, Abi‑Habib, Ralph, El‑Sibai, Mirvat · 2022 · International Journal of Oncology
FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis
Michelle Samuel Chattaragada, Chiara Riganti, Marco Sassoé‐Pognetto, Moitza Principe, M M Santamorena, Cecilia Roux, Claudia Curcio, Andrea Evangelista, Paola Allavena, Roberto Salvia et al. · 2017 · Oncogene
Cordycepin Induces Apoptosis and G2/M Phase Arrest through the ERK Pathways in Esophageal Cancer Cells
Jiacheng Xu, Xueping Zhou, Xu-An Wang, Mei-Dong Xu, Tao Chen, Tian‐Yin Chen, Ping‐Hong Zhou, Yiqun Zhang · 2019 · Journal of Cancer
Structure of two G-quadruplexes in equilibrium in the KRAS promoter
Julien Marquevielle, Coralie Robert, Olivier Lagrabette, Mona Wahid, Anne Bourdoncle, Luigi Emilio Xodo, Jean‐Louis Mergny, Gilmar F. J. Salgado · 2020 · Nucleic Acids Research
Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1
Palanivel Kandasamy, Inti Zlobec, Damian T. Nydegger, Jonai Pujol‐Giménez, Rajesh Bhardwaj, Senji Shirasawa, Toshiyuki Tsunoda, Matthias A. Hediger · 2021 · Molecular Oncology
Recent advances of human dihydroorotate dehydrogenase inhibitors for cancer therapy: Current development and future perspectives
Lele Zhang, Jifa Zhang, Jiaxing Wang, Changyu Ren, Pan Tang, Liang Ouyang, Yuxi Wang · 2022 · European Journal of Medicinal Chemistry
Overview of Cancer Metabolism and Signaling Transduction
Heesuk Chae, Seong‐Tshool Hong · 2022 · International Journal of Molecular Sciences
Enhanced Glutaminolysis Drives Hypoxia-Induced Chemoresistance in Pancreatic Cancer
Seung Joon Park, Hee Chan Yoo, Eunyong Ahn, Enzhi Luo, Yeabeen Kim, Yulseung Sung, Ya Chun Yu, Kibum Kim, Do Sik Min, Hee Seung Lee et al. · 2023 · Cancer Research
Mutant KRAS Drives Immune Evasion by Sensitizing Cytotoxic T‐Cells to Activation‐Induced Cell Death in Colorectal Cancer
Huashan Liu, Zhenxing Liang, Sijing Cheng, Liang Huang, Wenxin Li, Chi Zhou, Xiaobin Zheng, Shujuan Li, Ziwei Zeng, Liang Kang · 2023 · Advanced Science
KRAS mutation: The booster of pancreatic ductal adenocarcinoma transformation and progression
Zining Zhang, Heng Zhang, Xiang Liao, Hsiang‐i Tsai · 2023 · Frontiers in Cell and Developmental Biology
Receptor-interacting Protein Kinase 2 Is an Immunotherapy Target in Pancreatic Cancer
Wenhua Sang, Yiduo Zhou, Haiyan Chen, Chengxuan Yu, Lisi Dai, Zhongkun Liu, Lang Chen, Yimin Fang, Panpan Ma, Xiangji Wu et al. · 2023 · Cancer Discovery
Metabolic reprogramming: a hallmark of viral oncogenesis
Pierre L. Levy, Birke Bartosch · 2015 · Oncogene
Targeted Inhibition of Glutamine-Dependent Glutathione Metabolism Overcomes Death Resistance Induced by Chronic Cycling Hypoxia
Johann Matschke, Helena Riffkin, Diana Klein, René Handrick, Lutz Lüdemann, Eric Metzen, Tomer Shlomi, Martin Stuschke, Verena Jendrossek · 2016 · Antioxidants and Redox Signaling
Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells
María J. Bueno, Veronica Jimenez-Renard, Sara Samino, Jordi Capellades, Alexandra Junza, María Luz López-Rodríguez, Javier Garcı́a-Cárceles, Irene López-Fabuel, Juan Pedro Bolaños, Navdeep S. Chandel et al. · 2019 · Nature Communications
KRAS: Biology, Inhibition, and Mechanisms of Inhibitor Resistance
Ash, Leonard J., Busia-Bourdain, Ottavia, Okpattah, Daniel, Kamel, Avrosina, Liberchuk, Ariel, Wolfe, Andrew L. · 2024 · Current Oncology
Therapeutic resistance in pancreatic ductal adenocarcinoma: Current challenges and future opportunities
Aditi Jain, Vikas Bhardwaj · 2021 · World Journal of Gastroenterology
Oncogenic KRAS-Dependent Stromal Interleukin-33 Directs the Pancreatic Microenvironment to Promote Tumor Growth
Katelyn L. Donahue, Hannah R. Watkoske, Padma Kadiyala, Wenting Du, Kristee L. Brown, Michael K. Scales, Ahmed M. Elhossiny, Carlos E. Espinoza, Emily L. Lasse Opsahl, Brian D. Griffith et al. · 2024 · Cancer Discovery
Overcoming therapy resistance in pancreatic cancer: New insights and future directions
Margarita Espona‐Fiedler, Cédric Patthey, Stina Lindblad, Irina Sarró, Daniel Öhlund · 2024 · Biochemical Pharmacology
Autophagy-Dependent Metabolic Reprogramming Sensitizes TSC2-Deficient Cells to the Antimetabolite 6-Aminonicotinamide
Andrey A. Parkhitko, Carmen Priolo, Jonathan L. Coloff, Jihye Yun, Julia J. Wu, Kenji Mizumura, Wenping Xu, Izabela A. Malinowska, Jane J. Yu, David J. Kwiatkowski et al. · 2013 · Molecular Cancer Research
Mitochondrial pyruvate carrier function and cancer metabolism
Adam J. Rauckhorst, Eric B. Taylor · 2016 · Current Opinion in Genetics & Development
Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential
Erik S. Knudsen, Uthra Balaji, Elizaveta Freinkman, Peter A. McCue, Agnieszka Katarzyna Witkiewicz · 2016 · Oncotarget
Emerging therapeutic potential of graviola and its constituents in cancers
Asif Khurshid Qazi, Jawed Akhtar Siddiqui, Rahat Jahan, Sanjib Chaudhary, Larry Walker, Zafar Sayed, Dwight T. Jones, Surinder K. Batra, Muzafar Ahmad Macha · 2018 · Carcinogenesis
Combined intermittent fasting and ERK inhibition enhance the anti-tumor effects of chemotherapy via the GSK3β-SIRT7 axis
Xiaolong Tang, Guo Li, Lei Shi, Fengting Su, Minxian Qian, Zuojun Liu, Yuan Meng, Shimin Sun, Ji Li, Baohua Liu · 2021 · Nature Communications
Proliferation and tissue remodeling in cancer: the hallmarks revisited
Elke Katrin Markert, Arnold J. Levine, Alexei Vázquez · 2012 · Cell Death and Disease
The Role of Mitochondria in the Chemoresistance of Pancreatic Cancer Cells
Yibo Fu, Francesca Ricciardiello, Gang Yang, Jiangdong Qiu, Hua Huang, Jianchun Xiao, Zhe Cao, Fangyu Zhao, Yueze Liu, Wenhao Luo et al. · 2021 · Cells
Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma
Yonathan Lissanu, Yanxia Shi, Kunal Rai, Luigi Nezi, Samirkumar B. Amin, Chia-Chin Wu, Kadir Caner Akdemir, Mozhdeh Mahdavi, Qian Peng, Qing Chang et al. · 2016 · Proceedings of the National Academy of Sciences
Positron Emission Tomography Imaging of Tumor Cell Metabolism and Application to Therapy Response Monitoring
Amarnath Challapalli, Eric Ofori Aboagye · 2016 · Frontiers in Oncology
Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism
Weiguang Sun, Shanshan Luan, Changxing Qi, Qingyi Tong, Shan Yan, Hua Li, Yonghui Zhang · 2019 · Cell Communication and Signaling
Photodynamic Therapy for ras -Driven Cancers: Targeting G-Quadruplex RNA Structures with Bifunctional Alkyl-Modified Porphyrins
Annalisa Ferino, Giulia Nicoletto, Francesca D’Este, Sonia Zorzet, Sara Lago, Sara N. Richter, Alexander S. Tikhomirov, Andrey Egorovich Shchekotikhin, Luigi Emilio Xodo · 2020 · Journal of Medicinal Chemistry
Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF-PI3K pathway
Boyer, Seth, Lee, Ho-Joon, Steele, Nina, Zhang, Li, Sajjakulnukit, Peter, Andren, Anthony, Ward, Matthew H, Singh, Rima, Basrur, Venkatesha, Zhang, Yaqing et al. · 2022 · eLife
Tumor lactic acid: a potential target for cancer therapy
Jun‐Kyu Byun · 2023 · Archives of Pharmacal Research
KRAS: the Achilles’ heel of pancreas cancer biology
Kristina Drizyte‐Miller, Taiwo Talabi, Ashwin Somasundaram, Adrienne D. Cox, Channing J. Der · 2025 · Journal of Clinical Investigation
Metabolism and epigenetics of pancreatic cancer stem cells
Mirna Perusina Lanfranca, Joyce K. Thompson, Filip Bednar, Christopher J. Halbrook, Costas Andreas Lyssiotis, Benjamin Lévi, Timothy L. Frankel · 2018 · Seminars in Cancer Biology
Epigenetic regulation of the Warburg effect by H2B monoubiquitination
Yuanya Jing, Fengfeng Cai, Lei Zhang, Jing Han, Yang Lü, Fan Tang, Yabin Li, Jian-Feng Chang, Feng Sun, Xiaomei Yang et al. · 2019 · Cell Death and Differentiation
Inhibiting both proline biosynthesis and lipogenesis synergistically suppresses tumor growth
Miao Liu, Yuanyuan Wang, Chuanzhen Yang, Yuxia Ruan, Changsen Bai, Qiaoyun Chu, Yanfen Cui, Ceshi Chen, Guoguang Ying, Binghui Li · 2020 · The Journal of Experimental Medicine
Metabolomics profile in gastrointestinal cancers: Update and future perspectives
Giulia Nannini, Gaia Meoni, Amedeo Amedei, Leonardo Tenori · 2020 · World Journal of Gastroenterology
UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth
Andrew L. Wolfe, Qingwen Zhou, Eneda Toska, Jacqueline Galeas, Angel A. Ku, Richard P. Koche, Sourav Bandyopadhyay, Maurizio Scaltriti, Carlito B. Lebrilla, Frank P. McCormick et al. · 2021 · Proceedings of the National Academy of Sciences
Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo
Denada Dibra, Shunbin Xiong, Sydney M. Moyer, Adel K. El‐Naggar, Yuan Qi, Xiaoping Su, Elisabeth Kong, Anil Korkut, Guillermina Lozano · 2024 · Science Advances
Golgi N-glycan branching N-acetylglucosaminyltransferases I, V and VI promote nutrient uptake and metabolism
Anas M. Abdel Rahman, Michael C. Ryczko, Miyako Nakano, Judy Pawling, Tania Rodrigues, Anita Johswich, Naoyuki Taniguchi, James W. Dennis · 2014 · Glycobiology
Mass Spectrometry Imaging in Oncology Drug Discovery
Richard J. A. Goodwin, Josephine Bunch, Dermot F. McGinnity · 2017 · Advances in cancer research
De novo lipogenesis represents a therapeutic target in mutant Kras non‐small cell lung cancer
Anju Singh, Christian Felipe Ruiz, Kavita Bhalla, John D. Haley, Qing Kay Li, George K. Acquaah-Mensah, Emily D. Montal, Kuladeep R. Sudini, Ferdinandos Skoulidis, Ignacio Ivan Wistuba et al. · 2018 · The FASEB Journal
The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities
James L. Abbruzzese, Dana K. Andersen, Carl A.K. Borrebaeck, Suresh T. Chari, Eithne Costello, Zobeida Cruz‐Monserrate, Guido Eibl, Edgar G. Engleman, William E. Fisher, Aida Habtezion et al. · 2018 · Pancreas
Glutamine deprivation triggers NAGK-dependent hexosamine salvage
Campbell, Sydney, Mesaros, Clementina, Izzo, Luke, Affronti, Hayley, Noji, Michael, Schaffer, Bethany E, Tsang, Tiffany, Sun, Kathryn, Trefely, Sophie, Kruijning, Salisa et al. · 2021 · eLife
Homeodomain‐interacting protein kinase 2 suppresses proliferation and aerobic glycolysis via ERK/cMyc axis in pancreatic cancer
Yi Qin, Qiangsheng Hu, Shunrong Ji, Jin Xu, Weixing Dai, Wensheng Liu, Wenyan Xu, Qiqing Sun, Zheng Zhang, Quanxing Ni et al. · 2019 · Cell Proliferation
Metabolic shift to serine biosynthesis through 3-PG accumulation and PHGDH induction promotes tumor growth in pancreatic cancer
Rumi Itoyama, Noriko Yasuda‐Yoshihara, Fumimasa Kitamura, Tadahito Yasuda, Luke Bu, Atsuko Yonemura, Tomoyuki Uchihara, Kota Arima, Xichen Hu, Jun Zhang et al. · 2021 · Cancer Letters
Metabolic Reprogramming in Cancer: Implications for Immunosuppressive Microenvironment
Durre Aden, Niti Sureka, Samreen Zaheer, Jai Kumar Chaurasia, Sufian Zaheer · 2024 · Immunology
N-Linked Glycosylation Supports Cross-Talk between Receptor Tyrosine Kinases and Androgen Receptor
Harri M. Itkonen, Ian Geoffrey Mills · 2013 · PLoS ONE
Aberrant O-GlcNAcylated Proteins: New Perspectives in Breast and Colorectal Cancer
Parunya Chaiyawat, Pukkavadee Netsirisawan, Jisnuson Svasti, Voraratt Champattanachai · 2014 · Frontiers in Endocrinology
Probing the metabolic phenotype of breast cancer cells by multiple tracer stable isotope resolved metabolomics
Andrew N. Lane, Julie D. Tan, Yali Wang, Jun Yan, Richard M. Higashi, Teresa W.‐M. Fan · 2017 · Metabolic Engineering
Pancreatic Cancer and Its Microenvironment—Recent Advances and Current Controversies
Kinga B. Stopa, Agnieszka A. Kusiak, Mateusz D. Szopa, Paweł E. Ferdek, Monika A. Jakubowska · 2020 · International Journal of Molecular Sciences
Multimodal survival prediction in advanced pancreatic cancer using machine learning
Julius Keyl, Stefan Kasper, Marcel Wiesweg, Julian Götze, Martin Schönrock, Marianne Sinn, Aaron Berger, E. Nasca, Karina Kostbade, Brigitte M. Schumacher et al. · 2022 · ESMO Open
PAF-Mediated MAPK Signaling Hyperactivation via LAMTOR3 Induces Pancreatic Tumorigenesis
Sohee Jun, Sunhye Lee, Han-Cheon Kim, Christopher Ng, Andrea M. Schneider, Hong Long Ji, Haoqiang Ying, Huamin Wang, Ronald Anthony DePinho, Jae‐Il Park · 2013 · Cell Reports
Bis(acetylacetonato)-oxidovanadium(IV) and sodium metavanadate inhibit cell proliferation via ROS-induced sustained MAPK/ERK activation but with elevated AKT activity in human pancreatic cancer AsPC-1 cells
Jingxuan Wu, Yi-Hua Hong, Xiao-Gai Yang · 2016 · JBIC Journal of Biological Inorganic Chemistry
Mechanisms Governing Immunotherapy Resistance in Pancreatic Ductal Adenocarcinoma
Zoe C. Schmiechen, Ingunn M. Stromnes · 2021 · Frontiers in Immunology
Targeting Stromal-Cancer Cell Crosstalk Networks in Ovarian Cancer Treatment
Tsz-Lun Yeung, Cecilia Leung, Fuhai Li, Stephen T. C. Wong, Samuel C. Mok · 2016 · Biomolecules
A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells
Chiara Ghezzi, Alicia Wong, Bao Ying Chen, Bernard Ribalet, Robert D. Damoiseaux, Peter M. Clark · 2019 · Nature Communications
Extracellular citrate and metabolic adaptations of cancer cells
Eric Kenneth Parkinson, Jerzy Adamski, Grit Zahn, Andreas K.A. Gaumann, Fabian Flores‐Borja, Christine Maria Ziegler, Maria Elzbieta Mycielska · 2021 · Cancer and Metastasis Reviews
Molecular Pathways: Targeting the Dependence of Mutant RAS Cancers on the DNA Damage Response
Elda Grabocka, Cosimo Commisso, Dafna Bar‐Sagi · 2014 · Clinical Cancer Research
Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States
Jong Wook Kim, Omar O. Abudayyeh, Huwate Yeerna, Chen‐Hsiang Yeang, Michelle L. Stewart, Russell William Jenkins, Shunsuke Kitajima, David Joseph Konieczkowski, Kate Medetgul-Ernar, Taylor B. Cavazos et al. · 2017 · Cell Systems
SOX9 activity is induced by oncogenic Kras to affect MDC1 and MCMs expression in pancreatic cancer
H Zhou, Yi Qin, Shunrong Ji, J Ling, Jie Fu, Z Zhuang, Xiaolong Fan, Lijie Song, Xianjun Yu, Paul J. Chiao · 2017 · Oncogene
Targeting the RAS-dependent chemoresistance: The Warburg connection
Roberto Serna‐Blasco, Marta Sanz-Álvarez, Óscar Aguilera, Jesús García‐Foncillas · 2018 · Seminars in Cancer Biology
RAS signalling in energy metabolism and rare human diseases
Laetitia Dard, Nadège Bellancé, Didier Lacombe, Rodrigue Rossignol · 2018 · Biochimica et Biophysica Acta (BBA) - Bioenergetics
Current State of “Omics” Biomarkers in Pancreatic Cancer
Beste Turanlı, Esra Yildirim, Gizem Gülfidan, Kazım Yalçın Arğa, Raghu Sinha · 2021 · Journal of Personalized Medicine
REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors
Shuxi Qiao, Siang‐Boon Koh, Varunika Vivekanandan, Devika Salunke, Krushna Chandra Patra, Elma Zaganjor, Kenneth N. Ross, Yusuke Mizukami, Sarah Jeanfavre, Athena L. Chen et al. · 2020 · Genes & Development
Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma
Yexin Tong, Mingjun Sun, Lingli Chen, Yunzhi Wang, Li Yan, Lingling Li, Xuan Zhang, Yumeng Cai, Jingbo Qie, Yanrui Pang et al. · 2022 · Journal of Hematology & Oncology
Simultaneous Steady-state and Dynamic 13C NMR Can Differentiate Alternative Routes of Pyruvate Metabolism in Living Cancer Cells
Chendong Yang, Crystal E. Harrison, Eunsook S. Jin, David Chuang, A. Dean Sherry, Craig R. Malloy, Matthew E. Merritt, Ralph J. DeBerardinis · 2014 · Journal of Biological Chemistry
G4 DNA in ras genes and its potential in cancer therapy
Susanna Cogoi, Luigi Emilio Xodo · 2016 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
To Eat and to Be Eaten: Mutual Metabolic Adaptations of Immune Cells and Intracellular Bacterial Pathogens upon Infection
Wolfgang Eisenreich, Thomas Rudel, Jürgen Heesemann, Werner Goebel · 2017 · Frontiers in Cellular and Infection Microbiology
Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation
Ho‐Joon Lee, Mark P. Jedrychowski, Arunachalam Vinayagam, Ning Wu, Ng Shyh‐Chang, Yanhui Hu, Chua Min-Wen, Jodene K. Moore, John M. Asara, Costas Andreas Lyssiotis et al. · 2017 · Cell Reports
Role of metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) in pancreatic cancer
Yating Cheng, Parisa Imanirad, Indira Jutooru, Erik Hedrick, Un-Ho Jin, Aline Rodrigues Hoffmann, Jeann Leal de Araújo, Benjamin Morpurgo, Andrei Golovko, Stephen H Safe · 2018 · PLoS ONE
Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis
Haocheng Lin, Yiyin Chung, Chun-Ting Cheng, Ching Ouyang, Yong Fu, Ching‐Ying Kuo, Kevin K. Chi, Maryam Sadeghi, Peiguo G. Chu, Hsing-Jien Kung et al. · 2018 · Autophagy