Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism
Ying, Haoqiang, Kimmelman, Alec C., Lyssiotis, Costas A., Hua, Sujun, Chu, Gerald C., Fletcher-Sananikone, Eliot, Locasale, Jason W., Son, Jaekyoung, Zhang, Hailei, Coloff, Jonathan L., Yan, Haiyan, Wang, Wei, Chen, Shujuan, Viale, Andrea, Zheng, Hongwu, Paik, Ji-hye, Lim, Carol, Guimaraes, Alexander R., Martin, Eric S., Chang, Jeffery, Hezel, Aram F., Perry, Samuel R., Hu, Jian, Gan, Boyi, Xiao, Yonghong, Asara, John M., Weissleder, Ralph, Wang, Y. Alan, Chin, Lynda, Cantley, Lewis C., DePinho, Ronald A.·2012·Cell
Cited by (1,006)
Items 301–400 of 1,006
- Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12CZeng, Mei, Lu, Jia, Li, Lianbo, Feru, Frederic, Quan, Chunshan, Gero, Thomas W., Ficarro, Scott B., Xiong, Yuan, Ambrogio, Chiara, Paranal, Raymond M. et al. · 2017 · Cell Chemical Biology
- Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?R. Brooks Robey, Judith Weisz, Nancy B. Kuemmerle, Anna C. Salzberg, Arthur S Berg, Dustin G. Brown, Laura L. Maurer, Roberta Palorini, Fahd Al‐Mulla, Rabeah Abbas Al-Temaimi et al. · 2015 · Carcinogenesis
- Tumour microenvironment responsive nanoconstructs for cancer theranosticArif Gulzar, Jiating Xu, Chen Wang, Fei He, Dan Yang, Shili Gai, Piaoping Yang, Jun Lin, Dayong Jin, Bengang Xing · 2019 · Nano Today
- MAPK signaling is required for dedifferentiation of acinar cells and development of pancreatic intraepithelial neoplasia in miceCollins, Meredith A., Yan, Wei, Sebolt–Leopold, Judith S., Pasca di Magliano, Marina · 2014 · Gastroenterology
- A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatmentXiao Zhao, Liang Liu, Jiayan Lang, Keman Cheng, Yongwei Wang, Xueyan Li, Jian Ying Shi, Yanli Wang, Guangjun Nie · 2018 · Cancer Letters
- Characterization of Glycolysis-Associated Molecules in the Tumor Microenvironment Revealed by Pan-Cancer Tissues and Lung Cancer Single Cell DataJinfen Wei, Kaitang Huang, Meiling Hu, Zixi Chen, Yunmeng Bai, Shudai Lin, Hongli Du · 2020 · Cancers
- Lactate Dehydrogenase B Is Required for the Growth of KRAS-Dependent Lung AdenocarcinomasMark L. McCleland, Adam S. Adler, Laura Deming, Ely Cosino, Leslie B. Lee, Elizabeth M. Blackwood, Margaret Solon, Janet Tao, Li Li, David S. Shames et al. · 2012 · Clinical Cancer Research
- Fibroblasts in Pancreatic Ductal Adenocarcinoma: Biological Mechanisms and Therapeutic TargetsMartin C. Whittle, Sunil R. Hingorani · 2019 · Gastroenterology
- Cancer metabolism and tumor microenvironment: fostering each other?Yiyuan Yuan, Huimin Li, Pu Wang, Leilei Chen, Dong Sheng Guo, Hongfei Jiang, Bo He, Siyuan Qin, Kui Wang, Na Li et al. · 2021 · Science China Life Sciences
- Ornithine aminotransferase supports polyamine synthesis in pancreatic cancerMin-Sik Lee, Courtney Dennis, Insia Naqvi, Lucas Dailey, Alireza Lorzadeh, George Ye, Tamara Zaytouni, Ashley Adler, Daniel S. Hitchcock, Lin Lin et al. · 2023 · Nature
- PI3K Regulation of RAC1 Is Required for KRAS-Induced Pancreatic Tumorigenesis in MiceChia-Yen C. Wu, Eileen S. Carpenter, Kenneth K. Takeuchi, Christopher J. Halbrook, Louise V. Peverley, Harold Bien, Jason C. Hall, Kathleen E. DelGiorno, Debjani Pal, Yan Song et al. · 2014 · Gastroenterology
- KRAS-regulated glutamine metabolism requires UCP2-mediated aspartate transport to support pancreatic cancer growthSusanna Raho, Loredana Capobianco, Rocco Malivindi, Angelo Vozza, Carmela Piazzolla, Francesco De Leonardis, Ruggiero Gorgoglione, Pasquale Scarcia, Francesca Pezzuto, Gennaro Agrimi et al. · 2020 · Nature Metabolism
- Targeting metabolic reprogramming in KRAS-driven cancersKenji Kawada, Kosuke Toda, Yoshiharu Sakai · 2017 · International Journal of Clinical Oncology
- The biological underpinnings of therapeutic resistance in pancreatic cancerGregory Lawrence Beatty, Gregor Werba, Costas Andreas Lyssiotis, Diane M. Simeone · 2021 · Genes & Development
- Metabolism addiction in pancreatic cancerRoy Blum, Yoel Kloog · 2014 · Cell Death and Disease
- GEMMs as preclinical models for testing pancreatic cancer therapiesAarthi Gopinathan, Jennifer P. Morton, Duncan Ian Jodrell, Owen James Sansom · 2015 · Disease Models & Mechanisms
- Targeting RAS -mutant Cancers: Is ERK the Key?Meagan B. Ryan, Channing J. Der, Andrea Wang‐Gillam, Adrienne D. Cox · 2015 · Trends in cancer
- Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachoneGaurab Chakrabarti, Zachary Moore, Xiuquan Luo, Mariya Ilcheva, Aktar Ali, Mahesh S. Padanad, Yunyun Zhou, Yang Xie, Sandeep Burma, Pier Paolo Scaglioni et al. · 2015 · Cancer & Metabolism
- Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal CancerJosiah E. Hutton, Xiaojing Wang, Lisa J. Zimmerman, Robbert J.C. Slebos, Irina A. Trenary, Jamey D. Young, Ming Li, Daniel C. Liebler · 2016 · Molecular & Cellular Proteomics
- High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic CellsHu, Chun-Mei, Tien, Sui-Chih, Hsieh, Ping-Kun, Jeng, Yung-Ming, Chang, Ming-Chu, Chang, Yu-Ting, Chen, Yi-Ju, Chen, Yu-Ju, Lee, Eva Y.-H.P., Lee, Wen-Hwa · 2019 · Cell Metabolism
- Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrugRana Rais, Kathryn M. Lemberg, Lukáš Tenora, Matthew L. Arwood, Arindom Pal, Jesse Alt, Ying Wu, Jenny Lam, Joanna Marie H. Aguilar, Liang Zhao et al. · 2022 · Science Advances
- Therapeutic options for the management of pancreatic cancerMaria L Rossi · 2014 · World Journal of Gastroenterology
- Global Profiling Strategies for Mapping Dysregulated Metabolic Pathways in CancerDaniel I. Benjamin, Benjamin F. Cravatt, Daniel K. Nomura · 2012 · Cell Metabolism
- Metabolic requirement for GOT2 in pancreatic cancer depends on environmental contextKerk, Samuel A, Lin, Lin, Myers, Amy L, Sutton, Damien J, Andren, Anthony, Sajjakulnukit, Peter, Zhang, Li, Zhang, Yaqing, Jiménez, Jennifer A, Nelson, Barbara S et al. · 2022 · eLife
- Amplification of USP13 drives ovarian cancer metabolismCecil Han, Lifeng Yang, Hyun Ho Choi, Joelle Baddour, Abhinav Achreja, Yunhua Liu, Yujing Li, Jia‐Da Li, Guohui Wan, Cheng Huang et al. · 2016 · Nature Communications
- Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven CancersMalvika Koundinya, Judith Sudhalter, Albane Courjaud, Bruno Lionne, Gaetan Touyer, Luc Bonnet, Isabelle Menguy, Isabelle Schreiber, Christelle Perrault, Stéphanie Vougier et al. · 2018 · Cell chemical biology
- Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferationKathleen A. Boyle, Jonathan Van Wickle, R. Blake Hill, Adriano Marchese, Balaraman Kalyanaraman, Michael B. Dwinell · 2018 · Journal of Biological Chemistry
- SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of AspartateChi Chun Wong, Yun Qian, Xiaona Li, Jiaying Xu, Wei Kang, JOANNA H.M. TONG, Ka‐Fai To, Jin Ye, Weilin Li, Huarong Chen et al. · 2016 · Gastroenterology
- mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1Joseph Gennaro Moloughney, Peter K. Kim, Nicole M. Vega-Cotto, Chang‐Chih Wu, Sisi Zhang, Matthew Adlam, Thomas P. Lynch, Po-Chien Chou, Joshua D. Rabinowitz, Guy Werlen et al. · 2016 · Molecular Cell
- c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasisJia Zhang, Su Wang, Bin Jiang, Lihong Huang, Z. Ji, Xiaotong Li, Hua-Min Zhou, A. Han, Ai Chen, Yanan Wu et al. · 2017 · Nature Communications
- The hexosamine biosynthetic pathway and cancer: Current knowledge and future therapeutic strategiesChristine Lam, Jin‐Yih Low, Phuoc Tho Tran, Hailun Wang · 2021 · Cancer Letters
- Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancerRan Li, Thomas S.C. Ng, Stephanie J. Wang, Mark Prytyskach, Christopher B. Rodell, Hannes Mikula, Rainer H. Köhler, Michelle A. Garlin, Douglas A. Lauffenburger, Sareh Parangi et al. · 2021 · Nature Nanotechnology
- Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancersJeffrey A. Klomp, Jennifer E. Klomp, Clint A. Stalnecker, Kirsten L. Bryant, A. Cole Edwards, Kristina Drizyte‐Miller, Priya S. Hibshman, J. Nathaniel Diehl, Ye S. Lee, Alexis Jean Morales et al. · 2024 · Science
- Long-term effects of carbon containing engineered nanomaterials and asbestos in the lung: one year postexposure comparisonsAnna A. Shvedova, Naveena V. K. Yanamala, Elena R. Kisin, Alexey V. Tkach, Ashley R. Murray, Ann F. Hubbs, Madalina M. Chirila, Phouthone Keohavong, Lyudmila P. Sycheva, Valerian E. Kagan et al. · 2013 · American Journal of Physiology-Lung Cellular and Molecular Physiology
- The sweet trap in tumors: aerobic glycolysis and potential targets for therapyLi Yu, Xun Chen, Liantang Wang, Shangwu Chen · 2016 · Oncotarget
- Biological determinants of radioresistance and their remediation in pancreatic cancerParthasarathy Seshacharyulu, Michael J. Baine, Joshua J. Souchek, Melanie Menning, Sukhwinder Kaur, Ying Yan, Michel M. Ouellette, Maneesh Jain, Chi H. Lin, Surinder K. Batra · 2017 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Pancreatic Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem CellsElvira Pelosi, Germana Castelli, Ugo Testa · 2017 · Biomedicines
- HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic CancerHolly Brunton, Giuseppina Caligiuri, Richard Cunningham, Rosanna Upstill‐Goddard, Ulla‐Maja Bailey, Ian Garner, Craig Nourse, Stephan B. Dreyer, Marc D. Jones, Kim Moran‐Jones et al. · 2020 · Cell Reports
- Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formationZeqian Yu, Susu Zhao, Long Fang Ren, Lishan Wang, Zhangjun Chen, Robert M. Hoffman, Jiahua Zhou · 2017 · Oncotarget
- Glucose Metabolism in Pancreatic CancerYan Liang, P. Shalem Raj, Wantong Yao, Haoqiang Ying · 2019 · Cancers
- SOAT1 promotes mevalonate pathway dependency in pancreatic cancerTobiloba E. Oni, Giulia Biffi, Lindsey A. Baker, Hao Yuan, Claudia Tonelli, Tim D.D. Somerville, Astrid Deschênes, Pascal Belleau, Chang‐Il Hwang, Francisco J. Sánchez Rivera et al. · 2020 · The Journal of Experimental Medicine
- Modulation of the proteostasis network promotes tumor resistance to oncogenic KRAS inhibitorsLv, Xiangdong, Lu, Xuan, Cao, Jin, Luo, Qin, Ding, Yao, Peng, Fanglue, Pataer, Apar, Lu, Dong, Han, Dong, Malmberg, Eric et al. · 2023 · Science
- Elevated protein lactylation promotes immunosuppressive microenvironment and therapeutic resistance in pancreatic ductal adenocarcinomaKang Sun, Xiaozhen Zhang, Jiatao Shi, Jinyan Huang, Sicheng Wang, Xiang Li, Haixiang Lin, Danyang Zhao, Mao Ye, Sirui Zhang et al. · 2025 · Journal of Clinical Investigation
- Potential mechanisms of CD133 in cancer stem cellsJae-Woo Jang, Yeonhwa Song, Se-Hyuk Kim, Joon Kim, Haeng Ran Seo · 2017 · Life Sciences
- IL6 Mediates Suppression of T- and NK-cell Function in EMT-associated TKI-resistant EGFR-mutant NSCLCSonia A. Patel, Monique B. Nilsson, Yan Yang, Xiuning Le, Hai Thanh Tran, Yasir Y. Elamin, Xiaoxing Yu, Fahao Zhang, Alissa Poteete, Xiaoyang Ren et al. · 2023 · Clinical Cancer Research
- Current State and Future Challenges for PI3K Inhibitors in Cancer TherapySirico, Marianna, D’Angelo, Alberto, Gianni, Caterina, Casadei, Chiara, Merloni, Filippo, De Giorgi, Ugo · 2023 · Cancers
- Targeting cancer cell metabolism in pancreatic adenocarcinomaRomain Cohen, Cindy Neuzillet, Annemilaï Tijeras‐Raballand, Sandrine J. Faivre, Armand D.E. Gramont, Éric Raymond · 2015 · Oncotarget
- Stromal reengineering to treat pancreas cancerIngunn M. Stromnes, Kathleen E. DelGiorno, Philip D. Greenberg, Sunil R. Hingorani · 2014 · Carcinogenesis
- The complex landscape of pancreatic cancer metabolismC. M. Sousa, Alec C. Kimmelman · 2014 · Carcinogenesis
- Quantitative Super-Resolution Microscopy of the Mammalian GlycocalyxLeonhard Möckl, Kayvon Pedram, Anish R. Roy, Venkatesh Krishnan, Anna‐Karin Gustavsson, Oliver Dorigo, Carolyn Ruth Bertozzi, W. E. Moerner · 2019 · Developmental Cell
- Computer-aided drug repurposing for cancer therapy: Approaches and opportunities to challenge anticancer targetsCarla Mottini, Francesco Napolitano, Zhongxiao Li, Xin Gao, Luca Cardone · 2019 · Seminars in Cancer Biology
- Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancerEdward B. Garon, Heather R. Christofk, Wylie Hosmer, Carolyn D. Britten, Agnes Y. Bahng, Matthew Crabtree, Candice Sun Hong, Naeimeh Kamranpour, Sharon L. Pitts, Fairooz F. Kabbinavar et al. · 2014 · Journal of Cancer Research and Clinical Oncology
- Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancerKitamura, Fumimasa, Semba, Takashi, Yasuda-Yoshihara, Noriko, Yamada, Kosuke, Nishimura, Akiho, Yamasaki, Juntaro, Nagano, Osamu, Yasuda, Tadahito, Yonemura, Atsuko, Tong, Yilin et al. · 2023 · JCI Insight
- Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal CancersEdwin H. Yau, Indrasena Reddy Kummetha, Gianluigi Lichinchi, Rachel Tang, Yunlin Zhang, Tariq M. Rana · 2017 · Cancer Research
- Metabolic Regulation of Redox Balance in CancerVinee Purohit, Diane M. Simeone, Costas Andreas Lyssiotis · 2019 · Cancers
- Current Clinical Strategies of Pancreatic Cancer Treatment and Open Molecular QuestionsMaximilian Brunner, Z. Wu, Christian Krautz, Christian P. Pilarsky, Robert Grützmann, Georg F. Weber · 2019 · International Journal of Molecular Sciences
- Dysregulation of mitophagy in carcinogenesis and tumor progressionJoon Young Chang, Hyon‐Seung Yi, Hyeon-Woo Kim, Minho Shong · 2016 · Biochimica et Biophysica Acta (BBA) - Bioenergetics
- Oncogenes and tumor suppressor genes: functions and roles in cancersTikam Chand Dakal, Bhanupriya Dhabhai, Anuja Pant, Kareena Moar, Kanika Chaudhary, Vikas Yadav, Vipin Ranga, Narendra Kumar Sharma, Abhishek Kumar, Pawan Kumar Maurya et al. · 2024 · MedComm
- eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinomaChan, Karina, Robert, Francis, Oertlin, Christian, Kapeller-Libermann, Dana, Avizonis, Daina, Gutierrez, Johana, Handly-Santana, Abram, Doubrovin, Mikhail, Park, Julia, Schoepfer, Christina et al. · 2019 · Nature Communications
- Epithelial and stromal co-evolution and complicity in pancreatic cancerHingorani, Sunil R. · 2023 · Nature Reviews Cancer
- Complete regression of advanced pancreatic ductal adenocarcinomas upon combined inhibition of EGFR and C-RAFBlasco, María Teresa, Navas, Carolina, Martín-Serrano, Guillermo, Graña-Castro, Osvaldo, Lechuga, Carmen G., Martín-Díaz, Laura, Djurec, Magdolna, Li, Jing, Morales-Cacho, Lucia, Esteban-Burgos, Laura et al. · 2019 · Cancer Cell
- Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivationGuannan Li, Xuejiao Zhao, Zhen Wang, Meng-Shi Luo, Shen-Nan Shi, Danmei Yan, Huayi Li, Jiahao Liu, Yang Yang, Jiahong Tan et al. · 2022 · Signal Transduction and Targeted Therapy
- Gas‐Mediated Tumor Energy Remodeling for Sensitizing Mild Photothermal TherapyJunjie Cheng, Yang Zhu, Yiping Dai, Li Li, Miya Zhang, Duo Jin, Manman Liu, Jiaji Yu, Wenxin Yu, Dan Su et al. · 2023 · Angewandte Chemie International Edition
- IL1 Receptor Antagonist Inhibits Pancreatic Cancer Growth by Abrogating NF-κB ActivationZhuonan Zhuang, Huai‐Qiang Ju, Mitzi Aguilar, Takashi Gocho, Hao Li, Tomonori Iida, Harold Lee, Xiaoqiang Fan, Haijun Zhou, Jianhua Ling et al. · 2015 · Clinical Cancer Research
- Kras as a key oncogene and therapeutic target in pancreatic cancerMeredith A. Collins, Marina Pasca di Magliano · 2014 · Frontiers in Physiology
- Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growthHuanan Wang, Lei Wang, Yingjie Zhang, Ji Wang, Yibin Deng, Degui Lin · 2016 · Cancer Cell International
- Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine SynthetaseKosuke Toda, Kenji Kawada, Masayoshi Iwamoto, Susumu Inamoto, Takehiko Sasazuki, Senji Shirasawa, Suguru Hasegawa, Yoshiharu Sakai · 2016 · Neoplasia
- Tumor metabolic regulators: key drivers of metabolic reprogramming and the promising targets in cancer therapyKun Huang, Ying Han, Yihong Chen, Hong Shen, Shan Zeng, Changjing Cai · 2025 · Molecular Cancer
- A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathwaysGomes, Ana P, Blenis, John · 2015 · Current Opinion in Biotechnology
- Role and regulation of coordinately expressedde novopurine biosynthetic enzymesPPATandPAICSin lung cancerMoloy T. Goswami, Guoan Chen, Balabhadrapatruni V. S. K. Chakravarthi, Satya S. Pathi, Sharath Kumar Anand, Shannon L. Carskadon, Thomas J. Giordano, Arul M. Chinnaiyan, Dafydd G. Thomas, Nallasivam Palanisamy et al. · 2015 · Oncotarget
- Molecular, morphological and survival analysis of 177 resected pancreatic ductal adenocarcinomas (PDACs): Identification of prognostic subtypesAnna Melissa Schlitter, Angela Segler, Katja Steiger, Christoph W. Michalski, Carsten Jäger, Björn Konukiewitz, Nicole Pfarr, Volker Endris, Markus Bettstetter, Bo Kong et al. · 2017 · Scientific Reports
- Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung CancersRamon C. Sun, Vikas V. Dukhande, Zhengqiu Zhou, Lyndsay E.A. Young, Shane Emanuelle, Christine F. Brainson, Matthew S. Gentry · 2019 · Cell Metabolism
- Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasisBrian Yong Lee, Elizabeth K. J. Hogg, Christopher Below, Alexander Kononov, Adrián Blanco‐Gómez, Felix Heider, Jingshu Xu, Colin Hutton, Xiaohong Mary Zhang, Tamara Scheidt et al. · 2021 · Nature Communications
- Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1Nathaniel Weygant, Dongfeng Qu, William L. Berry, Randal J. May, Parthasarathy Chandrakesan, Daniel B. Owen, Sripathi M. Sureban, Naushad Ali, Ralf Janknecht, Courtney W. Houchen · 2014 · Molecular Cancer
- Galectin-1 Drives Pancreatic Carcinogenesis through Stroma Remodeling and Hedgehog Signaling ActivationNeus Martínez‐Bosch, Maite G. Fernández‐Barrena, Mireia Moreno, Elena Ortiz Zapater, Jessica Munné‐Collado, Mar Iglesias, Sabine André, Hans‐Joachim Gabius, Rosa F. Hwang, Françoise Poirier et al. · 2014 · Cancer Research
- The Central Role of Amino Acids in Cancer Redox Homeostasis: Vulnerability Points of the Cancer Redox CodeMilica Vučetić, Yann Cormerais, Scott K. Parks, Jacques Pouysségur · 2017 · Frontiers in Oncology
- Branched-chain amino acids sustain pancreatic cancer growth by regulating lipid metabolismJi Hyeon Lee, Young-Ra Cho, Ji Hye Kim, Jong-Wook Kim, Hae Yun Nam, Seong Who Kim, Jaekyoung Son · 2019 · Experimental & Molecular Medicine
- Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathwaysMin Li, Xuxiao He, Wei‐Xing Guo, Hongming Yu, Shicheng Zhang, Ningning Wang, Guijun Liu, Rina Sa, Xia Shen, Yabo Jiang et al. · 2020 · Nature Cancer
- Endothelial cell metabolism: parallels and divergences with cancer cell metabolismDries Verdegem, Stijn Moens, Peter Conrad Stapor, Peter Carmeliet · 2014 · Cancer & Metabolism
- The emerging roles of microRNAs in cancer metabolismBrian Chan, Jacob Manley, Jae Lee, Shree Ram Singh · 2014 · Cancer Letters
- CD4+ T lymphocyte ablation prevents pancreatic carcinogenesis in miceZhang, Yaqing, Yan, Wei, Mathew, Esha, Bednar, Filip, Wan, Shanshan, Collins, Meredith A., Evans, Rebecca A., Welling, Theodore H., Vonderheide, Robert H., di Magliano, Marina Pasca · 2014 · Cancer Immunology Research
- Genetic Diversity of Pancreatic Ductal Adenocarcinoma and Opportunities for Precision MedicineErik S. Knudsen, Eileen Mary O'Reilly, Jonathan Robert Brody, Agnieszka Katarzyna Witkiewicz · 2015 · Gastroenterology
- Mutant Kras co-opts a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells to initiate pancreatic cancerYong Li, Yi He, Junya Peng, Zhendong Su, Zeyao Li, Bingjie Zhang, Jing Ma, Meilian Zhuo, Di Zou, Xinde Liu et al. · 2020 · Nature Cancer
- Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancersArimichi Okazaki, Paulo A. Gameiro, Danos C. Christodoulou, Laura A. Laviolette, Meike Schneider, Frances L. Chaves, Anat O Stemmer-Rachamimov, Stephanie A. Yazinski, Richard E. Lee Jr., Gregory N Stephanopoulos et al. · 2017 · Journal of Clinical Investigation
- Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibitionSeungyeon Yang, Sunsook Hwang, Minjoong Kim, Sung Bin Seo, Jeong‐Hwa Lee, Seung Min Jeong · 2018 · Cell Death and Disease
- Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo modelsMarcel Alexander Heinrich, Ahmed M. R. H. Mostafa, Jennifer P. Morton, Lukas J.A.C. Hawinkels, Jai Prakash · 2021 · Advanced Drug Delivery Reviews
- O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1Qiang Zhu, Hong Zhou, Liming Wu, Zhenyuan Lai, Didi Geng, Weiwei Yang, Jie Zhang, Zhiya Fan, Weijie Qin, Yong Wang et al. · 2022 · Nature Chemical Biology
- Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant CancersIrem Ozkan‐Dagliyan, J. Nathaniel Diehl, Samuel D. George, Antje Schaefer, Bjoern Papke, Kathleen Klotz‐Noack, Andrew M. Waters, Craig M. Goodwin, Prson Gautam, Mariaelena Pierobon et al. · 2020 · Cell Reports
- Ras inhibition via direct Ras binding—is there a path forward?Weiru Wang, G. Fang, Joachim Rudolph · 2012 · Bioorganic & Medicinal Chemistry Letters
- Transforming growth factor beta‐induced, an extracellular matrix interacting protein, enhances glycolysis and promotes pancreatic cancer cell migrationBrunella Costanza, Gilles Rademaker, Assia Tiamiou, Pascal De Tullio, Justine Leenders, Arnaud Blomme, Justine Bellier, Elettra Bianchi, Andrei Turtoï, Philippe Delvenne et al. · 2019 · International Journal of Cancer
- Targeting KRAS in pancreatic cancer: new drugs on the horizonSahar F. Bannoura, Md. Hafiz Uddin, Misako Nagasaka, Farzeen Fazili, Mohammed Najeeb Al Hallak, Philip A. Philip, Bassel F. El‐Rayes, Asfar Sohail Azmi · 2021 · Cancer and Metastasis Reviews
- Critical role for arginase 2 in obesity-associated pancreatic cancerTamara Zaytouni, Pei-Yun Tsai, Daniel S. Hitchcock, Cory D. DuBois, Elizaveta Freinkman, Lin Lin, Vicente Morales‐Oyarvide, Patrick J. Lenehan, Brian Matthew Wolpin, Mari A. Mino-Kenudson et al. · 2017 · Nature Communications
- ATP-binding cassette transporters in progression and clinical outcome of pancreatic cancer: What is the way forward?Aleksandra Adamska, Marco Falasca · 2018 · World Journal of Gastroenterology
- Metabolomics identified new biomarkers for the precise diagnosis of pancreatic cancer and associated tissue metastasisXialin Luo, Jingjing Liu, Huaizhi Wang, Haitao Lu · 2020 · Pharmacological Research
- The Hallmarks of Cancer from a Redox PerspectiveMarten Hornsveld, Tobias B. Dansen · 2016 · Antioxidants and Redox Signaling
- Targeting tumor mitochondrial metabolism overcomes resistance to antiangiogenicsNavarro, Paloma, Bueno, Maria J., Zagorac, Ivana, Mondejar, Tamara, Sanchez, Jesus, Mourón, Silvana, Muñoz, Javier, Gómez-López, Gonzalo, Jimenez-Renard, Veronica, Mulero, Francisca et al. · 2016 · Cell Reports
- Metabolic Reprogramming for Producing Energy and Reducing Power in Fumarate Hydratase Null Cells from Hereditary Leiomyomatosis Renal Cell CarcinomaYoufeng Yang, Andrew N. Lane, Christopher J. Ricketts, Carole Sourbier, Ming-Hui Wei, Brian M. Shuch, Lisa S. Pike, Min Wu, Tracey Ann Rouault, László G. Boros et al. · 2013 · PLoS ONE
- Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM)Ronald C. Bruntz, Andrew N. Lane, Richard M. Higashi, Teresa W.‐M. Fan · 2017 · Journal of Biological Chemistry
- Regulation of Cancer Metabolism by Oncogenes and Tumor SuppressorsRaffaella Iurlaro, Clara Lucía León‐Annicchiarico, Cristina Muñoz‐Pinedo · 2014 · Methods in enzymology on CD-ROM/Methods in enzymology
- SF2312 is a natural phosphonate inhibitor of enolaseLeonard, Paul G, Satani, Nikunj, Maxwell, David, Lin, Yu-Hsi, Hammoudi, Naima, Peng, Zhenghong, Pisaneschi, Federica, Link, Todd M, Lee, Gilbert R, Sun, Duoli et al. · 2016 · Nature Chemical Biology