The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
RETRACTED: A Self-Produced Trigger for Biofilm Disassembly that Targets Exopolysaccharide
Open accessAbstract
Biofilms are structured communities of bacteria that are held together by an extracellular matrix consisting of protein and exopolysaccharide. Biofilms often have a limited lifespan, disassembling as nutrients become exhausted and waste products accumulate. D-amino acids were previously identified as a self-produced factor that mediates biofilm disassembly by causing the release of the protein component of the matrix in Bacillus subtilis. Here we report that B. subtilis produces an additional biofilm-disassembly factor, norspermidine. Dynamic light scattering and scanning electron microscopy experiments indicated that norspermidine interacts directly and specifically with exopolysaccharide. D-amino acids and norspermidine acted together to break down existing biofilms and mutants blocked in the production of both formed long-lived biofilms. Norspermidine, but not closely related polyamines, prevented biofilm formation by B. subtilis, Escherichia coli and Staphylococcus aureus.
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Citations
Cites
Fruiting body formation by Bacillus subtilis
Branda, S. S., González-Pastor, J. E., Ben-Yehuda, S., Losick, R., & Kolter, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191384198 · Cited by 1,129
Self-citationd -Amino Acids Trigger Biofilm Disassembly
Kolodkin-Gal, I., Romero, D., Cao, S., Clardy, J., Kolter, R., & Losick, R. (2010) · Science · doi:10.1126/science.1188628 · Cited by 874
Self-citation
Cited by
Biofilm-associated persistence of food-borne pathogens
Bridier, A., Sanchez-Vizuete, P., Guilbaud, M., Piard, J.-C., Naïtali, M., & Briandet, R. (2015) · Food Microbiology · doi:10.1016/j.fm.2014.04.015 · Cited by 507
Agents that Inhibit Bacterial Biofilm Formation
Rabin, N., Zheng, Y., Opoku-Temeng, C., Du, Y., Bonsu, E., & Sintim, H. O. (2015) · Future Medicinal Chemistry · doi:10.4155/fmc.15.7 · Cited by 273
Biosynthesis of polyamines and polyamine-containing molecules
Michael, A. J. (2016) · Biochemical Journal · doi:10.1042/bcj20160185 · Cited by 180
Biofilm and wound healing: from bench to bedside
Goswami, A. G., Basu, S., Banerjee, T., & Shukla, V. K. (2023) · European Journal of Medical Research · doi:10.1186/s40001-023-01121-7 · Cited by 178
Challenges of antibiotic resistance biofilms and potential combating strategies: a review
Khan, J., Tarar, S. M., Gul, I., Nawaz, U., & Arshad, M. (2021) · 3 Biotech · doi:10.1007/s13205-021-02707-w · Cited by 172
Metadata
- Authors
- Kolodkin-Gal, I., Cao, S., Chai, L., Böttcher, T., Kolter, R., Clardy, J., & Losick, R.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 149
- Issue
- 3
- Pages
- 684-692
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2167258145
- Cited by
- 159
- References
- 2
- FWCI
- 10.92
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- bronze
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- Kolodkin-Gal, I., Cao, S., Chai, L., Böttcher, T., Kolter, R., Clardy, J., & Losick, R. (2012). RETRACTED: A Self-Produced Trigger for Biofilm Disassembly that Targets Exopolysaccharide. Cell. https://doi.org/10.1016/j.cell.2012.02.055
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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