The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Controlling Long-Range Genomic Interactions at a Native Locus by Targeted Tethering of a Looping Factor
Open accessAbstract
Chromatin loops juxtapose distal enhancers with active promoters, but their molecular architecture and relationship with transcription remain unclear. In erythroid cells, the locus control region (LCR) and β-globin promoter form a chromatin loop that requires transcription factor GATA1 and the associated molecule Ldb1. We employed artificial zinc fingers (ZF) to tether Ldb1 to the β-globin promoter in GATA1 null erythroblasts, in which the β-globin locus is relaxed and inactive. Remarkably, targeting Ldb1 or only its self-association domain to the β-globin promoter substantially activated β-globin transcription in the absence of GATA1. Promoter-tethered Ldb1 interacted with endogenous Ldb1 complexes at the LCR to form a chromatin loop, causing recruitment and phosphorylation of RNA polymerase II. ZF-Ldb1 proteins were inactive at alleles lacking the LCR, demonstrating that their activities depend on long-range interactions. Our findings establish Ldb1 as a critical effector of GATA1-mediated loop formation and indicate that chromatin looping causally underlies gene regulation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In contrast to YY1 and ZNF143, LDB1 has been shown to form loops independently of both cohesin and CTCF [371, 375].”
From Transcriptional enhancers and their communication with gene promoters (2021) · cites this paper as [371]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“LDB1 was first identified as a looping factor in the mouse β-globin locus [317, 371].”
From Transcriptional enhancers and their communication with gene promoters (2021) · cites this paper as [371]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“The functional significance of the physical approximation of the promoter to the enhancer was demonstrated in experiments on the activation of transcription through the forced formation of enhancer-promoter loops [87,88].”
From Enhancer Function in the 3D Genome (2023) · cites this paper as [88]
The cited source says what the claim attributes to it.
In the citing paper
“Stimulation of promoter activity by forced looping with an enhancer is a strong argument in favor of this model [87,88,110,111].”
From Enhancer Function in the 3D Genome (2023) · cites this paper as [88]
In the citing paper
“and physical contact between enhancer-promoter pairs appears to be sufficient for gene activation.26”
From Recent evidence that TADs and chromatin loops are dynamic structures (2018) · cites this paper as [26]
In the citing paper
“Tethering the SA domain to the LCR (L-SA in Figure 1) or β-major promoter (Deng et al., 2012, and data not shown) did not activate βh1-globin expression”
From Reactivation of developmentally silenced globin genes by forced chromatin looping (2014) · cites this paper as Deng et al., 2012
In the citing paper
“In adult type murine erythroid cells, Ldb1 is required for the juxtaposition between the LCR and the adult β-major globin gene (Deng et al., 2012; Song et al., 2007).”
From Reactivation of developmentally silenced globin genes by forced chromatin looping (2014) · cites this paper as Deng et al., 2012
In the citing paper
“These results demonstrated that forced juxtaposition of an enhancer and promoter via chromatin looping can trigger gene activation”
From Reactivation of developmentally silenced globin genes by forced chromatin looping (2014) · cites this paper as Deng et al., 2012
In the citing paper
“Finally, previous 3C experiments demonstrated the sufficiency of tethered Ldb1 for full reconstitution of an LCR-β-globin promoter loop in immature adult erythroid cells in which the globin locus is otherwise unlooped (Deng et al., 2012).”
From Reactivation of developmentally silenced globin genes by forced chromatin looping (2014) · cites this paper as Deng et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Capturing Chromosome Conformation
Dekker, J., Rippe, K., Dekker, M., & Kleckner, N. (2002) · Science · doi:10.1126/science.1067799 · Cited by 3,652 · cited 2×
“The use of chromosome conformation capture (3C) and its derivatives has revealed that distant chromosomal elements can be juxtaposed to form chromatin loops, thus providing one mechanism of long-range enhancer function (Cullen et al., 1993; Dekker et al., 2002).”
Looping and Interaction between Hypersensitive Sites in the Active β-globin Locus
Tolhuis, B., Palstra, R.-J., Splinter, E., Grosveld, F., & de Laat, W. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00781-5 · Cited by 1,344 · cited 2×
“…arose from studies of the mammalian b-globin locus, which is among the first gene clusters at which long-range chromosomal interactions between a powerful distal enhancer, the locus control region (LCR), and the target b-globin promoters were described (Carter et al., 2002; Tolhuis et al., 2002).”
Pevny, L., Simon, M. C., Robertson, E., Klein, W. H., Tsai, S.-F., D'Agati, V., Orkin, S. H., & Costantini, F. (1991) · Nature · doi:10.1038/349257a0 · Cited by 1,308 · cited 1×
“GATA1 is a DNA-binding protein essential for normal erythroid differentiation and b-globin gene expression (Evans and Felsenfeld, 1989; Pevny et al., 1991; Tsai et al., 1989).”
Tsai, S., Martin, D. I. K., Zon, L. I., D’Andrea, A. D., Wong, G. G., & Orkin, S. H. (1989) · Nature · doi:10.1038/339446a0 · Cited by 884 · cited 1×
“GATA1 is a DNA-binding protein essential for normal erythroid differentiation and b-globin gene expression (Evans and Felsenfeld, 1989; Pevny et al., 1991; Tsai et al., 1989).”
The Discovery of Zinc Fingers and Their Applications in Gene Regulation and Genome Manipulation
Klug, A. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-010909-095056 · Cited by 710 · cited 3×
“ZFs have previously been linked to activation domains to successfully activate gene expression (Klug, 2010).”
InfluentialLong-range chromatin regulatory interactions in vivo
Carter, D., Chakalova, L., Osborne, C. S., Dai, Y.-F., & Fraser, P. (2002) · Nature Genetics · doi:10.1038/ng1051 · Cited by 663 · cited 3×
“Fundamental insights into these issues arose from studies of the mammalian b-globin locus, which is among the first gene clusters at which long-range chromosomal interactions between a powerful distal enhancer, the locus control region (LCR), and the target b-globin promoters were described (Carter et al., 2002; Tolhu…”
Transcriptional regulation of erythropoiesis: an affair involving multiple partners
Cantor, A. B., & Orkin, S. H. (2002) · Oncogene · doi:10.1038/sj.onc.1205326 · Cited by 610 · cited 1×
“However, physical interactions among all of these proteins have been reported (Cantor and Orkin, 2002), making it difficult to distinguish whether they function in linear or parallel pathways.”
The erythroid-specific transcription factor eryf1: A new finger protein
Evans, T., & Felsenfeld, G. (1989) · Cell · doi:10.1016/0092-8674(89)90940-9 · Cited by 580 · cited 1×
“GATA1 is a DNA-binding protein essential for normal erythroid differentiation and b-globin gene expression (Evans and Felsenfeld, 1989; Pevny et al., 1991; Tsai et al., 1989).”
The β-globin nuclear compartment in development and erythroid differentiation
Palstra, R.-J., Tolhuis, B., Splinter, E., Nijmeijer, R., Grosveld, F., & de Laat, W. (2003) · Nature Genetics · doi:10.1038/ng1244 · Cited by 559
Proximity among Distant Regulatory Elements at the β-Globin Locus Requires GATA-1 and FOG-1
Vakoc, C. R., Letting, D. L., Gheldof, N., Sawado, T., Bender, M. A., Groudine, M., Weiss, M. J., Dekker, J., & Blobel, G. A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2004.12.028 · Cited by 490 · cited 6×
“Using HS2 as the anchor region, we found that, in parental G1E cells, the 3C signals generally declined with increasing distance (Figure 3A), which is consistent with our previous observations (Vakoc et al., 2005).”
Influential
Research works printed but not linked: 1
- Tripic, T., Deng, W., Cheng, Y., Zhang, Y., Vakoc, C.R., Gregory, G.D., Hardison, R.C., and Blobel, G.A. (2009). SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood 113, 2191–2201. · DOI
Cited by
Sorted by citations
Items 601–700 of 733
String Mathematics, BLAST, and FASTA
Xia, X. (2018) · Springer eBooks · doi:10.1007/978-3-319-90684-3_1 · Cited by 2
Gene Therapy for Hemoglobinopathies
Dong, A., Breda, L., & Rivella, S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800563-7.00012-9 · Cited by 3
‘Enhancing’ red cell fate through epigenetic mechanisms
Rossmann, M. P., & Zon, L. I. (2021) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000654 · Cited by 2
“In contrast, forced looping between the LCR and the b-globin promoter by zinc fingermediated tethering of the transcription co-factor LDB1 to the b-globin locus can substantially induce b-globin expression in Gata1-null mouse (G1E) erythroblasts [35], and a similar mechanism can also re-activate the fetal bh1-globin g…”
BackgroundPlant In Situ Hi-C Experimental Protocol and Bioinformatic Analysis
Santos, F. J. P.-D. L., Sotelo-Fonseca, J. E., Ramírez-Colmenero, A., Nützmann, H., Fernández-Valverde, S. L., & Oktaba, K. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2429-6_13 · Cited by 2
Chromatin looping links gene expression to the assembly of transcription factories (Review)
Perillo, B., Migliaccio, A., & Castoria, G. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13221 · Cited by 2
Struhl, K. (2024) · Trends in Genetics · doi:10.1016/j.tig.2024.04.001 · Cited by 2
Scholz, B. A., Millán-Ariño, L., & Göndör, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803395-1.00017-4 · Cited by 2
The Protistan Cellular and Genomic Roots of Animal Multicellularity
de Mendoza, A., & Sebé-Pedrós, A. (2019) · Fascinating life sciences · doi:10.1007/978-3-030-18202-1_2 · Cited by 1
Locus architecture affects mRNA expression levels in Drosophila embryosPreprint
Lydiard‐Martin, T., Bragdon, M. D. J., Eckenrode, K. B., Wunderlich, Z., & DePace, A. H. (2014) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/005173 · Cited by 3
“Numerous studies have found correlations between enhancer-promoter looping and gene expression (Deng et al. 2012; Chopra et al. 2012).”
BackgroundInfluentialZhang, L., Song, T., Yao, M., Yang, Y., Liu, Z., & Li, W. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.04.325738 · Cited by 2
Trang, B. K., Sharma, P. K., Cook, L. E., Mount, Z., Thomas, R. M., Kulkarni, N. N., Cabrera, E. C., Rachimi, S., Pahl, M. C., Pippin, J. A., et al. (2024) · medRxiv · doi:10.1101/2024.08.12.24311676 · Cited by 2
3D organization of enhancers in MuSCs
He, L., Sun, H., & Wang, H. (2024) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2024.01.011 · Cited by 1
Enhancer-promoter communication in Drosophila developmental gene transcription
Hunt, G., & Mannervik, M. (2024) · The International Journal of Developmental Biology · doi:10.1387/ijdb.230218gh · Cited by 1
“…enhancer-promoter proximity correlates with gene activity (Bonev et al ., 2017; Ghavi-Helm et al ., 2014; Mateo et al ., 2019; Rao et al ., 2014; Sanyal et al ., 2012), and forced looping can induce transcription of some genes (Bartman et al ., 2016; Deng et al ., 2012; Deng et al ., 2014).”
BackgroundA guide to studying 3D genome structure and dynamics in the kidney
Beliveau, B. J., & Akilesh, S. (2024) · Nature Reviews Nephrology · doi:10.1038/s41581-024-00894-2 · Cited by 1
Yang, B., Guo, Y., Liu, L., Huang, T., Zhao, B., Bai, W., Zhang, G., Zhu, C., & Dong, J. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2412376122 · Cited by 1
Deleuze, V., Stephen, T., Salma, M., Orfeo, C., Jorna, R., Maas, A., Barroca, V., Arcangeli, M.-L., Lecellier, C., Andrieu‐Soler, C., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-94222-8 · Cited by 2
Engineering the Link: From Genome Interaction Maps to Functional Insight
Petersen, F., Westermann, S., Smialkovska, V., Mathony, J., Feldmann, A., & Niopek, D. (2025) · Advanced Biology · doi:10.1002/adbi.202500525 · Cited by 2
OptoLoop – an optogenetic tool to probe the functional role of genome organization
Stortz, M., Keikhosravi, A., Pegoraro, G., & Misteli, T. (2026) · Journal of Cell Science · doi:10.1242/jcs.264574 · Cited by 1
“Some of these methods were based on programmable DNA-binding proteins as targeting moieties and looping was not inducible (Deng et al., 2012; Benabdallah et al., 2019).”
InfluentialEndless forms – how genome organization underlies evolution and development
Edwards, A. N., & Finn, E. H. (2026) · Journal of Cell Science · doi:10.1242/jcs.264059 · Cited by 1
Conte, M., Bianco, S., Guha, S., Chiariello, A. M., Esposito, A., Abraham, A., Kundu, S., Vercellone, F., Fontana, A., Pierno, F. D., et al. (2026) · Physical review. E · doi:10.1103/g6k5-nkbd · Cited by 1
Epigenetic gene regulation and stem cell function
Benyoucef, A., & Brand, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-799958-6.00007-x · Cited by 1
Xia, X. (2018) · Springer eBooks · doi:10.1007/978-3-319-90684-3_19 · Cited by 1
Higher-Order Genome Organization in the Control of Neuronal Identity and Neural Circuit Plasticity
Yamada, T., Valnegri, P., & Yang, Y. (2024) · Springer eBooks · doi:10.1007/978-3-031-68550-7_8 · Cited by 1
Persistence of Long-Range Contacts at Insulators
Mourad, R., & Cuvier, O. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803480-4.00007-7 · Cited by 1
Security, Perception, and Practices: Challenges Facing Adoption of Online Banking in Pakistan
Shehzad, K., & Waqas, M. (2021) · Journal of Marketing Strategies · doi:10.52633/jms.v3i1.67 · Cited by 1
CRISPR-Mediated Reorganization of Chromatin Loop Structure
Morgan, S. L., Chang, E. Y., Mariano, N. C., Bermudez, A., Arruda, N. L., Wu, F., Luo, Y., Shankar, G., Huynh, S. K., Huang, C.-C., et al. (2018) · Journal of Visualized Experiments · doi:10.3791/57457-v · Cited by 1
Predicting Chromatin Interactions from DNA Sequence Using DeepC
Schweßinger, R. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-2962-8_3 · Cited by 1
Genome-wide Prediction of Potential Polycomb Response Elements and their FunctionsPreprint
Khabiri, M., & Freddolino, P. L. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/516500 · Cited by 1
“It has already been shown that the activation by enhancers and repression by the PcG proteins are involved in higher-order interactions, either by looping or forming discrete domains of interaction (50-52).”
BackgroundAssociation of Ddx5/p68 protein with the upstream erythroid enhancer element (EHS1) of the Klf1 genePreprint
Chen, X., Pillay, S., Lohmann, F., & Bieker, J. J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/743435 · Cited by 1
“Also drawn in are schematics of potential enhanceosome components at EHS1: Above includes the known multicomponent Gata/Tal1/Lmo2/Ldb1 multi-protein complex (based on (Deng et al., 2012; Li et al., 2013; Su et al., 2013; Ulirsch et al., 2014; Xu et al., 2012)); below brings in known Ddx5 protein interactions as discus…”
BackgroundDu, M., Zou, F., Yan, Y., & Bai, L. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.01.892448 · Cited by 1
Multiomics analysis reveals extensive epigenome remodeling during cortical developmentPreprint
Noack, F., Vangelisti, S., Carido, M., Chong, F., & Bonev, B. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.07.241828 · Cited by 1
“Previous studies have produced somewhat conflicting results regarding the importance of 3D genome architecture on gene regulation(Deng et al., 2012; Ghavi-Helm et al., 2019; Llinares-Benadero and Borrell, 2019; Lupiáñez et al., 2015; Nora et al., 2017) and the cell-type-specificity of regulatory…”
ResultRutten, L. J. J. (2020) · doi:10.18174/517889 · Cited by 1
Taylor, T., Sikorska, N., Shchuka, V. M., Chahar, S., Ji, C., Macpherson, N. N., Moorthy, S. D., Mitchell, J. A., & Sexton, T. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.09.479674 · Cited by 1
“, 2021); transcription factor and co-activator protein-protein interactions (Deng et al., 2012; Sabari et al., 2018); and ongoing transcription (Rowley et al.”
BackgroundInfluentialStatistical methods for biological sequence analysis for DNA binding motifs and protein contacts
Roth, C. (2021) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-8835 · Cited by 1
Large-scale analysis of the integration of enhancer-enhancer signals by promotersPreprint
Martinez-Ara, M., Comoglio, F., & van Steensel, B. (2024) · eLife · doi:10.7554/elife.91994.2 · Cited by 1
Context-dependent epigenome rewiring during neuronal differentiationPreprint
Manelli, V., Diwakar, J., Beşkardeş, S., Gil, D. A., Forné, I., Chong, F., Imhof, A., & Bonev, B. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.18.618996 · Cited by 1
“Such rewiring can occur across multiple modalities such as DNA methylation 6,7 , chromatin accessibility 7,8 , 3D genome rewiring 9–11, 7 , and frequently involve Direct neuronal differentiation or reprogramming is ideally suited to address these questions as it represents a fate change elicited by…”
BackgroundRakkannan, G., Kashyap, S., Debnath, B., Sahoo, D., Singh, Y. S., Patel, A. B., & Priyadarshi, H. (2023) · Research Square · doi:10.21203/rs.3.rs-2680847/v1 · Cited by 1
Globin gene regulation for treating β-thalassemias: progress, obstacles and future
Saliba, A. N., Alameddine, R. S., Harb, A., & Taher, A. T. (2015) · Expert Opinion on Orphan Drugs · doi:10.1517/21678707.2015.1074071
“The tethering of the self-association domain (SA) of Ldb1 to the b-globin promoter via zinc fingers induces LCR-promoter looping [64].”
BackgroundAssessing modularity of developmental enhancers in Drosophila melanogaster
Martin, T. L. (2014) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
Gene positioning and genome function
Vishnoi, N., & Yao, J. (2014) · Frontiers in Biology · doi:10.1007/s11515-014-1313-3
A generalized Potts model for confocal microscopy images
Máté, G., & Heermann, D. W. (2015) · International Journal of Modern Physics B · doi:10.1142/s0217979215500484
Keeping fetal hemoglobin in the loop
Grevet, J. D., & Blobel, G. A. (2014) · Cell Cycle · doi:10.4161/15384101.2014.969995
Dynamics of higher order chromatin structures
Chen, X. (2014) · Figshare
Maretty, L., Sibbesen, J. A., & Krogh, A. (2014)
Chromatin dynamics and genome organization in development and disease
Deng, C., Patel, B., Lin, X., Li, Y., & Huang, S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-799958-6.00005-6
Effects of glucocorticoids in macrophages
Jubb, A. W. (2015) · ERA
Barozzi, I. (2014) · Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · doi:10.13130/barozzi-iros-giacomo_phd2014-03-25
“Ldb1 was also found to be indispensable to the Gata1-mediated looping of the locus control region (LCR) of the β-globin with its core promoter (Deng et al., 2012).”
BackgroundJothi, R., Love, P. E., Freudenberg, J., Cui, K., Dale, R., & Zhao, K. (2014)
The long range regulation of breast cancer associated genes
Betts, J. A. (2016) · The University of Queensland · doi:10.14264/uql.2016.158
“A reduction of looping contacts in cells containing the risk allele would thus reduce promoter activity and the subsequent transcription of CUPID1 and CUPID2 [151].”
BackgroundInfluentialThe Role of Trim58 in Erythropoiesis
Thom, C. S. (2014) · ScholarlyCommons (University of Pennsylvania)
SURVEY AND SUMMARY Chromatin and epigenetic features of long-range gene regulation
Harmston, N., & Lenhard, B. (2013)
Regulatory architecture of the Pax6 locus
Buckle, A. (2014) · ERA
Chromatin regulation at the frontier of synthetic biology
Joung, J. K., Khalil, A. S., Keung, A. J., & Collins, J. J. (2015) · DSpace@MIT (Massachusetts Institute of Technology)
Chromatin Looping and Cell Type-specific Regulation of Sox2 Expression
Zhou, H. (2013) · TSpace (University of Toronto)
Strategies for Studying Chromatin Regulation and Organization
Nguyen, S. C. (2016) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
Long-Range Intranuclear Interactions
Krivega, I. V., & Dean, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803480-4.00008-9
Genetic and Epigenetic Deregulation of Enhancers in Cancer
Cao, K., & Shilatifard, A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.65063-8 · Cited by 1
Enhancer-Promoter Interactions and Their Role in the Control of Epidermal Differentiation
Oh, I. Y., & Strong, C. D. G. (2018) · Contributions to management science · doi:10.1007/978-3-319-16769-5_10
Layer, J. H., Christy, M., Placek, L., Unutmaz, D., Guo, Y. P., & Davé, U. P. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/706259
“The self-association domain of LDB1 mediates looping and proximity between the beta globin LCR and beta globin proximal promoters, a seminal example of enhancer-promoter communication (Deng et al., 2012; Krivega et al., 2014b; Liu and Dean, 2019; Song et al., 2007).”
BackgroundThe Control of Gene Expression in Macrophages
Ostuni, R., & Natoli, G. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1311-4_26
Dong, Y. (2020) · Louisiana State University · doi:10.31390/gradschool_dissertations.5233
“We call this a looping assay because, although various models have been proposed [28], there is strong evidence that looping is a key component of enhancer-promoter communication [20][21][119].”
MethodInvestigation of a transcription factor complex and intrinsically disordered proteins
Caldas, V. S. (2017) · The Sydney eScholarship Repository (The University of Sydney)
Allyn-Feuer, A. (2018) · Deep Blue (University of Michigan)
Chen, Y. (2020) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/140893
Molecular mechanisms of YY1 overexpression in human cancers and its prognostic significance
Gabriele, M., Testa, G., & Hansen, A. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821909-6.00015-8
RUNX1-ETO Orchestrates Dynamic Enhancer Promoter Communication in T(8;21) Acute Myeloid LeukaemiaPreprint
Ptasinska, A., Pickin, A., Assi, S. A., Chin, P. S., Cockerill, P. N., Osborne, C. S., & Bonifer, C. (2018) · SSRN Electronic Journal · doi:10.2139/ssrn.3281655
Wang, Z., Luo, S., Chen, M., Zhou, T., & Zhang, J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.17.444405
CRISPR/Cas9 technologies to manipulate human induced pluripotent stem cells
Jang, H., Moon, J., Kim, N., & Yoon, K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85766-6.00012-7
Functional analysis of human enhancers using the zebrafish embryo
Miguel-Escalada, I. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)
Sonneveld, S. (2021) · Utrecht University Repository (Utrecht University) · doi:10.33540/858
Liu, J. (2021) · doi:10.18174/555575
Xiong, L. (2022) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-9101
Polo, S. E. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736039849.793562666
OHLSSON, R. I., & Göndör, A. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732438469.793546047
Kenter, A. L. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.731077751.793558057
Russell, A. P. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733181278.793549748
Greer, C. A. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734827932.793555129
Faculty Opinions recommendation of YY1 Is a Structural Regulator of Enhancer-Promoter Loops.
OHLSSON, R. I., & Göndör, A. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732279386.793546049 · Cited by 1
Blelloch, R. H. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732438469.793549702
Targeting BET Bromodomains in Recalcitrant Cancers
Clift, S. H. (2016) · doi:10.18130/v3500v
Genomic Studies of BEAF-32 in Drosophila
McKowen, J. K. (2021) · doi:10.31390/gradschool_dissertations.5515
Fujita, T., & Fujii, H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91909-8.00020-7
Saw, A. K., Madhok, A., Bhattacharya, A., Nandi, S., & Galande, S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.08.515643
“Similarly, distal enhancers activate target genes through DNA looping, a mechanism that enables distally bound transcription factors to contact the transcription machinery of target promoters 79–81 .”
BackgroundExploring the roles of RNAPII in genome organization
Zhang, S. (2022) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-9632
Wang, M., & Liu, X. S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821785-6.00002-5
Action Mechanism of Enhancers for Activating Gene Transcription
Kim, Y. W., & Kim, A. (2023) · Journal of Experimental & Biomedical Sciences/Biomedical Science Letters · doi:10.15616/bsl.2023.29.3.103
Serin, N. (2023) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-10102
Epigenetic Control of Cell Fate Decisions by Enhancer-Derived Long Noncoding RNAs
Mattick, J. S. (2024) · Springer eBooks · doi:10.1007/978-3-031-59286-7_2
Narayanan, A., & West, A. E. (2024) · Springer eBooks · doi:10.1007/978-3-031-68550-7_7
Liu, M., Li, Y., Yuan, X. H., Rong, S., & Du, J. (2024) · Biochemistry and Cell Biology · doi:10.1139/bcb-2024-0094
He, X., Sun, Y., & Ma, H. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003009
Hardwick, J. A., Rodriguez-Hernaez, J., Gambi, G., Venters, B. J., Guo, Y. P., Li, L., Love, P. E., Copeland, N. G., Jenkins, N. A., Papaioannou, D., et al. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108233
Tastemel, M., Jussila, A., Saravanan, B., Huang, H., Xie, Y., Zhu, Q. K., Jiang, Y., Armand, E. J., & Ren, B. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.21.639596 · Cited by 2
Liu, Y., Liu, B., & Liu, J. (2025) · Genome Research · doi:10.1101/gr.279647.124
Is Enhancer Function Driven by Protein–Protein Interactions? From Bacteria to Leukemia
Crump, N. T., & Milne, T. A. (2025) · BioEssays · doi:10.1002/bies.70006 · Cited by 1
Research progress of chromatin imaging and manipulation
Liu, M., Li, Q., Ma, Y., Tang, H., Huang, K., & Wang, H. (2025) · Scientia Sinica Vitae · doi:10.1360/ssv-2025-0105
Bompadre, O., Rouco, R., Darbellay, F., Rauseo, A., Guerard-Millet, F., Gentile, C., Kmita, M., & Andrey, G. (2025) · Nature Communications · doi:10.1038/s41467-025-61615-2 · Cited by 1
“Generally, we observed homogenous marker gene enrichment among mutants, showing high similarity between EGFP+ cells (Supplementary Data 2).”
Influential
Metadata
- Authors
- Deng, W., Lee, J., Wang, H., Miller, J., Reik, A., Gregory, P. D., Dean, A., & Blobel, G. A.
- Affiliations
- Children's Hospital of Philadelphia (US)
- National Institutes of Health (US)
- Sangamo BioSciences (United States) (US)
- Corresponding author
- Blobel, Gerd A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 149
- Issue
- 6
- Pages
- 1233-1244
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3372860
- OpenAlex
- W1970831058
- Cited by
- 734
- References
- 49
- Citations by year
- 2026: 22 · 2025: 42 · 2024: 48 · 2023: 54 · 2022: 48 · 2021: 58 · 2020: 60 · 2019: 70 · 2018: 57 · 2017: 50 · 2016: 51 · 2015: 60 · 2014: 62 · 2013: 45 · 2012: 7
- FWCI
- 22.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL119479)
- National Institute of Diabetes and Digestive and Kidney Diseases (R37DK058044, R01DK054937)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- chromatin looping, locus control region, beta-globin promoter, LDB1, GATA-1, erythroid cells, enhancer-promoter interactions, RNA polymerase II phosphorylation, transcriptional activation
- MeSH terms
- Animals, Cell Line, Cell Separation, Chromatin, DNA-Binding Proteins, Embryo, Mammalian, Erythroblasts, Female, Gene Expression Regulation, Male, Promoter Regions, Genetic, Transcription, Genetic, Zinc Fingers, Protein Structure, Tertiary, GATA1 Transcription Factor, Mice, beta-Globins, LIM Domain Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
