A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis

Acharyya, Swarnali, Oskarsson, Thordur, Vanharanta, Sakari, Malladi, Srinivas, Kim, Juliet, Morris, Patrick G., Manova-Todorova, Katia, Leversha, Margaret +5 more·2012·Cell

DOI 10.1016/j.cell.2012.04.042

Cited by (1,000)

Items 101–200 of 1,000

Yes-Associated Protein Mediates Immune Reprogramming in Pancreatic Ductal Adenocarcinoma
S. Murakami, D. Shahbazian, R. Surana, Wei-Ying Zhang, Hengye Chen, G. Graham, Shannon M. White, L. Weiner, Chun-Ling Yi · 2016 · Oncogene
Exploring the crosstalk between endothelial cells, immune cells, and immune checkpoints in the tumor microenvironment: new insights and therapeutic implications
Jianwen Fang, Yue Lu, Jingyan Zheng, Xiaocong Jiang, Haixing Shen, Shang Xi, Yuexin Lu, Peifen Fu · 2023 · Cell Death and Disease
The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment
Katharina Helene Susek, Maria Karvouni, Evren Alici, Andreas Lundqvist · 2018 · Frontiers in Immunology
Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment
Huy Q. Dinh, Feng Pan, Geng Wang, Qingfeng Huang, Claire E. Olingy, Zhi‐Yong Wu, Shaohong Wang, Xin Xu, Xiu‐E Xu, Jianzhong He et al. · 2021 · Nature Communications
Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer
Cameron N. Johnstone, Yvonne E. Smith, Yuan Cao, Allan D. Burrows, Ryan Stanley Cross, Xiawei Ling, Richard P. Redvers, Judy P. Doherty, Bedrich L. Eckhardt, Anthony L. Natoli et al. · 2015 · Disease Models & Mechanisms
Exosomes miR-126a released from MDSC induced by DOX treatment promotes lung metastasis
Zhenghao Deng, Y Rong, Y Teng, X Zhuang, Abhilash Kumble Samykutty, J Mu, Luyao Zhang, Pengxiao Cao, Jun Yan, Donald Max Miller et al. · 2016 · Oncogene
Neutrophil-activating therapy for the treatment of cancer
Ian L. Linde, Tyler R. Prestwood, Jingtao Qiu, Genay O.W. Pilarowski, Miles Hamilton Linde, Xiangyue Zhang, Lei Shen, Nathan Edward Reticker-Flynn, David Kung‐Chun Chiu, Lauren Y. Sheu et al. · 2023 · Cancer Cell
Metastatic-niche labelling reveals parenchymal cells with stem features
Luigi Ombrato, Emma Nolan, Ivana Kurelac, Antranik Mavousian, Victoria Louise Bridgeman, Ivonne Heinze, Probir Chakravarty, Stuart D. Horswell, Estela González‐Gualda, Giulia Matacchione et al. · 2019 · Nature
SASP: Tumor Suppressor or Promoter? Yes!
Rao, Sonia G., Jackson, James G. · 2016 · Trends in Cancer
Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC
Junchao Cai, Lishan Fang, Yongbo Huang, Rong Li, Xiaonan Xu, Zhihuang Hu, Le Zhang, Yi Yang, Xun Zhu, Heng Zhang et al. · 2017 · Nature Communications
Fibronectin on circulating extracellular vesicles as a liquid biopsy to detect breast cancer
Pyong‐Gon Moon, Jeong‐Eun Lee, Young‐Eun Cho, Soo Jung Lee, Yee Soo Chae, Jin Hyang Jung, In-San Kim, Ho Yong Park, Moon‐Chang Baek · 2016 · Oncotarget
Targeting the tumour vasculature: from vessel destruction to promotion
Sophie Guelfi, Kairbaan Hodivala‐Dilke, Gabriele Bergers · 2024 · Nature reviews. Cancer
Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle
Wang, Gang, Biswas, Anup K., Ma, Wanchao, Kandpal, Manoj, Coker, Courtney, Grandgenett, Paul M., Hollingsworth, Michael A., Jain, Rinku, Tanji, Kurenai, Lόpez-Pintado, Sara et al. · 2018 · Nature Medicine
Inflammation amplifier, a new paradigm in cancer biology
Atsumi, Toru, Singh, Rajeev, Sabharwal, Lavannya, Bando, Hidenori, Meng, Jie, Arima, Yasunobu, Yamada, Moe, Harada, Masaya, Jiang, Jing-Jing, Kamimura, Daisuke et al. · 2014 · Cancer Research
A nineteen gene‐based risk score classifier predicts prognosis of colorectal cancer patients
Seon‐Young Kim, Seon‐Young Kim, Jeong‐Hwan Kim, Seon Ae Roh, Dong‐Hyung Cho, Seon‐Young Kim, Jin Cheon Kim · 2014 · Molecular Oncology
PI3K/AKT signaling pathway as a critical regulator of epithelial-mesenchymal transition in colorectal tumor cells
Amirhosein Maharati, Meysam Moghbeli · 2023 · Cell Communication and Signaling
Neutrophils in the Tumor Microenvironment
Lingyun Wu, Sugandha Saxena, Rakesh K. Singh · 2020 · Advances in experimental medicine and biology
Tenascin C in metastasis: A view from the invasive front
Lowy, Camille M, Oskarsson, Thordur · 2015 · Cell Adhesion & Migration
Targeting NF-κB signaling pathway in cancer by dietary polyphenols
Haroon Zaman Khan, Hammad Ullah, Paula C. Castilho, Antoni Sureda, Grazia D’Onofrio, Rosanna Filosa, Fang Wang, Seyed Mohammad Nabavi, Maria Daglia, Ana T. Sanches-Silva et al. · 2019 · Critical Reviews in Food Science and Nutrition
Tumor Microenvironment in Breast Cancer—Updates on Therapeutic Implications and Pathologic Assessment
Joshua Jing Xi Li, Julia Y. Tsang, Gary Man-Kit Tse · 2021 · Cancers
Emerging targeted agents in metastatic breast cancer
Dimitrios Zardavas, Jose M Baselga, Martine J Piccart · 2013 · Nature Reviews Clinical Oncology
Tumor Microenvironment Heterogeneity: Challenges and Opportunities
Farhana Runa, Sarkis Hamalian, Kayla Meade, Preston Shisgal, Peter Clarke Gray, Jonathan A. Kelber · 2017 · Current Molecular Biology Reports
Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors
Magdolna Djurec, Osvaldo Graña‐Castro, Albert Lee, Kevin Troulé, Elisa Espinet, Lavinia Cabras, Carolina Navas, María Teresa Blasco, Laura Martín-Díaz, Miranda Burdiel et al. · 2018 · Proceedings of the National Academy of Sciences
Myeloid‐derived suppressor cells: Important contributors to tumor progression and metastasis
Elham Safarzadeh, Mona Orangi, Hamed Mohammadi, Farhad Babaie, Behzad Baradaran · 2017 · Journal of Cellular Physiology
Molecular Mechanisms and Emerging Therapeutic Targets of Triple-Negative Breast Cancer Metastasis
Christiana Michael Neophytou, Panagiotis Boutsikos, Panagiotis Papageorgis · 2018 · Frontiers in Oncology
MLKL in cancer: more than a necroptosis regulator
Sofie Martens, Jolien Bridelance, Ria Roelandt, Peter Vandenabeele, Nozomi Takahashi · 2021 · Cell Death and Differentiation
NF-κB and STAT1 control CXCL1 and CXCL2 gene transcription
Susan J. Burke, Danhong Lu, Tim E. Sparer, Thomas J. Masi, Matthew Ray Goff, Michael D. Karlstad, J. Jason Collier · 2013 · American Journal of Physiology-Endocrinology and Metabolism
Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms
Marco Bezzi, Nina Seitzer, Tomoki Ishikawa, Markus Reschke, Ming Chen, Guocan Wang, Caitlin Mitchell, Christopher Ng, Jesse Mae Katon, Andrea Lunardi et al. · 2018 · Nature Medicine
Mechanisms of the Epithelial–Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer
Jacek Baj, Izabela Korona‐Głowniak, Alicja Forma, Amr Maani, Ryszard Sitarz, Mansur Rahnama, Elżbieta Radzikowska, Piero Portincasa · 2020 · Cells
CD146, from a melanoma cell adhesion molecule to a signaling receptor
Zhaoqing Wang, Qingji Xu, Nengwei Zhang, Xuemei Du, Guangzhong Xu, Xiyun Yan · 2020 · Signal Transduction and Targeted Therapy
The Role of Tumor-Stroma Interactions in Drug Resistance Within Tumor Microenvironment
Yanghong Ni, Xiaoting Zhou, Jia Yang, Houhui Shi, Hongyi Li, Xia Zhao, Xuelei Ma · 2021 · Frontiers in Cell and Developmental Biology
NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma
Wilson, C. L., Jurk, D., Fullard, N., Banks, P., Page, A., Luli, S., Elsharkawy, A. M., Gieling, R. G., Chakraborty, J. Bagchi, Fox, C. et al. · 2015 · Nature Communications
Metastatic niche functions and therapeutic opportunities
Toni Celià-Terrassa, Yibin Kang · 2018 · Nature Cell Biology
Nanomedicine‐Based Immunotherapy for the Treatment of Cancer Metastasis
Pengcheng Zhang, Yihui Zhai, Ying Cai, Yuliang Zhao, Yaping Li · 2019 · Advanced Materials
IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel
Zhen Ning Wee, Siti Maryam J. M. Yatim, Vera Kohlbauer, Min Feng, Jian Yuan Goh, Yi Bao, Puay Leng Lee, Songjing Zhang, Pan Pan Wang, Elgene Lim et al. · 2015 · Nature Communications
Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response
Camilla Salvagno, Metamia Ciampricotti, Sander Tuit, Cheei‐Sing Hau, Antoinette van Weverwijk, Seth B. Coffelt, Kelly Kersten, Kim Vrijland, Kevin Kos, Thomas Ulas et al. · 2019 · Nature Cell Biology
CXCR2 Receptor: Regulation of Expression, Signal Transduction, and Involvement in Cancer
Jan Korbecki, Patrycja Kupnicka, Mikołaj Chlubek, Jarosław Gorący, Izabela Gutowska, Irena Baranowska‐Bosiacka · 2022 · International Journal of Molecular Sciences
ISG15 Is a Critical Microenvironmental Factor for Pancreatic Cancer Stem Cells
Bruno Sáinz, Beatriz Martín, Marianthi N. Tatari, Christopher Heeschen, Susana Guerra · 2014 · Cancer Research
TLR4 Is a Novel Determinant of the Response to Paclitaxel in Breast Cancer
Sandeep Rajput, Lisa D. Volk-Draper, Sophia Ran · 2013 · Molecular Cancer Therapeutics
RAS–Mitogen-Activated Protein Kinase Signal Is Required for Enhanced PD-L1 Expression in Human Lung Cancers
Hidetoshi Sumimoto, Atsushi Takano, Koji Teramoto, Yataro Daigo · 2016 · PLoS ONE
Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy
Tavora, Bernardo, Reynolds, Louise E., Batista, Silvia, Demircioglu, Fevzi, Fernandez, Isabelle, Lechertier, Tanguy, Lees, Delphine M., Wong, Ping-Pui, Alexopoulou, Annika, Elia, George et al. · 2014 · Nature
CXCL1 mediates obesity-associated adipose stromal cell trafficking and function in the tumour microenvironment
Tao Zhang, Chieh Tseng, Yan Zhang, Olga Sirin, Paul Gettys Corn, Elsa M. Li-Ning-Tapia, Patricia Troncoso, John Warren Davis, Curtis Alvin Pettaway, John Francis Ward et al. · 2016 · Nature Communications
Marrow adipocyte-derived CXCL1 and CXCL2 contribute to osteolysis in metastatic prostate cancer
Aimalie Hardaway, Mackenzie K. Herroon, Erandi N. Rajagurubandara, Izabela Podgorski · 2015 · Clinical & Experimental Metastasis
Targeting IL-17B–IL-17RB signaling with an anti–IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines
Heng‐Hsiung Wu, Wendy W. Hwang‐Verslues, Wen-Hsin Lee, Chun-Kai Huang, Pei‐Chi Wei, Chia-Lin Chen, Jin‐Yuh Shew, Eva Y.-H.P. Lee, Yung‐Ming Jeng, Yu‐Wen Tien et al. · 2015 · The Journal of Experimental Medicine
A mutual activation loop between breast cancer cells and myeloid-derived suppressor cells facilitates spontaneous metastasis through IL-6 trans-signaling in a murine model
Keunhee Oh, Ok-Young Lee, Suh-Youn Shon, Onyou Nam, P. Ryu, M. Seo, Dong-Sup Lee · 2013 · Breast Cancer Research
Carcinoma-Associated Fibroblasts Are a Promising Therapeutic Target
Shinsaku Togo, Urszula M. Polanska, Yoshiya Horimoto, Akira Orimo · 2013 · Cancers
Chemokines and Chemokine Receptors: Orchestrating Tumor Metastasization
Elisabetta Marcuzzi, Roberta Angioni, Barbara Molon, Bianca Calì · 2018 · International Journal of Molecular Sciences
TNF-α/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells
Hiroko Oshima, T Ishikawa, Go J. Yoshida, Kuniko Naoi, Y Maeda, Kazuhito Naka, X Ju, Yoichi M. A. Yamada, Toshinari Minamoto, Naofumi Mukaida et al. · 2013 · Oncogene
CXCL1: Gene, Promoter, Regulation of Expression, mRNA Stability, Regulation of Activity in the Intercellular Space
Jan Korbecki, Katarzyna Barczak, Izabela Gutowska, Dariusz Chlubek, Irena Baranowska‐Bosiacka · 2022 · International Journal of Molecular Sciences
From sentinel cells to inflammatory culprits: cancer‐associated fibroblasts in tumour‐related inflammation
Charlotte Servais, Neta Erez · 2012 · The Journal of Pathology
Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction
Paul C. McDonald, Shawn C. Chafe, Shoukat Dedhar · 2016 · Frontiers in Cell and Developmental Biology
CXCL12/CXCR4 Blockade by Oncolytic Virotherapy Inhibits Ovarian Cancer Growth by Decreasing Immunosuppression and Targeting Cancer-Initiating Cells
Margaret Gil, Marcin P. Komorowski, Mukund Seshadri, Hanna Rokita, AJ Robert McGray, Mateusz Opyrchal, Kunle O. Odunsi, Danuta Kozbor · 2014 · The Journal of Immunology
IL-33 promotes growth and liver metastasis of colorectal cancer in mice by remodeling the tumor microenvironment and inducing angiogenesis
Yu Zhang, Celestia Davis, Sapana N. Shah, Daniel Titus Hughes, James C. Ryan, Diego Altomare, Maria Marjorette O. Peña · 2016 · Molecular Carcinogenesis
The lack of type I interferon induces neutrophil-mediated pre-metastatic niche formation in the mouse lung
Ching‐Fang Wu, Lisa Andzinski, Nadine Kasnitz, Andrea Kröger, Frank Klawonn, Stefan Lienenklaus, Siegfried Weiß, Jadwiga Jabłońska · 2015 · International Journal of Cancer
The CXCL5/CXCR2 axis is sufficient to promote breast cancer colonization during bone metastasis
Ricardo Romero-Moreno, Kimberly J. Curtis, Thomas R. Coughlin, María Cristina Miranda-Vergara, Shourik Dutta, Aishwarya Natarajan, Beth A. Facchine, Kristen M. Jackson, Lukas M. Nystrom, Jun Li et al. · 2019 · Nature Communications
Transmembrane (TMEM) protein family members: Poorly characterized even if essential for the metastatic process
Sébastien Marx, Thomas Dal Maso, Jia-Wei Chen, Marina Bury, Johan Wouters, Carine Michiels, Benjamin Le Calvé · 2019 · Seminars in Cancer Biology
Cancer-associated fibroblasts: how do they contribute to metastasis?
Mei Qi Kwa, Kate Møller Herum, Cord Brakebusch · 2019 · Clinical & Experimental Metastasis
Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells
A. Poh, R. O'Donoghue, M. Ernst · 2015 · OncoTarget
CCL15 Recruits Suppressive Monocytes to Facilitate Immune Escape and Disease Progression in Hepatocellular Carcinoma
Longzi Liu, Zhao Zhang, Bo‐Hao Zheng, Yang Shi, Men Duan, Lijie Ma, Zhichao Wang, Liangqing Dong, Ping‐Ping Dong, Jie-Yi Shi et al. · 2018 · Hepatology
Fusobacterium nucleatum induces proliferation and migration in pancreatic cancer cells through host autocrine and paracrine signaling
Barath Udayasuryan, Raffae N. Ahmad, Tam T. D. Nguyen, Ariana Umaña, LaDeidra Monét Roberts, Polina Sobol, Stephen D. Jones, Jennifer M. Munson, Daniel Joseph Slade, Scott S. Verbridge · 2022 · Science Signaling
Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment
Bruno Sáinz, Sonia Alcalá, Elena García, Yolanda Sanchez-Ripoll, Maria M. Azevedo, Michele Cioffi, Marianthi N. Tatari, Irene Miranda‐Lorenzo, Manuel M. Hidalgo, Gonzalo Goméz-López et al. · 2015 · Gut
Rationale and Means to Target Pro-Inflammatory Interleukin-8 (CXCL8) Signaling in Cancer
Laura M. Campbell, Pamela J. Maxwell, David J J Waugh · 2013 · Pharmaceuticals
Loss of SMAD4 Promotes Colorectal Cancer Progression by Recruiting Tumor-Associated Neutrophils via the CXCL1/8–CXCR2 Axis
Ryotaro Ogawa, Takamasa S. Yamamoto, Hideyo Hirai, Keita Hanada, Yoshiyuki Kiyasu, Gen Nishikawa, Rei Mizuno, Susumu Inamoto, Yoshiro Itatani, Yoshiharu Sakai et al. · 2019 · Clinical Cancer Research
CDK8/19 Mediator kinases potentiate induction of transcription by NFκB
Mengqian Chen, Jiaxin Liang, Hao Ji, Zhengguan Yang, Serena Altilia, Bing Hu, Adam Schronce, Martina S.J. McDermott, Gary P. Schools, Chang‐Uk Lim et al. · 2017 · Proceedings of the National Academy of Sciences
Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone
Hernan Roca, Jacqueline Jones, Marta C. Purica, Savannah Weidner, Amy J. Koh, Robert Kuo, John Erby Wilkinson, Yugang Wang, Stephanie Daignault‐Newton, Kenneth J. Pienta et al. · 2017 · Journal of Clinical Investigation
Hypoxia Pathway Proteins As Central Mediators of Metabolism in the Tumor Cells and Their Microenvironment
Sundary Sormendi, Ben Wielockx · 2018 · Frontiers in Immunology
CECR2 drives breast cancer metastasis by promoting NF-κB signaling and macrophage-mediated immune suppression
Meiling Zhang, Zongzhi Z. Liu, Keisuke Aoshima, Wesley L. Cai, Hongyin Sun, Tianrui Xu, Yangyi Zhang, Yongyan An, Jocelyn Fang-Yi Chen, Lok-Hei Chan et al. · 2022 · Science Translational Medicine
Mechanisms of resistance to anti-angiogenesis therapies
Sandy Giuliano, Gilles Pagès · 2013 · Biochimie
Immune-mediated mechanisms influencing the efficacy of anticancer therapies
Seth B. Coffelt, Karin E. de Visser · 2015 · Trends in Immunology
Tumor microenvironment-mediated chemoresistance in breast cancer
Kobra Velaei, Nasser Samadi, Balal Brazvan, Jafar Soleimani Rad · 2016 · The Breast
Curcumin mediates oxaliplatin-acquired resistance reversion in colorectal cancer cell lines through modulation of CXC-Chemokine/NF-κB signalling pathway
Vicenç Ruiz de Porras, Sara Bystrup, Anna Martínez‐Cardús, Raquel Pluvinet, Lauro Sumoy, Lynne M. Howells, Mark I. James, Chinenye Iwuji, José Luís Manzano, Laura Layos et al. · 2016 · Scientific Reports
Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations
Charlotte R. Bell, Victoria S. Pelly, Agrin Moeini, Shih‐Chieh Chiang, Eimear Flanagan, Christian P. Bromley, C I Clark, Charles H. Earnshaw, Maria A. Koufaki, Eduardo Bonavita et al. · 2022 · Nature Communications
Beyond Cell Motility: The Expanding Roles of Chemokines and Their Receptors in Malignancy
Dina Morein, Nofar Erlichman, Adit Ben‐Baruch · 2020 · Frontiers in Immunology
Epigenetic remodelling shapes inflammatory renal cancer and neutrophil-dependent metastasis
Nishida, Jun, Momoi, Yusaku, Miyakuni, Kosuke, Tamura, Yusuke, Takahashi, Kei, Koinuma, Daizo, Miyazono, Kohei, Ehata, Shogo · 2020 · Nature Cell Biology
Chronic inflammation and cancer; the two sides of a coin
Queenie Fernandes, Varghese Philipose Inchakalody, Takwa Bedhiafi, Sarra Mestiri, Nassiba Taib, Shahab Uddin M.S., Maysaloun Merhi, Said Dermime · 2023 · Life Sciences
BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer
Ashkan Shahbandi, Sonia G. Rao, Ashlyn Y. Anderson, Wesley D. Frey, Joy O. Olayiwola, Nathan Ungerleider, James G. Jackson · 2020 · Cell Death and Differentiation
The tumor microenvironment controls drug sensitivity
Arne Östman · 2012 · Nature Medicine
Targeting tumor–stromal interactions in bone metastasis
Mark Esposito, Yibin Kang · 2013 · Pharmacology & Therapeutics
Cancer stem cells and their unique role in metastatic spread
Teresa Bernadette Steinbichler, Dragana Savic, József Dudás, Irma Kvitsaridze, Sergej Skvortsov, Herbert Riechelmann, Ira Skvortsova · 2019 · Seminars in Cancer Biology
Neutrophil dynamics in the tumor microenvironment
Amanda J. McFarlane, Frédéric Fercoq, Seth B. Coffelt, Leo M. Carlin · 2021 · Journal of Clinical Investigation
The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer: New challenges and therapeutic opportunities
Umar Mehraj, Rais A. Ganai, Muzafar Ahmad Macha, Abid Hamid, Mohammed A. Zargar, Ajaz Ahmad Bhat, Mohd Wasim Nasser, Mohammad Haris, Surinder K. Batra, Bader Alshehri et al. · 2021 · Cellular Oncology
Regulation of tumor immune suppression and cancer cell survival by CXCL1/2 elevation in glioblastoma multiforme
Jiemiao Hu, Qingnan Zhao, Ling-Yuan Kong, Jian Wang, Jun Yan, Xueqing Xia, Zhiliang Jia, Amy B. Heimberger, Shulin Li · 2021 · Science Advances
Harnessing the chemokine system to home CAR-T cells into solid tumors
Jade Foeng, Iain Comerford, Shaun R. McColl · 2022 · Cell Reports Medicine
Awakened by Cellular Stress: Isolation and Characterization of a Novel Population of Pluripotent Stem Cells Derived from Human Adipose Tissue
Saleh G. Heneidi, Ariel A. Simerman, E. Keller, Prapti Singh, Xinmin Li, Daniel Anthony Dumesic, Gregorio Daniel Chazenbalk · 2013 · PLoS ONE
CXC family of chemokines as prognostic or predictive biomarkers and possible drug targets in colorectal cancer
Sara Cabrero‐de las Heras, Eva Martinez‐Balibrea · 2018 · World Journal of Gastroenterology
A C-X-C Chemokine Receptor Type 2–Dominated Cross-talk between Tumor Cells and Macrophages Drives Gastric Cancer Metastasis
Zhijun Zhou, Guanggai Xia, Zhen Xiang, Mingyang Liu, Zhewei Wei, Jie Yan, Wei Chen, Jintao Zhu, Niranjan Awasthi, Xiaotian Sun et al. · 2019 · Clinical Cancer Research
Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance
Fei Chen, Qilai Long, Da Fu, Dexiang Zhu, Yan Ji, Liu Han, Boyi Zhang, Qixia Xu, Bingjie Liu, Yan Li et al. · 2018 · Nature Communications
Systematic screen of chemotherapeutics in Drosophila stem cell tumors
Michele Markstein, Samantha Dettorre, Julio Cho, Ralph A. Neumüller, Soren Craig-Muller, Norbert Perrimon · 2014 · Proceedings of the National Academy of Sciences
Cancer Metastasis: A Reappraisal of Its Underlying Mechanisms and Their Relevance to Treatment
Nicolò Riggi, Michel Aguet, Ivan Stamenkovic · 2017 · Annual Review of Pathology Mechanisms of Disease
Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B
Martina Musella, Andrea Guarracino, Nicoletta Manduca, Claudia Galassi, Eliana Ruggiero, Alessia Potenza, Ester Maccafeo, Gwenola Manic, Luca Mattiello, Sara Soliman Abdel Rehim et al. · 2022 · Nature Immunology
Chemotherapy-Induced Metastasis: Molecular Mechanisms, Clinical Manifestations, Therapeutic Interventions
George S. Karagiannis, John S. Condeelis, Maja H. Oktay · 2019 · Cancer Research
H3K18 lactylation-mediated VCAM1 expression promotes gastric cancer progression and metastasis via AKT-mTOR-CXCL1 axis
Yupeng Zhao, Jiang Jiang, Peng Zhou, Kaiyuan Deng, Ziyuan Liu, Mengqi Yang, Xiao Yang, Jianfang Li, Ranran Li, Jiazeng Xia · 2024 · Biochemical Pharmacology
A Novel ACKR2-Dependent Role of Fibroblast-Derived CXCL14 in Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer
Elin Sjöberg, Max Meyrath, Laura Milde, Mercedes Herrera, John Lövrot, Daniel Hägerstrand, Oliver Frings, Margarita Bartish, Charlotte Rolny, Erik L. L. Sonnhammer et al. · 2019 · Clinical Cancer Research
miR141–CXCL1–CXCR2 Signaling–Induced Treg Recruitment Regulates Metastases and Survival of Non–Small Cell Lung Cancer
Mingming Lv, Yujun Xu, Ruijing Tang, Jing Ren, Sunan Shen, Yueqiu Chen, Baorui Liu, Yayi Hou, Tingting Wang · 2014 · Molecular Cancer Therapeutics
Pretreatment with probiotic Bifico ameliorates colitis‐associated cancer in mice: Transcriptome and gut flora profiling
Huan Song, Weiyi Wang, Bo Shen, Hao Jia, Zhaoyuan Hou, Ping Chen, Yunwei Sun · 2017 · Cancer Science
Granulocytic immune infiltrates are essential for the efficient formation of breast cancer liver metastases
Sébastien Tabariès, Véronique Ouellet, Brian E. Hsu, Matthew G. Annis, April A. N. Rose, Liliane Meunier, Eurı́dice Carmona, Christine Tam, Anne‐Marie Mes‐Masson, Peter M. Siegel · 2015 · Breast Cancer Research
Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression
Marta F Estrada, Sofia P. Rebelo, Emma Jane Davies, Marta Teixeira Pinto, Hugo Pereira, Vítor Espirito Santo, Matthew John Smalley, Simon T. Barry, Emilio J. Gualda, Paula M. Alves et al. · 2015 · Biomaterials
Cancer extracellular vesicles contribute to stromal heterogeneity by inducing chemokines in cancer-associated fibroblasts
Yutaka Naito, Yusuke Yamamoto, Naoya Sakamoto, Iwao Shimomura, Akiko Kogure, Minami Kumazaki, Akira Yokoi, Masakazu Yashiro, Tohru Kiyono, Kazuyoshi Yanagihara et al. · 2019 · Oncogene
Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes
Amy W. Ku, Jason B. Muhitch, Colin A. Powers, Michael R. Diehl, Minhyung Kim, Daniel T. Fisher, Anand P. Sharda, Virginia K. Clements, Kieran L. O’Loughlin, Hans Minderman et al. · 2016 · eLife
Tumor Microenvironment as a Regulator of Radiation Therapy: New Insights into Stromal-Mediated Radioresistance
Varintra E. Krisnawan, Jennifer Anne Stanley, Julie Kristina Schwarz, David G. DeNardo · 2020 · Cancers