Ironing out cell death mechanisms

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691 · see citing works

Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.

Yang, W. S., & Stockwell, B. R. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.02.010 · Cited by 1,876 · see citing works

RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels

Yagoda, N., von Rechenberg, M., Zaganjor, E., Bauer, A. J., Yang, W. S., Fridman, D. J., Wolpaw, A. J., Smukste, I., Peltier, J. M., Boniface, J. J., et al. (2007) · Nature · doi:10.1038/nature05859 · Cited by 1,631 · see citing works

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

Dolma, S., Lessnick, S. L., Hahn, W. C., & Stockwell, B. R. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00050-3 · Cited by 1,446 · see citing works

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate

Trachootham, D., Zhou, Y., Zhang, H., Demizu, Y., Chen, Z., Pelicano, H., Chiao, P. J., Achanta, G., Arlinghaus, R. B., Liu, J., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.009 · Cited by 1,080 · see citing works

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

Murphy, T. H., Miyamoto, M., Sastre, A., Schnaar, R. L., & COYLE, J. T. (1989) · Neuron · doi:10.1016/0896-6273(89)90043-3 · Cited by 1,033 · see citing works

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

Chipuk, J. E., McStay, G. P., Bharti, A., Kuwana, T., Clarke, C. J., Siskind, L. J., Obeid, L. M., & Green, D. R. (2012) · Cell · doi:10.1016/j.cell.2012.01.038 · Cited by 436 · see citing works

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress

Shaw, A. T., Winslow, M. M., Magendantz, M., Ouyang, C., Dowdle, J. A., Subramanian, A., Lewis, T. A., Maglathin, R. L., Tolliday, N. J., & Jacks, T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105941108 · Cited by 229 · see citing works

Phase I Pharmacokinetic and Pharmacodynamic Study of 17-dimethylaminoethylamino-17-demethoxygeldanamycin, an Inhibitor of Heat-Shock Protein 90, in Patients With Advanced Solid Tumors

Ramanathan, R. K., Egorin, M. J., Erlichman, C., Remick, S. C., Ramalingam, S. S., Naret, C., Holleran, J. L., TenEyck, C. J., Ivy, S. P., & Belani, C. P. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.25.0415 · Cited by 87 · see citing works

Iron and glutathione at the crossroad of redox metabolism in neurons

Aracena-Parks, P., Aguirre, P., Muñoz, P., & Núñez, M. T. (2006) · Biological Research · doi:10.4067/s0716-97602006000100017 · Cited by 28 · see citing works

ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation

Park, E., & Chung, S. W. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2064-5 · Cited by 897 · see citing works

Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs

Su, Y., Zhao, B., Zhou, L., Zhang, Z., Shen, Y., Lv, H., AlQudsy, L. H. H., & Shang, P. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.02.015 · Cited by 580 · see citing works

Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration

Masaldan, S., Bush, A. I., Devos, D., Rolland, A., & Moreau, C. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.033 · Cited by 485 · see citing works

Iron addiction: a novel therapeutic target in ovarian cancer

Basuli, D., Tesfay, L., Deng, Z., Paul, B., Yamamoto, Y., Ning, G., Xian, W., McKeon, F., Lynch, M. L., Crum, C. P., et al. (2017) · Oncogene · doi:10.1038/onc.2017.11 · Cited by 469 · see citing works

Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis

Masaldan, S., Clatworthy, S. A. S., Gamell, C., Meggyesy, P. M., Rigopoulos, A.-T., Haupt, S., Haupt, Y., Denoyer, D., Adlard, P. A., Bush, A. I., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2017.08.015 · Cited by 452 · see citing works

Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics

Wang, S., Li, F., Qiao, R., Hu, X., Liao, H., Chen, L., Wu, J., Wu, H., Zhao, M. L., Liu, J., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b06399 · Cited by 384 · see citing works

An essential role for functional lysosomes in ferroptosis of cancer cells

Torii, S., Shintoku, R., Kubota, C., Yaegashi, M., Torii, R., Sasaki, M., Suzuki, T., Mori, M., Yoshimoto, Y., Takeuchi, T., et al. (2016) · Biochemical Journal · doi:10.1042/bj20150658 · Cited by 349 · see citing works

Ferroptosis Affects the Progression of Nonalcoholic Steatohepatitis via the Modulation of Lipid Peroxidation–Mediated Cell Death in Mice

Qi, J., Kim, J.-W., Zhou, Z., Lim, C.-W., & Kim, B. (2020) · The American Journal of Pathology · doi:10.1016/j.ajpath.2019.09.011 · Cited by 338 · see citing works

Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy

Lv, H., Zhen, C., Liu, J., Yang, P., Hu, L., & Shang, P. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3150145 · Cited by 320 · see citing works

The Protective Role of Mitochondrial Ferritin on Erastin-Induced Ferroptosis

Wang, Y., Chang, S.-Y., Wu, Q., Gou, Y.-J., Jia, L., Cui, Y.-M., Yu, P., Shi, Z.-H., Wu, W.-S., Gao, G., et al. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00308 · Cited by 309 · see citing works

Simvastatin induced ferroptosis for triple-negative breast cancer therapy

Yao, X., Xie, R., Cao, Y., Tang, J., Men, Y., Peng, H., & Yang, W. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-01058-1 · Cited by 227 · see citing works

Artesunate activates the ATF4-CHOP-CHAC1 pathway and affects ferroptosis in Burkitt's Lymphoma

Wang, N., Zeng, G., Yin, J.-L., & Bian, Z. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.09.023 · Cited by 207 · see citing works

ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1

Zhang, T., Sun, L., Hao, Y., Suo, C., Shen, S., Wei, H., Ma, W., Zhang, P., Wang, T., Gu, X., et al. (2021) · Nature Cancer · doi:10.1038/s43018-021-00299-1 · Cited by 206 · see citing works

Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells

Ma, S., Dielschneider, R. F., Henson, E. S., Xiao, W., Choquette, T., Blankstein, A. R., Chen, Y., & Gibson, S. B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182921 · Cited by 204 · see citing works

Smart biomimetic metal organic frameworks based on ROS-ferroptosis-glycolysis regulation for enhanced tumor chemo-immunotherapy

Yang, J., Ma, S., Xu, R. F., Wei, Y., Zhang, J., Zuo, T., Wang, Z., Deng, H., Yang, N., & Shen, Q. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.04.013 · Cited by 186 · see citing works

Multifunctional nanoplatform for photoacoustic imaging-guided combined therapy enhanced by CO induced ferroptosis

Yao, X., Yang, P., Jin, Z., Jiang, Q., Guo, R., Xie, R., He, Q., & Yang, W. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.01.026 · Cited by 183 · see citing works

Ferroptosis-inducing agents compromise in vitro human islet viability and function

Bruni, A., Pepper, A. R., Pawlick, R. L., Gala-Lopez, B., Gamble, A. F., Kin, T., Seeberger, K., Korbutt, G. S., Bornstein, S. R., Linkermann, A., et al. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0506-0 · Cited by 180 · see citing works

Nanomaterial-induced ferroptosis for cancer specific therapy

Liu, M., Liu, B., Liu, Q., Du, K., Wang, Z., & He, N. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2018.12.015 · Cited by 180 · see citing works

Iron Accumulation and Lipid Peroxidation in the Aging Retina: Implication of Ferroptosis in Age-Related Macular Degeneration

Zhao, T., Guo, X., & Sun, Y. (2021) · Aging and Disease · doi:10.14336/ad.2020.0912 · Cited by 176 · see citing works

Astrocytes in heavy metal neurotoxicity and neurodegeneration

Li, B.-M., Xia, M.-S., Zorec, R., Parpura, V., & Verkhratsky, A. (2021) · Brain Research · doi:10.1016/j.brainres.2020.147234 · Cited by 160 · see citing works

Redox active metals in neurodegenerative diseases

Acevedo, K. M., Masaldan, S., Opazo, C., & Bush, A. I. (2019) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-019-01731-9 · Cited by 101 · see citing works

Metal–organic complex-based chemodynamic therapy agents for cancer therapy

Hwang, E., & Jung, H. S. (2020) · Chemical Communications · doi:10.1039/d0cc03012k · Cited by 100 · see citing works

Photothermal-Enhanced Inactivation of Glutathione Peroxidase for Ferroptosis Sensitized by an Autophagy Promotor

An, P., Gao, Z., Sun, K., Gu, D., Wu, H., You, C., Li, Y., Cheng, K., Zhang, Y., Wang, Z., et al. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b16124 · Cited by 98 · see citing works

Cytotoxicity of epunctanone and four other phytochemicals isolated from the medicinal plants Garcinia epunctata and Ptycholobium contortum towards multi-factorial drug resistant cancer cells

Mbaveng, A. T., Fotso, G. W., Ngnintedo, D., Kuete, V., Ngadjui, B. T., Keumedjio, F., Andrae‐Marobela, K., & Efferth, T. (2017) · Phytomedicine · doi:10.1016/j.phymed.2017.12.016 · Cited by 94 · see citing works

Emerging Mechanisms and Disease Implications of Ferroptosis: Potential Applications of Natural Products

Ge, C., Zhang, S., Mu, H., Shaojun, Z., Tan, Z., Huang, X., Chen, X., Zou, J., Zhu, Y., Dong, F., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.774957 · Cited by 77 · see citing works

Baicalein and luteolin inhibit ischemia/reperfusion-induced ferroptosis in rat cardiomyocytes

Wang, I.-C., Lin, J., Lee, W., Liu, C., Lin, T.-Y., & Yang, K. (2022) · International Journal of Cardiology · doi:10.1016/j.ijcard.2022.12.018 · Cited by 75 · see citing works

Ferroptosis-related small-molecule compounds in cancer therapy: Strategies and applications

Yin, L., Liu, P., Jin, Y., Ning, Z., Yang, Y., & Gao, H. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114861 · Cited by 66 · see citing works

Nanomedicine enables autophagy-enhanced cancer-cell ferroptosis

Yang, J., Ding, L., Yu, L., Wang, Y., Ge, M., Jiang, Q., & Chen, Y. (2020) · 中国科学通报：英文版 · doi:10.1016/j.scib.2020.10.021 · Cited by 64 · see citing works

A mini-review and perspective on ferroptosis-inducing strategies in cancer therapy

Wang, S., Liao, H., Li, F., & Ling, D. (2019) · Chinese Chemical Letters · doi:10.1016/j.cclet.2019.03.025 · Cited by 63 · see citing works

Dihydroartemisinin-Loaded Magnetic Nanoparticles for Enhanced Chemodynamic Therapy

Guo, S., Yao, X., Jiang, Q., Wang, K., Zhang, Y., Peng, H., Tang, J., & Yang, W. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00226 · Cited by 62 · see citing works

Regulation of Iron Homeostasis and Related Diseases

Li, Y., Huang, X., Wang, J., Huang, R., & Wan, D. (2020) · Mediators of Inflammation · doi:10.1155/2020/6062094 · Cited by 64 · see citing works

Chronic arsenic exposure induces ferroptosis via enhancing ferritinophagy in chicken livers

Yu, L., Lv, Z., Li, S., Jiang, H., Han, B., Zheng, X., Liu, Y., & Zhang, Z. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.164172 · Cited by 61 · see citing works

Engineering of bioactive metal sulfide nanomaterials for cancer therapy

Fei, W., Zhang, M., Fan, X., Ye, Y., Zhao, M., Zheng, C., Li, Y. Y., & Zheng, X. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00839-y · Cited by 59 · see citing works

Ferroptosis: The Entanglement between Traditional Drugs and Nanodrugs in Tumor Therapy

Liu, K., Huang, L., Qi, S., Liu, S., Xie, W., Du, L., Jing, C., Zhang, X., Zhang, B., Liu, L., et al. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202203085 · Cited by 59 · see citing works

Ferroptosis-enhanced chemotherapy for triple-negative breast cancer with magnetic composite nanoparticles

Zhang, J., Zhou, K., Lin, J., Yao, X., Ju, D., Zeng, X. L., Pang, Z., & Yang, W. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122395 · Cited by 55 · see citing works

Iron, Oxidative Damage and Ferroptosis in Rhabdomyosarcoma

Fanzani, A., & Poli, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081718 · Cited by 50 · see citing works

Nanoplatform‐Based In Vivo Gene Delivery Systems for Cancer Therapy

Luo, R., Le, H., Wu, Q., & Gong, C. (2024) · Small · doi:10.1002/smll.202312153 · Cited by 50 · see citing works

Regulated Cell Death Seen through the Lens of Islet Transplantation

Bruni, A. D. C., Bornstein, S. R., Linkermann, A., & Shapiro, A. M. J. (2018) · Cell Transplantation · doi:10.1177/0963689718766323 · Cited by 48 · see citing works

Aryl- and alkyl-phosphorus-containing flame retardants induced mitochondrial impairment and cell death in Chinese hamster ovary (CHO-k1) cells

Huang, C., Li, N., Yuan, S., Ji, X., Ma, M., Rao, K., & Wang, Z. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.07.024 · Cited by 48 · see citing works

Where ferroptosis inhibitors and paraquat detoxification mechanisms intersect, exploring possible treatment strategies

Rashidipour, N., Karami‐Mohajeri, S., Mandegary, A., Mohammadinejad, R., Wong, A., Mohit, M., Salehi, J., Ashrafizadeh, M., Najafi, A., & Abiri, A. (2020) · Toxicology · doi:10.1016/j.tox.2020.152407 · Cited by 47 · see citing works

Localized disruption of redox homeostasis boosting ferroptosis of tumor by hydrogel delivery system

Su, X., Cao, Y., Liu, Y., Ouyang, B., Ning, B., Wang, Y., Guo, H., Pang, Z., & Shen, S. (2021) · Materials Today Bio · doi:10.1016/j.mtbio.2021.100154 · Cited by 44 · see citing works

CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4

Chen, S., Fan, J., Xie, P., Ahn, J., Fernandez, M., Billingham, L. K., Miska, J. M., Wu, J. D., Wainwright, D. A., Fang, D., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci170071 · Cited by 42 · see citing works

Core–Shell–Satellite Nanomaces as Remotely Controlled Self‐Fueling Fenton Reagents for Imaging‐Guided Triple‐Negative Breast Cancer‐Specific Therapy

Du, Y., Yang, C., Li, F., Liao, H., Chen, Z., Lin, P., Wang, N., Zhou, Y. W., Lee, J. Y., Ding, Q., et al. (2020) · Small · doi:10.1002/smll.202002537 · Cited by 39 · see citing works

Targeting Ferroptosis for Lung Diseases: Exploring Novel Strategies in Ferroptosis‐Associated Mechanisms

Ma, T., Zhou, Y., Wang, C., Wang, L., Chen, J., Yang, H., Zhang, C.-Y., Zhou, Y., & Guan, C. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/1098970 · Cited by 62 · see citing works

Unraveling the interplay between iron homeostasis, ferroptosis and extramedullary hematopoiesis

Fernández-García, V., González-Ramos, S., Martín‐Sanz, P., Castrillo, A., & Boscá, L. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106386 · Cited by 34 · see citing works

Involvement of ferroptosis in human motor neuron cell death

Matsuo, T., Adachi-Tominari, K., Sano, O., Kamei, T., Nogami, M., Ogi, K., Okano, H., & Yano, M. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.05.095 · Cited by 31 · see citing works

CircRNA and ferroptosis in human disease: Insights for new treatments

Liu, R., Zhou, Y., & Cao, Y. (2023) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12365 · Cited by 30 · see citing works

Monitoring hydrogen polysulfide during ferroptosis with a two-photon fluorescent probe

Di, X., Ge, C., Liu, Y., Shao, C., Zhu, H., Liu, H., & Qian, Y. (2021) · Talanta · doi:10.1016/j.talanta.2021.122467 · Cited by 30 · see citing works

Iron plays a role in sulfasalazine-induced ferroptosis with autophagic flux blockage in K7M2 osteosarcoma cells

Liu, J., Lou, C., Zhen, C., Wang, Y., Shang, P., & Lv, H. (2022) · Metallomics · doi:10.1093/mtomcs/mfac027 · Cited by 28 · see citing works

Chronic iron limitation confers transient resistance to oxidative stress in marine diatoms

van Creveld, S. G., Rosenwasser, S., Levin, Y., & Vardi, A. (2016) · PLANT PHYSIOLOGY · doi:10.1104/pp.16.00840 · Cited by 27 · see citing works

An iron-dependent form of non-canonical ferroptosis induced by labile iron

Li, Y., Ouyang, Q., Chen, W., Liu, K., Zhang, B., Yao, J., Zhang, S., Ding, J., Cong, M., & Xu, A. (2022) · Science China Life Sciences · doi:10.1007/s11427-022-2244-4 · Cited by 23 · see citing works

Ferroptosis-targeting drugs in breast cancer

Zhang, S.-X., Guo, L., Tao, R., & Liu, S.-P. (2024) · Journal of drug targeting (Print) · doi:10.1080/1061186x.2024.2399181 · Cited by 22 · see citing works

Susceptibility to erastin‐induced ferroptosis decreases during maturation in a human oligodendrocyte cell line

Hoshino, T., Yamakado, H., Takahashi, R., & Matsuzawa, S. (2020) · FEBS Open Bio · doi:10.1002/2211-5463.12923 · Cited by 20 · see citing works

Therapeutic potential of iron modulating drugs in a mouse model of multiple system atrophy

Shukla, J. J., Stefanova, N., Bush, A. I., McColl, G., Finkelstein, D. I., & McAllum, E. J. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105509 · Cited by 20 · see citing works

AMP-activated protein kinase-driven lipid droplet dynamics govern melanoma sensitivity to polyunsaturated fatty acid and iron-induced ferroptosis

Motamedi, S., Ravoet, N., Dehairs, J., Vanderhoydonc, F., Escamilla‐Ayala, A., Śliwińska, M. A., Wang, S., Idkowiak, J., Soenen, S. J., Agostinis, P., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-66113-z · Cited by 19 · see citing works

Versatile iron-vitamin K3 derivative-based nanoscale coordination polymer augments tumor ferroptotic therapy

Zhang, Z., Ding, Y., Li, J., Wang, L., Xin, X., Yan, J., Wu, J., Yuan, A., & Hu, Y. (2020) · Nano Research · doi:10.1007/s12274-020-3241-7 · Cited by 19 · see citing works

Epithelial Membrane Protein 1 Promotes Sensitivity to RSL3‐Induced Ferroptosis and Intensifies Gefitinib Resistance in Head and Neck Cancer

Wang, Y., Zhang, L., Yao, C., Ma, Y., & Liu, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4750671 · Cited by 19 · see citing works

Metabolic control of cancer metastasis: role of amino acids at secondary organ sites

Karno, B. A., Edwards, D. N., & Chen, J. (2023) · Oncogene · doi:10.1038/s41388-023-02868-3 · Cited by 18 · see citing works

The Regulation Role of Ferroptosis Mechanism of Anti-Cancer Drugs and Noncoding RNAs

Ensoy, M., Bumin, Z. S., Jama, H. A., & Cansaran‐Duman, D. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220629154418 · Cited by 17 · see citing works

Research progress on ferroptosis in cerebral hemorrhage

Mao, N., Zhang, M., Shen, M., Yuan, J., & Lin, Z. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117932 · Cited by 16 · see citing works

Gas immnuo-nanomedicines fight cancers

Sun, M., Wang, T., Zhu, Y., Feng, L., Bai, J., & Tang, C. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117595 · Cited by 14 · see citing works

Induction of apoptosis by Fe(salen)Cl through caspase‐dependent pathway specifically in tumor cells

Pradhan, N., Pratheek, B. M., Garai, A., Kumar, A., Meena, V. S., Ghosh, S., Singh, S., Kumari, S., Chandrashekar, T. K., Goswami, C., et al. (2014) · Cell Biology International · doi:10.1002/cbin.10308 · Cited by 12 · see citing works

Co-targeting ferroptosis and immune evasion through small molecules in breast cancer

Zhou, J., Yang, W., Tang, H., Zou, Y., Zhou, Z., Peng, C., & Peng, F. (2025) · Journal of Translational Internal Medicine · doi:10.1515/jtim-2025-0093 · Cited by 11 · see citing works

CD36 Induces Inflammation by Promoting Ferroptosis in Pancreas, Epididymal Adipose Tissue, and Adipose Tissue Macrophages in Obesity-Related Severe Acute Pancreatitis

Zhang, R., Xin, L., Guo, X., & Ding, Z. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083482 · Cited by 8 · see citing works

Targeting Ferroptosis: A Novel Strategy for the Treatment of Atherosclerosis

Zhang, Y., Jiang, C., & Meng, N. (2024) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/0113895575273164231130070920 · Cited by 7 · see citing works

A Functionalized Metal–Organic Framework‐Based Controlled Dual‐Drug Delivery System with Short Hairpin RNA and Simvastatin for Ferroptosis in Colorectal Cancer

Liu, H., Yao, X., Zhu, W., Zhang, J., Ma, S., Lu, D., & Yang, W. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202200356 · Cited by 7 · see citing works

PSMA-targeted theranostic nanoplatform achieves spatiotemporally precise therapy and triggers ferroptosis in prostate cancer treatment

Zhang, L., Sun, Q., Zheng, D., Huang, X., Zhong, Y. M., Lan, Z., Xiong, W., Sun, K., & Liu, R. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03530-4 · Cited by 4 · see citing works

Recent research progress based on ferroptosis-related signaling pathways and the tumor microenvironment on it effects

Yu, S., Tong, L.-W., Shen, J., Li, C., Hu, Y., Feng, K.-K., & Shao, J. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116290 · Cited by 4 · see citing works

Ferroptosis—The “Double-Edged Sword” in Cancer: Mechanisms of Tumor Suppression/Resistance and Therapeutic Manipulation

Quaranto, D., DeSouza, N. R., Carnazza, M. A., Moscatello, A. L., Islam, H. K., Li, X.-M., Tiwari, R. K., & Geliebter, J. (2025) · Biology · doi:10.3390/biology15010067 · Cited by 3 · see citing works

Monitoring and Regulating Intracellular GPX4 mRNA Using Gold Nanoflare Probes and Enhancing Erastin-Induced Ferroptosis

Liu, X., Yang, Q., Sui, Y., Yue, Q., Yan, S., Li, C., & Hong, M. (2022) · Biosensors · doi:10.3390/bios12121178 · Cited by 3 · see citing works

The role of ferroptosis in breast cancer: tumor progression, immune microenvironment interactions and therapeutic interventions.

Wang, Y., Tang, C.-Y., Wang, K.-Q., Zhang, X.-A., Zhang, L., Xiao, X., Lin, H., & Xiong, L.-X. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177561 · Cited by 5 · see citing works

Ferroptosis in the adjuvant treatment of lung cancer-the potential of selected botanical drugs and isolated metabolites

Tian, X., Fu, K., Huang, X., Zou, H., Shi, N., Li, J., Bao, Y., He, S., & Lv, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1430561 · Cited by 2 · see citing works

Dissecting the mechanism of regulation of a ferroptosis-like form of cell death in Drosophila melanogaster

Saini, S., & Owusu-Ansah, E. (2023) · Frontiers in Cell Death · doi:10.3389/fceld.2023.1209641 · Cited by 2 · see citing works

Scaffold-leaping optimization of naphthoquinone derivatives as ferroptosis inducer against non-small lung cancer

Yang, H., Wu, X., Li, M., Wang, Y., Guo, M., Chen, L., Ma, R., & Sun, M. (2025) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2025.130360 · Cited by 1 · see citing works

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Iron Addiction In Tumor Initiating Cells: A Novel Therapeutic Target In Ovarian Cancer

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Additional file 1 of Simvastatin induced ferroptosis for triple-negative breast cancer therapy

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ATM functions as a rheostat of metabolic stress in small-cell lung cancerPreprint

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Dual-Response and Dual-Targeting Probe Based on the Quinolinothiazole Salt Capable of Decoding Cellular Stress and Cellular State

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Rutin alleviates LPS-induced injury in IPEC-J2 cells via suppression of ferroptosis: involvement of NFE2L2-KEAP1, TLR4 and ALOX5

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Unraveling cell death mysteries

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FERROPTOSIS: MECHANISMS AND THERAPEUTIC APPLICATIONS

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How do we fit ferroptosis in the family of regulated cell death?

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Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

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Ferroptosis

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