Simvastatin induced ferroptosis for triple-negative breast cancer therapy
Open accessAbstract
Triple-negative breast cancer (TNBC), a management of aggressive breast cancer, remains an unmet medical challenge. Although a wave of efforts had spurred to design novel therapeutic method of TNBC, unpredictable prognosis with lacking effective therapeutic targets along with the resistance to apoptosis seriously limited survival benefits. Ferroptosis is a non-apoptotic form of cell death that is induced by excessive lipid peroxidation, which provide an innovative way to combat cancer. Emerging evidence suggests that ferroptosis plays an important role in the treatment of TNBC cells. Herein, a novel ferroptosis nanomedicine was prepared by loading simvastatin (SIM), a ferroptosis drug, into zwitterionic polymer coated magnetic nanoparticles (Fe 3 O 4 @PCBMA) to improve the therapeutic effect of TNBC. The as-obtained Fe 3 O 4 @PCBMA-SIM nanoparticles demonstrated more cytotoxicity against MDA-MB-231 than MCF-7 due to the higher expression of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR), which demonstrated that statins could effectively kill TNBC. Further experiments showed that SIM could inhibit the expression of HMGCR to downregulate the mevalonate (MVA) pathway and glutathione peroxidase 4 (GPX4), thereby inducing cancer cell ferroptosis. What’s more, PCBMA endows Fe 3 O 4 @PCBMA longer blood circulation performance to enhance their accumulation at tumor sites. Given that Fe 3 O 4 have proven for clinical applications by the U.S. Food and Drug Administration (FDA) and SIM could induce cancer cell ferroptosis, the developed Fe 3 O 4 @PCBMA-SIM nanosystem would have great potential in clinics for overcoming the drug resistance brought about by apoptotic drugs to cancer cells.
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Breast cancer, particularly TNBC, has an inherent anti-apoptotic ability, which decreases the overall effectiveness of different treatments and the survival rate.
“Breast cancer, particularly TNBC, has an inherent anti-apoptotic ability, which decreases the overall effectiveness of different treatments and the survival rate [116].”
From Nanosensitizer-assisted sonodynamic therapy for breast cancer (2025) · cites this paper as [116]
The Introduction says acquired or intrinsic resistance to apoptosis contributes to chemotherapy failure in TNBC, and the Abstract says resistance to apoptosis limits survival benefits. The claim overstates this as an inherent ability of breast cancer generally and extends the treatment-effectiveness point beyond chemotherapy to different treatments. (LLM, conf=0.84)
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Qi, X., Wan, Z., Jiang, B., Ouyang, Y., Feng, W., Zhu, H., Tan, Y., He, R., Xie, L., & Li, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1038225 · Cited by 48 · see citing works
Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches
Luo, Y.-L., Bai, X., Zhang, L., Hu, Q.-Q., Zhang, N., Cheng, J.-Z., Hou, M.-Z., & Liu, X.-L. (2024) · Drug Design, Development and Therapy · doi:10.2147/dddt.s472178 · Cited by 41 · see citing works
“120 This redox-active complex triggers lipid peroxidation and decreases GSH-GPX4 production through the generation of ·OH via the Fenton reaction upon cellular entry, ultimately leading to ferroptosis induction in TNBC. Notably, serum biochemical indices of Fe(hino) 3 -treated tumor-bearing mice remained within normal…”
BackgroundInfluentialWang, N., Zhang, Q.-Y., Wang, Z., Liu, Y.-C., Yang, S., Zhao, X.-R., & Peng, J.-Y. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.121795 · Cited by 41
The association of statin therapy and cancer: a meta-analysis
Chen, Z., Wu, P., Wang, J., Chen, P., Fang, Z., & Luo, F. (2023) · Lipids in Health and Disease · doi:10.1186/s12944-023-01955-4 · Cited by 43 · see citing works
Targeting ferroptosis, the achilles’ heel of breast cancer: A review
Liu, Y., Hu, Y., Jiang, Y., Bu, J.-W., & Gu, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1036140 · Cited by 41
“Statins can inhibit HMGCR and reduce FSP1-mediated ferroptosis resistance which could be considered as a potential drug for the treatment of TNBC (Yao et al., 2021).”
BackgroundAdvanced Hydrogel Material for Meniscus Repair
Li, C., Deng, R., Yang, M., Yuan, F., Zhang, C., & Yu, J. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202312276 · Cited by 35 · see citing works
Ferroptosis in cancer: metabolism, mechanisms and therapeutic prospects
Wu, Y.-S., Li, H., Yue, K., Jing, C., & Duan, Y.-S. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02520-6 · Cited by 38 · see citing works
Harnessing ferroptosis for precision oncology: challenges and prospects
Fernández-Acosta, R., Vintea, I., Koeken, I., Hassannia, B., & Berghe, T. V. (2025) · BMC Biology · doi:10.1186/s12915-025-02154-6 · Cited by 37 · see citing works
Mitochondria-related signaling pathways involved in breast cancer regulate ferroptosis
Dong, X., Li, Y., Sheng, X., Zhou, W., Sun, A.-C., & Dai, H. (2023) · Genes and Diseases · doi:10.1016/j.gendis.2023.03.019 · Cited by 37 · see citing works
“These two pathways are also related to mitochondrial glycometabolism and lipid metabolism.(81) A Cu-tetra (4-carboxyphenyl) porphyrin chloride (Fe(III)) (Cu-TCPP(Fe)) metaleorganic framework (MOF)-based nanosystem was reported to be integrated with Au NPs and loaded with RSL3, which impedes GSH biosynthesis by disrupt…”
BackgroundRecent progress of ferroptosis in cancers and drug discovery
Wang, X., Ren, X., Lin, X., Li, Q., Zhang, Y.-Q., Deng, J., Chen, B.-X., Ru, G., Luo, Y., & Lin, N.-M. (2024) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2024.100939 · Cited by 36 · see citing works
“Metformin and simvastatin downregulated the levels of SLC7A11 and GPX4, respectively, and induced ferroptosis to inhibit tumor growth [ 78 ].”
BackgroundZhang, S., Ren, X., Zhang, B., Lan, T., & Liu, B. (2024) · Molecules · doi:10.3390/molecules29081859 · Cited by 36 · see citing works
“Subsequent research has elucidated that simvastatin could suppress the expression of HMG-CoA, consequently downregulating the mevalonate pathway and glutathione peroxidase 4 (GPX4), which in turn triggers ferroptosis in cancer cells [142].”
BackgroundTan, H., Shen, Z., Wang, X.-H., Shu, S., Deng, J., Lu, L., Fan, Z.-Y., Hu, D., Cheng, P., Cao, X., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.09.018 · Cited by 35
Ferroptosis induction via targeting metabolic alterations in triple-negative breast cancer
Wang, Y., Sun, Y., Wang, F., Wang, H., & Hu, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115866 · Cited by 35 · see citing works
Wang, J., Zhao, Z., Liu, Y., Cao, X., Li, F., Ran, H., Cao, Y., & Wu, C. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2126027 · Cited by 34 · see citing works
Self-citationProgrammed cell death network in cancer drug resistance: A framework for therapeutic intervention.
Guo, D.-Z., Guo, Y.-D., Zhu, C.-L., Liao, Y., Lin, Z.-H., Zhang, H.-L., Zhang, W., & Zou, Z. (2026) · Drug resistance updates · doi:10.1016/j.drup.2026.101387 · Cited by 33 · see citing works
A guide to ferroptosis in cancer
Yapici, F. I., Bebber, C. M., & von Karstedt, S. (2024) · Molecular Oncology · doi:10.1002/1878-0261.13649 · Cited by 33 · see citing works
“…III iFSP1 [110], icFPS1 [130], viFSP1 [129] FSP1 inhibitor FSEN1 [60], Brequinar [64] FSP1 inhibitor FIN56 [123,145] GPX4 degradation, squalene synthase inhibition Statins [110,146,147] Blocks CoQ10 synthesis FIN IV Artemisinin [148] Lysosomal degradation of ferritin & regulating the system xc (cid”
BackgroundTan, M.-D., He, Y.-Z., Yi, J., Chen, J.-J., Guo, Q., Liao, N., & Peng, L.-P. (2023) · Biochemical Genetics · doi:10.1007/s10528-023-10423-8 · Cited by 33 · see citing works
“Ferroptosis is closely related to TNBC development (Yao et al. 2021).”
Ferroptosis is a new therapeutic target for spinal cord injury
Bai, X., Liu, X.-L., Deng, Z.-Z., Wei, D., Zhang, D., Xi, H., Wang, Q., He, M., & Yang, Y.-L. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1136143 · Cited by 33 · see citing works
“The mevalonate (MVA) pathway plays a key role in the regulation of Ferroptosis (Yao et al., 2021).”
BackgroundInsights into emerging mechanisms of ferroptosis: new regulators for cancer therapeutics
Xu, S., Yin, S., Wang, L., Zhong, H., Wang, H., & Yu, H.-Y. (2025) · Cell Biology and Toxicology · doi:10.1007/s10565-025-10010-0 · Cited by 32 · see citing works
“For instance, simvastatin induces ferroptosis in triple-negative breast cancer cells by suppressing HMGR expression, thereby disrupting the MVA pathway and downregulating GPX4 (Yao et al. 2021).”
A guide to ferroptosis, the biological rust of cellular membranes
Veeckmans, G., San, E. V., & Berghe, T. V. (2023) · FEBS Journal · doi:10.1111/febs.16993 · Cited by 33 · see citing works
“Finally, different statins have been classified as class III inducers since it inhibits HMG-CoA reductase enzyme which in turn blocks CoQ 10 bio-synthesis [52,53].”
BackgroundOrganic Selenium induces ferroptosis in pancreatic cancer cells
Noè, R., Inglese, N., Romani, P., Serafini, T., Paoli, C., Calciolari, B., Fantuz, M., Zamborlin, A., Surdo, N. C., Spada, V., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102962 · Cited by 30 · see citing works
“We demonstrated that statins administration elicits oxidative stress and ferroptotic death in multiple PDA cells, in line with results obtained in other tumor types [65 – 68].”
ResultFerroptosis, a therapeutic target for cardiovascular diseases, neurodegenerative diseases and cancer
Li, Y.-H., Liu, C., Fang, B., Chen, X., Wang, K., Xin, H., Wang, K., & Yang, S. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05881-6 · Cited by 29 · see citing works
Non-apoptotic cell death programs in cervical cancer with an emphasis on ferroptosis
Samare‐Najaf, M., Samareh, A. N., Savardashtaki, A., Khajehyar, N., Tajbakhsh, A., Vakili, S., Moghadam, D., Rastegar, S., Mohsenizadeh, M., Jahromi, B. N., et al. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2023.104249 · Cited by 31 · see citing works
Recent advances of ferroptosis in tumor: From biological function to clinical application.
Hu, S., Chu, Y., Zhou, X., & Wang, X. (2023) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2023.115419 · Cited by 29 · see citing works
Targeting ferroptosis: a promising strategy to overcome drug resistance in breast cancer
Peng, C., Chen, Y., & Jiang, M. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1499125 · Cited by 28 · see citing works
Targeting lipid metabolism via nanomedicine: A prospective strategy for cancer therapy
Huang, X., Hou, S., Li, Y., Xu, G., Xia, N., Duan, Z., Luo, K., & Tian, B. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.123022 · Cited by 23 · see citing works
Compounds targeting ferroptosis in breast cancer: progress and their therapeutic potential
Xu, C., Chen, Y., Yu, Q., Song, J., Jin, Y. H., & Gao, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1243286 · Cited by 28 · see citing works
Broadening horizons: the multifaceted role of ferroptosis in breast cancer
Ge, A., Wang, X., Li, Y., Da, Z., Chen, J., Daga, P., Dai, C. C., Yang, K., Yan, Y., Hao, M., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1455741 · Cited by 25 · see citing works
Zhang, Z.-Q., Liang, X.-Y., Yang, X., Liu, Y., Zhou, X., & Li, C.-H. (2024) · ACS Applied Materials and Interfaces · doi:10.1021/acsami.3c15686 · Cited by 26 · see citing works
Wang, J.-G., Li, Y., Zhang, J., & Luo, C. (2023) · Immunopharmacology and immunotoxicology · doi:10.1080/08923973.2023.2165943 · Cited by 26 · see citing works
“The same inhibitory effect of 18-b-glycyrrhetinic acid [8] and simvastatin [9] on the proliferation of triple-negative breast cancer is confirmed by activating ferroptosis.”
BackgroundKuche, K., Yadav, V., Patel, M., Chaudhari, D., Date, T., & Jain, S. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213700 · Cited by 25
Progress in the Mechanism of the Effect of Fe3O4 Nanomaterials on Ferroptosis in Tumor Cells
Wang, Y.-X., Wu, X., Bao, X.-Y., & Mou, X. (2023) · Molecules · doi:10.3390/molecules28114562 · Cited by 25
“Yao et al. [108] prepared a novel ferroptosis nanodrug by loading simvastatin (SIM) into amphoteric polymer-coated magnetic nanoparticles (Fe 3 O 4 @PCBMA) to improve the therapeutic effect of TNBC. SIM could inhibit the expression of HMG-CoA reductase (HMGCR) and down-regulated the mevalonate…”
BackgroundZhao, X., Wang, X., & Pang, Y. (2022) · Pharmaceuticals · doi:10.3390/ph15111360 · Cited by 32 · see citing works
“Recent evidence suggests that the activation of ferroptosis is an efficient method to inhibit breast cancer [11,12].”
MethodThe Role of Cholesterol Metabolism and Its Regulation in Tumor Development
Wu, Y., Song, W., Su, M., He, J., Hu, R., & Zhao, Y. (2025) · Cancer Medicine · doi:10.1002/cam4.70783 · Cited by 23 · see citing works
Metabolic Regulation of Ferroptosis in Breast Cancer
Glibetic, N., & Weichhaus, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199686 · Cited by 23
“Natural compounds like toxicarioside H and statins deplete GSH to trigger ferroptosis in TNBC [163,164].”
Programmed Cell Death in Cancer
Wei, Y., Hankey, W., Xu, D.-L., & Yuan, F.-W. (2025) · MedComm · doi:10.1002/mco2.70357 · Cited by 23 · see citing works
Zhu, H., Jiang, C., Zhang, W., Yang, Z., & Sun, G. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02196-9 · Cited by 23
“Ferroptosis, an iron-dependent type of cell death, has been shown to be involved in resistance to TNBC [10, 11].”
BackgroundYuan, L.-F., Liu, J.-N., Bao, L., Qu, H.-J., Xiang, J.-Y., & Sun, P. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1032364 · Cited by 23 · see citing works
Senigagliesi, B., Samperi, G., Cefarin, N., Gneo, L., Petrosino, S., Apollonio, M., Caponnetto, F., Sgarra, R., Collavin, L., Cesselli, D., et al. (2022) · bioRxiv · doi:10.1101/2022.02.28.481921 · Cited by 23
“Therefore, shedding light on the biological mechanisms of the metastatic progression in TNBC is urgent to track down novel therapeutic approaches for effective interventions (Yao et al., 2021).”
Targeting ferroptosis in cancer: from mechanistic insights to therapeutic approaches
Wang, J., Guo, D.-W., Jiang, S.-X., Wu, W.-D., & Gao, X.-G. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00416-5 · Cited by 22 · see citing works
“Statins (e.g., simvastatin, lovastatin), inhibitors of HMG-CoA reductase in the mevalonate pathway, deplete CoQ10 and promote GPX4 degradation, inducing ferroptosis [297].”
Ferroptosis-targeting drugs in breast cancer
Zhang, S.-X., Guo, L., Tao, R., & Liu, S.-P. (2024) · Journal of drug targeting (Print) · doi:10.1080/1061186x.2024.2399181 · Cited by 22 · see citing works
“…3 O 4 @PcBMA-SiM nanoparticles inhibit the MvA pathway, leading to the inactivation of GPX4 and the initiation of ferroptosis. these findings indicate that Fe 3 O 4 @PcBMA-SiM nanoparticles exhibit a promising anti-tNBc effect, offering a novel therapeutic approach for the treatment of tNBc [112].”
Chen, Y., Pan, G., Wu, F., Zhang, Y., Li, Y., & Luo, D. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116971 · Cited by 22 · see citing works
Tamoxifen induces ferroptosis in MCF-7 organoid.
Ye, L., Zhong, F., Sun, S., Ou, X., Yuan, J., Zhu, J., & Zeng, Z.-Q. (2023) · Journal of Cancer Research and Therapeutics · doi:10.4103/jcrt.jcrt_608_23 · Cited by 22 · see citing works
PLAGL2 promotes bladder cancer progression via RACGAP1/RhoA GTPase/YAP1 signaling
Chen, H.-L., Yang, W.-J., Li, Y.-J., & Ji, Z. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05970-2 · Cited by 22 · see citing works
“Mechanistically, simvastatin could promote p-YAP by repressing RhoA GTPase activity and inhibit cancer cell proliferation and migration, such as in breast cancer [54] and pancreatic cancer [55].”
BackgroundSelf-citationSimvastatin inhibits PD-L1 via ILF3 to induce ferroptosis in gastric cancer cells
Sun, D., Cui, X., Yang, W., Meng, W., Yan, Z., Zhang, M., Yu, W., & Yu, W. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07562-8 · Cited by 19 · see citing works
“In breast cancer, simvastatin inhibits HMGCR expression and suppresses the mevalonate (MVA) pathway and glutathione peroxidase 4 (GPX4) production, which induces cancer cell ferroptosis [10].”
Self-citationTargeting regulated cell death pathways in cancers for effective treatment: a comprehensive review
Saxena, R., Welsh, C. M., & He, Y.-W. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1462339 · Cited by 26 · see citing works
Liu, J., Zhang, B., Zhang, G., & Shang, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1345838 · Cited by 21 · see citing works
Ferroptosis in Cancer: Epigenetic Control and Therapeutic Opportunities
Tranchese, R. V., Battista, S., Cerchia, L., & Fedele, M. (2024) · Biomolecules · doi:10.3390/biom14111443 · Cited by 19 · see citing works
“Cancer stem cell reduction [189] Melanoma Overcoming chemotherapy resistance [190] NSCLC Overcoming chemotherapy resistance [191] Neratinib Increase in intracellular iron levels Breast cancer Suppression of brain metastasis [192] Inhibition of anti-oxidant defense”
Ning, Y., Fang, S., Zhang, R., Fang, J., Lin, K., Ding, Y., Nie, H., Zhou, J., Zhao, Q., Ke, H., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113244 · Cited by 17 · see citing works
PTGER3 knockdown inhibits the vulnerability of triple‐negative breast cancer to ferroptosis
Wang, S., Zhang, Y.-Y., Zhang, D., Meng, J., Che, N., Zhao, X.-L., & Liu, T. (2024) · Cancer Science · doi:10.1111/cas.16169 · Cited by 20 · see citing works
Zhang, Z., Wu, Y., Liu, Y., Zhang, J.-Y., Zhang, Y., Dai, Y., & Liu, C.-G. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.06.052 · Cited by 19 · see citing works
“…3) GPX4 and GSH suppress LPO accumulation [250] Fe 3 O 4 @PCBMA-SIM EPR 1) GPX4 and GSH suppress LPO accumulation 2) Iron metabolism 1) SIM [252] BC - LNPs@PTX EPR 1) Mitochondrial lipid peroxidation 2) Iron metabolism 1) PTX 2) Alendronate [259] PEG - PDA@Mn EPR 1) Fenton-like reaction 2)…”
A Systematic Review of Nanoparticle-Mediated Ferroptosis in Glioma Therapy
Jing, L., Xiao, W., Hu, Z.-X., Liu, X., & Yuan, M.-Q. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s523008 · Cited by 19 · see citing works
“The mevalonate (MVA) pathway 45 further contributes to ferroptosis by influencing GPX4 biosynthesis through the regulation of selenocysteine tRNA maturation, thereby enhancing lipid peroxidation.”
Ferroptosis in cancer: Mechanisms, therapeutic strategies, and clinical implications.
Mamaghani, M. P., Mousavikia, S., & Azimian, H. (2025) · Pathology, Research and Practice · doi:10.1016/j.prp.2025.155907 · Cited by 19 · see citing works
Xie, C., Chan, L.-J., Pang, Y.-Y., Shang, Y.-F., Wang, W.-J., & Zhao, L.-C. (2025) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/s00210-025-03927-0 · Cited by 19 · see citing works
“In recent years, the mechanisms of ferroptosis have garnered widespread attention in the field of cancer therapy (Yao et al. 2021).”
Imam, M., Ji, J., Zhang, Z., & Yan, S. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1493188 · Cited by 17 · see citing works
Xie, M., Meng, F., Wang, P., Díaz, A., Parkhats, M. V., Santos‐Oliveira, R., Asim, M. H., Bostan, N., Gu, H., Yang, L., et al. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s477652 · Cited by 39 · see citing works
Cholesterol-ferroptosis nexus: Unveiling novel cancer therapeutic avenues.
Lee, J., & Roh, J.-L. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217046 · Cited by 19 · see citing works
Poddar, A., Rao, S. R., Prithviraj, P., Kannourakis, G., & Jayachandran, A. (2022) · Current Oncology · doi:10.3390/curroncol29100540 · Cited by 24 · see citing works
Peng, Z., Yi, Y., Nie, Y., Wang, T., Tang, J., Hong, S., Liu, Y., Huang, W., Sun, S., Tan, H. F., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.05.027 · Cited by 17 · see citing works
Self-citationFerroptosis: Potential opportunities for natural products in cancer therapy
Nie, A.-Z., Shen, C., Zhou, Z., Wang, J., Sun, B., & Zhu, C. (2023) · Phytotherapy Research · doi:10.1002/ptr.8088 · Cited by 18
“In addition to natural products, certain small-molecule compounds, including sorafenib, simvastatin, sulconazole, and erastin, may inhibit the development of various cancers by inducing ferroptosis (Bao et al., 2021; L. X. Liu, Heng, et al., 2023; Qian et al., 2023; X. Yao et al., 2021).”
Background
- Authors
- Yao, X., Xie, R., Cao, Y., Tang, J., Men, Y., Peng, H., & Yang, W.
- Affiliations
- Fudan University (CN)
- Stanford University (US)
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Peng, Haibao
- Yang, Wuli
- Venue
- Journal of Nanobiotechnology
- Published
- 2021-10-09
- Volume
- 19
- Issue
- 1
- Pages
- 311-311
- ISSN
- 1477-3155 (ISSN-L)
- PMC
- PMC8502296
- OpenAlex
- W3206510813
- Cited by
- 227
- References
- 41
- Citations by year
- 2026: 27 · 2025: 67 · 2024: 59 · 2023: 44 · 2022: 29 · 2021: 1
- FWCI
- 21.75
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Nanobiotechnology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- national natural science foundation of china (Grant Nos. 51933002, 51873041, 81902756)
- program of shanghai academic research leader (20XD1400400)
- the open project of state key laboratory of molecular engineering of polymers (No. K2021-19)
- shanghai sailing program (No.19Y1439900)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- triple-negative breast cancer, ferroptosis, simvastatin, statins, HMGCR, mevalonate pathway, GPX4, Fe3O4 magnetic nanoparticles, nanomedicine, lipid peroxidation, drug resistance, MDA-MB-231 cells, tumor accumulation
- MeSH terms
- Ferroptosis, Animals, Delayed-Action Preparations, Drug Carriers, Female, Humans, Male, Mice, Nude, Signal Transduction, Simvastatin, Cell Line, Tumor, Mice, Magnetite Nanoparticles, MCF-7 Cells, Triple Negative Breast Neoplasms
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