The origin and evolution of mutations in acute myeloid leukemia

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8. Clonal evolution and hierarchy in myeloid malignancies
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9. Comprehensive single-cell genome analysis at nucleotide resolution using the PTA Analysis Toolbox
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10. Preleukemia
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11. DNA replication stress and its impact on chromosome segregation and tumorigenesis
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12. Genetic and Epigenetic Perturbations by DNMT3A-R882 Mutants Impaired Apoptosis through Augmentation of PRDX2 in Myeloid Leukemia Cells
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17. Updates in molecular genetics of acute myeloid leukemia
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18. p53 biology and reactivation for improved therapy in MDS and AML
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19. Endothelial cell derived angiocrine support of acute myeloid leukemia targeted by receptor tyrosine kinase inhibition
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20. The Ins and Outs of Autophagy and Metabolism in Hematopoietic and Leukemic Stem Cells: Food for Thought
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21. Somatic mutations and T-cell clonality in patients with immunodeficiency
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22. The Role of Somatic Mutations in Acute Myeloid Leukemia Pathogenesis
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23. Clonal dynamics in a single AML case tracked for 9 years reveals the complexity of leukemia progression
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24. Precision oncology: lessons learned and challenges for the future
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25. CD123 as a Therapeutic Target Against Malignant Stem Cells
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26. Colony Stimulating Factor 1 Receptor in Acute Myeloid Leukemia
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27. Tumoral reprogramming: Plasticity takes a walk on the wild side.
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28. A pilot study of chromosomal aberrations and epigenetic changes in peripheral blood samples to identify patients with melanoma
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29. Genetic Mosaicism and Cancer: Cause and Effect
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30. Clonal dominance is an adverse prognostic factor in acute myeloid leukemia treated with intensive chemotherapy
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31. The meiosis-specific cohesin component stromal antigen 3 promotes cell migration and chemotherapeutic resistance in colorectal cancer
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32. The Genomics of Myelodysplastic Syndromes: Origins of Disease Evolution, Biological Pathways, and Prognostic Implications
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33. Genome wide CRISPR screening reveals a role for sialylation in the tumorigenesis and chemoresistance of acute myeloid leukemia cells
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34. Higher-order orchestration of hematopoiesis: Is cohesin a new player?
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35. The Fanconi anemia pathway is required for efficient repair of stress-induced DNA damage in haematopoietic stem cells
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36. <i>Txnip</i> Enhances Fitness of <i>Dnmt3a</i> -Mutant Hematopoietic Stem Cells via <i>p21</i>
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37. Genomic tools in acute myeloid leukemia: From the bench to the bedside
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38. Aldehyde dehydrogenases in acute myeloid leukemia
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39. Three patients with DeSanto‐Shinawi syndrome: Further phenotypic delineation
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40. Dual lysosomal-mitochondrial targeting by antihistamines to eradicate leukaemic cells
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41. Loss of ISWI ATPase SMARCA5 (SNF2H) in Acute Myeloid Leukemia Cells Inhibits Proliferation and Chromatid Cohesion
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42. The Mutational and Transcriptional Landscapes of Hepatocarcinogenesis in a Rat Model
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43. Pharmacological impact of FLT3 mutations on receptor activity and responsiveness to tyrosine kinase inhibitors
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44. Interrogating breast cancer heterogeneity using single and pooled circulating tumor cell analysis
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45. Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice
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46. Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome
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47. Revealing very small FLT3 ITD mutated clones by ultra-deep sequencing analysis has important clinical implications in AML patients
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48. The clonal evolution of leukemic stem cells in T-cell acute lymphoblastic leukemia
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49. Co-operative leukemogenesis in acute myeloid leukemia and acute promyelocytic leukemia reveals C/EBP as a common target of TRIB1 and PML/RARA
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50. Peripheral blood cell‐free DNA is an alternative tumor DNA source reflecting disease status in myelodysplastic syndromes
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51. MicroRNA-106b~25 cluster is upregulated in relapsed MLL-rearranged pediatric acute myeloid leukemia
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52. Replication stress in hematopoietic stem cells in mouse and man
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53. Discovery of a highly selective FLT3 inhibitor with specific proliferation inhibition against AML cells harboring FLT3-ITD mutation
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54. Clonal hematopoiesis driven by somatic mutations: A new player in atherosclerotic cardiovascular disease
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55. Nuclear α-catenin mediates the DNA damage response via β-catenin and nuclear actin
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56. PU.1-Dependent Enhancer Inhibition Separates <i>Tet2</i> -Deficient Hematopoiesis from Malignant Transformation
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57. Clonal evolution of hematopoietic stem cells after autologous stem cell transplantation
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58. Mutation Position Within Evolutionary Subclonal Architecture in AML
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59. Report of a new six-panel flow cytometry marker for early differential diagnosis of APL from HLA-DR negative Non-APL leukemia
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60. Acute Myeloid Leukemia: From Biology to Clinical Practices Through Development and Pre-Clinical Therapeutics
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61. The genetics of myelodysplastic syndromes and the opportunities for tailored treatments
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62. Sister chromatid cohesion defects are associated with chromosome instability in Hodgkin lymphoma cells
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63. Molecular Changes During Acute Myeloid Leukemia (AML) Evolution and Identification of Novel Treatment Strategies Through Molecular Stratification
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64. RNA-Guided CRISPR-Cas9 System-Mediated Engineering of Acute Myeloid Leukemia Mutations
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65. Self-assembling nanoparticles based on cytarabine prodrug for enhanced leukemia treatment
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66. Oncogenic N-Ras and Tet2 haploinsufficiency collaborate to dysregulate hematopoietic stem and progenitor cells
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67. Leukemia Stem Cells as a Potential Target to Achieve Therapy-Free Remission in Chronic Myeloid Leukemia
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68. Bone Marrow Micro‐Environment in Normal and Deranged Hematopoiesis: Opportunities for Regenerative Medicine and Therapies
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69. Acute myeloid leukaemia
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71. How aging influences the gut-bone marrow axis and alters hematopoietic stem cell regulation
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72. Why Is Progress in Acute Myeloid Leukemia So Slow?
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73. Novel Therapies for Acute Myeloid Leukemia: Are We Finally Breaking the Deadlock?
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74. Isoform-specific and signaling-dependent propagation of acute myeloid leukemia by Wilms tumor 1
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75. Causes of Clonal Hematopoiesis: a Review
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76. Cancer as a Disease of Development Gone Awry
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77. Stem cell heterogeneity, plasticity, and regulation
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78. Mutation Patterns Predict Drug Sensitivity in Acute Myeloid Leukemia
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79. Clonal evolution and tumor-initiating cells: New dimensions in cancer patient treatment
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80. The Impact of FLT3 Mutations on the Development of Acute Myeloid Leukemias
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81. GATA-1 Inhibits PU.1 Gene via DNA and Histone H3K9 Methylation of Its Distal Enhancer in Erythroleukemia
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82. MicroRNAs in Control of Stem Cells in Normal and Malignant Hematopoiesis
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83. Characterization of peritoneal leukemia-associated macrophages in Notch1-induced mouse T cell acute lymphoblastic leukemia
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84. Precision medicine in the treatment stratification of AML patients: challenges and progress
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85. Targeting leukemia-specific dependence on the de novo purine synthesis pathway
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87. FLT3 inhibitors in acute myeloid leukemia: Choosing the best when the optimal does not exist
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88. High mtDNA content identifies oxidative phosphorylation-driven acute myeloid leukemias and represents a therapeutic vulnerability
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89. Perspectives and future directions for epigenetics in hematology
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90. Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes
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92. Immuno-oncology from the perspective of somatic evolution
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93. Alternative splicing of the tumor suppressor ASPP2 results in a stress-inducible, oncogenic isoform prevalent in acute leukemia
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96. Molecular pathogenesis of AML: Translating insights to the clinic
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97. Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model
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98. Aurea Mediocritas: The Importance of a Balanced Genome
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99. Clonal Hematopoiesis and Premalignant Diseases
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100. The cancer genome: from structure to function
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