The origin and evolution of mutations in acute myeloid leukemia

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Items 201–300 of 1,001

1. Next-generation sequencing of acute myeloid leukemia identifies the significance of TP53, U2AF1, ASXL1, and TET2 mutations
   Robert Shigeo Ohgami, Lisa Ma, Jason D. Merker, Jason R. Gotlib, Iris Schrijver, James L. Zehnder, Daniel A. Arber · 2014 · Modern Pathology
2. Current treatment of acute myeloid leukemia
   Gail J. Roboz · 2012 · Current Opinion in Oncology
3. Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6
   Iris Z. Uras, Gina J. Walter, Ruth Scheicher, Florian Bellutti, Michaela Prchal‐Murphy, Anca-Sarmiza Tigan, Peter Valent, Florian Heinrich Heidel, Stefan Kubicek, Claudia Scholl et al. · 2016 · Blood
4. Cohesin acetylation and Wapl-Pds5 oppositely regulate translocation of cohesin along DNA
   Kanke, Mai, Tahara, Eri, Huis in't Veld, Pim J, Nishiyama, Tomoko · 2016 · The EMBO Journal
5. Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia
   Vikas Madan, Pavithra Shyamsunder, Lin Han, Anand Mayakonda, Yasunobu Nagata, Janani Sundaresan, Deepika Kanojia, Kenichi Yoshida, Saravanan Ganesan, Norimichi Hattori et al. · 2016 · Leukemia
6. Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia
   Pierre Hirsch, Yanyan Zhang, Ruoping Tang, Virginie Joulin, Hélène Boutroux, Elodie Pronier, Hannah Moatti, Pascale Flandrin‐Gresta, Christophe Marzac, Dominique Bories et al. · 2016 · Nature Communications
7. Performance of Common Analysis Methods for Detecting Low-Frequency Single Nucleotide Variants in Targeted Next-Generation Sequence Data
   David H. Spencer, Manoj G Tyagi, Francesco Vallania, Andrew J. Bredemeyer, John D. Pfeifer, Robi David Mitra, Eric James Duncavage · 2013 · Journal of Molecular Diagnostics
8. Somatic mutations, genome mosaicism, cancer and aging
   Jan Vijg · 2014 · Current Opinion in Genetics & Development
9. A simple one-tube assay for immunophenotypical quantification of leukemic stem cells in acute myeloid leukemia
   Wendelien Zeijlemaker, Angèle Kelder, Yvonne J.M Oussoren-Brockhoff, Willemijn J. Scholten, Alexander N. Snel, Dennis Veldhuizen, Jacqueline J Cloos, Gert Jan Ossenkoppele, Gerrit Jan Schuurhuis · 2015 · Leukemia
10. Cancer-mutation network and the number and specificity of driver mutations
    Jaime Iranzo, Iñigo Martincorena, Eugene V. Koonin · 2018 · Proceedings of the National Academy of Sciences
11. Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS
    Takuji Yamauchi, Takeshi Masuda, Matthew C. Canver, Michael Seiler, Yuichiro Semba, Mohammad Shboul, Mohammed Al‐Raqad, Manami Maeda, Vivien A. C. Schoonenberg, Mitchel A. Cole et al. · 2018 · Cancer Cell
12. Single-cell developmental classification of B cell precursor acute lymphoblastic leukemia at diagnosis reveals predictors of relapse
    Zinaida Good, Jolanda Sarno, Astraea Jager, Nikolay Samusik, Nima Aghaeepour, Erin F. Simonds, Leah White, Norman James Lacayo, Wendy J. Fantl, Grazia Fazio et al. · 2018 · Nature Medicine
13. Clonal hematopoiesis associated with epigenetic aging and clinical outcomes
    Daniel C. Nachun, Ake Tzu-Hui Lu, Alexander G. Bick, Pradeep Natarajan, Joshua S. Weinstock, Mindy D Szeto, Sekar Kathiresan, Gonçalo R. Abecasis, Kent D. Taylor, Xiuqing Guo et al. · 2021 · Aging Cell
14. Clonal Hematopoiesis: Mechanisms Driving Dominance of Stem Cell Clones
    Challen, Grant, Goodell, Margaret A · 2020 · Blood
15. Clonal Architecture of Secondary Acute Myeloid Leukemia Defined by Single-Cell Sequencing
    Andrew E. O. Hughes, Vincent J. Magrini, Ryan Demeter, Christopher A. Miller, Robert S. Fulton, Lucinda Fulton, William C. Eades, Kevin Elliott, Sharon E. Heath, Peter Westervelt et al. · 2014 · PLoS Genetics
16. MRD in AML: The Role of New Techniques
    Maria Teresa Voso, Tiziana Ottone, Serena Lavorgna, Adriano Venditti, Luca Maurillo, Francesco Lo‐Coco, Francesco Buccisano · 2019 · Frontiers in Oncology
17. Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging
    Jakobsen, Niels Asger, Turkalj, Sven, Zeng, Andy G.X., Stoilova, Bilyana, Metzner, Marlen, Rahmig, Susann, Nagree, Murtaza S., Shah, Sayyam, Moore, Rachel, Usukhbayar, Batchimeg et al. · 2024 · Cell Stem Cell
18. Genomic insights into cancer-associated aberrant CpG island hypermethylation
    Duncan Sproul, Richard R. Meehan · 2013 · Briefings in Functional Genomics
19. Biology of Cancer and Aging: A Complex Association With Cellular Senescence
    Claire Falandry, Marc Bonnefoy, Gilles Freyer, Éric Gilson · 2014 · Journal of Clinical Oncology
20. Somatic genetic rescue in Mendelian haematopoietic diseases
    Patrick Revy, Caroline Kannengiesser, Alain Fischer · 2019 · Nature Reviews Genetics
21. Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis
    Matthew A. Loberg, Rebecca K. Bell, Leslie O. Goodwin, Elizabeth Eudy, Linde A. Miles, Jennifer Myers SanMiguel, Kira A. Young, David E. Bergstrom, Ross L. Levine, Rebekka K. Schneider et al. · 2019 · Leukemia
22. Cohesin mutations in human cancer
    Victoria K. Hill, Jung-Sik Kim, Todd A. Waldman · 2016 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
23. Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure
    Maximilian Mossner, Johann-Christoph Jann, Janina Wittig, Florian Nolte, Stéphanie Fey, Verena Nowak, Julia Obländer, Jovita Pressler, Iris Palme, Christina Xanthopoulos et al. · 2016 · Blood
24. Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia
    Will, Britta, Vogler, Thomas O, Narayanagari, Swathi, Bartholdy, Boris, Todorova, Tihomira I, da Silva Ferreira, Mariana, Chen, Jiahao, Yu, Yiting, Mayer, Jillian, Barreyro, Laura et al. · 2015 · Nature Medicine
25. Next generation sequencing in cancer research and clinical application
    Derek Shyr, Qi Liu · 2013 · Biological Procedures Online
26. Somatic neurofibromatosis type 1 (NF1) inactivation characterizes NF1-associated pilocytic astrocytoma
    David H. Gutmann, Michael D. McLellan, Ibrahim Hussain, John W. Wallis, Lucinda Fulton, Robert S. Fulton, Vincent J. Magrini, Ryan Demeter, Todd Wylie, Cyriac Kandoth et al. · 2012 · Genome Research
27. APOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa
    Raymond Jaihyun Cho, Ludmil B. Alexandrov, Nicoline Y. den Breems, Velina S. Atanasova, Mehdi Farshchian, Elizabeth A. Purdom, Tran Nguyen, Cristian Coarfa, Kimal Rajapakshe, Marco di Prisco et al. · 2018 · Science Translational Medicine
28. Translational implications of somatic genomics in acute myeloid leukaemia
    Sara C. Meyer, Ross L. Levine · 2014 · The Lancet Oncology
29. Molecular and genetic alterations associated with therapy resistance and relapse of acute myeloid leukemia
    Hubert Hackl, Ksenia Astanina, Rotraud Wieser · 2017 · Journal of Hematology & Oncology
30. Somatic mutations and clonal hematopoiesis in congenital neutropenia
    Jun Xia, Christopher A. Miller, Jack Baty, Amrita Ramesh, Matthew R. M. Jotte, Robert S. Fulton, Tiphanie P. Vogel, Megan A. Cooper, Kelly J. Walkovich, Vahagn Makaryan et al. · 2017 · Blood
31. Clonal evolution of acute myeloid leukemia from diagnosis to relapse
    Sebastian Vosberg, Philipp A. Greif · 2019 · Genes Chromosomes and Cancer
32. Origins of aberrant DNA methylation in acute myeloid leukemia
    Till Schoofs, Wolfgang E. Berdel, Carsten Müller‐Tidow · 2013 · Leukemia
33. Mutational spectrum of adult T-ALL
    Martín Neumann, Sebastian Vosberg, Cornelia Schlee, Sandra Heesch, Stefan Schwartz, Nicola Gökbuget, Dieter F. Hoelzer, Alexander Graf, Stefan Krebs, Isabelle Bartram et al. · 2014 · Oncotarget
34. Molecular therapy for acute myeloid leukaemia
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35. Serum 2-Hydroxyglutarate Production in IDH1- and IDH2-Mutated De Novo Acute Myeloid Leukemia: A Study by the Acute Leukemia French Association Group
    Maxime Janin, Elena Mylonas, Véronique Saada, Jean‐Baptiste Micol, Aline Renneville, Cyril Quivoron, Serge Koscielny, Laurianne Scourzic, Sébastien Forget, Cécile Pautas et al. · 2013 · Journal of Clinical Oncology
36. Nuclear Lamins in Cancer
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37. Intratumoral heterogeneity and drug resistance in cancer
    Yue-Chun Fu, Shao-Bo Liang, Min Luo, Xue‐Ping Wang · 2025 · Cancer Cell International
38. Canine osteosarcoma genome sequencing identifies recurrent mutations in DMD and the histone methyltransferase gene SETD2
    Gardner, Heather L., Sivaprakasam, Karthigayini, Briones, Natalia, Zismann, Victoria, Perdigones, Nieves, Drenner, Kevin, Facista, Salvatore, Richholt, Ryan, Liang, Winnie, Aldrich, Jessica et al. · 2019 · Communications Biology
39. Secondary myelodysplastic syndrome and leukemia in acquired aplastic anemia and paroxysmal nocturnal hemoglobinuria
    Lova Sun, Daria V. Babushok · 2020 · Blood
40. Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia.
    B. Salik, H. Yi, Nunki Hassan, Nancy T. Santiappillai, B. Vick, Patrick Connerty, Alastair Duly, T. Trahair, A. Woo, D. Beck et al. · 2020 · Cancer Cell
41. Clonal hematopoiesis and measurable residual disease assessment in acute myeloid leukemia
    Robert Paul Hasserjian, David P. Steensma, Timothy Aaron Graubert, Benjamin L. Ebert · 2020 · Blood
42. Scalable Prediction of Acute Myeloid Leukemia Using High-Dimensional Machine Learning and Blood Transcriptomics
    Warnat-Herresthal, Stefanie, Perrakis, Konstantinos, Taschler, Bernd, Becker, Matthias, Baßler, Kevin, Beyer, Marc, Günther, Patrick, Schulte-Schrepping, Jonas, Seep, Lea, Klee, Kathrin et al. · 2020 · iScience
43. Emerging themes in cohesin cancer biology
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44. Diverse mutational landscapes in human lymphocytes
    Machado, Heather E., Mitchell, Emily, Øbro, Nina F., Kübler, Kirsten, Davies, Megan, Leongamornlert, Daniel, Cull, Alyssa, Maura, Francesco, Sanders, Mathijs A., Cagan, Alex T. J. et al. · 2022 · Nature
45. Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia
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46. Identification of Bruton’s tyrosine kinase as a therapeutic target in acute myeloid leukemia
    Stuart A. Rushworth, Megan Y. Murray, Lyubov Zaitseva, Kristian M. Bowles, David J. MacEwan · 2013 · Blood
47. Clonal Hematopoiesis
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48. The role of TP53 in acute myeloid leukemia: Challenges and opportunities
    Karina Barbosa, Sha Li, Peter D. Adams, Aniruddha J. Deshpande · 2019 · Genes Chromosomes and Cancer
49. DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages
    Isidoro Cobo, Tiffany N. Tanaka, Kailash Chandra Mangalhara, Addison J. Lana, Calvin Yeang, Claudia Z. Han, Johannes C. M. Schlachetzki, Jean Challcombe, Bethany R. Fixsen, Mashito Sakai et al. · 2022 · Immunity
50. Genetic and epigenetic determinants of AML pathogenesis
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51. Mass cytometry analysis reveals hyperactive NF Kappa B signaling in myelofibrosis and secondary acute myeloid leukemia
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52. Transcription Restores DNA Repair to Heterochromatin, Determining Regional Mutation Rates in Cancer Genomes
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53. Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models
    Lina Han, Qi Zhang, Monique Dail, Ce Shi, Antonio Cavazos, Vivian R. Ruvolo, Yang Zhao, Eugene S. Kim, Mohamed Rahmani, Duncan H. F. Mak et al. · 2019 · Haematologica
54. Preclinical efficacy of MEK inhibition in Nras-mutant AML
    Michael R. Burgess, Eugene Hwang, Ari J. Firestone, Tannie Q. Huang, Jin Xu, Johannes A. Zuber, Natacha Bohin, Tiffany Wen, Scott C. Kogan, Kevin M. Haigis et al. · 2014 · Blood
55. The Epigenetic Landscape of Acute Myeloid Leukemia
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56. Global mapping of cancers: The Cancer Genome Atlas and beyond
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57. Portrait of a cancer: mutational signature analyses for cancer diagnostics
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58. Whole-genome sequencing identifies genomic heterogeneity at a nucleotide and chromosomal level in bladder cancer
    Quaid Morris, Pengyuan Liu, Anna Woloszynska‐Read, Jianmin Zhang, Wei Feng Luo, Maochun Qin, Wiam Bshara, Jeffrey M. Conroy, Linda M. Sabatini, Peter T. Vedell et al. · 2014 · Proceedings of the National Academy of Sciences
59. An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state
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60. Anti-CD33 chimeric antigen receptor targeting of acute myeloid leukemia
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61. Mutations of myelodysplastic syndromes (MDS): An update
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62. Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy
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63. Clinical, molecular, and prognostic correlates of number, type, and functional localization of TET2 mutations in chronic myelomonocytic leukemia (CMML)—a study of 1084 patients
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64. Epigenetic Regulation of Genomic Stability by Vitamin C
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65. Inferring Clonal Composition from Multiple Sections of a Breast Cancer
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66. Clonal Hematopoiesis of Indeterminate Potential
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67. Aging and Hematopoiesis
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68. An evolutionary perspective on chronic myelomonocytic leukemia
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69. Adaptive endoplasmic reticulum stress signalling via IRE1α-XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells
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70. A cloud-based workflow to quantify transcript-expression levels in public cancer compendia
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71. Understanding genomic alterations in cancer genomes using an integrative network approach
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72. Tumor Evolutionary Principles: How Intratumor Heterogeneity Influences Cancer Treatment and Outcome
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73. DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells
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74. FLT3tyrosine kinase inhibitors in acute myeloid leukemia: clinical implications and limitations
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75. Prospective Isolation and Characterization of Genetically and Functionally Distinct AML Subclones
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76. Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan
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77. Clonal hematopoiesis and risk for hematologic malignancy
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78. How I treat refractory and relapsed acute myeloid leukemia
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79. Monitoring of residual disease by next-generation deep-sequencing of RUNX1 mutations can identify acute myeloid leukemia patients with resistant disease
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80. Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia
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81. Clonal hematopoiesis and associated diseases: A review of recent findings
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82. Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases
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83. Cancer-associated mutations in endometriosis: shedding light on the pathogenesis and pathophysiology
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84. Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia
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85. Clonality in context: hematopoietic clones in their marrow environment
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86. Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence
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87. Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia
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88. Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres
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89. A novel TCR-like CAR with specificity for PR1/HLA-A2 effectively targets myeloid leukemia in vitro when expressed in human adult peripheral blood and cord blood T cells
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90. Acute myelogenous leukemia in adolescents and young adults
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91. Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage
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92. Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia
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93. New Insights from Studies of Clonal Hematopoiesis
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94. Age influences on the molecular presentation of tumours
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95. The Changing Mutational Landscape of Acute Myeloid Leukemia and Myelodysplastic Syndrome
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96. Monitoring minimal residual disease in acute leukemia: Technical challenges and interpretive complexities
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97. DeTiN: overcoming tumor-in-normal contamination
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98. NCAM1 (CD56) promotes leukemogenesis and confers drug resistance in AML.
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99. Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia
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100. The shadowlands of MDS: idiopathic cytopenias of undetermined significance (ICUS) and clonal hematopoiesis of indeterminate potential (CHIP)
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