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Cited by 25Genetics, Aging, and Longevity in Model OrganismsDNA Repair MechanismsTelomeres, Telomerase, and Senescence

Aging genomes: A necessary evil in the logic of life

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Vijg, Jan·2014·BioEssays
DOI 10.1002/bies.201300127PMC PMC5985526
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Abstract

Genomes are inherently unstable because of the need for DNA sequence variation as a substrate for evolution through natural selection. However, most multicellular organisms have postmitotic tissues, with limited opportunity for selective removal of cells harboring persistent damage and deleterious mutations, which can therefore contribute to functional decline, disease, and death. Key in this process is the role of genome maintenance, the network of protein products that repair DNA damage and signal DNA damage response pathways. Genome maintenance is beneficial early in life by swiftly eliminating DNA damage or damaged cells, facilitating rapid cell proliferation. However, at later ages accumulation of unrepaired damage and mutations, as well as ongoing cell depletion, promotes cancer, atrophy, and other deleterious effects associated with aging. As such, genome maintenance and its phenotypic sequelae provide yet another example of antagonistic pleiotropy in aging and longevity.

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  • DNA damage is more abundant in old cells and tissues.

    “DNA damage is more abundant in old cells and tissues37,38.”

    From SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age (2014) · cites this paper as [38]

    In “DNA damage is abundant, but does it cause aging?” (page unavailable), Vijg reports age-related increases in some forms of DNA damage in animal cells and tissues, but says the results are often conflicting. The section also reports increases in double-strand-break markers in aging mouse tissues and in breaks in human and mouse oocytes. These findings support the general direction of the claim, but not its unqualified assertion about DNA damage in old cells and tissues. (LLM, conf=0.88)

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Sorted by citations

Authors
Vijg, J.
Affiliations
Albert Einstein College of Medicine (US)
Corresponding author
Vijg, Jan
ORCID
Vijg, Jan
Venue
BioEssays
Publisher
Wiley
Published
2014-01-25
Volume
36
Issue
3
Pages
282-292
ISSN
  • 0265-9247 (ISSN-L)
  • 1521-1878
DOI
10.1002/bies.201300127
PMC
PMC5985526
OpenAlex
W1546896073
Cited by
25
References
14
Citations by year
2026: 2 · 2024: 1 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 2
FWCI
0.33
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • BioEssays (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Aging (P01AG017242)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Keywords
genome maintenance, aging, DNA damage response, DNA repair, antagonistic pleiotropy, longevity, postmitotic tissues, somatic mutations, cancer, cellular senescence, functional decline
MeSH terms
Aging, Animals, DNA Damage, Humans, Mutation, Genome, Life

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