The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Transcription of Two Long Noncoding RNAs Mediates Mating-Type Control of Gametogenesis in Budding Yeast
Open accessAbstract
Summary The cell fate decision leading to gametogenesis is essential for sexual reproduction. In S. cerevisiae, only diploid MATa/α but not haploid MATa or MATα cells undergo gametogenesis, known as sporulation. We find that transcription of two long non-coding RNAs (lncRNAs) mediates mating type control of sporulation. In MATa or MATα haploids expression of IME1, the central inducer of gametogenesis, is inhibited in cis by transcription of the lncRNA IRT1, located in the IME1 promoter. IRT1 transcription recruits the Set2 histone methyltransferase and the Set3 histone deacetylase complex to establish repressive chromatin at the IME1 promoter. Inhibiting expression of IRT1 and an antisense transcript that antagonizes the expression of the meiotic regulator IME4, allows cells expressing the haploid mating-type to sporulate with kinetics that are indistinguishable from that of MATa/α diploids. Conversely, expression of the two lncRNAs abolishes sporulation in MATa/α diploids. Thus, transcription of two lncRNAs governs mating type control of gametogenesis in yeast.
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Cotranscriptional Set2 Methylation of Histone H3 Lysine 36 Recruits a Repressive Rpd3 Complex
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The logic of chromatin architecture and remodelling at promoters
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Chia, M., Li, C., Marques, S., Pelechano, V., Luscombe, N. M., & van Werven, F. J. (2021) · Genome Biology · doi:10.1186/s13059-020-02245-3 · Cited by 47
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Metadata
- Authors
- van Werven, F. J., Neuert, G., Hendrick, N., Lardenois, A., Buratowski, S., van Oudenaarden, A., Primig, M., & Amon, A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 150
- Issue
- 6
- Pages
- 1170-1181
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2134903961
- Cited by
- 257
- References
- 52
- FWCI
- 8.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- van Werven, F. J., Neuert, G., Hendrick, N., Lardenois, A., Buratowski, S., van Oudenaarden, A., Primig, M., & Amon, A. (2012). Transcription of Two Long Noncoding RNAs Mediates Mating-Type Control of Gametogenesis in Budding Yeast. Cell. https://doi.org/10.1016/j.cell.2012.06.049
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