The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
A Bistable Circuit Involving SCARECROW-RETINOBLASTOMA Integrates Cues to Inform Asymmetric Stem Cell Division
Open accessAbstract
SUMMARY In plants, where cells cannot migrate, asymmetric cell divisions (ACDs) must be confined to the appropriate spatial context. We investigate tissue-generating asymmetric divisions in a stem cell daughter within the Arabidopsis root. Spatial restriction of these divisions requires physical binding of the stem cell regulator SCARECROW (SCR) by the RETINOBLASTOMA-RELATED (RBR) protein. In the stem cell niche, SCR activity is counteracted by phosphorylation of RBR through a cyclinD6;1-CDK complex. This cyclin is itself under transcriptional control of SCR and its partner SHORT ROOT (SHR), creating a robust bistable circuit with either high or low SHR-SCR complex activity. Auxin biases this circuit by promoting CYCD6;1 transcription. Mathematical modeling shows that ACDs are only switched on after integration of radial and longitudinal information, determined by SHR and auxin distribution, respectively. Coupling of cell-cycle progression to protein degradation resets the circuit, resulting in a “flip flop” that constrains asymmetric cell division to the stem cell region.
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Cites
Network motifs: theory and experimental approaches
Alon, U. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2102 · Cited by 3,279
The Rb/E2F pathway: expanding roles and emerging paradigms
Harbour, J. W., & Dean, D. C. (2000) · Genes & Development · doi:10.1101/gad.813200 · Cited by 1,153 · cited 1×
“In animals, CyclinD/CDK complexes phosphorylate RB and inhibit RB binding to E2F/DP transcription factor complexes that modulate cell-cycle progression (Templeton et al., 1991; Krek et al., 1994; reviewed in Harbour and Dean, 2000).”
BackgroundDi Laurenzio, L., Wysocka-Diller, J., Malamy, J. E., Pysh, L., Helariutta, Y., Freshour, G., Hahn, M. G., Feldmann, K. A., & Benfey, P. N. (1996) · Cell · doi:10.1016/s0092-8674(00)80115-4 · Cited by 1,124
Self-citationJaeger, J., Irons, D., & Monk, N. (2008) · Development · doi:10.1242/dev.018697 · Cited by 110
Rb-Mediated Neuronal Differentiation through Cell-Cycle–Independent Regulation of E2f3a
Chen, D., Opavsky, R., Pacal, M., Tanimoto, N., Wenzel, P., Seeliger, M. W., Leone, G., & Bremner, R. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050179 · Cited by 91
Dick, F. A. (2007) · Cell Division · doi:10.1186/1747-1028-2-26 · Cited by 79
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Self-citationZmbZIP4 Contributes to Stress Resistance in Maize by Regulating ABA Synthesis and Root Development
Ma, H., Liu, C., Li, Z., Ran, Q., Xie, G., Wang, B., Fang, S., Chu, J., & Zhang, J. (2018) · Plant Physiology · doi:10.1104/pp.18.00436 · Cited by 309
Metadata
- Authors
- Cruz-Ramírez, A., Díaz-Triviño, S., Blilou, I., Grieneisen, V. A., Sozzani, R., Zamioudis, C., Miskolczi, P., Nieuwland, J., Benjamins, R., Dhonukshe, P., Caballero-Pérez, J., Horvath, B., Long, Y., Mähönen, A. P., Zhang, H., Xu, J., Murray, J. A. H., Benfey, P. N., Bako, L., Marée, A. F. M., & Scheres, B.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 150
- Issue
- 5
- Pages
- 1002-1015
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2098220565
- Cited by
- 315
- References
- 6
- FWCI
- 29.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cruz-Ramírez, A., Díaz-Triviño, S., Blilou, I., Grieneisen, V. A., Sozzani, R., Zamioudis, C., Miskolczi, P., Nieuwland, J., Benjamins, R., Dhonukshe, P., Caballero-Pérez, J., Horvath, B., Long, Y., Mähönen, A. P., Zhang, H., Xu, J., Murray, J. A. H., Benfey, P. N., Bako, L., . . . Scheres, B. (2012). A Bistable Circuit Involving SCARECROW-RETINOBLASTOMA Integrates Cues to Inform Asymmetric Stem Cell Division. Cell. https://doi.org/10.1016/j.cell.2012.07.017
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
