Structure-function analysis of the retinoblastoma tumor suppressor protein – is the whole a sum of its parts?
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Biochemical analysis of the retinoblastoma protein's function has received considerable attention since it was cloned just over 20 years ago. During this time pRB has emerged as a key regulator of the cell division cycle and its ability to block proliferation is disrupted in the vast majority of human cancers. Much has been learned about the regulation of E2F transcription factors by pRB in the cell cycle. However, many questions remain unresolved and researchers continue to explore this multifunctional protein. In particular, understanding how its biochemical functions contribute to its role as a tumor suppressor remains to be determined. Since pRB has been shown to function as an adaptor molecule that links different proteins together, or to particular promoters, analyzing pRB by disrupting individual protein interactions holds tremendous promise in unraveling the intricacies of its function. Recently, crystal structures have reported how pRB interacts with some of its molecular partners. This information has created the possibility of rationally separating pRB functions by studying mutants that disrupt individual binding sites. This review will focus on literature that investigates pRB by isolating functions based on binding sites within the pocket domain. This article will also discuss the prospects for using this approach to further explore the unknown functions of pRB.
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Among the E2F family, apoptosis induction is largely mediated by E2F1, and its repression by RB involves domains distinct from those controlling cell cycle progression.
“among the E2F family, induction of apoptosis is a function largely mediated by E2F1 and its repression is mediated by specific RB and E2F1 protein domains that are distinct from those through which RB interacts with E2F1, E2F2, E2F3 and E2F4 to control cell cycle progression78.”
From Cellular mechanisms of tumour suppression by the retinoblastoma gene (2008) · cites this paper as [78]
Ectopic RB expression in cultured cells can have nonspecific effects.
“Similarly, because ectopic expression of RB in cells in culture can produce nonspecific effects, a detailed structure–function analysis of RB in vivo will be key to our understanding of RB tumour suppressor functions78.”
From Cellular mechanisms of tumour suppression by the retinoblastoma gene (2008) · cites this paper as [78]
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1 retracted
RETRACTED: The E3 SUMO Ligase PIASy Is a Regulator of Cellular Senescence and Apoptosis
Bischof, O., Schwamborn, K., Martin, N., Werner, A., Sustmann, C., Grosschedl, R., & Dejean, A. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.016 · Cited by 173 · see citing works
RetractedSherr, C. J. (1996) · Science · doi:10.1126/science.274.5293.1672 · Cited by 5,379 · see citing works
The retinoblastoma protein and cell cycle control
Weinberg, R. A. (1995) · Cell · doi:10.1016/0092-8674(95)90385-2 · Cited by 4,862 · see citing works
GDNF: a Glial Cell Line-Derived Neurotrophic Factor for Midbrain Dopaminergic Neurons
Lin, L.-F. H., Doherty, D. H., Lile, J. D., Bektesh, S. L., & Collins, F. (1993) · Science · doi:10.1126/science.8493557 · Cited by 3,206 · see citing works
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
Friend, S. H., Bernards, R., Rogelj, S., Weinberg, R. A., Rapaport, J. M., Albert, D. M., & Dryja, T. P. (1986) · Nature · doi:10.1038/323643a0 · Cited by 2,948 · cited 1× · see citing works
“Background The retinoblastoma susceptibility gene (RB-1) was the first tumor suppressor gene to be cloned [1].”
BackgroundThe regulation of E2F by pRB-family proteins.
Dyson, N. (1998) · Genes & Development · doi:10.1101/gad.12.15.2245 · Cited by 2,317 · see citing works
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
Narita, M., Nuñez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., & Lowe, S. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00401-x · Cited by 2,278 · see citing works
The RB and p53 pathways in cancer
Sherr, C. J., & McCormick, F. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00102-2 · Cited by 1,690 · see citing works
Hyperactive Ras in developmental disorders and cancer
Schubbert, S., Shannon, K., & Bollag, G. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2109 · Cited by 1,583 · see citing works
DeCaprio, J. A., Ludlow, J. W., Figge, J., Shew, J.-Y., Huang, C.-M., Lee, W.-H., Marsilio, E., Paucha, E., & Livingston, D. M. (1988) · Cell · doi:10.1016/0092-8674(88)90559-4 · Cited by 1,459 · see citing works
(1993) · Genes & Development · doi:10.1101/gad.7.3.331 · Cited by 1,264 · see citing works
Retinoblastoma protein recruits histone deacetylase to repress transcription
Brehm, A., Miska, E. A., McCance, D. J., Reid, J. L., Bannister, A. J., & Kouzarides, T. (1998) · Nature · doi:10.1038/35404 · Cited by 1,231 · see citing works
Münger, K., Werness, B. A., Dyson, N. J., Phelps, W. C., Harlow, E. E., & Howley, P. M. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08594.x · Cited by 1,204 · see citing works
Sibling rivalry in the E2F family
Trimarchi, J. M., & Lees, J. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm714 · Cited by 1,158 · see citing works
Lundberg, A. S., & Weinberg, R. A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.2.753 · Cited by 1,077 · see citing works
Harbour, J. W., Luo, R. X., Santi, A. D., Postigo, A. A., & Dean, D. C. (1999) · Cell · doi:10.1016/s0092-8674(00)81519-6 · Cited by 1,057 · see citing works
Functional interactions of the retinoblastoma protein with mammalian D-type cyclins
Ewen, M. E., Sluss, H. K., Sherr, C. J., Matsushime, H., Kato, J.-Y., & Livingston, D. M. (1993) · Cell · doi:10.1016/0092-8674(93)90136-e · Cited by 1,010 · see citing works
The retinoblastoma protein is phosphorylated during specific phases of the cell cycle
Buchkovich, K., Duffy, L. A., & Harlow, E. (1989) · Cell · doi:10.1016/0092-8674(89)90508-4 · Cited by 995 · see citing works
Rb Interacts with Histone Deacetylase to Repress Transcription
Luo, R. X., Postigo, A. A., & Dean, D. C. (1998) · Cell · doi:10.1016/s0092-8674(00)80940-x · Cited by 957 · see citing works
Chen, P.-L., Scully, P., Shew, J.-Y., Wang, J. Y. J., & Lee, W.-H. (1989) · Cell · doi:10.1016/0092-8674(89)90517-5 · Cited by 952 · see citing works
Robertson, K. D., Ait-Si-Ali, S., Yokochi, T., Wade, P. A., Jones, P. L., & Wolffe, A. P. (2000) · Nature Genetics · doi:10.1038/77124 · Cited by 942 · see citing works
Retinoblastoma protein represses transcription by recruiting a histone deacetylase
Magnaghi-Jaulin, L., Groisman, R., Naguibneva, I., Robin, P., Lorain, S., Levillain, J. P., Troalen, F., Trouche, D., & Harel‐Bellan, A. (1998) · Nature · doi:10.1038/35410 · Cited by 906 · see citing works
Rb targets histone H3 methylation and HP1 to promoters
Nielsen, S. J., Schneider, R., Bauer, U., Bannister, A. J., Morrison, A. J., O’Carroll, D., Firestein, R., Cleary, M. L., Jenuwein, T., Herrera, R. E., et al. (2001) · Nature · doi:10.1038/35087620 · Cited by 901 · see citing works
Abnormalities in Structure and Expression of the Human Retinoblastoma Gene in SCLC
Harbour, J. W., Lai, S.-L., Whang‐Peng, J., Gazdar, A. F., Minna, J. D., & Kaye, F. J. (1988) · Science · doi:10.1126/science.2838909 · Cited by 900 · see citing works
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
Kaelin, W. G., Krek, W., Sellers, W. R., DeCaprio, J. A., Ajchenbaum, F., Fuchs, C. S., Chittenden, T. D., Li, Y., Farnham, P., Blanar, M. A., et al. (1992) · Cell · doi:10.1016/0092-8674(92)90108-o · Cited by 819 · see citing works
Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP
Feig, L. A., & Cooper, G. M. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.8.3235-3243.1988 · Cited by 799 · see citing works
Physical interaction of the retinoblastoma protein with human D cyclins
Dowdy, S. F., Hinds, P. W., Louie, K., Reed, S. I., Arnold, A., & Weinberg, R. A. (1993) · Cell · doi:10.1016/0092-8674(93)90137-f · Cited by 746 · see citing works
The retinoblastoma tumour suppressor in development and cancer
Classon, M., & Harlow, E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc950 · Cited by 738 · see citing works
Cellular targets for transformation by the adenovirus E1A proteins
Whyte, P., Williamson, N. M., & Harlow, E. (1989) · Cell · doi:10.1016/0092-8674(89)90984-7 · Cited by 729 · see citing works
Gu, W., Schneider, J. W., Condorelli, G., Kaushal, S., Mahdavi, V., & Nadal‐Ginard, B. (1993) · Cell · doi:10.1016/0092-8674(93)90110-c · Cited by 726 · see citing works
Mouse development and cell proliferation in the absence of D-cyclins
Kozar, K., Ciemerych, M. A., Rebel, V. I., Shigematsu, H., Zagozdzon, A., Sicinska, E., Geng, Y., Yu, Q., Bhattacharya, S., Bronson, R. T., et al. (2004) · Cell · doi:10.1016/j.cell.2004.07.025 · Cited by 647 · see citing works
The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest
Dunaief, J. L., Strober, B. E., Guha, S., Khavari, P. A., Ålin, K., Luban, J., Begemann, M., Crabtree, G. R., & Goff, S. P. (1994) · Cell · doi:10.1016/0092-8674(94)90405-7 · Cited by 625 · see citing works
A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F
Helin, K., Lees, J. A., Vidal, M., Dyson, N. J., Harlow, E., & Fattaey, A. (1992) · Cell · doi:10.1016/0092-8674(92)90107-n · Cited by 613 · see citing works
The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.Preprint
Hiebert, S. W., Chellappan, S., Horowitz, J. M., & Nevins, J. R. (1992) · Genes & Development · doi:10.1101/gad.6.2.177 · Cited by 576 · see citing works
Inhibition of E2F-1 Transactivation by Direct Binding of the Retinoblastoma Protein
Helin, K., Harlow, E. E., & Fattaey, A. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6501 · Cited by 472 · see citing works
Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7
Lee, J., Russo, A. A., & Pavletich, N. P. (1998) · Nature · doi:10.1038/36038 · Cited by 459 · see citing works
Cell cycle dependent regulation of phosphorylation of the human retinoblastoma gene product
Mihara, K., Cao, X.-R., Yen, A., Chandler, S., Driscoll, B., Murphree, A. L., T'Ang, A., & Fung, Y.-K. (1989) · Science · doi:10.1126/science.2588006 · Cited by 449 · see citing works
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
Klose, R. J., Yan, Q., Tóthová, Z., Yamane, K., Erdjument‐Bromage, H., Tempst, P., Gilliland, D. G., Zhang, Y., & Kaelin, W. G. (2007) · Cell · doi:10.1016/j.cell.2007.02.013 · Cited by 446 · see citing works
Chen, P., Riley, D. J., Chen, Y., & Lee, W. (1996) · Genes & Development · doi:10.1101/gad.10.21.2794 · Cited by 442 · see citing works
Altered control of cellular proliferation in the absence of mammalian brahma (SNF2α)
Reyes, J. C., Barra, J., Muchardt, C., Camus, A., Babinet, C., & Yaniv, M. (1998) · The EMBO Journal · doi:10.1093/emboj/17.23.6979 · Cited by 433 · see citing works
Structure–function–rescue: the diverse nature of common p53 cancer mutants
Joerger, A. C., & Fersht, A. R. (2007) · Oncogene · doi:10.1038/sj.onc.1210291 · Cited by 430 · see citing works
The retinoblastoma gene family in differentiation and development
Lipinski, M. M., & Jacks, T. (1999) · Oncogene · doi:10.1038/sj.onc.1203244 · Cited by 404 · see citing works
Identification of a growth suppression domain within the retinoblastoma gene product.Preprint
Qin, X. Q., Chittenden, T., Livingston, D. M., & Kaelin, W. G. (1992) · Genes & Development · doi:10.1101/gad.6.6.953 · Cited by 404 · see citing works
Litovchick, L., Sadasivam, S., Florens, L., Zhu, X., Swanson, S. K., Velmurugan, S., Chen, R., Washburn, M. P., Liu, X. S., & DeCaprio, J. A. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.04.015 · Cited by 396 · see citing works
Differential regulation of E2F transactivation by cyclin/cdk2 complexes.Preprint
Dynlacht, B. D., Flores, O. A., Lees, J. A., & Harlow, E. (1994) · Genes & Development · doi:10.1101/gad.8.15.1772 · Cited by 395 · see citing works
Dyson, N. J., Guida, P. M., Münger, K., & Harlow, E. E. (1992) · Journal of Virology · doi:10.1128/jvi.66.12.6893-6902.1992 · Cited by 385 · see citing works
Extra-embryonic function of Rb is essential for embryonic development and viability
Wu, L., de Bruin, A., Saavedra, H. I., Starovic, M., Trimboli, A. J., Yang, Y., Opavska, J., Wilson, P. L., Thompson, J. C., Ostrowski, M. C., et al. (2003) · Nature · doi:10.1038/nature01417 · Cited by 382 · see citing works
Ludlow, J. W., Shon, J. C., Pipas, J. M., Livingston, D. M., & DeCaprio, J. A. (1990) · Cell · doi:10.1016/0092-8674(90)90590-b · Cited by 381 · see citing works
Adams, P. D., Sellers, W. R., Sharma, S. K., Wu, A. D., Nalin, C. M., & Kaelin, W. G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.12.6623 · Cited by 373 · see citing works
Tsai, K. Y., Hu, Y., Macleod, K. F., Crowley, D., Yamasaki, L., & Jacks, T. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80274-9 · Cited by 372 · see citing works
Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A
Schulman, B. A., Lindstrom, D. L., & Harlow, E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10453 · Cited by 372 · see citing works
Iavarone, A., Garg, P. P., Lasorella, A., Hsu, J. C., & Israel, M. A. (1994) · Genes & Development · doi:10.1101/gad.8.11.1270 · Cited by 365 · see citing works
Thomas, D. M., Carty, S. A., Piscopo, D. M., Lee, J.-S., Wang, W.-F., Forrester, W. C., & Hinds, P. W. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00327-6 · Cited by 361 · see citing works
Retinoblastoma protein partners
(2001) · Advances in Cancer Research · doi:10.1016/s0065-230x(01)82001-7 · Cited by 349 · see citing works
Flemington, E. K., Speck, S. H., & Kaelin, W. G. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.15.6914 · Cited by 348 · see citing works
Sellers, W. R., Novitch, B. G., Miyake, S., Heith, A., Otterson, G. A., Kaye, F. J., Lassar, A. B., & Kaelin, W. G. (1998) · Genes & Development · doi:10.1101/gad.12.1.95 · Cited by 343 · see citing works
The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.
Lees, J. A., Buchkovich, K. J., Marshak, D. R., Anderson, C. W., & Harlow, E. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb05006.x · Cited by 337 · see citing works
The retinoblastoma gene family: cousins with overlapping interests
Mulligan, G. (1998) · Trends in Genetics · doi:10.1016/s0168-9525(98)01470-x · Cited by 334 · see citing works
Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product
Cavanaugh, A. H., Hempel, W. M., Taylor, L. J., Rogalsky, V., Todorov, G. I., & Rothblum, L. I. (1995) · Nature · doi:10.1038/374177a0 · Cited by 334 · see citing works
E2F-4 Switches from p130 to p107 and pRB in Response to Cell Cycle Reentry
Moberg, K. H., Starz‐Gaiano, M., & Lees, J. A. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1436 · Cited by 328 · see citing works
Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product
Defeo-Jones, D., Huang, P. S., Jones, R. E., Haskell, K., Vuocolo, G. A., Hanobik, M. G., Huber, H. E., & Oliff, A. (1991) · Nature · doi:10.1038/352251a0 · Cited by 323 · see citing works
Differential Regulation of Retinoblastoma Protein Function by Specific Cdk Phosphorylation Sites
Knudsen, E. S., & Wang, J. Y. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.14.8313 · Cited by 320 · see citing works
Hu, Q., Dyson, N. J., & Harlow, E. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08221.x · Cited by 315 · see citing works
Novitch, B. G., Mulligan, G., Jacks, T., & Lassar, A. B. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.135.2.441 · Cited by 303 · see citing works
Lin, B. T., Gruenwald, S., Morla, A. O., Lee, W., & Wang, J. Y. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb08018.x · Cited by 298 · see citing works
Coordinated regulation of life and death by RB
Chau, B. N., & Wang, J. Y. J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc993 · Cited by 292 · see citing works
Knudsen, E. S., & Wang, J. Y. J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.10.5771 · Cited by 286 · see citing works
Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation.Preprint
Lee, E. Y., Hu, N., Yuan, S. F., Cox, L. A., Bradley, A., Lee, W., & Herrup, K. (1994) · Genes & Development · doi:10.1101/gad.8.17.2008 · Cited by 285 · see citing works
Acetylation control of the retinoblastoma tumour-suppressor protein
Chan, H. M., Krstic–Demonacos, M., Smith, L. M., Demonacos, C., & Thangue, N. B. L. (2001) · Nature Cell Biology · doi:10.1038/35083062 · Cited by 282 · see citing works
Korenjak, M., Taylor‐Harding, B., Binné, U. K., Satterlee, J. S., Nolan-Stevaux, O., Aasland, R., White‐Cooper, H., Dyson, N. J., & Brehm, A. (2004) · Cell · doi:10.1016/j.cell.2004.09.034 · Cited by 281 · see citing works
A Direct Interaction between the Aryl Hydrocarbon Receptor and Retinoblastoma Protein
Ge, N.-L., & Elferink, C. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.35.22708 · Cited by 258 · see citing works
Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complexPreprint
Lewis, P. W., Beall, E. L., Fleischer, T. C., Georlette, D., Link, A. J., & Botchan, M. R. (2004) · Genes & Development · doi:10.1101/gad.1255204 · Cited by 255 · see citing works
Strober, B. E., Dunaief, J. L., Guha, S., & Goff, S. P. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1576 · Cited by 254 · see citing works
Rubin, S. M., Gall, A.-L., Zheng, N., & Pavletich, N. P. (2005) · Cell · doi:10.1016/j.cell.2005.09.044 · Cited by 253 · see citing works
Specific cleavage of the retinoblastoma protein by an ICE‐like protease in apoptosis.
Jänicke, R. U., Walker, P. A., Lin, X. Y., & Porter, A. G. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01089.x · Cited by 247 · see citing works
pRB plays an essential role in cell cycle arrest induced by DNA damage
Harrington, E. A., Bruce, J. L., Harlow, E., & Dyson, N. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11945 · Cited by 242 · see citing works
Binding of pRB to the PHD Protein RBP2 Promotes Cellular Differentiation
Benevolenskaya, E. V., Murray, H. L., Branton, P. E., Young, R. A., & Kaelin, W. G. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.05.012 · Cited by 241 · see citing works
p107 and p130: Versatile Proteins with Interesting Pockets
Classon, M., & Dyson, N. J. (2001) · Experimental Cell Research · doi:10.1006/excr.2000.5135 · Cited by 237 · see citing works
Dimova, D. K., Nolan-Stevaux, O., Frolov, M. V., & Dyson, N. J. (2003) · Genes & Development · doi:10.1101/gad.1116703 · Cited by 235 · see citing works
Ewen, M. E., Ludlow, J. W., Marsilio, E., DeCaprio, J. A., Millikan, R. C., Cheng, S. H., Paucha, E., & Livingston, D. M. (1989) · Cell · doi:10.1016/0092-8674(89)90840-4 · Cited by 228 · see citing works
RB-Dependent S-Phase Response to DNA Damage
Knudsen, K. E., Booth, D., Naderi, S., Sever-Chroneos, Z., Fribourg, A. F., Hunton, I. C., Feramisco, J. R., Wang, J. Y. J., & Knudsen, E. S. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.20.7751-7763.2000 · Cited by 224 · see citing works
Two regions of the adenovirus early region 1A proteins are required for transformation
Whyte, P., Ruley, H. E., & Harlow, E. (1988) · Journal of Virology · doi:10.1128/jvi.62.1.257-265.1988 · Cited by 221 · see citing works
Class I Histone Deacetylases Sequentially Interact with MyoD and pRb during Skeletal Myogenesis
Puri, P., Iezzi, S., Stiegler, P., Chen, T.-T., Schiltz, R. L., Muscat, G. E. O., Giordano, A., Kedes, L., Wang, J. Y. J., & Sartorelli, V. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00373-2 · Cited by 221 · see citing works
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
Wang, C.-Y., Petryniak, B., Thompson, C. B., Kaelin, W. G., & Leiden, J. M. (1993) · Science · doi:10.1126/science.8493578 · Cited by 213 · see citing works
Steele-Perkins, G., Fang, W., Yang, X.-H., Van Gele, M., Carling, T., Gu, J., Buyse, I. M., Fletcher, J. A., Liu, J., Bronson, R., et al. (2001) · Genes & Development · doi:10.1101/gad.870101 · Cited by 208 · see citing works
Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6.
Chen, P., Riley, D. J., Chen‐Kiang, S., & Lee, W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.465 · Cited by 208 · see citing works
Ziebold, U., Reza, T., Caron, A., & Lees, J. A. (2001) · Genes & Development · doi:10.1101/gad.858801 · Cited by 200 · see citing works
Novitch, B. G., Spicer, D. B., Kim, P. S., Cheung, W. L., & Lassar, A. B. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80210-3 · Cited by 199 · see citing works
Kaelin, W. G., Ewen, M. E., & Livingston, D. M. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.7.3761 · Cited by 197 · see citing works
Huang, S., Wang, N., Tseng, B., Lee, W., & Lee, E. H. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08306.x · Cited by 196 · see citing works
Singh, P., Coe, J. G. S., & Hong, W. (1995) · Nature · doi:10.1038/374562a0 · Cited by 191 · see citing works
Buyse, I. M., Shao, G. Q., & Huang, S. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4467 · Cited by 189 · see citing works
The Transcription Factor E2F-1 Is a Downstream Target of RB Action
Qin, X.-Q., Livingston, D. M., Ewen, M. E., Sellers, W. R., Arany, Z. P., & Kaelin, W. G. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.742 · Cited by 188 · see citing works
Meloni, A. R., Smith, E., & Nevins, J. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9574 · Cited by 183 · see citing works
Chen, C., Chen, Y., Dai, K., Chen, P., Riley, D. J., & Lee, W. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4691 · Cited by 183 · see citing works
Binné, U. K., Classon, M. K., Dick, F. A., Wei, W., Rape, M., Kaelin, W. G., Näär, A. M., & Dyson, N. J. (2007) · Nature Cell Biology · doi:10.1038/ncb1532 · Cited by 175 · see citing works
Self-citationJi, P., Jiang, H., Rekhtman, K., Bloom, J., Ichetovkin, M., Pagano, M., & Zhu, L. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.09.029 · Cited by 170 · see citing works
Degradation of Retinoblastoma Protein in Tumor Necrosis Factor- and CD95-induced Cell Death
Tan, X., Martin, S. J., Green, D. R., & Wang, J. Y. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.9613 · Cited by 170 · see citing works
Role of the LXCXE Binding Site in Rb Function
Dahiya, A., Gavin, M., Luo, R. X., & Dean, D. C. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6799-6805.2000 · Cited by 169 · see citing works
Lai, A., Lee, J. M., Yang, W., DeCaprio, J. A., Kaelin, W. G., Seto, E., & Branton, P. E. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.10.6632 · Cited by 169 · see citing works
The retinoblastoma tumor-suppressor gene, the exception that proves the rule
Goodrich, D. W. (2006) · Oncogene · doi:10.1038/sj.onc.1209616 · Cited by 166 · see citing works
Requirement for p27<sup>KIP1</sup> in Retinoblastoma Protein-Mediated Senescence
Alexander, K., & Hinds, P. W. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.11.3616-3631.2001 · Cited by 164 · see citing works
Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen
Kim, H., Ahn, B., & Cho, Y. (2001) · The EMBO Journal · doi:10.1093/emboj/20.1.295 · Cited by 161 · see citing works
Xiao, B., SPENCER, J. M., Clements, A. M., Ali‐Khan, N., Mittnacht, S., Broceño, C., Burghammer, M. C., Anastassis Perrakis, A., Marmorstein, R., & Gamblin, S. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0436813100 · Cited by 158 · see citing works
Lee, C., Chang, J. H., Lee, H. S., & Cho, Y. (2002) · Genes & Development · doi:10.1101/gad.1046102 · Cited by 153 · see citing works
Dick, F. A., & Dyson, N. J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00344-7 · Cited by 142 · see citing works
Self-citationHBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family.Preprint
Tevosian, S. G., Shih, H. H., Mendelson, K., Sheppard, K.-A., Paulson, K. E., & Yee, A. S. (1997) · Genes & Development · doi:10.1101/gad.11.3.383 · Cited by 141 · see citing works
Onadim, Z., Hogg, A., Baird, P. N., & Cowell, J. K. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.6177 · Cited by 138 · see citing works
The caspase-RB connection in cell death
Tan, X., & Wang, J. Y. J. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(97)01208-7 · Cited by 136 · see citing works
The Retinoblastoma Protein Regulates Pericentric Heterochromatin
Isaac, C. E., Francis, S. M., Martens, A. L., Julian, L. M., Seifried, L. A., Erdmann, N., Binné, U. K., Harrington, L., Sicinski, P., Bérubé, N. G., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.9.3659-3671.2006 · Cited by 128 · see citing works
Self-citationWells, J. M., Yan, P. S., Cechvala, M. M., Huang, T. H. ‐., & Farnham, P. (2003) · Oncogene · doi:10.1038/sj.onc.1206264 · Cited by 126 · see citing works
A Novel Rb- and p300-Binding Protein Inhibits Transactivation by MyoD
MacLellan, W. R., Xiao, G., Abdellatif, M., & Schneider, M. D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8903-8915.2000 · Cited by 125 · see citing works
A Bipartite Substrate Recognition Motif for Cyclin-dependent Kinases
Takeda, D. Y., Wohlschlegel, J. A., & Dutta, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005719200 · Cited by 124 · see citing works
Molecular Basis of Low-Penetrance Retinoblastoma
Harbour, J. W. (2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.11.1699 · Cited by 123 · see citing works
Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F‐1 after DNA damage
Inoue, Y., Kitagawa, M., & Taya, Y. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601652 · Cited by 119 · see citing works
Cumulative Effect of Phosphorylation of pRB on Regulation of E2F Activity
Brown, V. D., Phillips, R. A., & Gallie, B. L. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3246 · Cited by 116 · see citing works
Avni, D., Yang, H., Martelli, F., Hofmann, F., ElShamy, W. M., Ganesan, S., Scully, R., & Livingston, D. M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00355-1 · Cited by 114 · see citing works
Dick, F. A., Sailhamer, E. A., & Dyson, N. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.10.3715-3727.2000 · Cited by 113 · see citing works
Self-citationMiyake, S., Sellers, W. R., Safran, M., Li, X., Zhao, W., Grossman, S. R., Gan, J., DeCaprio, J. A., Adams, P. D., & Kaelin, W. G. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8889-8902.2000 · Cited by 112 · see citing works
Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb.
Saavedra, H. I., Wu, L., de Bruin, A., Timmers, C. D., Rosol, T. J., Weinstein, M. B., Robinson, M. L., & Leone, G. W. (2002) · PubMed · Cited by 108 · see citing works
Otterson, G. A., Chen, W.-D. D., Coxon, A. B., Khleif, S. N., & Kaye, F. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.22.12036 · Cited by 107 · see citing works
Acetylation regulates the differentiation‐specific functions of the retinoblastoma protein
Nguyen, D. X., Baglia, L. A., Huang, S.-M. A., Baker, C. M., & McCance, D. J. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600176 · Cited by 106 · see citing works
Binding of an Interferon-inducible Protein (p202) to the Retinoblastoma Protein
Choubey, D., & Lengyel, P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.11.6134 · Cited by 105 · see citing works
Leng, X., Connell‐Crowley, L., Goodrich, D. W., & Harper, J. W. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00301-0 · Cited by 105 · see citing works
Transcriptional repression by the Rb-related protein p107.
Zamanian, M., & Thangue, N. B. L. (1993) · Molecular Biology of the Cell · doi:10.1091/mbc.4.4.389 · Cited by 102 · see citing works
Deletion of RBExons 24 and 25 Causes Low-Penetrance Retinoblastoma
Bremner, R., Du, D., Connolly-Wilson, M., Bridge, P. J., Ahmad, K. F., Mostachfi, H., Rushlow, D., Dunn, J. M., & Gallie, B. L. (1997) · The American Journal of Human Genetics · doi:10.1086/515499 · Cited by 102 · see citing works
Role of pRB dephosphorylation in cell cycle regulation
Tamrakar, S. (2000) · Frontiers in bioscience · doi:10.2741/tamrakar · Cited by 101 · see citing works
Ledl, A., Schmidt, D., & Müller, S. P. (2005) · Oncogene · doi:10.1038/sj.onc.1208539 · Cited by 101 · see citing works
Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb
Chau, B. N., Borges, H. L., Chen, T.-T., Masselli, A., Hunton, I. C., & Wang, J. Y. J. (2002) · Nature Cell Biology · doi:10.1038/ncb853 · Cited by 93 · see citing works
TGF beta-induced growth inhibition in primary fibroblasts requires the retinoblastoma protein.
Herrera, R. E., Mäkelä, T. P., & Weinberg, R. A. (1996) · Molecular Biology of the Cell · doi:10.1091/mbc.7.9.1335 · Cited by 81 · see citing works
Beall, E. L., Bell, M., Georlette, D., & Botchan, M. R. (2004) · Genes & Development · doi:10.1101/gad.1206604 · Cited by 80 · see citing works
Molecular Cloning and Characterization of a Novel Retinoblastoma-Binding Protein
Fusco, C., Reymond, A., & Zervos, A. S. (1998) · Genomics · doi:10.1006/geno.1998.5368 · Cited by 77 · see citing works
Role of LXCXE motif-dependent interactions in the activity of the retinoblastoma protein
Chan, H. M., Smith, L. M., & Thangue, N. B. L. (2001) · Oncogene · doi:10.1038/sj.onc.1204793 · Cited by 75 · see citing works
Whitaker, L. L., Su, H., Rajasekaran, B., Knudsen, E. S., & Wang, J. Y. J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4032 · Cited by 74 · see citing works
Differential Regulation of Androgen and Glucocorticoid Receptors by Retinoblastoma Protein
Lü, J., & Danielsen, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.31528 · Cited by 74 · see citing works
Lukas, J., Sørensen, C. S., Lukas, C., Santoni‐Rugiu, E., & Bártek, J. (1999) · Oncogene · doi:10.1038/sj.onc.1202777 · Cited by 73 · see citing works
RBP1 induces growth arrest by repression of E2F-dependent transcription
Lai, A., Marcellus, R. C., Corbeil, H. B., & Branton, P. E. (1999) · Oncogene · doi:10.1038/sj.onc.1202520 · Cited by 73 · see citing works
Chen, T.-T., & Wang, J. Y. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.15.5571-5580.2000 · Cited by 71 · see citing works
The HBP1 Transcriptional Repressor Participates in RAS-Induced Premature Senescence
Zhang, X., Kim, J., Ruthazer, R., McDevitt, M. A., Wazer, D. E., Paulson, K. E., & Yee, A. S. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00604-06 · Cited by 69 · see citing works
HES1 Cooperates With pRb to Activate RUNX2-Dependent Transcription
Lee, J.-S., Thomas, D. M., Gutierrez, G. M., Carty, S. A., Yanagawa, S.-I., & Hinds, P. W. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060303 · Cited by 69 · see citing works
Examination of the pRb-Dependent and pRb-Independent Functions of E7 In Vivo
Balsitis, S. J., Dick, F. A., Lee, D., Farrell, L., Hyde, R. K., Griep, A. E., Dyson, N. J., & Lambert, P. F. (2005) · Journal of Virology · doi:10.1128/jvi.79.17.11392-11402.2005 · Cited by 67 · see citing works
Self-citationTaylor‐Harding, B., Binné, U. K., Korenjak, M., Brehm, A., & Dyson, N. J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.9124-9136.2004 · Cited by 66 · see citing works
Evidence for a protein domain superfamily shared by the cyclins, TFIIB and RB/p107
Gibson, T. J., Thompson, J., Blocker, A., & Kouzarides, T. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.6.946 · Cited by 66 · see citing works
Hertel, L., Rolle, S., Andrea, M. D., Azzimonti, B., Osello, R., Gribaudo, G., Gariglio, M., & Landolfo, S. (2000) · Oncogene · doi:10.1038/sj.onc.1203697 · Cited by 65 · see citing works
DNA‐damage‐responsive acetylation of pRb regulates binding to E2F‐1
Markham, D., Munro, S., Soloway, J., O'Connor, D. P., & La Thangue, N. B. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400591 · Cited by 62 · see citing works
The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A
Lavender, P., Vandel, L., Bannister, A. J., & Kouzarides, T. (1997) · Oncogene · doi:10.1038/sj.onc.1201243 · Cited by 61 · see citing works
A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability
Woitach, J. T., Zhang, M., Niu, C., & Thorgeirsson, S. S. (1998) · Nature Genetics · doi:10.1038/1258 · Cited by 60 · see citing works
Jiang, Z., & Zacksenhaus, E. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200106084 · Cited by 55 · see citing works
Kaelin, W. G., Ewen, M. E., & Livingston, D. M. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.7.3761-3769.1990 · Cited by 54 · see citing works
Pennaneach, V., Salles-Passador, I., Munshi, A., Brickner, H., Regazzoni, K., Dick, F. A., Dyson, N. J., Chen, T.-T., Wang, J. Y. J., Fotedar, R., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00217-9 · Cited by 50 · see citing works
Self-citationRB activation defect in tumor cell lines
Broceño, C., Wilkie, S., & Mittnacht, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212519499 · Cited by 47 · see citing works
Binda, O., Roy, J.-S., & Branton, P. E. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.5.1917-1931.2006 · Cited by 44 · see citing works
Rb Enhances p160/SRC Coactivator-dependent Activity of Nuclear Receptors and Hormone Responsiveness
Batsché, É., Desroches, J., Bilodeau, S., Gauthier, Y., & Drouin, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413428200 · Cited by 43 · see citing works
Julian, L. M., Palander, O., Seifried, L. A., Foster, J., & Dick, F. A. (2007) · Oncogene · doi:10.1038/sj.onc.1210803 · Cited by 41 · see citing works
Self-citationOtterson, G. A., Modi, S., Nguyen, K., Coxon, A. B., & Kaye, F. J. (1999) · The American Journal of Human Genetics · doi:10.1086/302581 · Cited by 41 · see citing works
Direct Binding of Apoptosis Signal-regulating Kinase 1 to Retinoblastoma Protein
Dasgupta, P., Betts, V., Rastogi, S., Joshi, B., Morris, M. D., Brennan, B. M., Ordonez‐Ercan, D., & Chellappan, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312273200 · Cited by 39 · see citing works
Barrientes, S., Cooke, C. P., & Goodrich, D. W. (2000) · Oncogene · doi:10.1038/sj.onc.1203332 · Cited by 38 · see citing works
Bischof, O., & Dejean, A. (2007) · Cell Cycle · doi:10.4161/cc.6.6.4021 · Cited by 36 · see citing works
Sun, H., Chang, Y., Schweers, B. A., Dyer, M. A., Zhang, X., Hayward, S. W., & Goodrich, D. W. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.4.1527-1537.2006 · Cited by 34 · see citing works
Retinoblastoma protein acts as Pax 8 transcriptional coactivator
Miccadei, S., Provenzano, C., Mojžíšek, M., Natali, P. G., & Civitareale, D. (2005) · Oncogene · doi:10.1038/sj.onc.1208861 · Cited by 33 · see citing works
Tumor promotion by caspase-resistant retinoblastoma protein
Borges, H. L., Bird, J., Wasson, K., Cardiff, R. D., Varki, N. M., Eckmann, L., & Wang, J. Y. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503925102 · Cited by 31 · see citing works
Retinoblastoma Protein Enhances the Fidelity of Chromosome Segregation Mediated by hsHec1p
Zheng, L., Chen, Y., Riley, D. J., Chen, P., & Lee, W. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.10.3529-3537.2000 · Cited by 30 · see citing works
Functional analysis at the Cys706 residue of the retinoblastoma protein.
Kratzke, R. A., Otterson, G. A., Lin, A. Y., Shimizu, E., Alexandrova, N., Zajac‐Kaye, M., Horowitz, J. M., & Kaye, F. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35707-7 · Cited by 30 · see citing works
G1 cyclin-dependent kinases are insufficient to reverse dE2F2-mediated repressionPreprint
Frolov, M. V., Nolan-Stevaux, O., Moon, N.-S., Dimova, D. K., Kwon, E.-J., Morris, E. J., & Dyson, N. J. (2003) · Genes & Development · doi:10.1101/gad.1031803 · Cited by 29 · see citing works
Tumour suppressor genes, the cell cycle and cancer
Levine, A. J. (1992) · Cold Spring Harbor Laboratory eBooks · Cited by 25 · see citing works
Tumor Suppression by a Severely Truncated Species of Retinoblastoma Protein
Yang, H., Williams, B. O., Hinds, P. W., Shih, T. S., Jacks, T., Bronson, R. T., & Livingston, D. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.9.3103-3110.2002 · Cited by 24 · see citing works
Chau, B. N., Pan, C. W., & Wang, J. Y. J. (2006) · PLoS ONE · doi:10.1371/journal.pone.0000082 · Cited by 22 · see citing works
Pax-2 interacts with RB and reverses its repression on the promoter of Rig-1, a Robo member
Yuan, S. F., Yeh, Y., & Lee, E. Y.-H. P. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02032-6 · Cited by 22 · see citing works
Docking-Dependent Regulation of the Rb Tumor Suppressor Protein by Cdk4
Wallace, M., & Ball, K. L. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.12.5606-5619.2004 · Cited by 21 · see citing works
Krucher, N. A., Zygmunt, A., Mazloum, N. A., Tamrakar, S., Ludlow, J. W., & Lee, M. (2000) · Oncogene · doi:10.1038/sj.onc.1203930 · Cited by 12 · see citing works
Siervi, A. D., Méndez, M., Parera, V. E., Varela, L. S., Batlle, A. M. D. C., & Rossetti, M. V. (1999) · Human Mutation · doi:10.1002/(sici)1098-1004(199910)14:4 · Cited by 11 · see citing works
Role of pRB dephosphorylation in cell cycle regulation
Ludlow, J. W. (2000) · Frontiers in bioscience · doi:10.2741/a501 · Cited by 9 · see citing works
Induction of apoptosis in Mv1Lu cells by expression of competitive RB1 mutants
Whitaker, L. L., & Hansen, M. F. (1997) · Oncogene · doi:10.1038/sj.onc.1201277 · Cited by 6 · see citing works
Dyson, N. J. (2003) · Nature · doi:10.1038/421903a · Cited by 5 · see citing works
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2 of the 176 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Dunaief JL Strober BE Guha S Khavari PA Alin K Luban J Begemann M Crabtree GR Goff SP The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Cell 1994 79 119 30 7923370 10.1016/0092-8674(94)90405-7 · DOI
Cited by
Sorted by citations
Cellular mechanisms of tumour suppression by the retinoblastoma gene
Burkhart, D. L., & Sage, J. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2399 · Cited by 974 · see citing works
Conserved functions of the pRB and E2F families
van den Heuvel, S., & Dyson, N. J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2469 · Cited by 489 · see citing works
RB1 : a prototype tumor suppressor and an enigmaPreprint
Dyson, N. J. (2016) · Genes & Development · doi:10.1101/gad.282145.116 · Cited by 437 · see citing works
A Jasmonate Signaling Network Activates Root Stem Cells and Promotes Regeneration
Zhou, W., Lozano‐Torres, J. L., Blilou, I., Zhang, X., Zhai, Q., Smant, G., Li, C., & Scheres, B. (2019) · Cell · doi:10.1016/j.cell.2019.03.006 · Cited by 363 · see citing works
Cruz‐Ramírez, A., Trivino, S. D., Blilou, I., Grieneisen, V. A., Sozzani, R., Zamioudis, C., Miskolczi, P., Nieuwland, J., Benjamins, R., Dhonukshe, P., et al. (2012) · Cell · doi:10.1016/j.cell.2012.07.017 · Cited by 307 · see citing works
Henley, S. A., & Dick, F. A. (2012) · Cell Division · doi:10.1186/1747-1028-7-10 · Cited by 279 · see citing works
Self-citationZanet, J., Freije, A., Ruiz‐Soto, M., Coulon, V., Sanz, J. R., Chiésa, J., & Gandarillas, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015701 · Cited by 111 · see citing works
Zhu, Y., Gu, J., Li, Y., Peng, C., Shi, M., Wang, X., Wei, G., Ge, O., Wang, D., Zhang, B., et al. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.09.044 · Cited by 91 · see citing works
The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple Regulations
Bisteau, X., Caldez, M. J., & Kaldis, P. (2014) · Cancers · doi:10.3390/cancers6010079 · Cited by 91 · see citing works
Regulation of transcription and chromatin structure by pRB: Here, there and everywhere
Talluri, S., & Dick, F. A. (2012) · Cell Cycle · doi:10.4161/cc.21263 · Cited by 88 · see citing works
Self-citationRegulation of the retinoblastoma proteins by the human herpesviruses
Hume, A. J., & Kalejta, R. F. (2009) · Cell Division · doi:10.1186/1747-1028-4-1 · Cited by 84 · see citing works
Oncoapoptotic signaling and deregulated target genes in cancers: Special reference to oral cancer
Khan, Z., & Bisen, P. S. (2013) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2013.04.002 · Cited by 76 · see citing works
MacDonald, J. I., & Dick, F. A. (2012) · Genes & Cancer · doi:10.1177/1947601912473305 · Cited by 69 · see citing works
Self-citationChinnaswamy, S., Yarbrough, I., Palaninathan, S. K., Ranjith-Kumar, C. T., Vijayaraghavan, V., Demeler, B., Lemon, S. M., Sacchettini, J. C., & Kao, C. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801490200 · Cited by 68 · see citing works
Understanding pRb: toward the necessary development of targeted treatments for retinoblastoma
Sachdeva, U. M., & O’Brien, J. M. (2012) · Journal of Clinical Investigation · doi:10.1172/jci57114 · Cited by 67 · see citing works
Harashima, H., & Sugimoto, K. (2016) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2015.12.003 · Cited by 60 · see citing works
HAUSP , a novel deubiquitinase for Rb – MDM 2 the critical regulator
Bhattacharya, S., & Ghosh, M. K. (2014) · FEBS Journal · doi:10.1111/febs.12843 · Cited by 57 · see citing works
Perilli, S., Pérez‐Pérez, J. M., Mambro, R. D., Llavata‐Peris, C. I., Trivino, S. D., Bianco, M. D., Pierdonati, E., Moubayidin, L., Cruz‐Ramírez, A., Costantino, P., et al. (2013) · The Plant Cell · doi:10.1105/tpc.113.116632 · Cited by 56 · see citing works
p107 in the public eye: an Rb understudy and more
Wirt, S. E., & Sage, J. (2010) · Cell Division · doi:10.1186/1747-1028-5-9 · Cited by 51 · see citing works
Targeting mechanism of the retinoblastoma tumor suppressor by a prototypical viral oncoprotein
Chemes, L. B., Sanchez, I. E., Smal, C., & Gay, G. D. P. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07540.x · Cited by 49 · see citing works
ATM Mediates pRB Function To Control DNMT1 Protein Stability and DNA Methylation
Shamma, A., Suzuki, M., Hayashi, N., Kobayashi, M., Sasaki, N., Nishiuchi, T., Doki, Y., Okamoto, T., Kohno, S., Muranaka, H., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01597-12 · Cited by 45 · see citing works
Roles of pRB in the Regulation of Nucleosome and Chromatin Structures
Uchida, C. (2016) · BioMed Research International · doi:10.1155/2016/5959721 · Cited by 42 · see citing works
Palópoli, N., Foutel, N. S. G., Gibson, T. J., & Chemes, L. B. (2018) · Protein Engineering Design and Selection · doi:10.1093/protein/gzx068 · Cited by 40 · see citing works
Modeling human osteosarcoma in mice through 3AB‐OS cancer stem cell xenografts
Fiore, R. D., Guercio, A., Puleio, R., Marco, P. D., Drago‐Ferrante, R., D’Anneo, A., BLASIO, A. D., Carlisi, D., Bella, S. D., Pentimalli, F., et al. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24214 · Cited by 39 · see citing works
Kinetic Recognition of the Retinoblastoma Tumor Suppressor by a Specific Protein Target
Chemes, L. B., Sanchez, I. E., & Gay, G. D. P. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.07.015 · Cited by 37 · see citing works
Kianianmomeni, A., Nematollahi, G., & Hallmann, A. (2008) · The Plant Cell · doi:10.1105/tpc.107.057836 · Cited by 36 · see citing works
Loss of the Mammalian DREAM Complex Deregulates Chondrocyte Proliferation
Forristal, C., Henley, S. A., MacDonald, J. I., Bush, J., Ort, C., Passos, D. T., Talluri, S., Ishak, C. A., Thwaites, M. J., Norley, C. J. D., et al. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01523-13 · Cited by 33 · see citing works
Self-citationIwahori, S., Hakki, M., Chou, S., & Kalejta, R. F. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.660043 · Cited by 30 · see citing works
Twists in views on RB functions in cellular signaling, metabolism and stem cells
Takahashi, C., Sasaki, N., & Kitajima, S. (2012) · Cancer Science · doi:10.1111/j.1349-7006.2012.02284.x · Cited by 29 · see citing works
Tadesse, S., Mekonnen, L. B., Tomusange, K., Yu, M., Islam, S., Bykovska, N., Noll, B. D., Zhu, G., Li, P., Lam, F., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13974 · Cited by 29 · see citing works
Kurimchak, A., Haines, D. S., Garriga, J., Wu, S., Luca, F. D., Sweredoski, M. J., Deshaies, R. J., Hess, S. Y., & Graña, X. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00082-13 · Cited by 28 · see citing works
Lentine, B., Antonucci, L., Hunce, R., Edwards, J., Marallano, V. J., & Krucher, N. A. (2012) · Cell Cycle · doi:10.4161/cc.21693 · Cited by 26 · see citing works
Kurimchak, A., & Graña, X. (2012) · Genes & Cancer · doi:10.1177/1947601912473479 · Cited by 26 · see citing works
Acharya, P., Negre, N. N., Johnston, J., Wei, Y., White, K. P., Henry, R. W., & Arnosti, D. N. (2012) · G3 Genes Genomes Genetics · doi:10.1534/g3.112.004424 · Cited by 24 · see citing works
The potential role of PD0332991 (Palbociclib) in the treatment of multiple myeloma
Altenburg, J. D., & Farag, S. S. (2014) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2015.993753 · Cited by 25 · see citing works
Bertin-Ciftci, J., Barré, B., Pen, J. L., Maillet, L., Couriaud, C., Juin, P. P., & Braun, F. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.6 · Cited by 23 · see citing works
Faridi, U. A., Dhawan, S. S., Pal, S., Gupta, S., Shukla, A. K., Darokar, M. P., Sharma, A. K., & Shasany, A. K. (2016) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2015.0118 · Cited by 23 · see citing works
HDAC activity is dispensable for repression of cell-cycle genes by DREAM and E2F:RB complexes
Barrett, A. K., Shingare, M. R., Rechtsteiner, A., Rodriguez, K. M., Le, Q. N., Wijeratne, T. U., Mitchell, C. E., Membreño, M. W., Rubin, S. M., & Müller, G. A. (2024) · Nature Communications · doi:10.1038/s41467-024-48724-0 · Cited by 23 · see citing works
Chemes, L. B., Noval, M. G., Sanchez, I. E., & Gay, G. D. P. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.467316 · Cited by 22 · see citing works
Noval, M. G., Gallo, M. L., Perrone, S., Salvay, A. G., Chemes, L. B., & Gay, G. D. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072760 · Cited by 20 · see citing works
pRb-E2F signaling in life of mesenchymal stem cells: Cell cycle, cell fate, and cell differentiation
Popov, B. V., & Ns, P. (2014) · Genes & Diseases · doi:10.1016/j.gendis.2014.09.007 · Cited by 20 · see citing works
Talluri, S., & Dick, F. A. (2013) · Cell Cycle · doi:10.4161/cc.27527 · Cited by 18 · see citing works
Self-citationMAZ induces MYB expression during the exit from quiescence via the E2F site in the MYB promoter
Álvaro-Blanco, J., Urso, K., Chiodo, Y., Martín-Cortázar, C., Kourani, O., Arco, P. G., Rodríguez‐Martínez, M., Calonge, E., Alcamı́, J., Redondo, J. M., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx641 · Cited by 18 · see citing works
LXCXE-independent chromatin remodeling by Rb/E2f mediates neuronal quiescence
Andrusiak, M. G., Vandenbosch, R., Dick, F. A., Park, D. S., & Slack, R. S. (2013) · Cell Cycle · doi:10.4161/cc.24527 · Cited by 15 · see citing works
Self-citationRB Family Tumor Suppressor Activity May Not Relate to Active Silencing of E2F Target Genes
Vormer, T. L., Wojciechowicz, K., Dekker, M., de Vries, S., van der Wal, A., Delzenne‐Goette, E., Naik, S. H., Song, J., Dannenberg, J., Hansen, J. B., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3706 · Cited by 12 · see citing works
Genetic screening in Iranian patients with retinoblastoma
Shahraki, K., Ahani, A., Sharma, P., Faranoush, M., Bahoush, G., Torktaz, I., Gahl, W. A., Naseripour, M., & Behnam, B. (2016) · Eye · doi:10.1038/eye.2016.289 · Cited by 12 · see citing works
Zluhan‐Martínez, E., Pérez‐Koldenkova, V., Ponce-Castañeda, M. V., Sánchez, M. D. L. P., García‐Ponce, B., Miguel-Hernández, S., Alvarez-Buylla, E. R., & Garay‐Arroyo, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144925 · Cited by 10 · see citing works
Phosphorylation puts the pRb tumor suppressor into shape: Figure 1.Preprint
Heilmann, A. M. F., & Dyson, N. J. (2012) · Genes & Development · doi:10.1101/gad.195552.112 · Cited by 11 · see citing works
Pérez‐Morales, J., Mejías-Morales, D., Rivera-Rivera, S., González-Flores, J., González-Loperena, M., Cordero-Báez, F. Y., Pedreira-Garcia, W., Chardón-Colón, C., Caban‐Rivera, J., Cress, W. D., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0207483 · Cited by 10 · see citing works
Diversification of Retinoblastoma Protein Function Associated with Cis and Trans Adaptations
Mouawad, R., Prasad, J., Thorley, D., Himadewi, P., Kadiyala, D., Wilson, N. J., Kapranov, P., & Arnosti, D. N. (2019) · Molecular Biology and Evolution · doi:10.1093/molbev/msz187 · Cited by 10 · see citing works
Henley, S. A., Francis, S. M., Demone, J., Ainsworth, P., & Dick, F. A. (2010) · Cancer Cell International · doi:10.1186/1475-2867-10-8 · Cited by 9 · see citing works
Self-citationGeneration of a Retinoblastoma (Rb)1-inducible dominant-negative (DN) mouse model
Tarang, S., Doi, S. M. D. S. R., Gurumurthy, C. B., Harms, D. W., Quadros, R. M., & Rocha-Sanchez, S. M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00052 · Cited by 10 · see citing works
Regenerative Medizin in der Therapie der Innenohrschwerhörigkeit
Löwenheim, H., Waldhaus, J., Hirt, B., Sandke, S., & Müller, M. C. (2008) · HNO · doi:10.1007/s00106-008-1689-y · Cited by 7 · see citing works
Ouzounoglou, E., Dionysiou, D. D., & STAMATAKOS, G. S. (2016) · BMC Systems Biology · doi:10.1186/s12918-016-0264-5 · Cited by 7 · see citing works
Key elements of the retinoblastoma tumor suppressor pathway inVolvox carteri
Hallmann, A. (2009) · Communicative & Integrative Biology · doi:10.4161/cib.2.5.8761 · Cited by 7 · see citing works
Li, L., Hu, Q., Zhao, Y., Jiang, T., Yang, H., & Zheng, B. (2025) · New Phytologist · doi:10.1111/nph.20399 · Cited by 6 · see citing works
Increased phosphorylation on residue S795 of the retinoblastoma protein in esophageal adenocarcinoma
Davelaar, A. L., Straub, D., Parikh, K., Lau, L., Fockens, P., & Krishnadath, K. K. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.3040 · Cited by 6 · see citing works
Kugalingam, N., Silva, D. D., Abeysekera, H., Nanayakkara, S., Tirimanne, S., Ranaweera, D. M., Suravajhala, P., & Chandrasekharan, V. (2023) · BMC Medical Genomics · doi:10.1186/s12920-023-01721-6 · Cited by 4 · see citing works
Johnson, E. M., Jayabalan, R., Patra, S. K., & Suh, J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.05.539559 · Cited by 4 · see citing works
Predicted landscape of RETINOBLASTOMA‐RELATED LxCxE ‐mediated interactions across the Chloroplastida
León‐Ruiz, J. A., & Cruz‐Ramírez, A. (2022) · The Plant Journal · doi:10.1111/tpj.16012 · Cited by 3 · see citing works
Retinoblastoma protein activity revealed by CRISPRi study of divergent Rbf1 and Rbf2 paralogs
Raicu, A., Castanheira, P., & Arnosti, D. N. (2024) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkae238 · Cited by 3 · see citing works
Popov, B. V., Watt, S. M., Rosanov, J. M., & Chang, L. (2010) · Molecular Biology · doi:10.1134/s0026893310020147 · Cited by 3 · see citing works
A Reverse Structure-based Design of HPV E7 Inhibitor
Othman, S., Tan, W. C., Lim, S. K., Rashid, N. N., & Heh, C. H. (2022) · Current Computer - Aided Drug Design · doi:10.2174/1573409918666220509214449 · Cited by 2 · see citing works
The retinoblastoma protein: multitasking to suppress tumorigenesis
Vormer, T. L., Hansen, J. B., & Riele, H. T. (2015) · Molecular & Cellular Oncology · doi:10.4161/23723548.2014.968062 · Cited by 2 · see citing works
Dagnino, L., Kaur, R., & Judah, D. (2011) · InTech eBooks · doi:10.5772/22159 · Cited by 1 · see citing works
The RB Epigenetic Functions in Cancer Progression Control
Shamma, A. (2013) · Journal of Cancer Biology & Research · Cited by 1 · see citing works
Fiancette, R. (2011) · OpenGrey (Institut de l'Information Scientifique et Technique)
Zarrizi, R. (2015) · Lund University Publications (Lund University)
Amiri, M. (2014) · Scholarship@Western (Western University)
Mechanisms of interfering with HPV-induced carcinogenesis by natural products.
Chaney, T., & Renee, D. (2009) · Europe PMC (PubMed Central)
The Role of the Retinoblastoma Protein Family in Skeletal Myogenesis
Ciavarra, G. (2011) · Library and Archives Canada (Government of Canada)
Talluri, S. (2013) · Scholarship@Western (Western University)
Ganguly, A. A., & Chen, Z. (2016) · Springer eBooks · doi:10.1007/978-3-319-19674-9_29
Veit, B. E. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717954054.793461775
Keshava, K. P., Bhattacherjee, A., Ghosh, I., & Tiwari, S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.27.656056
Kugalingam, N., De Silva, D., Abeysekera, H., Nanayakkara, S., Tirimanne, S., Ranaweera, D. M., Suravajhala, P., & Chandrasekharan, V. (2024) · Figshare · doi:10.6084/m9.figshare.26636403
Kugalingam, N., De Silva, D., Abeysekera, H., Nanayakkara, S., Tirimanne, S., Ranaweera, D. M., Suravajhala, P., & Chandrasekharan, V. (2024) · Figshare · doi:10.6084/m9.figshare.26636400
Reprogrammation comportementale : modèles, algorithmes et application aux maladies complexes
Biane, C. (2018) · theses.fr (ABES) · doi:10.70675/2c367370z3ea6z46cez997czc25478fd2287
- Authors
- Dick, F. A.
- Affiliations
- Western University (CA)
- Corresponding author
- Dick, Frederick A
- ORCID
- Dick, Frederick A
- Venue
- Cell Division
- Published
- 2007
- Volume
- 2
- Issue
- 1
- Pages
- 26
- ISSN
- 1747-1028 (ISSN-L)
- PMC
- PMC2082274
- OpenAlex
- W2164026919
- Cited by
- 79
- References
- 176
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 2 · 2022: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 7 · 2015: 5 · 2014: 7 · 2013: 11 · 2012: 13
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Cell Division (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Canadian Institutes of Health Research (MOP64253)
- National Cancer Institute
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- retinoblastoma protein, tumor suppressor, E2F transcription factors, cell cycle regulation, protein-protein interaction, binding sites, crystal structure, functional domains, cell proliferation
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