Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590

The hallmarks of cancer

Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219

A method and server for predicting damaging missense mutations.

Adzhubei, I. A., Schmidt, S., Peshkin, L., Ramensky, V. E., Gerasimova, A., Bork, P., Kondrashov, A. S., & Sunyaev, S. R. (2010) · Nature Methods · doi:10.1038/nmeth0410-248 · Cited by 13,194

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

Lynch, T. J., Bell, D. W., Sordella, R., Gurubhagavatula, S., Okimoto, R. A., Brannigan, B. W., Harris, P. L., Haserlat, S. M., Supko, J. G., Haluska, F. G., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040938 · Cited by 11,486

Circos: An information aesthetic for comparative genomicsPreprint

Krzywinski, M. I., Schein, J. E., Birol, İ., Connors, J. M., Gascoyne, R. D., Horsman, D. E., Jones, S. J. M., & Marra, M. A. (2009) · Genome Research · doi:10.1101/gr.092759.109 · Cited by 11,073

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

Paez, J. G., Jänne, P. A., Lee, J. C., Tracy, S., Greulich, H., Gabriel, S., Herman, P., Kaye, F. J., Lindeman, N., Boggon, T. J., et al. (2004) · Science · doi:10.1126/science.1099314 · Cited by 9,368

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Barretina, J., Caponigro, G., Stransky, N., Venkatesan, K., Margolin, A. A., Kim, S., Wilson, C. J., Lehár, J., Kryukov, G. V., Sonkin, D., et al. (2012) · Nature · doi:10.1038/nature11003 · Cited by 7,950

Integrated genomic analyses of ovarian carcinoma

Perou, C. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/hvp3-wg08 · Cited by 7,927

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

Gerlinger, M., Rowan, A. J., Horswell, S., Larkin, J., Endesfelder, D., Gronroos, E., Martinez, P., Matthews, N., Stewart, A., Tarpey, P., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1113205 · Cited by 7,774

Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer

Kwak, E. L., Bang, Y., Camidge, D. R., Shaw, A. T., Solomon, B., Maki, R. G., Ou, S. I., Dezube, B. J., Janne, P. A., Costa, D. B., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1006448 · Cited by 4,477

Circulating Tumor Cell and Metabolites as Novel Biomarkers for Early-Stage Lung Cancer Diagnosis

Wan, L., He, Y., Liu, Q., Liang, D., Guo, Y., 刘广杰, Ren, J., & Shan, B. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.630672 · Cited by 31

Complementary Sequential Circulating Tumor Cell (CTC) and Cell-Free Tumor DNA (ctDNA) Profiling Reveals Metastatic Heterogeneity and Genomic Changes in Lung Cancer and Breast Cancer

Kong, S. L., Liu, X., Tan, S. J., Tai, J. A., Phua, L. Y., Poh, H. M., Yeo, T., Chua, Y. W., Haw, Y. X., Ling, W. H., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.698551 · Cited by 31

WNT Signalling in Lung Physiology and Pathology

Hu, Y., Ciminieri, C., Hu, Q., Lehmann, M., Königshoff, M., & Gosens, R. (2021) · Handbook of experimental pharmacology · doi:10.1007/164_2021_521 · Cited by 31

EFNA3 as a predictor of clinical prognosis and immune checkpoint therapy efficacy in patients with lung adenocarcinoma

Deng, M., Tong, R., Zhang, Z., Wang, T., Liang, C.-N., Zhou, X., & Hou, G. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02226-x · Cited by 33

Discordance of Mutation Statuses of Epidermal Growth Factor Receptor and K-ras between Primary Adenocarcinoma of Lung and Brain Metastasis

Rau, K., Chen, H.-K., Shiu, L., Chao, T.-L., Lo, Y.-P., Wang, C., Lin, M., & Huang, C. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040524 · Cited by 31

RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation

Kopparam, J., Chiffelle, J., Angelino, P., Piersigilli, A., Zangger, N., Delorenzi, M., & Meylan, E. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.81 · Cited by 31

Targeting genome integrity dysfunctions impedes metastatic potency in non–small cell lung cancer circulating tumor cell–derived explants

Tayoun, T., Faugeroux, V., Oulhen, M., Déas, O., Michels, J., Brullé, L., Cairo, S., Scoazec, J., Marty, V., Aberlenc, A., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.155804 · Cited by 33

Mutations in RIT1 cause Noonan syndrome with possible juvenile myelomonocytic leukemia but are not involved in acute lymphoblastic leukemia

Cavé, H., Caye‐Eude, A., Ghedira, N., Capri, Y., Pouvreau, N., Fillot, N., Trimouille, A., Vignal, C., Fenneteau, O., Alembik, Y., et al. (2016) · European Journal of Human Genetics · doi:10.1038/ejhg.2015.273 · Cited by 30

Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer

Ni, T. K., & Kuperwasser, C. (2016) · eLife · doi:10.7554/elife.14730 · Cited by 31

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment

Zaman, A., & Bivona, T. G. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.05.02 · Cited by 29

Adoptive cell therapy with tumour-infiltrating lymphocytes: the emerging importance of clonal neoantigen targets for next-generation products in non-small cell lung cancer

Robertson, J. D., Salm, M., & Dangl, M. (2019) · Immuno-Oncology Technology · doi:10.1016/j.iotech.2019.09.003 · Cited by 31

Cellular Heterogeneity–Adjusted cLonal Methylation (CHALM) improves prediction of gene expression

Xu, J., Shi, J., Cui, X., Cui, Y., Li, J. J., Goel, A., Chen, X., Issa, J. J., Su, J., & Li, W. (2021) · Nature Communications · doi:10.1038/s41467-020-20492-7 · Cited by 31

Survival analysis for non-squamous NSCLC patients harbored STK11 or KEAP1 mutation receiving atezolizumab

Shang, X., Li, Z., Sun, J., Zhao, C., Lin, J., & Wang, H. (2021) · Lung Cancer · doi:10.1016/j.lungcan.2021.02.010 · Cited by 30

Characterization With KRAS Mutant Is a Critical Determinant in Immunotherapy and Other Multiple Therapies for Non-Small Cell Lung Cancer

Shen, M., Qi, R., Ren, J., Lv, D., & Yang, H. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2021.780655 · Cited by 31

Prevalence of KRAS p.(G12C) in stage IV NSCLC patients in the Netherlands; a nation-wide retrospective cohort study

Garcia, B. N. C., van Kempen, L. C. L. T., Kuijpers, C. C. H. J., Schuuring, E. M. D., Willems, S. M., & van der Wekken, A. J. (2022) · Lung Cancer · doi:10.1016/j.lungcan.2022.03.015 · Cited by 30

Somatic Mutations in Core Spliceosome Components Promote Tumorigenesis and Generate an Exploitable Vulnerability in Human Cancer

Sette, C., & Paronetto, M. P. (2022) · Cancers · doi:10.3390/cancers14071827 · Cited by 30

ECT 2 amplification and overexpression as a new prognostic biomarker for early‐stage lung adenocarcinoma

Murata, Y., Minami, Y., Iwakawa, R., Yokota, J., Usui∥, S., Tsuta, K., Shiraishi, K., Sakashita, S., Satomi, K., Iijima, T., et al. (2014) · Cancer Science · doi:10.1111/cas.12363 · Cited by 30

Genomic and Transcriptional Alterations in Lung Adenocarcinoma in Relation to Smoking History

Karlsson, A., Ringnér, M., Lauss, M., Botling, J., Micke, P., Planck, M., & Staaf, J. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-0246 · Cited by 29

Dissecting Pulmonary Large-Cell Carcinoma by Targeted Next Generation Sequencing of Several Cancer Genes Pushes Genotypic-Phenotypic Correlations to Emerge

Pelosi, G., Fabbri, A., Papotti, M. G., Rossi, G., Cavazza, A., Righi, L., Tamborini, E., Perrone, F., Settanni, G., Busico, A., et al. (2015) · Journal of Thoracic Oncology · doi:10.1097/jto.0000000000000658 · Cited by 30

SMT and TOFT: Why and How They are Opposite and Incompatible Paradigms

Bizzarri, M., & Cucina, A. (2016) · Acta Biotheoretica · doi:10.1007/s10441-016-9281-4 · Cited by 31

In silico learning of tumor evolution through mutational time series

Auslander, N., Wolf, Y. I., & Koonin, E. V. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901695116 · Cited by 27

Silencing of LINC00461 enhances radiosensitivity of lung adenocarcinoma cells by down‐regulating HOXA10 via microRNA‐195

Hou, J., Wang, Y., Zhang, H., Hu, Y., Xin, X., & Li, X. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14859 · Cited by 30

Analysis of intratumor heterogeneity unravels lung cancer evolution

de Bruin, E. C., McGranahan, N., & Swanton, C. (2015) · Molecular & Cellular Oncology · doi:10.4161/23723556.2014.985549 · Cited by 29

Strategies for improving outcomes in NSCLC: A look to the future

Stahel, R. A., Peters, S., Baas, P., Brambilla, E. M., Cappuzzo, F., Ruysscher, D. D., Eberhardt, W., Felip, E., Fennell, D. A., Marchetti, A., et al. (2013) · Lung Cancer · doi:10.1016/j.lungcan.2013.08.025 · Cited by 29

Therapeutic approach to treating patients with BRAF-mutant lung cancer: latest evidence and clinical implications

de Langen, A. J., & Smit, E. F. (2016) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758834016670555 · Cited by 31

Epigenetic Regulation of the Epithelial to Mesenchymal Transition in Lung Cancer

Roche, J., Gemmill, R. M., & Drabkin, H. A. (2017) · Cancers · doi:10.3390/cancers9070072 · Cited by 31

Advancements in CRISPR/Cas9 technology—Focusing on cancer therapeutics and beyond

Mirza, Z., & Karim, S. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.05.026 · Cited by 29

SP1 induced long non-coding RNA LINC00958 overexpression facilitate cell proliferation, migration and invasion in lung adenocarcinoma via mediating miR-625-5p/CPSF7 axis

Yang, L., Li, X., Zhou, Z., Liu, Y., Sun, J., Zhang, X., Pan, H.-Y., & Liu, S. (2020) · Cancer Cell International · doi:10.1186/s12935-020-1099-0 · Cited by 29

Driver and novel genes correlated with metastasis of non-small cell lung cancer: A comprehensive analysis

Wu, Y., Ni, H., Yang, D., Niu, Y., Chen, K., Xu, J., Wang, F., Tang, S., Shi, Y., Zhang, H., et al. (2021) · Pathology - Research and Practice · doi:10.1016/j.prp.2021.153551 · Cited by 29

Natural Compounds Targeting Major Signaling Pathways in Lung Cancer

Kumar, S., Sharma, A. K., Lalhlenmawia, H., & Kumar, D. (2021) · Springer eBooks · doi:10.1007/978-981-33-6827-9_37 · Cited by 29

Targeting Receptor Tyrosine Kinases in Cancer

Köstler, W. J., & Zielinski, C. C. (2014) · Springer eBooks · doi:10.1007/978-1-4939-2053-2_10 · Cited by 26

Factors associated with a poor response to gefitinib in the NEJ002 study: Smoking and the L858R mutation

Fukuhara, T., Maemondo, M., Inoue, A., Kobayashi, K., Sugawara, S., Oizumi, S., Isobe, H., Gemma, A., Harada, M., Yoshizawa, H., et al. (2015) · Lung Cancer · doi:10.1016/j.lungcan.2015.02.004 · Cited by 29

ContrastRank: a new method for ranking putative cancer driver genes and classification of tumor samples

Tian, R., Basu, M. K., & Capriotti, E. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu466 · Cited by 29

The molecular landscape of synchronous colorectal cancer reveals genetic heterogeneity

Wang, X., Hu, F., Cheng, Y., Li, L., Sun, X., Fu, T., Huang, P., Zhang, A., Feng, Z., Li, C., et al. (2018) · Carcinogenesis · doi:10.1093/carcin/bgy040 · Cited by 29

Src Family Tyrosine Kinase Signaling Regulates FilGAP through Association with RBM10

Yamada, H., Tsutsumi, K., Nakazawa, Y., Shibagaki, Y., Hattori, S., & Ohta, Y. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146593 · Cited by 28

Personalized treatment of advanced non-small-cell lung cancer in routine clinical practice

Pirker, R., & Filipits, M. (2016) · Cancer and Metastasis Reviews · doi:10.1007/s10555-016-9612-6 · Cited by 28

Targeted deep sequencing improves outcome stratification in chronic myelomonocytic leukemia with low risk cytogenetic features

Palomo, L., García, O., Arnan, M., Xicoy, B., Fuster‐Tormo, F., Cabezón, M., Coll, R., Ademà, V., Grau, J., Jimenez, M. J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10937 · Cited by 28

Discovery of targetable genetic alterations in advanced non-small cell lung cancer using a next-generation sequencing-based circulating tumor DNA assay

Hou, H., Yang, X., Zhang, J., Zhang, Z., Xu, X., Zhang, X., Zhang, C., Liu, D., Yan, W., Zhu, H., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-14962-0 · Cited by 28

Beyond tissue biopsy: a diagnostic framework to address tumor heterogeneity in lung cancer

Voigt, W., Manegold, C., Pilz, L. R., Wu, Y.-L. L. C., Müllauer, L., Pirker, R., Filipits, M., Nikliński, J., Petruzelka, L. B., & Prosch, H. (2019) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000598 · Cited by 29

Coexisting EGFR and TP53 Mutations in Lung Adenocarcinoma Patients Are Associated With COMP and ITGB8 Upregulation and Poor Prognosis

Zheng, C. J., Li, X., Ren, Y., Yin, Z., & Zhou, B. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00030 · Cited by 28

Identification and Validation of Immune-Related LncRNA Prognostic Signature for Lung Adenocarcinoma

Wu, G., Wang, Q., Zhu, T., Fu, L., Li, Z., Wu, Y., & Zhang, C. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.681277 · Cited by 28

Molecular charcterization of lung adenocarcinoma combining whole exome sequencing, copy number analysis and gene expression profiling

Testa, U., Pelosi, E., & Castelli, G. (2021) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2022.2017774 · Cited by 28

GSTM3 deficiency impedes DNA mismatch repair to promote gastric tumorigenesis via CAND1/NRF2-KEAP1 signaling

Chen, T., Jinlin, D., Wang, F., Yuan, Z., Xue, J., Lu, T., Huang, W., Liu, Y., & Zhang, Y. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215692 · Cited by 28

R-loops, type I topoisomerases and cancer

Saha, S. T., & Pommier, Y. G. (2023) · NAR Cancer · doi:10.1093/narcan/zcad013 · Cited by 27

Transforming growth factor-beta signaling network regulates plasticity and lineage commitment of lung cancer cells

Ischenko, I., Liu, J., Petrenko, O., & Hayman, M. J. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.38 · Cited by 28

Disease mutant analysis identifies a novel function of DAXX in telomerase regulation and telomere maintenance

Tang, M., Li, Y., Zhang, Y., Chen, Y., Huang, W., Wang, D., Zaug, A. J., Liu, D., Zhao, Y. B., Cech, T. R., et al. (2014) · Journal of Cell Science · doi:10.1242/jcs.159467 · Cited by 27

Cancer-Associated Mutations Mapped on High-Resolution Structures of the U2AF2 RNA Recognition Motifs

Glasser, E., Agrawal, A. A., Jenkins, J. L., & Kielkopf, C. L. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b00551 · Cited by 29

SERINC2‑knockdown inhibits proliferation, migration and invasion in lung adenocarcinoma

Zeng, Y., Xiao, D., He, H., He, J., Pan, H., Yang, W., Chen, Y., & He, J. (2018) · Oncology Letters · doi:10.3892/ol.2018.9403 · Cited by 28

High-throughput RNAi screening reveals cancer-selective lethal targets in the RNA spliceosome

Blijlevens, M., van der Meulen‐Muileman, I. H., de Menezes, R. X., Smit, E. F., & van Beusechem, V. W. (2019) · Oncogene · doi:10.1038/s41388-019-0711-z · Cited by 27

Visualizing biological data

Wong, B. (2012) · Nature Methods · doi:10.1038/nmeth.2258 · Cited by 28

Prevalence and Therapeutic Targeting of High-Level ERBB2 Amplification in NSCLC

Odintsov, I., Makarem, M., Nishino, M., Bachert, S. E., Zhang, T., LoPiccolo, J., Paweletz, C. P., Gokhale, P. C., Ivanova, E. V., Saldanha, A. L., et al. (2023) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2023.12.019 · Cited by 27

Anakoinosis: Communicative Reprogramming of Tumor Systems - for Rescuing from Chemorefractory Neoplasia

Hart, C., Vogelhuber, M., Wolff, D., Klobuch, S., Ghibelli, L., Foell, J. L., Corbacioglu, S., Rehe, K., Haegeman, G., Thomas, S., et al. (2015) · Cancer Microenvironment · doi:10.1007/s12307-015-0170-1 · Cited by 27

Proteomic signatures associated with p53 mutational status in lung adenocarcinoma

Taguchi, A., Delgado, O., Çeliktaş, M., Katayama, H., Wang, H., Gazdar, A. F., & Hanash, S. (2014) · PROTEOMICS · doi:10.1002/pmic.201400378 · Cited by 28

Genomic Rearrangements Define Lineage Relationships between Adjacent Lepidic and Invasive Components in Lung Adenocarcinoma

Murphy, S. J., Wigle, D. A., Lima, J. F., Harris, F. R., Johnson, S. H., Halling, G. C., Asiedu, M. K., Seto, C. T., Terra, S. B. S. P., Kosari, F., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-1727 · Cited by 27

Histology-Related Associations of ERCC1, RRM1, and TS Biomarkers in Patients with Non–Small-Cell Lung Cancer: Implications for Therapy

Maus, M. K. H., Mack, P. C., Astrow, S. H., Stephens, C. L., Zeger, G. D., Grimminger, P., Hsiang, J., Huang, E. C., Li, T., Lara, P. N., et al. (2013) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e318287c3c5 · Cited by 27

Evaluation of an integrated clinical workflow for targeted next-generation sequencing of low-quality tumor DNA using a 51-gene enrichment panel

Choudhary, A., Mambo, E., Sanford, T., Boedigheimer, M. J., Twomey, B., Califano, J. A., Hadd, A. G., Oliner, K. S., Beaudenon, S. L., Latham, G. J., et al. (2014) · BMC Medical Genomics · doi:10.1186/s12920-014-0062-0 · Cited by 27

Characterization of the cell of origin and propagation potential of the fibroblast growth factor 9-induced mouse model of lung adenocarcinoma

Arai, D., Hegab, A., Soejima, K., Kuroda, A., Ishioka, K., Yasuda, H., Naoki, K., Kagawa, S., Hamamoto, J., Yin, Y.-J., et al. (2014) · Journal of Pathology · doi:10.1002/path.4486 · Cited by 25

Identification of an “Exceptional Responder” Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy

Gannon, H., Kaplan, N. O., Tsherniak, A., Vázquez, F., Weir, B. A., Hahn, W. C., & Meyerson, M. M. (2015) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-15-0321 · Cited by 27

Genomic Testing in Lung Cancer: Past, Present, and Future

Mascaux, C., Tsao, M., & Hirsch, F. R. (2018) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2017.7019 · Cited by 27

DNA methylation profiling analysis identifies a DNA methylation signature for predicting prognosis and recurrence of lung adenocarcinoma

Wang, R. Y., Zhu, H., Yang, M., & Zhu, C. (2019) · Oncology Letters · doi:10.3892/ol.2019.10931 · Cited by 27

Diagnostic significance and prognostic role of the ARID1A gene in cancer outcomes (Review)

Pavlidou, E., & Balis, V. (2020) · World Academy of Sciences Journal · doi:10.3892/wasj.2020.37 · Cited by 28

Genomics and Functional Genomics of Malignant Pleural Mesothelioma

Çakıroğlu, E., & Şentürk, Ş. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176342 · Cited by 29

Medicinal herbs and bioactive compounds overcome the drug resistance to epidermal growth factor receptor inhibitors in non‑small cell lung cancer (Review)

Lee, H., Meng, M., Liu, Y., Su, T., & Kwan, H. Y. (2021) · Oncology Letters · doi:10.3892/ol.2021.12907 · Cited by 29

Co-Mutation of FAT3 and LRP1B in Lung Adenocarcinoma Defines a Unique Subset Correlated With the Efficacy of Immunotherapy

Zhu, M., Zhang, L., Cui, H., Zhao, Q., Wang, H., Zhai, B., Jiang, R., & Jiang, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.800951 · Cited by 30

The recent advancements in circRNA research: From biogenesis to therapeutic interventions

Malviya, A., & Bhuyan, R. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154697 · Cited by 31

Rhabdoid Tumors: An Initial Clue to the Role of Chromatin Remodeling in Cancer

Lee, R. S., & Roberts, C. W. M. (2013) · Brain Pathology · doi:10.1111/bpa.12021 · Cited by 27

Pathogenic mechanisms of lung adenocarcinoma in smokers and non-smokers determined by gene expression interrogation

Hu, Y., & Chen, G. (2015) · Oncology Letters · doi:10.3892/ol.2015.3462 · Cited by 27

The evolving role of cancer cell line-based screens to define the impact of cancer genomes on drug response

Garnett, M. J., & McDermott, U. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.12.002 · Cited by 27

Genomic Alteration During Metastasis of Lung Adenocarcinoma

Tan, Q., Cui, J., Huang, J. M., Ding, Z., Lin, H., Niu, X., Li, Z., Wang, G., Luo, Q., & Lu, S. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000438644 · Cited by 28

Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer

Beck, T. N., Chikwem, A. J., Solanki-Patel, N., & Golemis, E. A. (2014) · Physiological Genomics · doi:10.1152/physiolgenomics.00062.2014 · Cited by 26

Inhibiting the RAS–PI3K Pathway in Cancer Therapy

Sheridan, C., & Downward, J. (2013) · The Enzymes · doi:10.1016/b978-0-12-420146-0.00005-6 · Cited by 25

c-Cbl mediates the degradation of tumorigenic nuclear β-catenin contributing to the heterogeneity in Wnt activity in colorectal tumors

Shashar, M., Siwak, J. F., Tapan, Ü., Lee, S. Y., Meyer, R., Parrack, P. H., Tan, J. N. M., Khatami, F., Francis, J. M., Zhao, Q., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.12107 · Cited by 26

Long non-coding RNA LINC00485 acts as a microRNA-195 sponge to regulate the chemotherapy sensitivity of lung adenocarcinoma cells to cisplatin by regulating CHEK1

Zuo, W., Zhang, W., Xu, F., Zhou, J., & Bai, W. (2019) · Cancer Cell International · doi:10.1186/s12935-019-0934-7 · Cited by 26

Epigenetic Control of a Local Chromatin Landscape

Chiarella, A. M., Lu, D., & Hathaway, N. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030943 · Cited by 31

High expression of PKM2 synergizes with PD-L1 in tumor cells and immune cells to predict worse survival in human lung adenocarcinoma

Long, L., Chen, M., Yuan, Y. J., Ming, A. L., Guo, W., Wu, K., & Chen, H. (2020) · Journal of Cancer · doi:10.7150/jca.42610 · Cited by 27

Innovative Therapeutic and Delivery Approaches Using Nanotechnology to Correct Splicing Defects Underlying Disease

Suñé-Pou, M., Limeres, M. J., Moreno‐Castro, C., Hernández-Munaín, C., Suñé-Negre, J. M., Cuestas, M. L., & Suñé, C. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00731 · Cited by 27

AURKA and FAM83A are prognostic biomarkers and correlated with Tumor-infiltrating Lymphocytes in smoking related Lung Adenocarcinoma

Zhang, M., Chen, H., Jiang, Y., Liu, J., Yang, Y.-C., Yin, Y., & Qu, Y.-Q. (2021) · Journal of Cancer · doi:10.7150/jca.51321 · Cited by 26

Discoidin domain receptor inhibitors as anticancer agents: A systematic review on recent development of DDRs inhibitors, their resistance and structure activity relationship

Shenoy, G. P., Pal, R., Matada, G. S. P., Singh, E., Raghavendra, N. M., & Dhiwar, P. S. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.106215 · Cited by 26

Spectrum of germline mutations in smokers and non-smokers in Brazilian non-small-cell lung cancer (NSCLC) patients

Couto, P. P., Bastos‐Rodrigues, L., Schayek, H., Melo, F. M., Cardenas, R. G. C. D. C. L., de Miranda, D. M., Vilhena, A. F., Bale, A. E., Friedman, E., & Marco, L. A. D. (2017) · Carcinogenesis · doi:10.1093/carcin/bgx089 · Cited by 26

The Pan-Cancer Landscape of Coamplification of the Tyrosine Kinases KIT, KDR, and PDGFRA

Dişel, U., Madison, R. W., Abhishek, K., Chung, J., Trabucco, S. E., Matos, A. O., Frampton, G. M., Albacker, L. A., Reddy, V. P., Karadurmuş, N., et al. (2019) · The Oncologist · doi:10.1634/theoncologist.2018-0528 · Cited by 27

Expression of OPN3 in lung adenocarcinoma promotes epithelial‐mesenchymal transition and tumor metastasis

Xu, C., Wang, R., Yang, Y., Xu, T., Li, Y., Xu, J., & Jiang, Z. (2019) · Thoracic Cancer · doi:10.1111/1759-7714.13254 · Cited by 25

Hydroxychloroquine suppresses lung tumorigenesis via inducing FoxO3a nuclear translocation through STAT3 inactivation

Lyu, X., Zeng, L., Zhang, H., Ke, Y., Liu, X., Zhao, N., Yuan, J., Chen, G., & Yang, S. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117366 · Cited by 25

mTOR in Lung Neoplasms

Krencz, I., Sebestyén, A. R., & Khoór, A. (2020) · Pathology & Oncology Research · doi:10.1007/s12253-020-00796-1 · Cited by 26

RBM10, a New Regulator of p53

Jung, J. H., Lee, H., Zeng, S. X., & Lu, H. (2020) · Cells · doi:10.3390/cells9092107 · Cited by 27

Immunohistochemistry-based prognostic biomarkers in NSCLC: novel findings on the road to clinical use?

Lindskog, C., Edlund, K., Mattsson, J. S. M., & Micke, P. (2015) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2015.1002772 · Cited by 25

MET Gene Amplification and MET Receptor Activation Are Not Sufficient to Predict Efficacy of Combined MET and EGFR Inhibitors in EGFR TKI-Resistant NSCLC Cells

Presutti, D., Santini, S., Cardinali, B., Papoff, G., Lalli, C., Samperna, S., Fustaino, V., Giannini, G., & Ruberti, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143333 · Cited by 25

Mutations of RNA splicing factors in hematological malignancies

Shukla, G. C., & Singh, J. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.08.042 · Cited by 25

IGFBP7 Drives Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition in Lung Cancer

Wu, S., Chang, T., Tsai, M., Liu, Y., Hsu, C., Chang, Y., Yu, C., & Shih, J. (2019) · Cancers · doi:10.3390/cancers11010036 · Cited by 25

RNA-binding motif protein 10 represses tumor progression through the Wnt/β- catenin pathway in lung adenocarcinoma

Cao, Y., Geng, J., Wang, X., Meng, Q., Xu, S., Lang, Y., Zhou, Y., Qi, L., Wang, Z., Wei, Z., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.63598 · Cited by 25

The engagement of histone lysine methyltransferases with nucleosomes: structural basis, regulatory mechanisms, and therapeutic implications

Li, Y., Ge, K., Li, T., Run, C., & Chen, Y. (2022) · Protein & Cell · doi:10.1093/procel/pwac032 · Cited by 25

RET rearrangements in non-small cell lung cancer: Evolving treatment landscape and future challenges

Servetto, A., Esposito, D., Ferrara, R., Signorelli, D., Belli, S., Napolitano, F., Santaniello, A., Ciciola, P., Formisano, L., & Bianco, R. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188810 · Cited by 25

MYC Synergizes with Activated BRAFV600E in Mouse Lung Tumor Development by Suppressing Senescence

Tabor, V., Bocci, M., Alikhani, N., Kuiper, R., & Larsson, L. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3234 · Cited by 25

Collection, integration and analysis of cancer genomic profiles: from data to insight

Gao, J., Ciriello, G., Sander, C., & Schultz, N. D. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.12.003 · Cited by 25

Genes associated with succeptibility to lung adenocarcinoma among never smokers suggest the mechanism of disease.

Okazaki, I., Ishikawa, S., & Sohara, Y. (2014) · PubMed · Cited by 26

Cell death in cancer therapy of lung adenocarcinoma

Zagryazhskaya, A., Gyurászová, K., & Zhivotovsky, B. (2015) · The International Journal of Developmental Biology · doi:10.1387/ijdb.150044bz · Cited by 25

EphB4: A promising target for upper aerodigestive malignancies

Salgia, R., Kulkarni, P., & GILL, P. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.01.003 · Cited by 25

Profiling the Mutational Landscape in Known Driver Genes and Novel Genes in African American Non–Small Cell Lung Cancer Patients

Lusk, C. M., Watza, D., Dyson, G. E., Craig, D., Ratliff, V., Wenzlaff, A. S., Lonardo, F., Bollig-Fischer, A. B., Bepler, G., Purrington, K. S., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-2439 · Cited by 25

High CTHRC1 expression may be closely associated with angiogenesis and indicates poor prognosis in lung adenocarcinoma patients

Chen, Y., Sun, Y., Cui, Y., Lei, Y., Jiang, N., Jiang, W., Wang, H., Chen, L., Luo, J., Chen, Y., et al. (2019) · Cancer Cell International · doi:10.1186/s12935-019-1041-5 · Cited by 25

Dasatinib–SIK2 Binding Elucidated by Homology Modeling, Molecular Docking, and Dynamics Simulations

Shi, M., Wang, L., Li, P., Liu, J., Chen, L., & Xu, D. (2021) · ACS Omega · doi:10.1021/acsomega.1c00947 · Cited by 27

Abstract 1112: Whole exome and whole genome sequence analysis of lung adenocarcinoma.

Chmielecki, J., Rosenberg, M. W., Imielinski, M. B., Hernandez, B., Lawrence, M. S., Sivachenko, A., Cibulskis, K., Voet, D., Sougnez, C. L., Gabriel, S., et al. (2013) · Cancer Research · doi:10.1158/1538-7445.am2013-1112

Somatic mutations affect key pathways in lung adenocarcinoma

Ding, L., Getz, G., Wheeler, D. A., Mardis, E. R., McLellan, M. D., Cibulskis, K., Sougnez, C., Greulich, H., Muzny, D. M., Morgan, M. B., et al. (2008) · Nature · doi:10.1038/nature07423 · Cited by 2,681

Abstract 1113: The comprehensive mutational profiling of lung adenocarcinoma through large-scale RNA sequencing analysis.

Lee, W., Ju, Y. S., Shin, J.-Y., Lee, J. J.-K., Bleazard, T., Lee, J.-H., Kim, J.-O., Yu, S.-B., Kim, J., Rhee, H., et al. (2013) · Cancer Research · doi:10.1158/1538-7445.am2013-1113

Abstract 1682: Uncovering signals of somatic selection through whole exome and whole genome sequencing of lung adenocarcinoma

Imielinski, M. B., Hernandez, B., Lawrence, M. S., Hodis, E., Kryukov, G., Stojanov, P., Sivachenko, A., Cibulskis, K., Sougnez, C. L., Auclair, D., et al. (2012) · Cancer Research · doi:10.1158/1538-7445.am2012-1682

The transcriptional landscape and mutational profile of lung adenocarcinomaPreprint

Seo, J., Ju, Y. S., Lee, W., Shin, J.-Y., Lee, J. J.-K., Bleazard, T., Lee, J., Jung, Y. J., Kim, J. O., Shin, J.-Y., et al. (2012) · Genome Research · doi:10.1101/gr.145144.112 · Cited by 603